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Department of Biochemistry profile

Professor Parry Guilford

PositionResearch Professor
DepartmentDepartment of Biochemistry
QualificationsMSc PhD
Research summaryCancer susceptibility, translational cancer research, personalised medicine

Research

Professor Parry Guilford is the Director of the Centre for Translational Cancer Research and the Research Director of Pacific Edge Biotechnology Ltd. He completed his MSc at Otago in 1983, and his PhD at Cambridge University in 1989. His research interests include the genetics of inherited cancers, in particular gastric cancer, and the application of gene expression analysis to the diagnosis and management of cancer.

Awards

  • Parry Guilford
    2016, Elected as Fellow of the Royal Society of New Zealand
  • Parry Guilford
    2016, BMS Senior Researcher Award
  • Chris Harris
    2014, Otago Medical School Research Society's Student Science Writing Prize, 1st place
    Chris's entry was entitled ‘Unlocking Prostate Cancer’.
  • Parry Guilford
    2014, Sir Charles Hercus Medal for excellence in biomedical and health sciences
    For the discovery of the gene mutation that can lead to hereditary stomach cancer in families.
  • Bryony Telford
    2013, Otago School of Medical Sciences Postgraduate Symposium Speaking Award, 2nd place
  • Parry Guilford
    2013, HRC Beaven Medal for Translational Research
  • Parry Guilford
    2013, OSMS Commercialisation Award
  • ’translation of technological innovation to commercial reality’
  • Parry Guilford
    2009, James Cook Fellowship

Publications

Kavalieris, L., O'Sullivan, P., Frampton, C., Guilford, P., Darling, D., Jacobson, E., … Lotan, Y. (2017). Performance characteristics of a multigene urine biomarker test for monitoring for recurrent urothelial carcinoma in a multicenter study. Journal of Urology, 197(6), 1419-1426. doi: 10.1016/j.juro.2016.12.010

Lotan, Y., OʼSullivan, P., Raman, J. D., Shariat, S. F., Kavalieris, L., Frampton, C., Guilford, P., … Darling, D. (2017). Clinical comparison of noninvasive urine tests for ruling out recurrent urothelial carcinoma. Urologic Oncology. Advance online publication. doi: 10.1016/j.urolonc.2017.03.008

Ellison-Loschmann, L., Sporle, A., Corbin, M., Cheng, S., Harawira, P., Gray, M., … Guilford, P., … Pearce, N. (2017). Risk of stomach cancer in Aotearoa/New Zealand: A Māori population based case-control study. PLoS ONE, 12(7), e0181581. doi: 10.1371/journal.pone.0181581

McInnes, T., Zou, D., Rao, D. S., Munro, F. M., Phillips, V. L., McCall, J. L., Black, M. A., Reeve, A. E., & Guilford, P. J. (2017). Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer. BMC Cancer, 17, 228. doi: 10.1186/s12885-017-3226-4

Hoeksema, K., Wee, R., Macdonald, A., Guilford, P., Wall, J., & Cornwall, J. (2017). Where to from here? Posthumous healthcare data, digital e(lectronic)-mortality and New Zealand’s healthcare future. New Zealand Medical Journal, 130(1459), 64-70. Retrieved from http://www.nzma.org.nz/journal

Chapter in Book - Research

Dunbier, A. K., & Guilford, P. J. (2002). Gastric cancer: Inherited predisposition. In S. R. Hamilton & L. A. Aaltonen (Eds.), Encyclopedia of Cancer, Volume 2. (2nd ed.) (pp. 253-258). USA: Elsevier Science.

Fenoglio-Preiser, C., Carneiro, F., Correa, P., Guilford, P., & et al (2000). Gastric carcinoma. In S. R. Hamilton & L. A. Aaltonen (Eds.), World Health Organization classification of tumours: Pathology and genetics of tumours of the digestive system. (pp. 39-52). Lyon, France: IARC Press.

