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Neuroscience Research Group

ex19-pretty_226pxThe Neuroscience Research Group (NRG) comprises thirteen laboratories whose members are also part of the Brain Health Research Centre (BHRC), the Brain Research New Zealand Centre of Research Excellence (CoRE) and the Centre for Neuroendocrinology (CNE).

Our research focuses on:

1. Understanding brain structure and function, including the mechanisms of brain health, disease and repair.

2. Understanding neurological disorders including Alzheimer’s, ADHD, Ataxias, Autism, Cerebral Palsy, Epilepsy, Fetal Alcohol Spectrum Disorder, Parkinson’s, Schizophrenia and Stroke and identifying new biomarkers and developing new treatments for these disorders.

3. Understanding how the brain controls hormone levels and how hormones control brain function.

We also engage in raising awareness of brain health and disease in schools and to the general public. We are committed to developing active educational links with the community.

Principal Investigators (PIs)

Associate Professor Beulah Leitch (Head of the Neuroscience Research Group)

Beulah LeitchThe Leitch Group research interests are in cellular and molecular neuroscience. Our research focuses on the structural and functional development of neurons and their synapses; also changes occurring at synapses during aging and in various brain disorders. We are particularly interested in the impact of altered expression of receptors and their trafficking proteins at synapses.

Projects include investigations into: the effect of AMPA receptor deficits in corticothalamic networks as a result of a mutation in a TARP trafficking protein in the Stargazer model of absence epilepsy; changes in receptor expression at synapses in the maternal immune activation model of schizophrenia; calcium channels in normal and diseased brain; agmatine and age-related cognitive decline; and the effects of BDNF deficits on synaptic plasticity in the cerebellum.

We also have research interests in the detection of newly synthesized receptor proteins at dendritic locations and synapses in collaboration with the Max Planck Institute in Brain Research, Frankfurt Germany. This project uses new methodologies to detect recently synthesized protein molecules at synapses, from their pre-existing counter-parts, with ultrastructural resolution. This research will lay the groundwork for studying whether defects in local protein synthesis contributes to synaptic dysfunction underlying various brain disorders such as Alzheimer's disease.

“Our brain cells (neurons) talk to each other at specialized connections called synapses. Understanding the mechanisms underlying synaptic dysfunction is fundamental to understanding many brain disorders”.

The Leitch Research Group expertise includes: electron microscopy (EM); immmunogold-cytochemistry; molecular biology; immunoblotting; immunocytochemistry; confocal microscopy; high-resolution imaging techniques; neuronal cell culture and electrophysiology.

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GregAnderson

Associate Professor Greg Anderson

The Anderson Research Group are focused on the regulation of fertility by nutritional factors (the hormones leptin, insulin and ghrelin) and the mechanisms by which the brain peptide RFamide-related peptide-3 (RFRP-3, a.k.a. gonadotrophin inhibitory hormone) regulates reproductive activity and anxiety in mammals.

The ‘big picture’ goal is the development of new and improved treatments for infertility and anxiety-related disorders.

Greg is also a member of the 'Reproduction, Genomics and Development Research Group'. His research expertise include: transgenic mouse models, behavioural phenotyping, in vivo and in vitro cell signaling assays.

Anderson Lab on CNE website

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StephenBunn

Associate Professor Stephen Bunn

Stephen's major research interest is in the neuroendocrinology of stress.

Current research focuses on two major areas. First, understanding the complex regulation of the adrenal medullary chromaffin cell, specifically how it regulates its secretory output of catecholamines and peptides in response to multiple stress-activated inputs. Much recent work has been directed at understanding how cytokines interact with this stress response.

Our second major interest concerns the role of another cytokine, prolactin, on the stress axis. Specifically we are interested in how stressors alter prolactin secretion from the pituitary and what role this prolactin then plays in stress adaptation under different physiological states.

Stephen's research expertise include: neuronal cell culture, immunocytochemistry, confocal microscopy and immunoblotting.

Bunn Lab on CNE website

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Dr Yusuf Cakmak

Our major interest is the neuromodulation of internal organs and the brain structures to modulate their functions and blood flow. We focus on the effects of different frequencies of non-invasive electrostimulation on internal organs blood flow to increase and decrease the blood flow.

