Research in Professor Hughes' lab is aimed at identifying molecular pathways that regulate neuronal development, maintenance and disease. Her current research focuses on transcription factors of the forebrain embryonic zinc finger family and their role in neuronal development and maintenance. She is also investigating the molecular consequences of mutations in Batten disease, a childhood neurodegenerative disorder. The lab is developing tools and gene therapy vectors for Batten, Alzheimer's and Parkinson's disease.
Funding is provided by the Marsden Fund, the Health Research Council of New Zealand, the Neurological Foundation of New Zealand, the Otago Medical Research Foundation and the Otago School of Medical Sciences Deans Bequest Fund.
Find out more about Professor Stephanie Hughes' research
Publications
Davies, J., Abraham, C., Mockett, B., & Hughes, S. (2023). When genes go viral: Viral gene therapy for Alzheimer’s disease. Proceedings of the Psycolloquy Symposium. (pp. 27). Dunedin, New Zealand: Department of Psychology, University of Otago. Retrieved from https://www.otago.ac.nz/psychology/research/otago059081.html Conference Contribution - Published proceedings: Abstract
Stokes, C., Basak, I., Tate, W., & Hughes, S. (2023). Identifying superheroes in neurodegenerative disease. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go Conference Contribution - Published proceedings: Abstract
Basak, I., Harfoot, R., Palmer, J. E., Kumar, A., Quiñones‑Mateu, M. E., Schweitzer, L., & Hughes, S. M. (2023). Neuroproteomic analysis after SARS-CoV-2 infection reveals overrepresented neurodegeneration pathways and disrupted metabolic pathways. Biomolecules, 13(11), 1597. doi: 10.3390/biom13111597 Journal - Research Article
Hughes, S. M., Basak, I., Eboda, O., McDonald, K. O., Peppercorn, K., & Schoderboeck, L. (2023). Development of iPSC-derived neuronal models to study Batten disease: A group of childhood dementias. In K.-L. Horne (Ed.), Proceedings of the 39th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 66). Retrieved from https://www.awcbr.org Conference Contribution - Published proceedings: Abstract
McDonald, K. O., Diermeier, S., Basak, I., & Hughes, S. M. (2023). Deciphering the role of IncRNAs in lysosome and neuron health. In K.-L. Horne (Ed.), Proceedings of the 39th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 64). Retrieved from https://www.awcbr.org Conference Contribution - Published proceedings: Abstract
2023
Journal - Research Article
Basak, I., Harfoot, R., Palmer, J. E., Kumar, A., Quiñones‑Mateu, M. E., Schweitzer, L., & Hughes, S. M. (2023). Neuroproteomic analysis after SARS-CoV-2 infection reveals overrepresented neurodegeneration pathways and disrupted metabolic pathways. Biomolecules, 13(11), 1597. doi: 10.3390/biom13111597
Peppercorn, K., Kleffmann, T., Hughes, S. M., & Tate, W. P. (2023). Secreted amyloid precursor protein alpha (sAPPα) regulates the cellular proteome and secretome of mouse primary astrocytes. International Journal of Molecular Sciences, 24, 7165. doi: 10.3390/ijms24087165
Conference Contribution - Published proceedings: Abstract
Davies, J., Abraham, C., Mockett, B., & Hughes, S. (2023). When genes go viral: Viral gene therapy for Alzheimer’s disease. Proceedings of the Psycolloquy Symposium. (pp. 27). Dunedin, New Zealand: Department of Psychology, University of Otago. Retrieved from https://www.otago.ac.nz/psychology/research/otago059081.html
Stokes, C., Basak, I., Tate, W., & Hughes, S. (2023). Identifying superheroes in neurodegenerative disease. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go
Hughes, S. M., Basak, I., Eboda, O., McDonald, K. O., Peppercorn, K., & Schoderboeck, L. (2023). Development of iPSC-derived neuronal models to study Batten disease: A group of childhood dementias. In K.-L. Horne (Ed.), Proceedings of the 39th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 66). Retrieved from https://www.awcbr.org
McDonald, K. O., Diermeier, S., Basak, I., & Hughes, S. M. (2023). Deciphering the role of IncRNAs in lysosome and neuron health. In K.-L. Horne (Ed.), Proceedings of the 39th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 64). Retrieved from https://www.awcbr.org
Conference Contribution - Poster Presentation (not in published proceedings)
Seo, S., Parr-Brownlie, L., Bilkey, D., Hughes, S., & Oorschot, D. (2023, June). Opposite changes in midbrain dopamine microcircuitry in the repeated hypoxic rat model of ADHD-like hyperactivity/impulsivity versus the maternal immune activation rat model of schizophrenia: Potential bases for new therapies. Poster session presented at the International Basal Ganglia Society (IBAGS) XIV Meeting, Stockholm, Sweden.