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Journal - Research Article

Kavalieris, L., O'Sullivan, P., Frampton, C., Guilford, P., Darling, D., Jacobson, E., … Lotan, Y. (2017). Performance characteristics of a multigene urine biomarker test for monitoring for recurrent urothelial carcinoma in a multicenter study. Journal of Urology, 197(6), 1419-1426. doi: 10.1016/j.juro.2016.12.010

McInnes, T., Zou, D., Rao, D. S., Munro, F. M., Phillips, V. L., McCall, J. L., Black, M. A., Reeve, A. E., & Guilford, P. J. (2017). Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer. BMC Cancer, 17, 228. doi: 10.1186/s12885-017-3226-4

Ellison-Loschmann, L., Sporle, A., Corbin, M., Cheng, S., Harawira, P., Gray, M., … Guilford, P., … Pearce, N. (2017). Risk of stomach cancer in Aotearoa/New Zealand: A Māori population based case-control study. PLoS ONE, 12(7), e0181581. doi: 10.1371/journal.pone.0181581

Lotan, Y., OʼSullivan, P., Raman, J. D., Shariat, S. F., Kavalieris, L., Frampton, C., Guilford, P., … Darling, D. (2017). Clinical comparison of noninvasive urine tests for ruling out recurrent urothelial carcinoma. Urologic Oncology. Advance online publication. doi: 10.1016/j.urolonc.2017.03.008

Hansford, S., Kaurah, P., Li-Chang, H., Woo, M., Senz, J., Pinheiro, H., … Guilford, P., … Huntsman, D. G. (2015). Hereditary diffuse gastric cancer syndrome: CDH1 mutations and beyond. JAMA Oncology, 1(1), 23-32. doi: 10.1001/jamaoncol.2014.168

Telford, B. J., Chen, A., Beetham, H., Frick, J., Brew, T. P., Gould, C. M., Single, A., Godwin, T., … Guilford, P. (2015). Synthetic lethal screens identify vulnerabilities in GPCR signalling and cytoskeletal organization in E-cadherin-deficient cells. Molecular Cancer Therapeutics, 14(5), 1213-1223. doi: 10.1158/1535-7163.mct-14-1092

Single, A., Beetham, H., Telford, B. J., Guilford, P., & Chen, A. (2015). A comparison of real-time and endpoint cell viability assays for improved synthetic lethal drug validation. Journal of Biomolecular Screening, 20(10), 1286-1293. doi: 10.1177/1087057115605765

van der Post, R. S., Vogelaar, I. P., Carneiro, F., Guilford, P., Huntsman, D., Hoogerbrugge, N., … Fitzgerald, R. C. (2015). Hereditary diffuse gastric cancer: Updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. Journal of Medical Genetics, 52, 361-374. doi: 10.1136/jmedgenet-2015-103094

Chen, A., Beetham, H., Black, M. A., Priya, R., Telford, B. J., Guest, J., Wiggins, G. A. R., Godwin, T. D., … Guilford, P. J. (2014). E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition. BMC Cancer, 14, 552. doi: 10.1186/1471-2407-14-552

Evans, J. J., Chitcholtan, K., Dann, J. M., Guilford, P., Harris, G., Lewis, L. K., Nagase, J., … Sykes, P. H. (2012). Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades. Gynecologic Oncology, 125(1), 214-219. doi: 10.1016/j.ygyno.2011.12.429

Huang, R. Y.-J., Guilford, P., & Thiery, J. P. (2012). Early events in cell adhesion and polarity during epithelial-mesenchymal transition. Journal of Cell Science, 125(19), 4417-4422. doi: 10.1242/jcs.099697

O'Sullivan, P., Sharples, K., Dalphin, M., Davidson, P., Gilling, P., Cambridge, L., … Luxmanan, C., … Yoon, H.-S., … Guilford, P. J. (2012). A multigene urine test for the detection and stratification of bladder cancer in patients presenting with hematuria. Journal of Urology, 188(3), 741-747. doi: 10.1016/j.juro.2012.05.003

Guise, C. P., Abbattista, M. R., Singleton, R. S., Holford, S. D., Connolly, J., Dachs, G. U., Fox, S. B., Pollock, R., Harvey, J., Guilford, P., … Patterson, A. V. (2010). The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3. Cancer Research, 70(4), 1573-1584. doi: 10.1158/0008-5472.CAN-09-3237

Guilford, P., Humar, B., & Blair, V. (2010). Hereditary diffuse gastric cancer: Translation of CDH1 germline mutations into clinical practice. Gastric Cancer, 13(1), 1-10. doi: 10.1007/s10120-009-0531-x

Fitzgerald, R. C., Hardwick, R., Huntsman, D., Carneiro, F., Guilford, P., Blair, V., … on behalf of the International Gastric Cancer Linkage Consortium. (2010). Hereditary diffuse gastric cancer: Updated consensus guidelines for clinical management and directions for future research. Journal of Medical Genetics, 47(7), 436-444. doi: 10.1136/jmg.2009.074237