We had six neuromodulation related Patent Cooperation Treaties (PCTs) and we are interested in investigating more novel non-invasive stimulation techniques to normalize the neuronal network functions and alleviate the symptoms of neurological diseases.

Southwest Research Institute (Texas) is producing a prototype for one of our PCT related neuromodulation devices for internal organ blood flow modulation. Inventram company supports our Parkinson’s Disease related biomedical device clinical trials.

We are also researching for Interactive Virtual Reality (Hand and Forearm Muscular Avatar project is the recent one) and 3D image processing as a treatment modality, teaching and as a diagnostic tool.

Yusuf is also a member of the 'Clinical Anatomy Research Group. His research expertise includes neuromodulation and electrostimulation.

Cakmak Lab

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Dr Andrew Clarkson

Our major research focus is in the field of post-stroke neuroprotection, regeneration and repair.

Our goal is directed at promoting recovery of sensory and motor functions following a stroke and investigating underlying mechanisms associated with delayed impairment in memory.

We use novel combinations of intensive rehabilitation and drug therapies to enhance brain repair processes. These approaches utilise behavioural, electrophysiological, optical imaging and anatomical measures to assess post-stroke protection, regeneration and repair.

We are working with leading medicinal chemists and pharmaceutical companies with an aim of developing novel pharmacotherapies and drug delivery modalities to take into the clinic.

Andrew's research expertise include in vivo animal models, cell culture, immunohistochemistry, electrophysiology, behavior and pharmacology.

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Professor Dave Grattan

The Grattan Lab are interested in the neuroendocrine functions of the hormone prolactin, and in particular, the role of prolactin in the neuroendocrine and neurobiological adaptations of the maternal brain.

Specific interests include the control of appetite and body weight during pregnancy and obesity, plasticity in oxytocin neurons during late pregnancy and lactation, and the role of prolactin in changes in mood and behaviour in the post partum period.

Dave is one of a number of researchers whose work combines neuroscience with reproduction and developmental biology, and who are members of both the 'Neuroscience Group' and the 'Reproduction, Genomics and Development Research Group'.

Grattan Lab on CNE website

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ChristineJasoni

Associate Professor Christine Jasoni

The overarching goal of Christine's lab is to understand how complications of pregnancy - such as obesity, gestational diabetes, and infection - increase the risk that offspring will acquire neurodevelopmental abnormalities later in life – such as autism spectrum disorder, obesity, learning disabilities, and depression.

To do this we are identifying factors that are unique to complicated pregnancies, and discovering how they derail the process of normal brain development.

We use an array of techniques including molecular & cellular biology, mouse genetic models, live cell imaging, and bioinformatics to address our scientific questions.

The research has the potential to discover markers that can be used to predict potential neurobehavioural disorders, and to provide research-informed guidelines for healthy pregnancy.

Christine is also a member of the 'Reproduction, Genomics and Development Research Group'. Her research expertise includes neuronal cell culture, immunocytochemistry, confocal microscopy, NextGeneration sequencing, DNA methylation analysis, qPCR, flow cytometry and multiplex cytokine analysis.

Laboratory of Developmental Neuroscience

Jasoni Lab on the CNE website

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Associate Professor Ping Liu

Our main research areas are:

  1. Neurobiological basis and intervention of brain aging, Alzheimer's disease and schizophrenia
  2. Biological basis of learning and memory.

We have been focusing on arginine metabolism, and the functional role of agmatine and its therapeutic potential.

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Dr Ruth Napper

Our major research interest is assessing the effects of binge alcohol exposure on the developing (foetal) brain. We focus on two major aspects.

First we assess acute cell death following a single binge exposure. We quantify apoptotic cell death using stereological methods and use immuno-histochemistry to phenotype dying cells. We are aiming to identify which brain regions are damaged and the window of vulnerability of each region. Secondly we assess the behavioural impact of this binge ethanol paradigm in adulthood and quantify the number of cells in the key brain regions.

More recent work has used electron microscopy to assess changes in synaptic structure in the mature brain following ethanol induced loss of neurons.

Ruth's research expertise include stereology, electron microscopy, electron tomography and immunocytochemistry.

