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Biomedical imaging

MARS Spectral Molecular ImagingLogo_MARS_small_220

The MARS group is a world leader in spectral x-ray technology for molecular imaging of pre-clinical models of disease.

Overview

The goal of the project is to work with industrial partners to develop a commercial spectral scanner for molecular imaging. MARS spectral imaging is a new 3D quantitative colour imaging modality. This technology is based on x-ray transmission and has the potential to advance diagnosis and treatment of major health diseases in new ways. The novel features of this scanner are: an ability to differentiate and quantify simultaneously several targeted cell types, biomarkers, and drug delivery at the target tissue. It provides molecular imaging at the histological scale by measuring x-ray attenuation of the tissues at different energies (also known as wavelength or colour).

The MARS Project is a collaborative effort between the universities of Canterbury (UC), Otago (UO), Auckland (UA), and Lincoln University (LU). Its main outside funding is from by a 6 year MBIE (Ministry of Business, Innovation, and Employment) contract ("Taking MARS Spectral CT to Human Imaging"), and a parallel contract with MARS Bioimaging Ltd (MBI). A number health related and collaboration grants provide additional funding to the project. These include the National Health Foundation, the NZ Arthritis Foundation, the New Zealand Royal Society, and the Royal Australian and New Zealand College of Radiologists.

Lead researchers

The team consists of engineers, physicists, computer scientists, biologist, radiologists, and surgeons.

Full and part-time staff

Post-docs

  • Dr Niels de Ruiter (Bioengineering UO & HITLab UC)
  • Dr Chris Bateman (Bioengineering UO & Physics and Astronomy UC)
  • Dr Raj Panta (Bioengineering UO)
  • Dr Aamir Raja (Bioengineering, UO)
  • Dr Mike Walsh (Bioengineering, MBI)
  • Dr Geoff Rodgers (UO)
  • Dr Alex Chernoglazov (MBI, UC)

Current students

  • Emmauel Marfo (Radiology, UO, PhD)
  • Rayhan Uddin (Physics and Astronomy, UC, PhD)
  • Lieza Vanden Brooke (Physics and Astronomy, UC, PhD)
  • Srinidhi Bheesette (Radiology, UO, PhD)
  • Mahdieh Moghiseh (Radiology, UO, PhD)
  • Marzieh Anjomrouz (Radiology, UO, PhD)
  • Muhammad Shamshad (Radiology, UO, PhD)
  • Ali Atharifard (Radiology, UO, PhD)
  • Mohsen Ramyar (Radiology, UO, PhD)
  • Joe Healy (Biological Sciences, UC, PhD)
  • Claire Chambers (Medical Physics, UC, MSc)

Visiting students

Recent students

  • Dr Kishore Rajendran (Radiology, UO, PhD awarded exceptional March 2016)
  • David Knight (Physics, UC, MSc submitted 2015)
  • Grey Lu (Physics and Astronomy, UC, MSc submitted February 2016)
  • Dr Raj Panta (Bioengineering, UO, PhD submitted Jan 2015)
  • Dr Harish Mandalika (HITLab NZ, UC, PhD submitted 2015)
  • Dr Alex Chernoglazov (Radiology, UC, PhD submitted 2016)
  • Dr Chris Bateman (Radiology, UO, PhD submitted Dec 2014)
  • Dr Niels de Ruiter (Radiology, UO, PhD, submitted Oct 2014)
  • Niome Ganet (MARS, School of applied physics and engineering, Grenoble INP, Fr, MSc)
  • Malte Schmidt (Fachhochschule Südwestfalen, Germany, BSc)
  • Ian Glass (Electrical and Computer Engineering, UC, BE(Hons))
  • Dr Mike Walsh (Bioengineering, UO, PhD submitted December 2013)
  • Tejraj Janmale (Biological Sciences, UC, PhD, submitted December 2013)
  • Dr Raja Aamir (Medical Physics, UC, PhD completed August 2013)
  • Amber Malpas (Physics, UC, PHYS480)
  • Jamie Mc Mahon (Physics, UC, PHYS480)
  • Alex Opie (Electrical and Computer Engineering, UC, PhD, submitted August 2013)
  • Syen Nik (Medical Physics, UC, PhD completed June 2013)
  • Daniel (Kwang Hyuk) Kim (Medical Physics, UC, MSc completed February 2013)
  • Nate Tang (Medical Physics, UC, MSc completed March 2013)
  • Sahina Haq (Psychology, UC, PhD)
  • Dr Robert Doesburg (Physics, UC, PhD completed December 2012)
  • Dr Anas Sedayo (Physics Medical, UC, PhD completed November 2012)
  • Dr Rafidah Zainon (Medical Physics, UC, PhD completed October 2012)
  • Dr Paul Ronaldson (Radiology, UO, PhD completed July 2012)

