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Health Sciences staff profiles

Associate Professor Greg Anderson

PositionAssociate Professor
DepartmentDepartment of Anatomy
QualificationsBSc(Hons) PhD (Linc)
Research summaryNeuroendocrinology

Research

The neuroendocrine control of reproduction.

Dr Anderson's neuroendocrinology research group focuses on the neuroendocrine regulation of fertility by nutritional factors (leptin, insulin and ghrelin) and novel neuropeptides (RFamide-related peptide or gonadotrophin inhibitory hormone). The group also investigates effects of reproductive experience on central effects of prolactin. The Anderson Neuroendocrinology Research Group forms one of the laboratories that make up the University of Otago's Centre for Neuroendocrinology (www.neuroendocrinology.otago.ac.nz).

Research Interests

  1. The neural pathways by which the central drivers of fertility, GnRH neurons, sense the hormone leptin in order to respond to the animal's nutritional status (Health Research Council funded).
  2. The mechanisms by which the recently-discovered brain peptide RFRP-3 regulates GnRH and LH secretion in mammals (Marsden funded)..

    Using a combination of transgenic animal models, single cell measurement techniques and visualisation of cell signalling in specific target neurons, we hope to elucidate the neural pathways by which leptin and GnIH regulate reproduction. This knowledge may lead to new and improved treatment strategies for infertility. In addition, we may discover novel neurochemical targets that could be safely exploited for contraceptive purposes.

Publications

Evans, M. C., & Anderson, G. M. (2017). Neuroendocrine integration of nutritional signals on reproduction. Journal of Molecular Endocrinology, 58(2), R107-R128. doi: 10.1530/jme-16-0212

Evans, M. C., & Anderson, G. M. (2017). Dopamine neuron-restricted leptin receptor (Lepr) signaling reduces some aspects of food reward but exacerbates the obesity of Lepr-deficient male mice. Endocrinology. Advance online publication. doi: 10.1210/en.2017-00513

Ancel, C., Inglis, M. A., & Anderson, G. M. (2017). Central RFRP-3 stimulates LH secretion in male mice and has cycle stage-dependent inhibitory effects in females. Endocrinology. Advance online publication. doi: 10.1210/en.2016-1902

Egan, O. K., Inglis, M. A., & Anderson, G. M. (2017). Leptin signalling in AgRP neurons modulates puberty onset and adult fertility in mice. Journal of Neuroscience. Advance online publication. doi: 10.1523/jneurosci.3138-16.2017

Kim, J. S., Brown, C. H., & Anderson, G. M. (2016). Anti-opioid effects of RFRP-3 on magnocellular neuron activity in morphine-naïve and morphine-treated female rats. Endocrinology, 157(10), 4003-4011. doi: 10.1210/en.2016-1374

Journal - Research Article

Evans, M. C., & Anderson, G. M. (2017). Neuroendocrine integration of nutritional signals on reproduction. Journal of Molecular Endocrinology, 58(2), R107-R128. doi: 10.1530/jme-16-0212

Egan, O. K., Inglis, M. A., & Anderson, G. M. (2017). Leptin signalling in AgRP neurons modulates puberty onset and adult fertility in mice. Journal of Neuroscience. Advance online publication. doi: 10.1523/jneurosci.3138-16.2017

Ancel, C., Inglis, M. A., & Anderson, G. M. (2017). Central RFRP-3 stimulates LH secretion in male mice and has cycle stage-dependent inhibitory effects in females. Endocrinology. Advance online publication. doi: 10.1210/en.2016-1902

Evans, M. C., & Anderson, G. M. (2017). Dopamine neuron-restricted leptin receptor (Lepr) signaling reduces some aspects of food reward but exacerbates the obesity of Lepr-deficient male mice. Endocrinology. Advance online publication. doi: 10.1210/en.2017-00513

Kim, J. S., Brown, C. H., & Anderson, G. M. (2016). Anti-opioid effects of RFRP-3 on magnocellular neuron activity in morphine-naïve and morphine-treated female rats. Endocrinology, 157(10), 4003-4011. doi: 10.1210/en.2016-1374

Kim, J. S., Rizwan, M. Z., Clegg, D. J., & Anderson, G. M. (2016). Leptin signaling is not required for anorexigenic estradiol effects in female mice. Endocrinology. doi: 10.1210/en.2015-1594

