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Associate Professor Christine Jasoni

Christine JasoniAssociate Professor Jasoni is the Deputy Director of the Brain Health Research Centre. Her research focuses on discovering how the maternal environment affects the formation of the fetal brain and seeks to establish how maternal obesity during pregnancy alters the development of the fetal brain circuits that regulate offspring body weight. With conditions such as obesity and diabetes on the rise, it is critical to fully understand the health implications of these disorders for future generations. There is clear epidemiological data showing that maternal obesity can greatly increase the likelihood that offspring will also be obese. Assoc Prof Jasoni is looking for epigenetic changes in the brains of the offspring of obese or diabetic mothers, as a further mechanism to explain the influence of maternal health on offspring brain function.

To address their scientific questions, Assoc Prof Jasoni’s research team uses an array of techniques including molecular and cellular biology, mouse genetic models, live cell imaging, and bioinformatics. In addition, they have active collaborations with laboratories in the Centre for Neuroendocrinology, the National Research Centre for Growth and Development, and overseas collaborations. This collaborative research creates a vibrant, intellectually invigorating environment in which to conduct cutting-edge internationally recognised science and will have beneficial health outcomes in New Zealand and the world.

Dr Jasoni is also a member of the Centre for Neuroendocrinology

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Publications

Kim, D. W., Young, S. L., Grattan, D. R., & Jasoni, C. L. (2014). Obesity during pregnancy disrupts placental morphology, cell proliferation, and inflammation in a sex-specific manner across gestation in the mouse. Biology of Reproduction, 90(6), 130. doi: 10.1095/biolreprod.113.117259

Sanders, T. R., Kim, D. W., Glendining, K. A., & Jasoni, C. L. (2014). Maternal obesity and IL-6 lead to aberrant developmental gene expression and deregulated neurite growth in the fetal arcuate nucleus. Endocrinology, 155(7), 2566-2577. doi: 10.1210/en.2013-1968

Hale, M. W., Spencer, S. J., Conti, B., Jasoni, C. L., Kent, S., Radler, M. E., … Sominsky, L. (2015). Diet, behavior and immunity across the lifespan. Neuroscience & Biobehavioral Reviews, 58, (pp. 46-62). doi: 10.1016/j.neubiorev.2014.12.009

Fiorini, Z., & Jasoni, C. L. (2010). A novel developmental role for Kisspeptin in the growth of GnRH neurites to the median eminence in the mouse. Journal of Neuroendocrinology, 22(10), 1113-1125. doi: 10.1111/j.1365-2826.2010.02059.x

Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007). Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology, 148(9), 4344-4351.

Journal - Research Article

Jasoni, C. L., Sanders, T. R., & Kim, D. W. (2015). Do all roads lead to Rome? The role of neuro-immune interactions before birth in the programming of offspring obesity. Frontiers in Neuroscience, 8, 455. doi: 10.3389/fnins.2014.00455

Franz, E. A., Chiaroni-Clarke, R., Woodrow, S., Glendining, K. A., Jasoni, C. L., Robertson, S. P., Gardner, R. J. M., & Markie, D. (2015). Congenital mirror movements: Phenotypes associated with DCC and RAD51 mutations. Journal of the Neurological Sciences, 351(1-2), 140-145. doi: 10.1016/j.jns.2015.03.006

Sanders, T. R., Kim, D. W., Glendining, K. A., & Jasoni, C. L. (2014). Maternal obesity and IL-6 lead to aberrant developmental gene expression and deregulated neurite growth in the fetal arcuate nucleus. Endocrinology, 155(7), 2566-2577. doi: 10.1210/en.2013-1968

Kim, D. W., Young, S. L., Grattan, D. R., & Jasoni, C. L. (2014). Obesity during pregnancy disrupts placental morphology, cell proliferation, and inflammation in a sex-specific manner across gestation in the mouse. Biology of Reproduction, 90(6), 130. doi: 10.1095/biolreprod.113.117259

Wyatt, A. K., Zavodna, M., Viljoen, J. L., Stanton, J.-A. L., Gemmell, N. J., & Jasoni, C. L. (2013). Changes in methylation patterns of Kiss1 and Kiss1r gene promoters across puberty. Genetics & Epigenetics, 5, 51-62.

Constantin, S., Jasoni, C. L., Wadas, B., & Herbison, A. E. (2010). γ-aminobutyric acid and glutamate differentially regulate intracellular calcium concentrations in mouse gonadotropin-releasing hormone neurons. Endocrinology, 151(1), 262-270. doi: 10.1210/en.2009-0817

Jasoni, C. L., Romanò, N., Constantin, S., Lee, K., & Herbison, A. E. (2010). Calcium dynamics in gonadotropin-releasing hormone neurons. Frontiers in Neuroendocrinology, 31, 259-269. doi: 10.1016/j.yfrne.2010.05.005

Fiorini, Z., & Jasoni, C. L. (2010). A novel developmental role for Kisspeptin in the growth of GnRH neurites to the median eminence in the mouse. Journal of Neuroendocrinology, 22(10), 1113-1125. doi: 10.1111/j.1365-2826.2010.02059.x

Jasoni, C. L., Porteous, R. W., & Herbison, A. E. (2009). Anatomical location of mature GnRH neurons corresponds with their birthdate in the developing mouse. Developmental Dynamics, 238(3), 524-531.