Recent postdocs

  • Dr Judy Mohr (Bioengineering, UO)
  • Dr Nicola Scott (Medicine, UO)

Collaborators

Industrial partners (current)

Industrial partners (previous)

  • Dr Derek Smithes (IT Specialist)
  • Quarticom (Mechanical design)
  • Draw2-3D (Mechanical design)
  • Veronese Design (Engineering)
  • Geoff Graham Ltd (Electronics)

 

Publications

The Centre for Bioengineering supports a number of research projects, enabling researchers to attend conferences and present their work to an international audience.

The following publications have resulted from the MARS project since the launch of the Centre for Bioengineering:

Refereed Journals

  1. Kishore Rajendran, Caroline Löbker, Benjamin S. Schon, Christopher J. Bateman, Raja Aamir Younis, Niels J. A. de Ruiter, Alex I. Chernoglazov, Mohsen Ramyar, Gary J. Hooper, Anthony P. H. Butler, Tim B. F. Woodfield, Nigel G. Anderson, Quantitative imaging of excised osteoarthritic cartilage using spectral CT, European Radiology, (May 2016), 1-9, DOI 10.1007/s00330-016-4374-7
  2. Panta R, Walsh M, Bell S, Anderson N, Butler A, Butler P, Energy Calibration of the Pixels of Spectral X-ray Detectors, Medical Imaging, IEEE Transactions, Vol PP issue 99, http://ieeexplore.ieee.org/xpl/abstractAuthors.jsp?arnumber=6855321
  3. Nigel G. Anderson, Anthony P. Butler. Clinical applications of spectral molecular imaging: potential and challenges. Contrast Media Mol. Imaging 2014, 9 3–12. http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1550/abstract
  4. Alex M.T. Opie, James Bennet, Anthony Butler, Phil Butler, Michael Walsh, Kishore Rajendran, Hengyong Yu, Qiong Xu, Guohua Cao, Aaron M. Mohs, Ge Wang. Study of scan protocol for exposure reduction in hybrid spectral micro-CT, Journal of Scanning Microscopies. http://www.ncbi.nlm.nih.gov/m/pubmed/24604215/
  5. K. Rajendran, M. F. Walsh, N. J. A. de Ruiter, A. I. Chernoglazov, R. K. Panta, A. P. H. Butler, P. H. Butler, S. T. Bell, N. G. Anderson, T. B. F. Woodfield, S. J. Tredinnick, J. L. Healy, C. J. Bateman, R. Aamir, R. M. N. Doesburg, P. F. Renaud, S. P. Gieseg, D. J. Smithies, J. L. Mohr, V. B. H. Mandalika, A. M. T. Opie, N. J. Cook, J. P. Ronaldson, S. J. Nik, A. Atharifard, M. Clyne, P. J. Bones, C. Bartneck, R. Grasset, N. Schleich, M. Billinghurst. Reducing beam hardening effects and metal artefacts in spectral CT using Medipix3RX. JINST 2014. DOI 10.1088/1748-0221/9/03/P03015
  6. R Aamir, A Chernoglazov, C J Bateman, A P H Butler, P H Butler, N G Anderson, S T Bell, R Panta, J L Healy, J L Mohr, K Rajendran, M F Walsh, N J de Ruiter, S P Gieseg, T Woodfield, P F Renaud, L Brooke, S Abdul-Majid, M Clyne, R Glendenning, P J Bones, M Billinghurst, C Bartneck, H Mandalika, R Grasset, N Schleich, N Scott, S J Nik, A Opie, T Janmale, D N Tang, D Kim, R M Doesburg, R Zainon, J P Ronaldson, N J Cook, D J Smithies, K Hodge. MARS spectral molecular imaging of lamb tissue: data collection and image analysis. JINST 2013. DOI 10.1088/1748-0221/9/02/P02005