Zuure, W. A., Quennell, J. H., & Anderson, G. M. (2016). Leptin responsive and GABAergic projections to the rostral preoptic area in mice. Journal of Neuroendocrinology, 28(3). doi: 10.1111/jne.12357

Decourt, C., Anger, K., Robert, V., Lomet, D., Bartzen-Sprauer, J., Caraty, A., … Anderson, G., & Beltramo, M. (2016). No evidence that RFamide related peptide 3 directly modulates LH secretion in the ewe. Endocrinology, 157(4), 1566-1575. doi: 10.1210/en.2015-1854

Decourt, C., Robert, V., Anger, K., Galibert, M., Madinier, J.-B., Liu, X., … Herbison, A. E., Anderson, G. M., … Beltramo, M. (2016). A synthetic kisspeptin analog that triggers ovulation and advances puberty. Scientific Reports, 6, 26908. doi: 10.1038/srep26908

McEwen, H. J. L., Inglis, M. A., Quennell, J. H., Grattan, D. R., & Anderson, G. M. (2016). Deletion of suppressor of cytokine signaling 3 from forebrain neurons delays infertility and onset of hypothalamic leptin resistance in response to a high caloric diet. Journal of Neuroscience, 36(27), 7142-7153. doi: 10.1523/jneurosci.2714-14.2016

Evans, M. C., Rizwan, M. Z., & Anderson, G. M. (2015). Insulin does not target CamkIIα neurones to critically regulate the neuroendocrine reproductive axis in mice. Journal of Neuroendocrinology, 27(12), 899-910. doi: 10.1111/jne.12330

Kim, J. S., Brownjohn, P. W., Dyer, B. S., Beltramo, M., Walker, C. S., Hay, D. L., … Tyndall, J. D. A., & Anderson, G. M. (2015). Anxiogenic and stressor effects of the hypothalamic neuropeptide RFRP-3 are overcome by the NPFFR antagonist GJ14. Endocrinology, 156(11), 4152-4162. doi: 10.1210/en.2015-1532

Rizwan, M. Z., Harbid, A. A., Inglis, M. A., Quennell, J. H., & Anderson, G. M. (2014). Evidence that hypothalamic RFamide related peptide-3 neurones are not leptin-responsive in mice and rats. Journal of Neuroendocrinology, 26(4), 247-257. doi: 10.1111/jne.12140

Evans, M. C., Rizwan, M., Mayer, C., Boehm, U., & Anderson, G. M. (2014). Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice. Journal of Neuroendocrinology, 26(7), 468-479. doi: 10.1111/jne.12166

Evans, M. C., Rizwan, M. Z., & Anderson, G. M. (2014). Insulin action on GABA neurons is a critical regulator of energy balance but not fertility in mice. Endocrinology, 155(11), 4368-4379. doi: 10.1210/en.2014-1412

Singireddy, A. V., Inglis, M. A., Zuure, W. A., Kim, J. S., & Anderson, G. M. (2013). Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice. Endocrinology, 154(7), 2434-2445. doi: 10.1210/en.2013-1109

Zuure, W. A., Roberts, A. L., Quennell, J. H., & Anderson, G. M. (2013). Leptin signaling in GABA neurons, but not glutamate neurons, is required for reproductive function. Journal of Neuroscience, 33(45), 17874-17883. doi: 10.1523/jneurosci.2278-13.2013

Harbid, A. A., McLeod, B. J., Caraty, A., & Anderson, G. M. (2013). Seasonal changes in RFamide-related peptide-3 neurons in the hypothalamus of a seasonally breeding marsupial species, the brushtail possum (Trichosurus vulpecula). Journal of Comparative Neurology, 521(13), 3030-3041. doi: 10.1002/cne.23328

Poling, M. C., Quennell, J. H., Anderson, G. M., & Kauffman, A. S. (2013). Kisspeptin neurones do not directly signal to RFRP-3 neurones but RFRP-3 may directly modulate a subset of hypothalamic kisspeptin cells in mice. Journal of Neuroendocrinology, 25(10), 876-886. doi: 10.1111/jne.12084