Other Research Output
Hughes, S. (2023, April). Keeping it in the family: The search for a cure for childhood Batten disease. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
2022
Journal - Research Article
Peppercorn, K., Kleffmann, T., Jones, O., Hughes, S., & Tate, W. (2022). Secreted amyloid precursor protein alpha, a neuroprotective protein in the brain has widespread effects on the transcriptome and proteome of human inducible pluripotent stem cell-derived glutamatergic neurons related to memory mechanisms. Frontiers in Neuroscience, 16, 858524. doi: 10.3389/fnins.2022.858524
Kip, E., Bentall, L., Underwood, C. F., Hughes, S. M., & Parr-Brownlie, L. C. (2022). Patterned stimulation of the Chrimson opsin in glutamatergic motor thalamus neurons improves forelimb akinesia in parkinsonian rats. Neuroscience, 507, 64-78. doi: 10.1016/j.neuroscience.2022.10.026
Dearborn, J. T., Nelvagal, H. R., Rensing, N. R., Takahashi, K., Hughes, S. M., Wishart, T. M., … Sands, M. S. (2022). Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures. Scientific Reports, 12, 11286. doi: 10.1038/s41598-022-15134-5
Smyth, L. C. D., Murray, H. C., Hill, M., van Leeuwen, E., Highet, B., Magon, N. J., … Mathiesen, S. N., Mockett, B., … Clarkson, A. N., … Abraham, W. C., Hughes, S. M., … Kettle, A. J., … Hampton, M. B. (2022). Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease. Acta Neuropathologicca Communications, 10, 38. doi: 10.1186/s40478-022-01347-2
Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1
Conference Contribution - Published proceedings: Abstract
He, Y., Mockett, B., Schweitzer, L., McDonald, K., Sateesh, S., Jones, O., Hughes, S., & Abraham, W. C. (2022). Peripheral gene therapy for Alzheimer's disease. Proceedings of the Psycolloquy Symposium. (pp. 9). Dunedin, New Zealand: Department of Psychology, University of Otago. Retrieved from https://www.otago.ac.nz/psychology/research/otago059081.html
Kip, E., Bentall, L., Underwood, C. F., Hughes, S. M., & Parr-Brownlie, L. C. (2022). Patterned simulation of the chrimson opsin in glutamatergic motor thalamus neurons improves forelimb akinesia in a chronic rat model of Parkinson's disease. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 85). Retrieved from https://www.queenstownresearchweek.org
Schweitzer, L., Lyons, N., Wicky, H., & Hughes, S. (2022). A bad influence: Do glia with defective lysosomes harm healthy neurons? In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 69). Retrieved from https://www.queenstownresearchweek.org
Peppercorn, K., Kleffmann, T., Jones, O., Hughes, S., & Tate, W. (2022). Secreted amyloid precursor protein alpha has widespread effects on the transcriptome and proteome of human neurons related to memory mechanisms. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 64). Retrieved from https://www.queenstownresearchweek.org
Ohline, S. M., Hughes, S. M., & Abraham, W. C. (2022). Immediate early gene expression and intrinsic excitability are not linked in adult-born hippocampal neurons. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 62). Retrieved from https://www.queenstownresearchweek.org
Deeney, E., Ibrahim, M., Potapov, K., Hughes, S., & Empson, R. (2022). Voluntary exercise restores motor performance in a mouse model of spinocerebellar ataxia type 1 (SCA1). In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 61). Retrieved from https://www.queenstownresearchweek.org
Mathiesen, S. N., Schoderboeck, L., Ohline, S. M., Mockett, B. G., Abraham, W. C., & Hughes, S. M. (2022). Peripheral administration of AAV-PHP.eB encoding TFEB causes toxicity in mice. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 55). Retrieved from https://www.queenstownresearchweek.org
Jardine, K., Palmer, J., Xu, J., Basak, I., & Hughes, S. (2022). The role of RNF167 in lysosomal regulation within neuronal dendrites. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 38). Retrieved from https://www.queenstownresearchweek.org
Basak, I., Hansen, R., Dolan, H., Clegg, J., Ward, M. E., & Hughes, S. M. (2022). Loss of Batten disease associated CLN5 leads to neuronal lysosomal defects, altered cell proliferation and ion transport in human neurons. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 30). Retrieved from https://www.queenstownresearchweek.org
He, Y., Mockett, B., Schweitzer, L., McDonald, K., Sateesh, S., Jones, O., Hughes, S., & Abraham, W. C. (2022). Peripheral gene therapy for Alzheimer's disease. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 29). Retrieved from https://www.queenstownresearchweek.org
van der Weerden, A., Hughes, S., & Basak, I. (2022). Human neuronal models of Batten disease exhibit altered lysosome function and accumulation of alpha-synuclein protein. New Zealand Medical Journal, 135(1557), (pp. 103-104). Retrieved from https://journal.nzma.org.nz/
Conference Contribution - Verbal presentation and other Conference outputs
Hughes, S. (2022, July). Across the lifespan: What childhood brain disorders can teach us about ageing. Verbal presentation at the Brain Health Research Centre (BHRC) Hui ā Tau Annual Conference: Te Haerenga o te tangata: Lifespan, Dunedin, New Zealand.
2021
Journal - Research Article
Basak, I., Hansen, R. A., Ward, M. E., & Hughes, S. M. (2021). Deficiency of the lysosomal protein CLN5 alters lysosomal function and movement. Biomolecules, 11, 1412. doi: 10.3390/biom11101412
Barnett, S. C., Parr-Brownlie, L. C., Perry, B. A. L., Young, C. K., Wicky, H. E., Hughes, S. M., McNaughton, N., & Dalrymple-Alford, J. C. (2021). Anterior thalamic nuclei neurons sustain memory. Current Research in Neurobiology, 2, 100022. doi: 10.1016/j.crneur.2021.100022
Seo, S., Sizemore, R. J., Reader, K. L., Smither, R. A., Wicky, H. E., Hughes, S. M., Bilkey, D. K., Parr-Brownlie, L. C., & Oorschot, D. E. (2021). A schizophrenia risk factor induces marked anatomical deficits at GABAergic-dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies. Journal of Comparative Neurology, 529, 3946-3973. doi: 10.1002/cne.25225
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., … Hughes, S. M., … Katare, R. G., … Tong, C.-K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), 1-382. doi: 10.1080/15548627.2020.1797280
Ryan, M., Tan, V. T. Y., Thompson, N., Guévremont, D., Mockett, B. G., Tate, W. P., Abraham, W. C., Hughes, S. M., & Williams, J. (2021). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 79, 1075-1090. doi: 10.3233/JAD-200757
Journal - Research Other
Basak, I., Wicky, H. E., McDonald, K. O., Xu, J. B., Palmer, J. E., Best, H. L., … Schoderboeck, L., & Hughes, S. M. (2021). A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis. Cellular & Molecular Life Sciences, 78, 4735-4763. doi: 10.1007/s00018-021-03813-x