Romanò, N., Lee, K., Ábrahám, I. M., Jasoni, C. L., & Herbison, A. E. (2008). Nonclassical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone neurons. Endocrinology, 149(11), 5335-5344. doi: 10.1210/en.2008-0424

Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007). Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology, 148(9), 4344-4351.

Jasoni, C. L., Todman, M. G., Strumia, M. M., & Herbison, A. E. (2007). Cell type-specific expression of a genetically encoded calcium indicator reveals intrinsic calcium oscillations in adult gonadotropin-releasing hormone neurons. Journal of Neuroscience, 27(4), 860-867.

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Conference Contribution - Published proceedings: Full paper

Hale, M. W., Spencer, S. J., Conti, B., Jasoni, C. L., Kent, S., Radler, M. E., … Sominsky, L. (2015). Diet, behavior and immunity across the lifespan. Neuroscience & Biobehavioral Reviews, 58, (pp. 46-62). doi: 10.1016/j.neubiorev.2014.12.009

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Conference Contribution - Published proceedings: Abstract

Jasoni, C. (2011). Epigenetics and the timing of puberty. Proceedings of the Centre for Reproduction and Genomics Third Annual Research Colloquium. (pp. 13). Retrieved from http://www.crg.org.nz/colloquium/programme-2011.pdf

Tan, C., & Jasoni, C. (2011). Sonic hedgehog is expressed in the ventral forebrain, where it stimulates gonadotropin releasing-hormone neuron axon growth. New Zealand Medical Journal, 124(1344). Retrieved from http://journal.nzma.org.nz/journal/124-1344/4919/content.pdf

Constantin, S. S., Jasoni, C., Wadas, B., & Herbison, A. E. (2009). Amino acid regulation of intracellular calcium levels in GnRH neurons. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Jasoni, C. L., & Fiorini, Z. (2009). Effects of kisspeptin on neurite outgrowth from GnRH neurons of the embryonic mouse. Proceedings of the Endocrine Society's 91st Annual Meeting. Retrieved from http://www.abstracts2view.com/endo/

Romanò, N., Jasoni, C., & Herbison, A. (2007). Multiple effects of estrogen on intracellular calcium levels in adult gonadotropin-releasing hormone neurons. New Zealand Medical Journal, 120(1262). Retrieved from http://journal.nzma.org.nz/journal/120-1262/2740/content.pdf

Jasoni, C., Wadas, B., & Herbison, A. (2007). Acute calcium responses of postnatal GnRH neurons to GABA and glutamate change with development. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp

Romano, N., Jasoni, C., & Herbison, A. (2006). Multiple mechanisms of rapid estrogen action upon intracellular calcium levels in adult GnRH neurons. Proceedings of the Society for Neuroscience Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

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Conference Contribution - Poster Presentation (not in published proceedings)

Tan, C. L., & Jasoni, C. (2010, September). Does sonic hedgehog regulate the axonal development of gonadotropin-releasing hormone neurons? Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.

Romano, N., Jasoni, C., & Herbison, A. (2006, October). Multiple mechanisms of rapid estrogen action upon intracellular calcium levels in adult GnRH neurons. Poster session presented at the Neuroscience Society's 36th Annual Meeting, Atlanta, GA.

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Conference Contribution - Verbal presentation and other Conference outputs

Jasoni, C. (2008, June). The long and winding road: Understanding axon guidance in neuroendocrine cells of the basal forebrain. Verbal presentation at the Brain Health and Repair Research Centre 2nd Annual Conference, Dunedin, New Zealand.

Jasoni, C., & Fiorini, Z. (2008, November). Effects of kisspeptin on axon outgrowth from GnRH neurons in the embryonic mouse. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Tan, C. L., & Jasoni, C. L. (2008, November). Sonic hedgehog has an inhibitory effect on the growth of axons from gonadotropin-releasing hormone neurons. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Grattan, D. R., Jasoni, C., Liu, X., & Herbison, A. E. (2007, June). Detection of prolactin receptor mRNA in identified GnRH neurons by single cell RT-PCR. Verbal presentation at the Endocrine Society 89th Annual Meeting, Toronto, Canada.

Herbison, A. E., Campbell, R., Clarkson, J., Jasoni, C., Porteous, R., & Wintermantle, T. (2006, June). New horizons in the biology of the GnRH neuron. Verbal presentation at the 6th International Congress of Neuroendocrinology, Pittsburgh, Pennsylvania.

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Other Research Output

Jasoni, C. (2010, October). Re-wiring the brain. Genetics Otago Southern Science Series. Wanaka, New Zealand. [Public Lecture].

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