Mai, P. L., Friedlander, M., Tucker, K., Phillips, K.-A., Hogg, D., Jewett, M. A. S., … Guilford, P., … Greene, M. H. (2010). The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. Urologic Oncology, 28(5), 492-499. doi: 10.1016/j.urolonc.2008.10.004

Nasri, S., Anjomshoaa, A., Song, S., Guilford, P., McNoe, L., Black, M., Phillips, V., Reeve, A., & Humar, B. (2010). Oligonucleotide array outperforms SNP array on formalin-fixed paraffin-embedded clinical samples. Cancer Genetics & Cytogenetics, 198(1), 1-6. doi: 10.1016/j.cancergencyto.2009.12.002

Zou, D., Yoon, H.-S., Anjomshoaa, A., Perez, D., Fukuzawa, R., Guilford, P., & Humar, B. (2009). Increased levels of active c-Src distinguish invasive from in situ lobular lesions. Breast Cancer Research, 11(4), R45. doi: 10.1186/bcr2332

Humar, B., Blair, V., Charlton, A., More, H., Martin, I., & Guilford, P. (2009). E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man. Cancer Research, 69(5), 2050-2056.

Zou, D., Yoon, H.-S., Perez, D., Weeks, R. J., Guilford, P., & Humar, B. (2009). Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. Journal of Pathology, 218(2), 265-272. doi: 10.1002/path.2541

Kawanishi, H., Matsui, Y., Ito, M., Watanabe, J., Takahashi, T., Nishizawa, K., … Guilford, P., Reeve, A., … Ogawa, O. (2008). Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer. Clinical Cancer Research, 14(9), 2579-2587. doi: 10.1158/1078-0432.CCR-07-1922

Nasri, S., More, H., Graziano, F., Ruzzo, A., Wilson, E., Dunbier, A., McKinney, C., Merriman, T., Guilford, P., … Humar, B. (2008). A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population. BMC Cancer, 8, 138. doi: 10.1186/1471-2407-8-138

John, T., Black, M. A., Toro, T. T., Leader, D., Gedye, C. A., Davis, I. D., Guilford, P. J., & Cebon, J. S. (2008). Predicting clinical outcome through molecular profiling in stage III melanoma. Clinical Cancer Research, 14(16), 5173-5180.

Humar, B., & Guilford, P. (2008). Hereditary diffuse gastric cancer and lost cell polarity: A short path to cancer. Future Oncology, 4(2), 229-239.

Kwak, M. K., Lee, H.-J., Hur, K., Park, D. J., Lee, H. S., Kim, W. H., … Guilford, P., & Yang, H.-K. (2008). Expression of Krüppel-like factor 5 in human gastric carcinomas. Journal of Cancer Research & Clinical Oncology, 134(2), 163-167. doi: 10.1007/s00432-007-0265-2

Holyoake, A., O'Sullivan, P., Pollock, R., Best, T., Watanabe, J., Kajita, Y., … da Silva Tatley, F., Cambridge, L., Toro, T., … Guilford, P. (2008). Development of a multiplex RNA urine test for the detection and stratification of transitional cell carcinoma of the bladder. Clinical Cancer Research, 14(3), 742-749. doi: 10.1158/1078-0432.CCR-07-1672

Linger, R., Dudakia, D., Huddart, R., Tucker, K., Friedlander, M., Phillips, K.-A., … Guilford, P., … Rapley, E. A. (2008). Analysis of the DND I gene in men with sporadic and familial testicular germ cell tumors. Genes Chromosomes & Cancer, 47(3), 247-252. doi: 10.1002/gcc.20526

Lin, Y.-H., Friederichs, J., Black, M. A., Mages, J., Rosenberg, R., Guilford, P. J., Phillips, V., Thompson-Fawcett, M., … van Rij, A., Yoon, H.-S., McCall, J. L., … Reeve, A. E. (2007). Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer. Clinical Cancer Research, 13(2), 498-507. doi: 10.1158/1078-0432.CCR-05-2734

Humar, B., Fukuzawa, R., Blair, V., Dunbier, A., More, H., Charlton, A., … Reeve, A. E., … Guilford, P. (2007). Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. Cancer Research, 67(6), 2480-2489. doi: 10.1158/0008-5472.CAN-06-3021

Matsui, S., Ito, M., Nishiyama, H., Uno, H., Kotani, H., Watanabe, J., Guilford, P., Reeve, A., … Ogawa, O. (2007). Genomic characterization of multiple clinical phenotypes of cancer using multivariate linear regression models. Bioinformatics, 23(6), 732-738.