Conference Contribution - Published proceedings: Abstract
Kip, E., Bentall, L., Underwood, C. F., Hughes, S. M., & Parr-Brownlie, L. C. (2021). Specific patterns of optogenetic stimulation of glutamatergic motor thalamus neurons improve akinesia in a chronic rat model of Parkinson's disease. New Zealand Medical Journal, 134(1539), (pp. 88). Retrieved from https://www.nzma.org.nz/journal
Lyons, N., Schoderboeck, L., Ibrahim, M. F., Hughes, S. M., & Empson, R. M. (2021). The light activated chloride channel GtACR2 is a novel potential therapeutic to treat chronic pain. New Zealand Medical Journal, 134(1537), (pp. 104). Retrieved from https://www.nzma.org.nz/journal
2020
Journal - Research Article
Best, H. L., Clare, A. J., McDonald, K. O., Wicky, H. E., & Hughes, S. M. (2020). An altered secretome is an early marker of the pathogenesis of CLN6 Batten disease. Journal of Neurochemistry, 157, 764-780. doi: 10.1111/jnc.15285
Mathiesen, S. N., Lock, J. L., Schoderboeck, L., Abraham, W. C., & Hughes, S. M. (2020). CNS transduction benefits of AAV-PHP.eB over AAV9 are dependent on administration route and mouse strain. Molecular Therapy: Methods & Clinical Development, 19, 447-458. doi: 10.1016/j.omtm.2020.10.011
Huber, R. J., Hughes, S. M., Liu, W., Morgan, A., Tuxworth, R. I., & Russell, C. (2020). The contribution of multicellular model organisms to neuronal ceroid lipofuscinosis research. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1866, 165614. doi: 10.1016/j.bbadis.2019.165614
Conference Contribution - Published proceedings: Abstract
Mathiesen, S. N., Schoderboeck, L., Ohline, S. M., Wicky, H. E., Abraham, W. C., & Hughes, S. M. (2020). Improved gene transfer for the treatment of neurological disease using modified viral vector AAV-PHP.eB. New Zealand Medical Journal, 133(1527), (pp. 126-127). Retrieved from https://www.nzma.org.nz/journal
2019
Journal - Research Article
Morrissey, J. A., Bigus, E., Necarsulmer, J. C., Srinivasan, V., Peppercorn, K., O'Leary, D. J., Mockett, B. G., Tate, W. P., Hughes, S. M., … Abraham, W. C. (2019). The tripeptide RER mimics secreted amyloid precursor protein-alpha in upregulating LTP. Frontiers in Cellular Neuroscience, 13, 459. doi: 10.3389/fncel.2019.00459
Cain, J. T., Likhite, S., White, K. A., Timm, D. J., Davis, S. S., Johnson, T. B., … Hughes, S. M., … Weimer, J. M. (2019). Gene therapy corrects brain and behavioral pathologies in CLN6-Batten disease. Molecular Therapy, 27(10), 1836-1847. doi: 10.1016/j.ymthe.2019.06.015
Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670
Schoderboeck, L., Wicky, H. E., Abraham, W. C., & Hughes, S. M. (2019). Genetic targeting and chemogenetic inhibition of newborn neurons. Human Gene Therapy Methods, 29(6), 259-268. doi: 10.1089/hgtb.2018.182
Conference Contribution - Published proceedings: Abstract
Kleffmann, T., Tate, W., & Hughes, S. (2019). Does secreted amyloid precursor protein alpha affect the global proteome of astrocytes? Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 13247. Retrieved from https://www.ans.org.au
Eboda, O. N., Basak, I., Ward, M. E., & Hughes, S. M. (2019). ATP13A2: Characterization of a novel human iPS cell model of Parkinson's and Batten disease. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 13203. Retrieved from https://www.ans.org.au
Kwakowsky, A., Chawdhary, B., Kim, S., Hughes, S., Parr-Brownlie, L., Waldvogel, H., & Faull, R. (2019). Miniaturized wireless optoelectronic subdermal implants: A novel device for the optogenetic stimulation of hippocampal neurons. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 12508. Retrieved from https://www.ans.org.au
Ganesh, M., Clare, A. J., Dragunow, M., Hughes, S. M., Clarkson, A. N., & Empson, R. M. (2019). Deciphering the fate of integrated pericytes in mouse motor cortex. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 12491. Retrieved from https://www.ans.org.au
Basak, I., Hansen, R., Eboda, O., Ward, M. E., & Hughes, S. M. (2019). Characterisation of CLN5 Batten disease in induced pluripotent stem cell derived human neurons. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 12146. Retrieved from https://www.ans.org.au
Ohline, S. M., Chan, C. H., Whelan, J., Smith, H., Logan, B. J., Morrissey, J. A., Schoderboeck, L., Peppercorn, K., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). Stimulation of neurogenesis by a potential therapeutic protein. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 57). Retrieved from http://www.otago.ac.nz/awcbr
Chawdhary, B., Kim, S. H., Hughes, S., Parr-Brownlie, L., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019). Miniaturized wireless optolectronic subdermal implants: A novel device for the optogenetic stimulation of hippocampal neurons. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 53). Retrieved from http://www.otago.ac.nz/awcbr
Ganesh, M., Clare, A. J., Dragunow, M., Hughes, S. M., Clarkson, A. N., & Empson, R. M. (2019). Deciphering the fate of integrate pericytes in mouse motor cortex. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 35). Retrieved from http://www.otago.ac.nz/awcbr
Barnett, S. C., Young, C. K., Perry, B. A. L., McNaughton, N., Hughes, S. M., Parr-Brownlie, L. C., & Dalrymple-Alford, J. C. (2019). Optogenetic stimulation of the anterior thalamic nuclei ameliorates impaired spatial memory in rats with mammillothalamic tract lesions. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 27). Retrieved from http://www.otago.ac.nz/awcbr
Mathiesen, S. N., Schoderboeck, L., Ohline, S. M., Wicky, H. E., Abraham, W. C., & Hughes, S. M. (2019). Investigating enhanced gene transfer to the mouse central nervous system using modified viral vectors. Proceedings of the Society for Neuroscience Annual Meeting. 175.13/BB83. SfN. Retrieved from https://www.sfn.org
Mathiesen, S. N., Ohline, S. M., Wicky, H. E., Cheong, M. Y. I., Abraham, W. C., & Hughes, S. M. (2019). Assessing the efficacy of a novel adeno-associated viral capsid in targeting the brain. New Zealand Medical Journal, 132(1499), (pp. 87). Retrieved from https://www.nzma.org.nz/journal
2018
Journal - Research Article
Clare, A. J., Day, R. C., Empson, R. M., & Hughes, S. M. (2018). Transcriptome profiling of layer 5 intratelencephalic projection neurons from the mature mouse motor cortex. Frontiers in Molecular Neuroscience, 11, 410. doi: 10.3389/fnmol.2018.00410
Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., … Hughes, S. M., & Palmer, D. N. (2018). Longitudinal in vivo monitoring of CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease. Molecular Therapy, 26(10), 2366-2378. doi: 10.1016/j.ymthe.2018.07.015
