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Biochemistry PhD Seminar | Murray Cadzow

Positive Selection of Serum Urate in the Pacific

'Signatures of selection' in a population can be identified in regions of the genome 
that exhibit a reduction in genetic variability.  This reduction in variation can arise 
when the phenotype of a neutral beneficial allele experiences a favourable change in 
environmental conditions.  This results in an increased frequency of both the allele, 
and linked sites, within a population. Polynesian populations share a common genetic 
ancestry with East Asia, but little characterisation of genetic selection has been 
undertaken in Polynesian populations. 

Serum urate has been associated with metabolic disorders.  It is hypothesised that 
serum urate may have undergone positive selection in Polynesians due to some of 
the beneficial properties, such as its role as an anti‑oxidant, or as an adjuvant for the 
innate immune system.  New Zealand Polynesians have inherently elevated serum 
urate levels and increased rates of gout.  In this talk I will present the results of a 
genome-wide study of selection in Polynesian (and other) populations, focusing on 
testing the hypothesis that genomic loci containing genes involved in urate 
processing have undergone selection. 

Date Tuesday, 28 November 2017
Time 12:00pm - 1:00pm
Audience Public
Event Category Health Sciences
Event Type Departmental Seminar
CampusDunedin
DepartmentBiochemistry
LocationBiochemistry Seminar rm 231

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