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Department of Biochemistry profile

Dr Monica Gerth

PositionSenior Research Fellow
DepartmentDepartment of Biochemistry
QualificationsBSc PhD
Research summaryMolecular evolution

Research

  • Protein engineering and directed evolution
    • Engineering biofilm-blocking enzymes
  • Microbial chemotaxis
    • Functional and structural diversity of bacterial chemoreceptors
    • Phytophthora chemotaxis (e.g. Kauri dieback)

More information is available on our lab website.

Background

  • BSc, The Evergreen State College, USA (2002)
  • PhD, Emory University, USA (2007)
  • FRST Postdoctoral Fellow, Massey University (2008–2012)

Positions available

Enquires about projects from prospective students are welcome and should be sent to monica.gerth@otago.ac.nz. Please include a CV and a decription of your research interests.

Publications

Maddock, D. J., Gerth, M. L., & Patrick, W. M. (2017). An engineered glycerol dehydratase with improved activity for the conversion of meso 2,3-butanediol to butanone. Biotechnology. Advance online publication. doi: 10.1002/biot.201700480

Lawrence, S. A., Armstrong, C. B., Patrick, W. M., & Gerth, M. L. (2017). High-throughput chemical screening identifies compounds that inhibit different stages of the Phytophthora agathidicida and Phytophthora cinnamomi life cycles. Frontiers in Microbiology, 8, 1340. doi: 10.3389/fmicb.2017.01340

Gerth, M. L., Liu, Y., Jiao, W., Zhang, X.-X., Baker, E. N., Lott, J. S., … Johnston, J. M. (2017). Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas. Proteins. Advance online publication. doi: 10.1002/prot.25303

Mesarich, C. H., Rees-George, J., Gardner, P. P., Ghomi, F. A., Gerth, M. L., Andersen, M. T., … Fineran, P. C., & Templeton, M. D. (2017). Transposon insertion libraries for the characterization of mutants from the kiwifruit pathogen Pseudomonas syringae pv. actinidiae. PLoS ONE, 12(3), e0172790. doi: 10.1371/journal.pone.0172790

Brewster, J. L., McKellar, J. L. O., Finn, T. J., Newman, J., Peat, T. S., & Gerth, M. L. (2016). Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae. Scientific Reports, 6, 35198. doi: 10.1038/srep35198

Chapter in Book - Research

Patrick, W. M., & Gerth, M. L. (2014). ITCHY: Incremental Truncation for the Creation of Hybrid Enzymes. In E. M. J. Gillam, J. N. Copp & D. F. Ackerley (Eds.), Directed evolution library creation: Methods and protocols. (2nd ed.) (pp. 225-244). New York: Springer. doi: 10.1007/978-1-4939-1053-3_16

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Journal - Research Article

Maddock, D. J., Gerth, M. L., & Patrick, W. M. (2017). An engineered glycerol dehydratase with improved activity for the conversion of meso 2,3-butanediol to butanone. Biotechnology. Advance online publication. doi: 10.1002/biot.201700480

Mesarich, C. H., Rees-George, J., Gardner, P. P., Ghomi, F. A., Gerth, M. L., Andersen, M. T., … Fineran, P. C., & Templeton, M. D. (2017). Transposon insertion libraries for the characterization of mutants from the kiwifruit pathogen Pseudomonas syringae pv. actinidiae. PLoS ONE, 12(3), e0172790. doi: 10.1371/journal.pone.0172790

Gerth, M. L., Liu, Y., Jiao, W., Zhang, X.-X., Baker, E. N., Lott, J. S., … Johnston, J. M. (2017). Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas. Proteins. Advance online publication. doi: 10.1002/prot.25303

Lawrence, S. A., Armstrong, C. B., Patrick, W. M., & Gerth, M. L. (2017). High-throughput chemical screening identifies compounds that inhibit different stages of the Phytophthora agathidicida and Phytophthora cinnamomi life cycles. Frontiers in Microbiology, 8, 1340. doi: 10.3389/fmicb.2017.01340

Brewster, J. L., McKellar, J. L. O., Finn, T. J., Newman, J., Peat, T. S., & Gerth, M. L. (2016). Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae. Scientific Reports, 6, 35198. doi: 10.1038/srep35198

Maddock, D. J., Patrick, W. M., & Gerth, M. L. (2015). Substitutions at the cofactor phosphate-binding site of a clostridial alcohol dehydrogenase lead to unexpected changes in substrate specificity. Protein Engineering, Design & Selection, 28(8), 251-258. doi: 10.1093/protein/gzv028

McKellar, J. L. O., Minnell, J. J., & Gerth, M. L. (2015). A high-throughput screen for ligand binding reveals the specificities of three amino acid chemoreceptors from Pseudomonas syringae pv. actinidiae. Molecular Microbiology, 96(4), 694-707. doi: 10.1111/mmi.12964

Köpke, M., Gerth, M. L., Maddock, D. J., Mueller, A. P., Llew, F., Simpson, S. D., & Patrick, W. M. (2014). Reconstruction of an acetogenic 2,3-butanediol pathway involving a novel NADPH-dependent primary-secondary alcohol dehydrogenase. Applied & Environmental Microbiology, 80(11), 3394-3403. doi: 10.1128/AEM.00301-14

Wilson, R. H., Morton, S. K., Deiderick, H., Gerth, M. L., Paul, H. A., Gerber, H., … Patrick, W. M. (2013). Engineered DNA ligases with improved activities in vitro. Protein Engineering, Design & Selection, 26(7), 471-478. doi: 10.1093/protein/gzt024

Gerth, M. L., Ferla, M. P., & Rainey, P. B. (2012). The origin and ecological significance of multiple branches for histidine utilization in Pseudomonas aeruginosa PAO1. Environmental Microbiology, 14(8), 1929-1940. doi: 10.1111/j.1462-2920.2011.02691.x

Gerth, M. L., Nigon, L. V., & Patrick, W. M. (2012). Characterization of the indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa PAO1. Protein Journal, 31(5), 359-365. doi: 10.1007/s10930-012-9412-y

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