  7. Bennett JR, Opie AMT, Xu Q, Yu H, Walsh M, Butler A, Butler PH, Cao G,Mohs A, Wang G. Hybrid Spectral Micro-CT: System Design, Implementation & Preliminary Results. IEEE Transactions on Biomedical Engineering, 2014. DOI 10.1109/TBME.2013.2279673
  8. Peng He, Hengyong Yu, James Bennett, Paul Ronaldson, Rafidah Zainon,
    Anthony Butler, Phil Butler, Biao Wei and Ge Wang. Energy-discriminative performance of a spectral CT system. Journal of X-Ray Science and Technology 21 (2013) 335–345 DOI 10.3233/XST-130382.
  9. Walsh, M. F., Nik, S. J., Procz, S., Pichotka, M., Bell, S. T., Bateman, C. J., … De Ruiter, N., … Panta, R. K., Butler, A. P. H., Butler, P. H. Spectral CT data acquisition with Medipix3.1.Journal of Instrumentation 2013. DOI 10.1088/1748-0221/8/10/P10012
  10. Tappenden, R., Hegarty, J., Broughton, R., Butler, A., Coope, I., & Renaud, P. (2013). X-ray image enhancement via determinant based feature selection. Australasian Physical & Engineering Sciences in Medicine (2013). DOI 10.1007/s13246-013-0221-1
  11. Tappenden, R., Hegarty, J., Broughton, R., Butler, A., Coope, I., & Renaud, P. (2013). X-ray image enhancement via determinant based feature selection. Australasian Physical & Engineering Sciences in Medicine (2013). DOI 10.1007/s13246-013-0221-1
  12. Xu Q, Yu H, Bennett J, He P, Zainon R, Doesburg R, Opie A, Walsh M, Shen H, Butler A, Butler P, Mou X, Wang G. Image reconstruction for hybrid true-color micro-CT. IEEE Trans Biomed Eng. 2012 Jun;59(6):1711-9. http://dx.doi.org/10.1109/TBME.2012.2192119.
  13. Doesburg RMN, Koenig T, Nik SJ, Bell ST, Ronaldson JP, Walsh MF, Butler APH, Butler PH. Spectrum measurement using Medipix3 in charge summing mode. J Instrum. 2012; 7(11): C11004. DOI 10.1088/1748-0221/7/11/C11004.
  14. A.J. Bell, N. Bernardino Rodrigues, A.P.H. Butler, P.H. Butler, R. Doesburg, D. Pfeiffer, S. Reucroft, H. Silverwood, J.C. Williams, P. Allfrey, D. Krofcheck. Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC. Physics Letters B. Volume 716, Issue 1, 17 September 2012, Pages 30–61. DOI 
  15. Aamir R, Walsh MF, Lansley SP, Doesburg RM, Zainon R, de Ruiter NJA, Butler PH, Butler APH. Characterization of CdTe x-ray sensor layer on Medipix detector chips. Materials Science Forum 2012; 700: 170-173. DOI 10.4028/www.scientific.net/MSF.700.170
  16. Anderson NG, Butler AP, Butler PH. Clinical applications of spectral molecular imaging: potential and challenges Contrast Media Mol Imaging 2013 (in print). http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1550/abstract
  17. Ronaldson JP, Zainon R, Scott N, Gieseg S, Butler A, Butler P, Anderson N. Towards quantifying the composition of soft-tissues by spectral CT with Medipix3. Med Phys 2012 39(11):6847-6857 DOI http://dx.doi.org/10.1118/1.4760773.
