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Professor Brian Hyland is interested in systems neuroscience, in particular the neurophysiology of midbrain dopamine systems and other brain structures which modulate dopamine neuron activity. He is also investigating the activity of these systems in reward-mediated learning, as well as the functions of circuits concerned with control of movement. His research extends from normal to abnormal functioning of these circuits in disease states such as Parkinson's disease and attention deficit-hyperactivity disorder.

Professor Hyland has ongoing collaborations with Professors Jeff Wickens and Gordon Arbuthnott, Okinawa Institute of Science & Technology, Japan, Associate Professor J. Greg Anson, University of Auckland, Dr Alessandro Villa, Lausanne Switzerland, Professor Jason Chen, Tainan, Taiwan and members of the University of Otago Basal Ganglia Research Group.

His funding is, or has recently been, provided by the Health Research Council of New Zealand, the Marsden Fund, Boehringer Ingelheim Pharma GmbH, and the Neurological Foundation of New Zealand.

Publications

Reynolds, J. N. J., Hyland, B. I., & Wickens, J. (2001). A cellular mechanism of reward-related learning. Nature, 413, 67-70.

Hyland, B. I., Reynolds, J. N. J., Hay, J., Perk, C. G., & Miller, R. (2002). Firing modes of midbrain dopamine cells in the freely moving rat. Neuroscience, 114(2), 475-492.

Pan, W.-X., Schmidt, R., Wickens, J. R., & Hyland, B. I. (2005). Dopamine cells respond to predicted events during classical conditioning: Evidence for eligibility traces in the reward-learning network. Journal of Neuroscience, 25(26), 6235-6242.

Dejean, C., Arbuthnott, G., Wickens, J. R., Le Moine, C., Boraud, T., & Hyland, B. I. (2011). Power fluctuations in beta and gamma frequencies in rat globus pallidus: Association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors. Journal of Neuroscience, 31(16), 6098-6107. doi: 10.1523/JNEUROSCI.3311-09.2011

Li, Y., Dalphin, N., & Hyland, B. I. (2013). Association with reward negatively modulates short latency phasic conditioned responses of dorsal raphe nucleus neurons in freely moving rats. Journal of Neuroscience, 33(11), 5065-5078. doi: 10.1523/jneurosci.5679-12.2013

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