More, H., Humar, B., Weber, W., Ward, R., Christian, A., Lintott, C., … Guilford, P. (2007). Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. Human Mutation, 28(2). doi: 10.1002/humu.9473

Guilford, P., Blair, V., More, H., & Humar, B. (2007). A short guide to hereditary diffuse gastric cancer. Hereditary Cancer in Clinical Practice, 5(4), 183-194.

Ito, M., Nishiyama, H., Kawanishi, H., Matsui, S., Guilford, P., Reeve, A., & Ogawa, O. (2007). P21-activated kinase 1: A new molecular marker for intravesical recurrence after transurethral resection of bladder cancer. Journal of Urology, 178, 1073-1079.

Blair, V., Martin, I., Shaw, D., Winship, I., Kerr, D., Arnold, J., … Cox, B., Humar, B., More, H., & Guilford, P. (2006). Hereditary diffuse gastric cancer: Diagnosis and management. Clinical Gastroenterology & Hepatology, 4, 262-275. doi: 10.1016/j.cgh.2005.12.003

Ramos-de la Medina, A., More, H., Medina-Franco, H., Humar, B., Gamboa, A., Ortiz, L. J., … Guilford, P. (2006). Single nucleotide polymorphisms (SNPs) at CDH1 promoter region in familial gastric cancer. Revista Española de Enfermedades Digestivas, 98(1), 36-41.

Crockford, G. P., Linger, R., Hockley, S., Dudakia, D., Johnson, L., Huddart, R., … Guilford, P., … Rapley, E. A. (2006). Genome-wide linkage screen for testicular germ cell tumour susceptibility loci. Human Molecular Genetics, 15(3), 443-451. doi: 10.1093/hmg/ddi459

Nathanson, K. L., Kanetsky, P. A., . . ., Guilford, P., & et al (2005). The Y deletion gr/gr and susceptibility to testicular germ cell tumor. American Journal of Human Genetics, 77, 1034-1043.

Shaw, D., Blair, V., Framp, A., Harawira, P., McLeod, M., & Guilford, P. (2005). Chromoendoscopic surveillance in hereditary diffuse gastric cancer: An alternative to prophylactic gastrectomy? Gut, 54, 461-468.

Rapley, E. A., Hockley, S., Warren, W., Johnson, L., Huddart, R., Crockford, G., … Guilford, P., … Stratton, M. R. (2004). Somatic mutations of KIT in familial testicular germ cell tumours. British Journal of Cancer, 90, 2397-2401. doi: 10.1038/sj.bjc.6601880

Graziano, F., Arduini, F., Ruzzo, A., Bearzi, I., Humar, B., More, H., … Guilford, P., … Cascinu, S. (2004). Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. Clinical Cancer Research, 10, 2784-2789.

Charlton, A., Blair, V., Shaw, D., Parry, S., Guilford, P., & Martin, I. G. (2004). Hereditary diffuse gastric cancer: Predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone. Gut, 53, 814-820.

da Silva Tatley, F. M., Aldwell, F., Dunbier, A. K., & Guilford, P. J. (2003). N-terminal E-cadherin peptides act as decoy receptors for Listeria monocytogenes. Infection & Immunity, 71(3), 1580-1583.

Humar, B., Toro, T. T., Graziano, F., Muller, H., Dobbie, Z., Kwang-Yang, H., … Merriman, T. R., & Guilford, P. J. (2002). Novel Germline CDH1 mutations in hereditary diffuse gastric cancer families. Human Mutation, 19, 518-525.

Humar, B., Graziano, F., Cascinu, S., Catalano, V., Ruzzo, A. M., Magnani, M., Toro, T. T., Burchill, T., Futschik, M., Merriman, T. R., & Guilford, P. J. (2002). Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer. Oncogene, 21, 8192-8195.

Dunbier, A. K., & Guilford, P. J. (2002). Gastric cancer: Inherited predisposition. Encyclopedia of Cancer, Second Edition, 2, 253-258.

Pharoah, P. D., Guilford, P. J., & Caldas, C. (2001). Incidence of gastric cancer and breast cancer in CDH1 (E-Cadherin) mutation carriers from hereditary diffuse gastric cancer families. Gastroenterology, 121, 1348-1353.