  18. Zainon R, Ronaldson JP, Janmale T, Scott NJ, Buckenham TM, Butler AP, Butler PH, Doesburg RM, Gieseg SP, Roake JA, Anderson NG. Spectral CT of carotid atherosclerotic plaque: comparison with histology. Eur Radiol. 2012; 22 (12): 2581-2588. DOI:10.1007/s00330-012-2538-7
  19. Doesburg RMN, Koenig T, Nik SJ, Bell ST, Ronaldson JP, Walsh MF, Butler APH, Butler PH. Spectrum measurement using Medipix3 in charge summing mode. J Instrum. 2012; 7(11): C11004. Available on-line before print at http://dx.doi.org/10.1088/1748-0221/7/11/C11004.
  20. Bennett J, Aamir R, Dobbs B, Xuanqin M, Biao W, Butler A, Butler P. Energy-discriminative performance analysis for spectral CT. CT theoretical and applied research. 2012; v.21; No.92(04): 3-16. (This is an English translation of the title and journal name from a publication in a Chinese journal.)
  21. Yu H, Xu Q, He P, Bennett J, Aamir R, Dobbs B, Xuanqin M, Biao W, Butler A, Butler P, Wang G. Medipix-based Spectral Micro-CT. CT Theory and Applications. 2012; 21(4): 583-596. http://www.ncbi.nlm.nih.gov/pubmed/24194631
  22. Ronaldson JP, Zainon R, Scott NJA, Gieseg SP, Butler AP, Butler PH, Anderson NG. Toward quantifying the composition of soft tissues by spectral CT with Medipix3. Med Phys. 2012; 39(11): 6847-6857. DOI: 10.1118/1.4760773
  23. Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC CMS collaboration. This was the CERN discovery of the Higgs boson. I am an engineer with the CMS collaboration. This paper has >3000 authors. In the first two months after publication this paper has was cited more 130 times. Physics Letters B. 2012; 716(1): 30-61. arXiv:1207.7235. doi:10.1016/j.physletb.2012.08.021
  24. A new boson at a mass of 125 GeV observed with the CMS Experiment at the Large Hadron Collider. Science. 2012; 338:1569. DOI: 10.1126/science.1230816 This paper from the CMS collaboration has >3000 authors.
  25. Zainon R, Ronaldson JP, Janmale T, Scott NJ, Buckenham TM, Butler AP, Butler PH, Doesburg RM, Gieseg SP, Roake JA, Anderson NG. Spectral CT of carotid atherosclerotic plaque: comparison with histology. Eur Radiol. 2012; 22(12):2581-2588. DOI: 10.1007/s00330-012-2538-7
  26. He P, Yu H, Thayer P, Jin X, Xu Q, Bennett J, Tappenden R, Wei B, Goldstein A, Renaud P, Butler A, Butler P, Wang G. Preliminary experimental results from a MARS Micro-CT system. J Xray Sci Technol. 2012; 20:199-211. DOI 10.3233/XST-2012-0329
  27. Aamir R, Walsh MF, Lansley SP, Doesburg RM, Zainon R, de Ruiter NJA, Butler PH, Butler APH. Characterization of CdTe x-ray sensor layer on Medipix detector chips. Materials Science Forum. 2012; 700: 170-173. DOI 10.4028/www.scientific.net/MSF.700.170
  28. M.A Hurrell, A.P.H. Butler , N.J. Cook, P.H. Butler , J.P. Ronaldson , and R. Zainon. Spectral Hounsfield units: a new radiological concept, European Radiology, December 2011. DOI 10.1007/s00330-011-2348-3