Ohline, S. M., Wake, K. L., Hawkridge, M.-V., Dinnunhan, M. F., Hegemann, R. U., Wilson, A., Schoderboeck, L., Logan, B. J., … Hughes, S. M., & Abraham, W. C. (2018). Adult-born dentate granule cell excitability depends on the interaction of neuron age, ontogenetic age and experience. Brain Structure & Function, 223(7), 3213-3228. doi: 10.1007/s00429-018-1685-2
Tan, V. T. Y., Mockett, B. G., Ohline, S. M., Parfitt, K. D., Wicky, H. E., Peppercorn, K., Schoderboeck, L., Yahaya, M. F. b., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2018). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease. Molecular Brain, 11, 7. doi: 10.1186/s13041-018-0348-9
Conference Contribution - Published proceedings: Abstract
Parr-Brownlie, L. C., Sizemore, R. J., Smither, R. A., Hughes, S. M., & Bosch-Bouju, C. (2018). Substania nigra pars reticulata-ventroanterior motor thalamus synpases are altered in parkinsonian rats. Proceedings of the Society for Neuroscience 48th Annual Meeting. 146.13/II17. SfN. Retrieved from https://www.sfn.org
Parr-Brownlie, L. C., Smither, R. A., Sizemore, R. J., Wicky, H. E., Hughes, S. M., & Bosch-Bouju, C. (2018). Anatomical and physiological changes at basal ganglia-motor thalamus synapses in rat model of Parkinson's disease. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 67). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Mathiesen, S. N., Schoderboeck, L., Ohline, S. M., Wicky, H. E., Abraham, W. C., & Hughes, S. M. (2018). Assessing the efficacy of adeno-associated viral vectors in targeting the brain. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 63). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Eboda, O. N., Ward, M. E., & Hughes, S. M. (2018). ATP13A2: Characterization of novel human iPS cell models of Parkinson's and Batten's disease. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 58). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Seo, S., Sizemore, R. J., Bilkey, D. K., Hughes, S. M., Parr-Brownlie, L. C., & Oorschot, D. E. (2018). Changes in midbrain dopamine circuitry in the maternal immune activation rat model of schizophrenia. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 30). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Oorschot, D. E., Seo, S., Bilkey, D. K., Hughes, S. M., Parr-Brownlie, L. C., & Sizemore, R. J. (2018). Synaptic triad arrangement within an aversive pathway in the normal uninjured brain. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 29). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Conference Contribution - Poster Presentation (not in published proceedings)
Eboda, O. N., Ward, M. E., & Hughes, S. M. (2018, August). ATP13A2: Characterisation of novel human iPS cell models of Parkinson's and Batten's disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Biggs, H., Brown, C., & Hughes, S. (2018, August). Meta-analysis of mRNAs loaded into exosomes suggests cell type specific RNA localisation elements. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., … Hughes, S. M., & Palmer, D. N. (2018, August). Efficacy of gene therapy in a sheep model of CLN5 Batten disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2017
Journal - Research Article
Clare, A. J., Wicky, H. E., Empson, R. M., & Hughes, S. M. (2017). RNA-sequencing analysis reveals a regulatory role for transcription factor Fezf2 in the mature motor cortex. Frontiers in Molecular Neuroscience, 10, 283. doi: 10.3389/fnmol.2017.00283
Best, H. L., Neverman, N. J., Wicky, H. E., Mitchell, N. L., Leitch, B., & Hughes, S. M. (2017). Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics. Neurobiology of Disease, 100, 62-74. doi: 10.1016/j.nbd.2017.01.001
Conference Contribution - Published proceedings: Abstract
Yip, J. J. R., Wicky, H. E., Best, H. L., Mace, P. D., & Hughes, S. M. (2017). Understanding the Batten disease associated protein CLN5. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 666. Retrieved from http://gen2017.w.events4you.currinda.com
Ganesh, M., Clare, A., Dragunow, M., Hughes, S., Clarkson, A., & Empson, R. (2017). Pericyte therapeutics to repair the stroke-lesioned brain. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 28). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html
Ohline, S. M., Hegemann, R. U., Wake, K. L., Dinnunhan, M. F., Schweitzer, L., Hughes, S. M., & Abraham, W. C. (2017). Dormant adult-born neurons can be activated by exposure to an enriched environment. Proceedings of the Society for Neuroscience 47th Annual Meeting. 115.19/B27. SfN. Retrieved from https://www.sfn.org/
Clare, A. J., Wicky, H. E., Dearden, P. K., Empson, R. M., & Hughes, S. M. (2017). Developmentally important transcription factor Fezf2 has a molecular and functional role in the mature brain. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 693. Retrieved from http://gen2017.w.events4you.currinda.com
Wicky, H. E., Best, H. L., & Hughes, S. M. (2017). A role for secreted proteins in CLN6 Batten disease therapy. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 57). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Yip, J. J. R., Wicky, H. E., Best, H. L., Mace, P. D., & Hughes, S. M. (2017). Understanding the Batten disease associated protein CLN5. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 51). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Ganesh, M., Clare, A., Dragunow, M., Hughes, S., Clarkson, A., & Empson, R. (2017). Pericyte therapeutics to repair the stroke-lesioned brain. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 51). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Best, H. L., White, K., Weimer, J. M., & Hughes, S. M. (2017). Therapeutic targeting of autophagy in neurodegenerative Batten disease. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 44). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Clare, A. J., Day, R. C., Empson, R. M., & Hughes, S. M. (2017). Transcriptome profiling of layer 5 intratelencephalic-projection neurons in the mature mouse motor cortex. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 37). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Conference Contribution - Poster Presentation (not in published proceedings)
Seeger-Armbruster, S., Smither, R. A., Wicky, H. E., Bosch-Bouju, C., Hughes, S. M., & Hyland, B. I. (2017, March ). Neuronal responses at motor thalamus-motor cortex synapses are altered in parkinsonian rats. Poster session presented at the 12th International Basal Ganglia Society Meeting (IBAGS XII), Mérida, Mexico.