Rizwan, M. Z., Poling, M. C., Corr, M., Cornes, P. A., Augustine, R. A., Quennell, J. H., … Anderson, G. M. (2012). RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology, 153(8), 3770-3779. doi: 10.1210/en.2012-1133

Evans, J. J., & Anderson, G. M. (2012). Balancing ovulation and anovulation: Integration of the reproductive and energy balance axes by neuropeptides. Human Reproduction Update, 18(3), 313-332. doi: 10.1093/humupd/dms004

Quennell, J. H., Howell, C. S., Roa, J., Augustine, R. A., Grattan, D. R., & Anderson, G. M. (2011). Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology, 152(4), 1541-1550. doi: 10.1210/en.2010-1100

Anderson, G. M. (2011). Pituitary actions of RFamide peptides: A critique of the evidence. Open Neuroendocrinology Journal, 4, 51-63. doi: 10.2174/1876528901104010051

Sjoeholm, A., Bridges, R. S., Grattan, D. R., & Anderson, G. M. (2011). Region-, neuron-, and signaling pathway-specific increases in prolactin responsiveness in reproductively experienced female rats. Endocrinology, 152(5), 1979-1988. doi: 10.1210/en.2010-1220

Quennell, J. H., Rizwan, M. Z., Relf, H.-L., & Anderson, G. M. (2010). Developmental and steroidogenic effects on the gene expression of RFRP and its receptor in the rat brain and pituitary gland. Journal of Neuroendocrinology, 22, 309-316. doi: 10.1111/j.1365-2826.2010.01963.x

Szawka, R. E., Ribeiro, A. B., Leite, C. M., Helena, C. V. V., Franci, C. R., Anderson, G. M., … Anselmo-Franci, J. A. (2010). Kisspeptin regulates prolactin release through hypothalamic dopaminergic neurons. Endocrinology, 151, 3247-3257. doi: 10.1210/en.2009-1414

Tups, A., Anderson, G. M., Rizwan, M., Augustine, R. A., Chaussade, C., Shepherd, P. R., & Grattan, D. R. (2010). Both p110α and p110β isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of Neuroendocrinology, 22(6), 534-542. doi: 10.1111/j.1365-2826.2010.01975.x

Koch, C., Augustine, R. A., Steger, J., Ganjam, G. K., Benzler, J., Pracht, C., … Anderson, G. M., Grattan, D. R., & Tups, A. (2010). Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. Journal of Neuroscience, 30(48), 16180-16187. doi: 10.1523/JNEUROSCI.3202-10.2010

Quennell, J. H., Mulligan, A. C., Tups, A., Liu, X., Phipps, S. J., Kemp, C. J., Herbison, A. E., Grattan, D. R., & Anderson, G. M. (2009). Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology, 150(6), 2805-2812. doi: 10.1210/en.2008-1693

Ducret, E., Anderson, G. M., & Herbison, A. E. (2009). RFamide-related peptide-3, a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone neuron firing in the mouse. Endocrinology, 150(6), 2799-2804. doi: 10.1210/en.2008-1623

Rizwan, M. Z., Porteous, R., Herbison, A. E., & Anderson, G. M. (2009). Cells expressing RFamide-related peptide-1/3, the mammalian gonadotropin-inhibitory hormone orthologs, are not hypophysiotropic neuroendocrine neurons in the rat. Endocrinology, 150(3), 1413-1420. doi: 10.1210/en.2008-1287

Anderson, G. M., Relf, H.-L., Rizwan, M. Z., & Evans, J. J. (2009). Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats. Endocrinology, 150(4), 1834-1840. doi: 10.1210/en.2008-1359

Anderson, G. M., Kieser, D. C., Steyn, F. J., & Grattan, D. R. (2008). Hypothalamic prolactin receptor messenger ribonucleic acid levels, prolactin signaling, and hyperprolactinemic inhibition of pulsatile luteinizing hormone secretion are dependent on estradiol. Endocrinology, 149(4), 1562-1570. doi: 10.1210/en.2007-0867

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2008). Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancy. Endocrinology, 149(6), 3206-3214. doi: 10.1210/en.2007-1623

Grattan, D. R., Steyn, F. J., Kokay, I. C., Anderson, G. M., & Bunn, S. J. (2008). Pregnancy-induced adaptation in the neuroendocrine control of prolactin secretion. Journal of Neuroendocrinology, 20(4), 497-507. doi: 10.1111/j.1365-2826.2008.01661.x