  29. S J Nik, J Meyer and R Watts. Optimal material discrimination using spectral x-ray imaging. 2011 accepted  Phys. Med. Biol. DOI 10.1088/0031-9155/56/18/012
  30. M.F. Walsh, A.M.T. Opie, J.P. Ronaldson, R.M.N. Doesburg, S.J. Nik, J.L. Mohr, R. Ballabrig, A.P.H. Butler, and P.H. Butler. First CT using Medipix3 and the MARS-CT-3 Spectral Scanner. Journal of Instrumentation, January 2011, doi:10.1088/1748-0221/6/01/C01095. Web version available before print. http://dx.doi.org/10.1088/1748-0221/6/01/C01095
  31. J P Ronaldson, M Walsh, S J Nik, J Donaldson, R M N Doesburg, D van Leeuwen, R Ballabrig, M N Clyne, A P H Butler and P H Butler. Characterization of Medipix3 with the MARS readout and software. Journal of Instrumentation, January 2011, doi: 10.1088/1748-0221/6/01/C01056. Web version available before print http://dx.doi.org/10.1088/1748-0221/6/01/C01056
  32. R Aamir, S P Lansley, R Zainona, M Fiederle, A Fauler, D Greiffenberg, P H Butler and A P H Butler. Pixel sensitivity variations in a CdTe-Medipix2 detector using poly-energetic x-rays. Journal of Instrumentation, January 2011, doi: 10.1088/1748-0221/6/01/C01059. Web version available before print http://dx.doi.org/10.1088/1748-0221/6/01/C01059
  33. Austin Ball, Alan Bell, Anthony Butler, Philip Butler, Richard Hall-Wilton, Jeroen Hegeman, Stuart Lansley, Gary Keen, David Krofcheck, Steffen Mueller, Alick Macpherson, Dorothea Pfeiffer, Stanislav Pospisil ,Hamish Silverwood, Emmanuel Tsesmelis, Zdenek Vykydald Design, Implementation and First Measurements with the Medipix Neutron Camera in CMS. Journal of Instrumentation 2011 (in print) doi: 10.1088/1748-0221/6/08/P08005
  34. Fornaro J, Leschka S, Hibbeln D, Butler AB, Anderson NG, Pache G, Scheffel H, Wildermuth S, Alkadhi H, Stolzmann P. Dual- and multi-energy CT: approach to functional imaging. Insights Imaging 2011;2(2):149-159, DOI: 10.1007/s13244-010-0057-0
  35. R. Zainon, A.P.H. Butler, N. J. Cook, J. S. Butzer, N. Schleich, N. de Ruiter, L. Tlustos, M. J. Clark, R. Heinz and P.H. Butler. Construction and Operation of the MARS-CT Scanner. Internetworking Indonesia Journal, Vol.2/No.1, pp2-10 (2010)
  36. Anderson NG, Butler AP. Scott NJA, Cook NJ, Butzer JS, Schleich N, Firsching M, Grasset R , de Ruiter N, Campbell M, Butler PH. Spectroscopic (multi-energy) colour CT distinguishes iodine and barium contrast in mice. Eur Radiol. (2010) 20: 2126-2134 . DOI 10.1007/s00330-010-1768-9.
  37. Anthony P. H. Butler,  Jochen Butzer, Nanette Schleich, Nicholas J. Cook, Nigel G.Anderson, Nicola Scott, Niels de Ruiter, Raphael Grasset, Lukas Tlustos, Philip H. Butler. Processing of spectral X-ray data with principal components analysis. DOI: 10.1016/j.nima.2010.06.149. In press for Nuclear Instruments and Methods A. Web version available before print: http://dx.doi.org/10.1016/j.nima.2010.06.149