2016
Journal - Research Article
Sizemore, R. J., Seeger-Armbruster, S., Hughes, S. M., & Parr-Brownlie, L. C. (2016). Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology. Journal of Neurophysiology, 115, 2124-2146. doi: 10.1152/jn.01131.2015
Tantirigama, M. L. S., Oswald, M. J., Clare, A. J., Wicky, H. E., Day, R. C., Hughes, S. M., & Empson, R. M. (2016). Fezf2 expression in layer 5 projection neurons of mature mouse motor cortex. Journal of Comparative Neurology, 524(4), 829-845. doi: 10.1002/cne.23875
Conference Contribution - Published proceedings: Abstract
Mercer, S., Cheong, M. Y. I., Abraham, W., & Hughes, S. (2016). In vivo tolerability and effects of autophagy enhancers as potential therapeutic interventions for Alzheimer's disease. Proceedings of the Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au
Clare, A. J., Day, R. C., Empson, R. M., & Hughes, S. M. (2016). Transcriptome profiling of Fezƒ2-expressing intratelencephalic-projection neurons in the mature mouse motor cortex. Proceedings of the Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au
Best, H. L., Neverman, N. J., Wicky, H. E., Mitchell, N. L., Palmer, D. N., & Hughes, S. M. (2016). Correction of autosomal, lysosomal, and synaptic changes present in ovine neuronal cultures of neurodegenerative Batten disease. Proceedings of the Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au
Clare, A. J., Day, R. C., Empson, R. M., & Hughes, S. M. (2016). Transcriptome profiling of Fezf2 expressing intratelencephalic projection neurons in the mature mouse motor cortex. Proceedings of the 16th International Conference of Biochemistry and Molecular Biology (IUBMB): Signalling Pathways in Development, Disease and Aging. (pp. 78). Retrieved from http://www.iubmb2016.org
Morrissey, J., Mockett, B. G., Peppercorn, K., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2016). Peptides of amyloid precursor protein alpha mimic the parent molecule's enhancement of hippocampal LTP. Proceedings of the Society for Neuroscience 46th Annual Meeting. 131.19/K17. SfN. Retrieved from https://www.sfn.org/
Abraham, W. C., Ohline, S. M., Hegemann, R. U., Wake, K. L., Dinnunhan, M. F., Schweitzer, L., & Hughes, S. M. (2016). Do adult-born granule cells "retire"? Proceedings of the Society for Neuroscience 46th Annual Meeting. 740.27/III30. SfN. Retrieved from https://www.sfn.org/
Mercer, S. A., Cheong, M. Y. I., Abraham, W. C., & Hughes, S. M. (2016). In vivo tolerability and effects of autophagy enhancers as potential therapeutic interventions for Alzheimer’s disease. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 38). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Ohline, S. M., Hegemann, R. U., Wake, K. L., Dinnunhan, M. F., Wilson, A. D., Schoderböck, L., Hughes, S. M., & Abraham, W. C. (2016). Adult born neurons: Do cells “retire” and does developmental age matter? New Zealand Medical Journal, 129(1442), (pp. 97). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Verbal presentation and other Conference outputs
Mitchell, N. L., Barrell, G. K., Russell, K. N., Wellby, M. P., Melzer, T. R., Wicky, H. E., Hughes, S. M., … Palmer, D. N. (2016, October). Gene transfer can prevent stereotypical disease development in ovine CLN5 and CLN6 models of NCL. Verbal presentation at the 15th International Conference on Neuronal Ceroid Lipofuscinosis (Batten Disease), Boston, USA.
Mitchell, N. L., Barrell, G. K., Russell, K. N., Wellby, M. P., Melzer, T. R., Wicky, H. E., Hughes, S. M., … Palmer, D. N. (2016, November). In vivo efficacy of viral-mediated gene transfer in ovine Batten disease. Verbal presentation at the Joint Meeting of the New Zealand Microbiological Society (NZMS) and the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), Christchurch, New Zealand.
