Probing complex molecular interactions at high concentrations
Biomolecular interactions do not take place in dilute, highly‐purified solutions, though that is how we usually characterize them. Instead, these interactions must take place in highly concentrated, complex mixtures of molecules. How do these complex, crowded conditions affect the interactions? Are they stronger or weaker? Do sizes of the interacting molecules and their resultant complexes matter? Of equal interest to what forces stabilize the ‘right’ complexes is the reverse problem… how are ‘wrong’ complexes prevented? This talk will cover the processes that govern interactions, and present data that show how these interactions may begin to be characterized using analytical ultracentrifugation.
|Date||Monday, 16 October 2017|
|Time||12:00pm - 1:00pm|
|Event Category||Health Sciences|
|Location||Biochemistry seminar rm 231|