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2007). Differential effects of centrally-administered oestrogen antagonist ICI-182,780 on oestrogen-sensitive functions in the hypothalamus. Journal of Neuroendocrinology, 19(1), 26-33. doi: 10.1111/j.1365-2826.2006.01499.x

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2007). Expression of ovarian steroid hormone receptors in tuberoinfundibular dopaminergic neurones during pregnancy and lactation. Journal of Neuroendocrinology, 19(10), 788-793. doi: 10.1111/j.1365-2826.2007.01590.x

Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007). Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology, 148(9), 4344-4351.

Anderson, G. M., Grattan, D. R., van den Ancker, W., & Bridges, R. S. (2006). Reproductive experience increases prolactin responsiveness in the medial preoptic area and arcuate nucleus of female rats. Endocrinology, 147(10), 4688-4694.

Anderson, G. M., Beijer, P., Bang, A. S., Fenwick, M. A., Bunn, S. J., & Grattan, D. R. (2006). Suppression of prolactin-induced signal transducer and activator of transcription 5b signaling and induction of suppressors of cytokine signaling messenger ribonucleic acid in the hypothalamic arcuate nucleus of the rat during late pregnancy and lactation. Endocrinology, 147(10), 4996-5005.

Ma, F. Y., Anderson, G. M., Gunn, T. D., Goffin, V., Grattan, D. R., & Bunn, S. J. (2005). Prolactin specifically activates signal transducer and activator of transcription 5b in neuroendocrine dopaminergic neurons. Endocrinology, 146(12), 5112-5119.

Goodman, R. L., Coolen, L. M., Anderson, G. M., Hardy, S. L., Valent, M., Connors, J. M., … Lehman, M. N. (2004). Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep. Endocrinology, 145(6), 2959-2967. doi: 10.1210/en.2003-1305

Anderson, G. M., Hardy, S. L., Valent, M., Billings, H. J., Connors, J. M., & Goodman, R. L. (2003). Evidence that thyroid hormones act in the ventromedial preoptic area and the premammillary region of the brain to allow the termination of the breeding season in the ewe. Endocrinology, 144(7), 2892-2901.

Anderson, G. M., Lapwood, K. R., Knight, P. G., & Parkinson, T. J. (2003). The reproductive response of rams to thyroidectomy: Mediation by impaired inhibin feedback rather than a change in LH pulsatility. Reproduction, 126, 353-364.

Anderson, G. M., Connors, J. M., Hardy, S. L., Valent, M., & Goodman, R. L. (2002). Thyroid hormones mediate steroid-independent seasonal changes in luteinizing hormone pulsatility in the ewe. Biology of Reproduction, 66, 701-706.

Hardy, S. L., Anderson, G. M., Valent, M., Connors, J. M., & Goodman, R. L. (2002). Evidence that estrogen receptor alpha, but not beta, mediates seasonal changes in the response of the ovine retrochiasmatic area to estradiol. Biology of Reproduction, 68, 846-852.

Billings, H. J., Viguié, C., Karsch, F. J., Goodman, R. L., Connors, J. M., & Anderson, G. M. (2002). Temporal requirements of thyroid hormones for seasonal changes in LH secretion. Endocrinology, 143, 2618-2625.

Anderson, G. M., Connors, J. M., Hardy, S. L., Valent, M., & Goodman, R. L. (2001). Oestradiol microimplants in the ventromedial preoptic area inhibit secretion of luteinising hormone via dopaminergic neurons in anoestrous ewes. Journal of Neuroendocrinology, 13, 1051-1058.

Barrell, G. K., Anderson, G. M., & Villa-Diaz, L. G. (2000). New directions for the control of seasonal breeding in red deer. Asian-Australasian Journal of Animal Sciences, 13(Suppl. C), 60-63.

Anderson, G. M., & Barrell, G. (1998). Effects of thyroidectomy and thyroxine replacement on seasonal reproduction in the red deer hind. Journal of Reproduction & Fertility, 113, 239-250.

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Journal - Research Other

Anderson, G. M. (2016). Tet enzymes: Developmental fleas of Gnrh gene methylation. Endocrinology, 157(9), 3398-3399. doi: 10.1210/en.2016-1489

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