Mitchell, N. L., Barrell, G. K., Russell, K. N., Wellby, M., Melzer, T. R., Wicky, H. E., Hughes, S. M., … Palmer, D. N. (2016, August). Viral-mediated gene transfer prevents stereotypical disease development in ovine Batten disease. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
2015
Chapter in Book - Research
Empson, R. M., Tantirigama, M. L. S., Oswald, M. J., Hughes, S. M., & Knöpfel, T. (2015). Combined immunochemistry and live imaging of fluorescent protein expressing neurons in mouse brain. In A. Merighi & L. Lossi (Eds.), Immunocytochemistry and related techniques. (pp. 357-373). New York: Springer. doi: 10.1007/978-1-4939-2313-7_19
Journal - Research Article
Neverman, N. J., Best, H. L., Hofmann, S. L., & Hughes, S. (2015). Experimental therapies in the neuronal ceroid lipofuscinoses. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1852(10, Part B), 2292-2300. doi: 10.1016/j.bbadis.2015.04.026
Palmer, D. N., Neverman, N. J., Chen, J. Z., Chang, C.-T., Houweling, P. J., Barry, L. A., … Hughes, S. M., & Mitchell, N. L. (2015). Recent studies of ovine neuronal ceroid lipofuscinoses from BARN, the Batten Animal Research Network. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1852(10, Part B), 2279-2286. doi: 10.1016/j.bbadis.2015.06.013
Parr-Brownlie, L. C., Bosch-Bouju, C., Schoderboeck, L., Sizemore, R. J., Abraham, W. C., & Hughes, S. M. (2015). Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms. Frontiers in Molecular Neuroscience, 8, 14. doi: 10.3389/fnmol.2015.00014
Schoderboeck, L., Riad, S., Bokor, A. M., Wicky, H. E., Strauss, M., Bostina, M., Oswald, M. J., Empson, R. M., & Hughes, S. M. (2015). Chimeric rabies SADB19-VSVg-pseudotyped lentiviral vectors mediate long-range retrograde transduction from the mouse spinal cord. Gene Therapy, 22, 357-364. doi: 10.1038/gt.2015.3
Seeger-Armbruster, S., Bosch-Bouju, C., Little, S. T. C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2015). Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced Parkinsonian rats. Journal of Neuroscience, 35(3), 1211-1216. doi: 10.1523/jneurosci.3277-14.2015
Conference Contribution - Published proceedings: Abstract
Morrissey, J., Mockett, B. G., Peppercorn, K., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2015). Fragments of amyloid precursor protein enhance rat hippocampal LTP. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 65). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Clare, A. J., Day, R. C., Empson, R. M., & Hughes, S. M. (2015). Optimisation of fluorescent activated cell sorting and RNA extraction from dissociated mature mouse cortex tissue for transcriptome profiling. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 61). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Dinnunhan, M. F. K., Ohline, S. M., Wake, K. L., Schoderböck, L., Hughes, S. M., & Abraham, W. C. (2015). Reawakening adult-generated hippocampal granule cells: The effects of enriched environment on an established trend. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 60). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Best, H. L., Neverman, N. J., Wicky, H. E., Mitchell, N. L., Palmer, D. N., & Hughes, S. M. (2015). Correction of pathology in ovine CLN5 Batten disease neural cultures. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 47). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Smither, R. A., Seeger-Armbruster, S., Hughes, S., Hyland, B., & Parr-Brownlie, L. C. (2015). Characterising ventroanterior motor thalamus inputs to motor cortex. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 45). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Sizemore, R. J., Parr-Brownlie, L. C., Hughes, S. M., & Oorschot, D. E. (2015). Complex GABAergic innervation onto ventral tegmental dopamine neurons. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 30). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Seeger-Armbruster, S., Bosch-Bouju, C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2015). Optogenetic stimulation of motor thalamic terminals modulates motor cortex activity in freely moving Parkinsonian rats. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 30). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Ohline, S., Hegemann, R., Wake, K., Wilson, A., Schoderboeck, L., Hughes, S., & Abraham, W. (2015). Adult born neurons: Do cells "retire" and does developmental age matter? Journal of Neurochemistry, 134(Suppl. 1), (pp. 182). doi: 10.1111/jnc.13188
Conference Contribution - Verbal presentation and other Conference outputs
Mitchell, N. L., Wicky, H. E., Schoderböck, L., Barrell, G. K., Wellby, M. P., Russell, K. N., … Hughes, S. M., & Palmer, D. N. (2015, October). Viral-mediated gene therapy prevents disease development in ovine models of neuronal ceroid lipofuschinosis. Verbal presentation at the 20th European Study Group on Lysosomal Diseases (ESGLD) Workshop, Naples, Italy.
Hughes, S. (2015, June). Sheep, sheep dogs and childhood brain diseases. Verbal presentation at the 9th Annual Brain Health Research Centre Conference: Science for a Healthy Brain, Dunedin, New Zealand.
2014
Journal - Research Article
Tantirigama, M. L. S., Oswald, M. J., Duynstee, C., Hughes, S. M., & Empson, R. M. (2014). Expression of the developmental transcription factor Fezf2 identifies a distinct subpopulation of layer 5 intratelencephalic-projection neurons in mature mouse motor cortex. Journal of Neuroscience, 34(12), 4303-4308. doi: 10.1523/jneurosci.3111-13.2014
Hughes, S. M., Hope, K. M., Xu, J. B., Mitchell, N. L., & Palmer, D. N. (2014). Inhibition of storage pathology in prenatal CLN5-deficient sheep neural cultures by lentiviral gene therapy. Neurobiology of Disease, 62, 543-550. doi: 10.1016/j.nbd.2013.11.011
Conference Contribution - Published proceedings: Abstract
Hughes, S. M., Palmer, D. N., Schoderboeck, L., Mitchell, N. L., McIntyre, K., Haskell, R. E., Anderson, R. D., Wicky, H. E., & Xu, J. B. (2014). New antibodies predict an interaction between CLN5 and CLN6. Medicina, 74(Suppl. 2), (pp. 24-25). [Abstract]
Mitchell, N. L., Barrell, G. K., Wellby, M., Wicky, H. E., & Hughes, S. M. (2014). Gene therapy using adeno-associated virus serotype 9 in the sheep brain. Medicina, 74(Suppl. 2), (pp. 23). [Abstract]
Tantirigama, M. L. S., Oswald, M. J., Duynstee, C., Hughes, S. M., & Empson, R. M. (2014). Expression of the developmental transcription factor FEZF2 identifies a distinct subpopulation of layer 5 callosal projection neurons in mature mouse motor cortex. Proceedings of the Australasian Neuroscience Society 34th Annual Meeting. Retrieved from http://www.ans.org.au/
Yahaya, M. F., Parfitt, K. D., Mockett, B. G., Schoderböck, L., Peacock, H. E., Bourne, K., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2014). Secreted amyloid precursor protein-α overexpression in vivo rescues the long-term potentiation deficit in a mouse model of Alzheimer’s disease. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts
