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Health Sciences staff profiles

Dr Louise Parr-Brownlie

PositionSenior Lecturer
DepartmentDepartment of Anatomy
QualificationsBPhEd MSc PhD(Otago)
Research summaryBrain control of movement and changes in brain activity with Parkinson's disease

Research

Research focuses on the neural mechanisms that underlie voluntary movements and the movement deficits of Parkinson's disease.

We are interested in understanding how activity in the motor thalamus, motor cortex, cerebellum and basal ganglia controls normal movements and is altered in Parkinson's disease. We use a combination of optogenetic stimulation (Seeger-Armbruster et al., Journal of Neuroscience, 2015), electrophysiological recordings, electron and confocal microscopy to investigate brain function and structure. We used advanced microscopy techniques to investigate if Parkinson's disease alters the connections between brain cells. Optogenetic stimulation allows activation or silencing of sub-types of brain cells in specific brain pathways to explore how they usually work and how they are altered in Parkinson's disease. We have applied optogenetic stimulation to determine if there are better places and ways to stimulate the brain to improve movements in models of Parkinson's disease.

Publications

Sizemore, R. J., Zhang, R., Lin, N., Goddard, L., Wastney, T. B., Parr-Brownlie, L. C., Reynolds, J. N. J., & Oorschot, D. E. (2016). Marked differences in the number and type of synapses innervating the somata and primary dendrites of midbrain dopaminergic neurons, striatal cholinergic interneurons and striatal spiny projection neurons in the rat. Journal of Comparative Neurology, 524(5), 1062-1080. doi: 10.1002/cne.23891

Smith, L. M., Parr-Brownlie, L. C., Duncan, E. J., Black, M. A., Gemmell, N. J., Dearden, P. K., & Reynolds, J. N. J. (2016). Striatal mRNA expression patterns underlying peak dose L-DOPA-induced dyskinesia in the 6-OHDA hemiparkinsonian rat. Neuroscience, 324, 238-251. doi: 10.1016/j.neuroscience.2016.03.012

Sizemore, R. J., Seeger-Armbruster, S., Hughes, S. M., & Parr-Brownlie, L. C. (2016). Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology. Journal of Neurophysiology, 115, 2124-2146. doi: 10.1152/jn.01131.2015

Parr-Brownlie, L. C., Bosch-Bouju, C., Schoderboeck, L., Sizemore, R. J., Abraham, W. C., & Hughes, S. M. (2015). Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms. Frontiers in Molecular Neuroscience, 8, 14. doi: 10.3389/fnmol.2015.00014

Seeger-Armbruster, S., Bosch-Bouju, C., Little, S. T. C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2015). Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced Parkinsonian rats. Journal of Neuroscience, 35(3), 1211-1216. doi: 10.1523/jneurosci.3277-14.2015

Journal - Research Article

Sizemore, R. J., Zhang, R., Lin, N., Goddard, L., Wastney, T. B., Parr-Brownlie, L. C., Reynolds, J. N. J., & Oorschot, D. E. (2016). Marked differences in the number and type of synapses innervating the somata and primary dendrites of midbrain dopaminergic neurons, striatal cholinergic interneurons and striatal spiny projection neurons in the rat. Journal of Comparative Neurology, 524(5), 1062-1080. doi: 10.1002/cne.23891

Sizemore, R. J., Seeger-Armbruster, S., Hughes, S. M., & Parr-Brownlie, L. C. (2016). Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology. Journal of Neurophysiology, 115, 2124-2146. doi: 10.1152/jn.01131.2015

Smith, L. M., Parr-Brownlie, L. C., Duncan, E. J., Black, M. A., Gemmell, N. J., Dearden, P. K., & Reynolds, J. N. J. (2016). Striatal mRNA expression patterns underlying peak dose L-DOPA-induced dyskinesia in the 6-OHDA hemiparkinsonian rat. Neuroscience, 324, 238-251. doi: 10.1016/j.neuroscience.2016.03.012

Parr-Brownlie, L. C., Bosch-Bouju, C., Schoderboeck, L., Sizemore, R. J., Abraham, W. C., & Hughes, S. M. (2015). Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms. Frontiers in Molecular Neuroscience, 8, 14. doi: 10.3389/fnmol.2015.00014

Seeger-Armbruster, S., Bosch-Bouju, C., Little, S. T. C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2015). Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced Parkinsonian rats. Journal of Neuroscience, 35(3), 1211-1216. doi: 10.1523/jneurosci.3277-14.2015

Bosch-Bouju, C., Smither, R. A., Hyland, B. I., & Parr-Brownlie, L. C. (2014). Reduced reach-related modulation of motor thalamus neural activity in a rat model of Parkinson's disease. Journal of Neuroscience, 34(48), 15836-15850. doi: 10.1523/jneurosci.0893-14.2014

Bosch-Bouju, C., Hyland, B. I., & Parr-Brownlie, L. C. (2013). Motor thalamus integration of cortical, cerebellar and basal ganglia information: Implications for normal and Parkinsonian conditions. Frontiers in Computational Neuroscience, 7, 163. doi: 10.3389/fncom.2013.00163

Avila, I., Parr-Brownlie, L. C., Brazhnik, E., Castañeda, E., Bergstrom, D. A., & Walters, J. R. (2010). Beta frequency synchronization in basal ganglia output during rest and walk in a hemiparkinsonian rat. Experimental Neurology, 221(2), 307-319. doi: 10.1016/j.expneurol.2009.11.016

Parr-Brownlie, L., Poloskey, S. L., Bergstrom, D. A., & Walters, J. R. (2009). Parafascicular thalamic nucleus activity in a rat model of Parkinson's disease. Experimental Neurology, 217(2), 269-281. doi: 10.1016/j.expneurol.2009.02.010

Aravamuthan, B. R., Bergstrom, D. A., French, R. A., Taylor, J. J., Parr-Brownlie, L. C., & Walters, J. R. (2008). Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease. Experimental Neurology, 213, 268-280. doi: 10.1016/j.expneurol.2008.05.023

Parr-Brownlie, L. C., Poloskey, S. L., Flanagan, K. K., Eisenhofer, G., Bergstrom, D. A., & Walters, J. R. (2007). Dopamine lesion-induced change in subthalamic nucleus activity are not associated with alterations in firing rate or pattern in layer V neurons of the anterior cingulate cortex in anesthetized rats. European Journal of Neuroscience, 26, 1925-1939.

Walters, J. R., Hu, D., Itoga, C. A., Parr-Brownlie, L. C., & Bergstrom, D. A. (2007). Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine. Neuroscience, 144, 762-776.

Parr-Brownlie, L. C., & Hyland, B. I. (2005). Bradykinesia induced by dopamine D2 receptor blockade is associated with reduced motor cortex activity in the rat. Journal of Neuroscience, 25(24), 5700-5709.

Parr-Brownlie, L. C., Wickens, J., Anson, J. G., & Hyland, B. I. (1998). Does having to remember the position of a target improve reaction time? Motor Control, 2, 142-147.

Mohagheghi, A. A., Anson, J. G., Hyland, B. I., Parr-Brownlie, L. C., & Wickens, J. (1998). Foreperiod length, but not memory, affects human reaction time in a precued, delayed response. Motor Control, 2, 133-141.

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