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Associate Professor Dorothy Oorschot

The structure and function of the normal or hypoxic basal ganglia is the main focus of our research. In the normal basal ganglia, neural circuits are being researched to test hypotheses on the cellular basis of movement and learning. For the hypoxic basal ganglia, treatments (eg. hypothermia, stem cells) are being researched to determine whether striatal neurons can be rescued or restored after hypoxic-induced death.

A new animal model of brain injury in infants born extremely prematurely has been developed. This model was published in the prestigious Journal of Neuroscience in 2013. Further characterization of this model and investigation of treatments to rescue the brain injury and behavioural deficits are underway.

Dorothy is also an member of the 'Reproduction, Genomics and Development Research Group'. Her research expertise includes immunocytochemistry, stereology, electron microscopy, behavioural phenotyping, tissue culture.

Oorschot Lab (part of Basal Ganglia Research Group)

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Dr Louise Parr-Brownlie

LouiseParr-brownlie226pxResearch in my lab explores changes in neural activity that underlie the movement deficits of Parkinson’s disease.

We apply the knowledge obtained from cell recording studies to test novel stimulation protocols aimed at improving movements in Parkinson’s disease. To do this we combine optogenetic stimulation, electrophysiological recordings and assessments of movement performance.

We have found that stimulating the motor thalamus with complex patterns that mimic real cell activity significantly improves reaching movements, and is better than the 130Hz pattern currently applied to the subthalamic nucleus of patients.

These data may revolutionise deep brain stimulation protocols for patients of many neurological disorders.

Louise's research expertise includes optogenetic stimulation, single neuron recordings, Parkinson's models, motor thalamus and behaviour.

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Professor John Reynolds

The primary focus of the Reynolds' lab is on learning and movement generation processes in the basal ganglia and cerebral cortex.

In the basal ganglia the emphasis is on unraveling the normal role of dopamine in learning and memory in vivo. Normal functioning of this process is critical to our ability to learn and perform new skills, whereas dysfunction of dopamine cells and their basal ganglia targets underlies the pathophysiology of brain disorders such as Parkinson's and Huntington's diseases and addiction.

Their most recent work is focused on investigating synaptic plasticity processes in the cerebral cortex and the mechanisms of invasive and non-invasive stimulation therapies, and taking a translational approach to their application to stroke recovery.

John's research expertise include electrophysiological recording, molecular biology, immunohistochemistry and behavioural analysis.

Reynolds lab (part of Basal Ganglia Research Group)

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Dr Margaret Ryan

Margaret’s research is focused on understanding the basis of learning and memory, including how memory-related brain regions are affected in neurodegenerative diseases such as Alzheimer’s disease. Her work utilises numerous molecular approaches to identify gene networks and pathways which are associated with learning, memory and which are altered in neurological diseases.

Recent projects are centered on investigating the therapeutic potential of a neuroprotective protein for the treatment of Alzheimer’s disease and exploring the role of small RNA molecules in the development of Alzheimer’s disease.

Margaret’s research expertise includes bioinformatics, molecular profiling, qPCR, microarrays, sequencing, Western blotting, cell culture and animal models of Alzheimer’s disease.

“New Zealand has an increasing number of people developing Alzheimer’s disease and so there is an urgent need to find treatments which can slow or halt the disease"

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Dr Joanna Williams

Our research covers three main areas:

Memory mechanisms: Using modern molecular biological, bioinformatics and proteomic techniques we have built up a portfolio of studies focused on the regulation of key glutamate receptors involved in memory processes as well as how gene and microRNA expressions are altered in response to memory events. Understanding how memories are formed will lead to a greater understanding of the molecular pathology underlying aging-related memory loss and diseases of the brain.

Amyloid precursor protein: The lab is intensively researching a protein called sAPPα. Unlike amyloid-ß, the pathological agent in Alzheimer's Disease, sAPPα, has neuroprotective and memory enhancing functions and the group aims to uncover both molecular mechanisms underlying these positive functions and the specific regions within sAPPα which confer these properties as these may have therapeutic potential.

Biomarkers Discovery: We have added a new dimension to our research portfolio which aims to identify biomarkers within plasma which may be predictive of neurological diseases. Currently this work focuses on Alzheimer's Disease, Schizophrenia and Parkinson's disease.

Joanna's research expertise includes molecular profiling - Western blotting, qPCR, qPCR arrays, microarrays, epigenetics assay, bioinformatics, human and animal models of Alzheimer’s disease.

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