Seeger-Armbruster, S., Bosch, C., Little, S. T. C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2014). Physiological patterns of optogenetic stimulation in the motor thalamus restore reaching in parkinsonian rats. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts
Seeger-Armbruster, S., Bosch, C., Little, S. T. C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2014). Does optogenetic stimulation of motor thalamus improve reaching in Parkinsonian rats? In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 33). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Yahaya, M. F., Hughes, S. M., & Abraham, W. C. (2014). Using gene transfer to combat Alzheimer's Disease. Proceedings of the Psycolloquy Seminar. (pp. 12). Dunedin, New Zealand: Department of Psychology, University of Otago. Retrieved from http://www.otago.ac.nz/psychology/research/otago059081.html
Parr-Brownlie, L. C., Sizemore, R. J., Hughes, S. M., & Oorschot, D. E. (2014). Virus infects electron microscopy: Combining techniques for enhanced imaging of brain circuitry. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 83). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Hughes, S. M., Palmer, D. N., Neverman, N. J., Mitchell, N. L., Xu, J. B., McIntyre, K. M., Wicky, H. E., & Schoderböck, L. (2014). Batten disease in sheep: Understanding lysosomal biology en route to therapies. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 82). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Schoderböck, L., van der Salm, L., Abraham, W. C., & Hughes, S. M. (2014). The role of recently born neurons in the adult mouse hippocampus in memory storage. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 79). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Tan, V. T. Y., Yahaya, M. F., Mockett, B., Schoderböck, L., Jones, O., Wicky, H., Abraham, W. C., & Hughes, S. M. (2014). Addressing Alzheimer's disease symptoms using lentiviral-mediated sAPPα overexpression in the hippocampus of a transgenic mouse model. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 69). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Ohline, S. M., Hegemann, R. U., Wilson, A. D., Hughes, S. M., & Abraham, W. C. (2014). Awakening adult-born neurons in rats by exposure to an enriched environment. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 65). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Neverman, N. J., Palmer, D. N., & Hughes, S. M. (2014). Synaptic pathology in CLN6 ovine neuronal ceroid lipofuscinosis. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 28). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Conference Contribution - Verbal presentation and other Conference outputs
Hughes, S. (2014, August). Clearing out the garbage: Understanding lysosomal biology en route to therapies. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2013
Journal - Research Article
Oswald, M. J., Tantirigama, M. L. S., Sonntag, I., Hughes, S. M., & Empson, R. M. (2013). Diversity of layer 5 projection neurons in the mouse motor cortex. Frontiers in Cellular Neuroscience, 7, 174. doi: 10.3389/fncel.2013.00174
Conference Contribution - Published proceedings: Abstract
Ohline, S. M., Wake, K. L., Hughes, S. M., & Abraham, W. C. (2013). Birthdating two cohorts of adult-born granule cells within-animal for comparisons of maturity-dependent cell excitability. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 63). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Yahaya, M. F., Parfitt, K. D., Hughes, S. M., & Abraham, W. C. (2013). Lentivirus-mediated aAPPα overexpression in Alzheimer disease mouse model rescues the deficit in long-term potentiation. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 58). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Bosch-Bouju, C., Prier, J., Smither, R., Hughes, S., Hyland, B., & Parr-Brownlie, L. (2013). Optogenetic stimulation of basal ganglia inputs to motor thalamus affects reaching in parkinsonian rats. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 40). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Schoderböck, L., Abraham, W., & Hughes, S. (2013). Memory formation and retrieval without newborn neurons: Are they necessary? New Zealand Medical Journal, 126(1377). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Poster Presentation (not in published proceedings)
Vick, K. A., Betz, A., O'Connor, K. M., Hughes, S. M., Ledgerwood, E. C., & Hampton, M. B. (2013, August). Functional consequences of lowering mitochondrial peroxiredoxin 3 expression. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2012
Journal - Research Article
Jarvis, R. M., Hughes, S. M., & Ledgerwood, E. C. (2012). Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells. Free Radical Biology & Medicine, 53(7), 1522-1530. doi: 10.1016/j.freeradbiomed.2012.08.001
Conference Contribution - Published proceedings: Abstract
Oswald, M. J., Tantirigama, M. L. S., Hughes, S. M., & Empson, R. M. (2012). Functional characterisation of layer 5 projection neurons in the mouse motor cortex. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 91). Retrieved from http://www.ans.org.au/ans-annual-conference/
Mitchell, N. L., Palmer, D. N., Barry, L. A., Peacock, H. E., & Hughes, S. M. (2012). Viral vector gene therapy for CLN5 and CLN6 Batten disease in ovine models. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 72). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Neverman, N. J., Xu, J., Mitchell, N. L., Palmer, D. N., & Hughes, S. M. (2012). Early pathology in ovine CLN6 Batten disease: Assays for testing therapies. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 63). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Peacock, H. E., Empson, R. M., & Hughes, S. M. (2012). A role for FEZF2 in projection maintenance and cell survival. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 43). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Bosch, C., Prier, J., Hughes, S., Hyland, B., & Parr-Brownlie, L. (2012). New light-activated protein constructs to dissect the function of GABAergic neurons in the brain. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 42). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Schoderböck, L., Sedlak, P., Sah, P., Abraham, W. C., & Hughes, S. M. (2012). Reversible inactivation of primary neurons in vitro. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 40). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Tantirigama, M. L. S., Oswald, M. J., McTavish, E., Hughes, S. M., & Empson, R. M. (2012). Diversity of layer 5 projection neurons in mouse motor cortex. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 32). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Conference Contribution - Verbal presentation and other Conference outputs
Parr-Brownlie, L. C., Hughes, S. M., & Hyland, B. I. (2012, August). Highlighting a novel treatment for Parkinson's disease. Verbal presentation at the Hui Poutama: Māori Research Symposium: Ka Haere Whakamua, Ka Titiro Whakamuri, Dunedin, New Zealand.