Chun, Y. S., Lindor, N. M., Smyrk, T. C., Petersen, B. T., Burgart, L. J., Guilford, P. J., & Donohue, J. H. (2001). Germline E-cadherin gene mutations - Is prophylactic total gastrectomy indicated? Cancer, 92(1), 181-187.

Dunbier, A. K., & Guilford, P. J. (2001). Hereditary diffuse gastric cancer. Advances in Cancer Research, 83, 55-65.

Guilford, P. J. (2000). The inherited susceptibility to cancer. Cellular & Molecular Life Sciences, 57, 589-603.

Grady, W. M., Willis, J., Guilford, P. J., Dunbier, A. K., Toro, T. T., Lynch, H., … Markowitz, S. D. (2000). Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genetics, 26, 16-17.

Gardner, R. J. M., Gaff, C. L., Macrae, F. A., St John, D. J. B., Hopkins, J., Guilford, P. J., & Reeve, A. E. (1999). E-cadherin unlikely to be a common "low penetrance" gene for colorectal cancer. American Journal of Medical Genetics, 84(2), 169-171.

Guilford, P. J., Hopkins, J. B. W., Grady, W. M., Markowitz, S. D., Willis, J., Lynch, H., … Toro, T. T., … Shaw, D. P., Findlay, M. P. N., & Reeve, A. E. (1999). E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. Human Mutation, 14(3), 249-255. doi: 10.1002/(SICI)1098-1004

Shinmura, K., Kohno, T., Takahashi, M., Sasaki, A., Ochiai, A., Guilford, P., Hunter, A. K., Reeve, A. E., … Yokota, J. (1999). Familial gastric cancer: Clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations. Carcinogenesis, 20(6), 1127-1131. doi: 10.1093/carcin/20.6.1127

Choi, K.-L., McNoe, L. A., French, M. C., Guilford, P. J., & Eccles, M. R. (1998). Absence of PAX2 gene mutations in patients with primary familial vesicoureteric reflux. Journal of Medical Genetics, 35(4), 338-339. doi: 10.1136/jmg.35.4.338

Guilford, P., Hopkins, J. B. W., Harraway, J., McLeod, M., McLeod, N., Harawira, P., … Miller, A., & Reeve, A. E. (1998). E-cadherin germline mutations in familial gastric cancer. Nature, 392(6674), 402-405. doi: 10.1038/32918

Guilford, P., Prakash, S., Zhu, J. M., Rikkerink, E., Gardiner, S., Bassett, H., & Forster, R. (1997). Microsatellites in Malus X domestica (apple): Abundance, polymorphism and cultivar identification. Theoretical & Applied Genetics, 94(2), 249-254. doi: 10.1007/s001220050407

Guilford, P., Dode, C., Crozet, F., Blanchard, S., Chaib, H., Levilliers, J., … Petit, C. (1995). A YAC contig and an EST map in the pericentromeric region of chromosome 13q surrounding the loci for neurosensory non-syndromic deafness (DFNB1 and DFNA3) and the limb-girdle muscular dystrophy type 2C (LGMD2C). Genomics, 29(1), 163-169. doi: 10.1006/geno.1995.1227

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Journal - Research Other

Hoeksema, K., Wee, R., Macdonald, A., Guilford, P., Wall, J., & Cornwall, J. (2017). Where to from here? Posthumous healthcare data, digital e(lectronic)-mortality and New Zealand’s healthcare future. New Zealand Medical Journal, 130(1459), 64-70. Retrieved from http://www.nzma.org.nz/journal

Cornwall, J., Slatter, T., Guilford, P., Print, C. G., Henaghan, M., & Wee, R. (2014). Culture, law, ethics, and social implications: Is society ready for advanced genomic medicine? Australasian Medical Journal, 7(4), 200-202. doi: 10.4066/amj.2014.2069

Willson, J. S. B., Godwin, T. D., Wiggins, G. A. R., Guilford, P. J., & McCall, J. L. (2013). Primary hepatocellular neoplasms in a MODY3 family with a novel HNF1A germline mutation. Journal of Hepatology, 59(4), 904-907. doi: 10.1016/j.jhep.2013.05.024

Humar, B., & Guilford, P. (2009). Hereditary diffuse gastric cancer: A manifestation of lost cell polarity. Cancer Science, 100(7), 1151-1157. doi: 10.1111/j.1349-7006.2009.01163.x

Graziano, F., Humar, B., & Guilford, P. J. (2003). The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: From the laboratory to clinical practice. Annals of Oncology, 14, 1705-1713.

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