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Department of Biochemistry profile

Dr Wayne Patrick

PositionSenior Lecturer
DepartmentDepartment of Biochemistry
QualificationsBSc Hons, PhD
Research summaryEnzyme engineering and evolution

Research

We borrow tools from functional genomics, directed evolution, microbiology and enzymology to address a fundamental question in molecular evolution: where do new enzymes and metabolic pathways come from? Grappling with this question gives us insights for designing proteins that have biomedical and biotechnological applications.

Interests include:

  • The origins and evolution of new enzymes.
  • Enzyme-based strategies for bioremediation and chemical manufacture.
  • Engineering better enzymes for biotechnology.

More information can be found on our lab website.

Publications

Ferla, M. P., Brewster, J. L., Hall, K. R., Evans, G. B., & Patrick, W. M. (2017). Primordial-like enzymes from bacteria with reduced genomes. Molecular Microbiology. Advance online publication. doi: 10.1111/mmi.13737

Newton, M. S., Guo, X., Söderholm, A., Näsvall, J., Lundström, P., Andersson, D. I., … Patrick, W. M. (2017). Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes. PNAS. Advance online publication. doi: 10.1073/pnas.1618552114

Soo, V. W. C., Yosaatmadja, Y., Squire, C. J., & Patrick, W. M. (2016). Mechanistic and evolutionary insights from the reciprocal promiscuity of two pyridoxal phosphate-dependent enzymes. Journal of Biological Chemistry, 291(38), 19873-19887. doi: 10.1074/jbc.M116.739557

Brewster, J. L., Finn, T. J., Ramirez, M. A., & Patrick, W. M. (2016). Whither life? Conjectures on the future evolution of biochemistry. Biology Letters, 12(8), 20160269. doi: 10.1098/rsbl.2016.0269

Maddock, D. J., Patrick, W. M., & Gerth, M. L. (2015). Substitutions at the cofactor phosphate-binding site of a clostridial alcohol dehydrogenase lead to unexpected changes in substrate specificity. Protein Engineering, Design & Selection, 28(8), 251-258. doi: 10.1093/protein/gzv028

Journal - Research Article

Newton, M. S., Guo, X., Söderholm, A., Näsvall, J., Lundström, P., Andersson, D. I., … Patrick, W. M. (2017). Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes. PNAS. Advance online publication. doi: 10.1073/pnas.1618552114

Ferla, M. P., Brewster, J. L., Hall, K. R., Evans, G. B., & Patrick, W. M. (2017). Primordial-like enzymes from bacteria with reduced genomes. Molecular Microbiology. Advance online publication. doi: 10.1111/mmi.13737

Soo, V. W. C., Yosaatmadja, Y., Squire, C. J., & Patrick, W. M. (2016). Mechanistic and evolutionary insights from the reciprocal promiscuity of two pyridoxal phosphate-dependent enzymes. Journal of Biological Chemistry, 291(38), 19873-19887. doi: 10.1074/jbc.M116.739557

Maddock, D. J., Patrick, W. M., & Gerth, M. L. (2015). Substitutions at the cofactor phosphate-binding site of a clostridial alcohol dehydrogenase lead to unexpected changes in substrate specificity. Protein Engineering, Design & Selection, 28(8), 251-258. doi: 10.1093/protein/gzv028

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Journal - Research Other

Brewster, J. L., Finn, T. J., Ramirez, M. A., & Patrick, W. M. (2016). Whither life? Conjectures on the future evolution of biochemistry. Biology Letters, 12(8), 20160269. doi: 10.1098/rsbl.2016.0269

More publications...