2011
Journal - Research Article
Linterman, K. S., Palmer, D. N., Kay, G. W., Barry, L. A., Mitchell, N. L., McFarlane, R. G., Black, M. A., … Hughes, S. M. (2011). Lentiviral-mediated gene transfer to the sheep brain: Implications for gene therapy in Batten disease. Human Gene Therapy, 22(8), 1011-1020. doi: 10.1089/hum.2011.026
Dottori, M., Tay, C., & Hughes, S. M. (2011). Neural development in human embryonic stem cells—Applications of lentiviral vectors. Journal of Cellular Biochemistry, 112(8), 1955-1962. doi: 10.1002/jcb.23116
Conference Contribution - Published proceedings: Abstract
Tantirigama, M. L. S., Oswald, M. J., Hughes, S. M., & Empson, R. M. (2011). Projection neuron identity in the mouse motor cortex. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.48. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Oswald, M. J., Hughes, S. M., & Empson, R. M. (2011). Sublayer-specific colocalisation of corticospinal neurons with the lamina 5 pyramidal neuron marker Fezf2. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.47. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Hope, K., Mitchell, N. L., Palmer, D. N., & Hughes, S. M. (2011). Characterisation of neurons and processing of CLN5 in CLN5-deficient sheep. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.6. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Peacock, H. E., Black, M. A., Empson, R. M., & Hughes, S. M. (2011). FEZF2 regulates projection maintenance in postnatal neurons in vitro. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 1.2. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Hughes, S. (2011). Developing gene therapies in a sheep brain. Proceedings of the Centre for Reproduction and Genomics Third Annual Research Colloquium. (pp. 5). Retrieved from http://www.crg.org.nz/colloquium/programme-2011.pdf
2010
Conference Contribution - Published proceedings: Abstract
Tantirigama, M. L. S., Hughes, S. M., & Empson, R. M. (2010). GFP expression in Fezf2-GFP adult mouse brain. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 38). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Conference Contribution - Verbal presentation and other Conference outputs
Linterman, K., Mitchell, N. L., Barry, L. A., Jay, N. P., McFarlane, R. G., Black, M. A., … Hughes, S. M. (2010, February). Viral therapy for batten disease in sheep. Verbal presentation at the New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.
2009
Conference Contribution - Published proceedings: Abstract
Parker, S., & Hughes, S. (2009). The many roles of Fezf2. New Zealand Medical Journal, 122(1295). Retrieved from http://journal.nzma.org.nz/journal/122-1295/3623/content.pdf
2008
Conference Contribution - Published proceedings: Abstract
Hughes, S. M., Mitchell, N., Linterman, K., Jay, N. P., McFarlane, R. G., Kay, G. W., & Palmer, D. N. (2008). Towards gene therapy in ovine batten disease. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 25). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
2007
Journal - Research Article
Kells, A. P., Henry, R. A., Hughes, S. M., & Connor, B. (2007). Verification of functional AAV-mediated neurotrophic and anti-apoptotic factor expression. Journal of Neuroscience Methods, 161(2), 291-300. doi: 10.1016/j.jneumeth.2006.11.006
Henry, R. A., Hughes, S. M., & Connor, B. (2007). AAV-mediated delivery of BDNF augments neurogenesis in the normal and quinolinic acid-lesioned adult rat brain. European Journal of Neuroscience, 25(12), 3513-3525. doi: 10.1111/j.1460-9568.2007.05625.x
Gibbons, H. M., Hughes, S. M., Van Roon-Mom, W., Greenwood, J. M., Narayan, P. J., Teoh, H. H., … Dragunow, M. (2007). Cellular composition of human glial cultures from adult biopsy brain tissue. Journal of Neuroscience Methods, 166(1), 89-98. doi: 10.1016/j.jneumeth.2007.07.005
Gordon, R. J., Tattersfield, A. S., Vazey, E. M., Kells, A. P., McGregor, A. L., Hughes, S. M., & Connor, B. (2007). Temporal profile of subventricular zone progenitor cell migration following quinolinic acid–induced striatal cell loss. Neuroscience, 146(4), 1704-1718. doi: 10.1016/j.neuroscience.2007.03.011
Chen, K., Henry, R. A., Hughes, S. M., & Connor, B. (2007). Creating a neurogenic environment: The role of BDNF and FGF2. Molecular & Cellular Neuroscience, 36(1), 108-120. doi: 10.1016/j.mcn.2007.06.004
Chen, K., Hughes, S. M., & Connor, B. (2007). Neural progenitor cells derived from the adult rat subventricular zone: Characterization and transplantation. Cell Transplantation, 16(8), 799-810.
2006
Journal - Research Article
Vazey, E. M., Chen, K., Hughes, S. M., & Connor, B. (2006). Transplanted adult neural progenitor cells survive, differentiate and reduce motor function impairment in a rodent model of Huntington's disease. Experimental Neurology, 199(2), 384-396. doi: 10.1016/j.expneurol.2006.01.034
Conference Contribution - Published proceedings: Abstract
Palmer, D. N., Kay, G. W., Oswald, M. J., Hughes, S. M., & Cooper, J. D. (2006). Initial studies towards gene therapy in ovine batten disease. In J. G. Anson (Ed.), Proceedings of the 24th International Australasian Winter Conference on Brain Research. 24, (pp. 26). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2006Abstracts.pdf
2001
Journal - Research Article
Hughes, S. M., Moroni-Rawson, P., Jolly, R. D., & Jordan, T. W. (2001). Sub-mitochondrial distribution and delayed proteolysis of subunit c of the H+-transporting ATP synthase in ovine ceroid-lipofuscinosis. Electrophoresis, 22, 1785-1794.
2000
Conference Contribution - Published proceedings: Abstract
Palmer, D. N., Kay, G. W., Hughes, S. M., & Oswald, M. J. (2000). Ovine neuron cultures for studying Batten disease. Journal of Inherited Metabolic Disease. 23(Suppl. 1), (pp. 213). [Abstract]