Conference proceedings

  1. Ganet N, Anderson NG, Bell S, Butler APH, Butler PH, Carbonez P, Cook N, Cotterill T, Marsh S, Panta RK, Laban J, Walker S, Yeabsley A, Damet J. Dosimetry for spectral molecular imaging of small animals with MARS-CT. SPIE Medical Imaging, 21-26 February 2015. Orlando, Florida, USA.
  2. Anderson NG, Keynote Address. MARS Spectral CT Imaging. “Medical Technology” ABI Research Forum. 19 February 2015. Auckland, New Zealand.
  3. Woodfield T, Lobker C, Schon B, Rajendran K, Anderson NG, Butler APH, Hooper GJ. Quantitative detection of cartilage and bone health via MARS spectral CT imaging. NZ Orthopaedic Association Conference. 21 October 2014. Tauranga, NZ.
  4. M. Shamshad, M. Anjomrouz, D.J. Smithies, S.T. Bell, B. P. Goulter, J. Humphrey, A. Atharifard, A.P.H. Butler, P.H. Butler, Spectral Beam Brightness Model for X-ray Tubes, Proceedings of NZPEM 2014 Nov 20-21st, Christchurch, New Zealand.
  5. M. Anjomrouz, M. Shamshad, M.F. Walsh, S.T. Bell, R.M.N. Doesburg, A.P.H. Butler, P.H. Butler, Energy Response of Medipix Pixels, Proceedings of NZPEM 2014 Nov 20-21st, Christchurch, New Zealand.
  6. RK. Panta, R. Aamir, JL. Healy, K. Rajendran, NJA. de Ruiter, M. Moghiseh, APH. Butler, NG. Anderson, SP. Gieseg and PH Butler. Multiple K-edges imaging with MARS-CT: Proof of concept, Proceedings of NZPEM 2014 Nov 20-21st , Christchurch, New Zealand.
  7. A. Atharifard, S. T. Bell, M. Ramyar, B. Goulter, M. F. Walsh, L. V. Broeke, A. P. H. Butler, P. H. Butler, Pixel by pixel energy calibration of MARS camera, Proceedings of NZPEM 2014 Nov 20-21st, Christchurch, New Zealand.
  8. Schelich N, Bell ST, Midgley SM, Aamir R, Mohr JL, Healy JL, Rajendran K, Butler APHb, Anderson NG and Butler PH. Spectral CT imaging: a non-invasive technique for studying composition and function of tissues , Annual Scientific Meeting, RANZCR, Melbourne , 4-7 Sep, 2014 http://www.researchgate.net/publication/266079831_Spectral_CT_imaging_A_non-invasive_technique_for_studying_composition_and_function_of_tissues
  9. Raj Kumar Panta, Christopher Bateman, Joe Healy, Alex Chernoglazov, Steven P. Gieseg, Anthony Butler, Phil Butler, Nigel G Anderson. Implementing spectral molecular imaging (spectral CT) in soft tissue. Conference Proceeding of 34th National Conference of Association of Medical Physicist in India (AMPICON-2013, November 13-16, Kolkata, India) 2013, 90 : 91
  10. Nigel Anderson Invited Presentation: Spectral Molecular Imaging – a new modality RANZCR Annual Scientific Meeting, Auckland 17-20 October 2013
  11. RK Panta, CJ Bateman, J Healy, JL Mohr, N de Ruiter, AP Butler, NG Anderson, SP Gieseg, Simultaneous discrimination of multiple intrinsic bio-markers in excised atheroma with spectral molecular imaging. NZMJ 31 May 2013, Vol 126 No 1375; ISSN 1175 8716.
  12. Opie AMT, Butler APH, Bones PJ. Energy-resolved scatter estimation for micro-CT. Proc. SPIE 8506, Developments in X-Ray Tomography VIII, 850616 (October 17, 2012). DOI:10.1117/12.930319.
  13. Nate D. Tang, Niels de Ruiter, J. L. Mohr, A. P. H. Butler, P. H. Butler, R. Aamir. Using Algebraic Reconstruction in Computed Tomography. In proceeding of Image and Vision Computing New Zealand, IVCNZ '12, Dunedin, New Zealand - November 26 - 28, 2012. 2012, p216-221, DOI: 10.1145/2425836.2425881.
  14. P H Butler, S J Nik, Physics and biomedical imaging - spectroscopic X-ray CT. 2012 AIP Conference Proceedings Series (submitted).
  15. Bateman, C.J. ; McMahon, J. ; Malpas, A. ; de Ruiter, N. ; Bell, S. ;Butler, A.P. ; Butler, P.H. ; Renaud, P.F. Segmentation enhances material analysis in multi-energy CT: A simulation study, Image and Vision Computing New Zealand (IVCNZ), 2013 28th International Conference of, Page(s): 190 - 195. DOI: 10.1109/IVCNZ.2013.6727014
  16. S. Gieseg, R. Zainon, N. Scott, T. Janmale, Justin Roake, A. Butler, P. Butler, Imaging of advanced atherosclerotic plaque by high resolution, multi-energy X ray computer tomography: Identification of iron and calcium deposition. Presentation at the XVI International Symposium on Atherosclerosis (ISA), Sydney, 25-29th March 2012.
  17. Anderson NG. Imaging in Medicine –challenges and future direction. 2012 AIP Conference Proceedings (accepted).
  18. T. Woodfield, A. Siegert, B. Schon, A. Butler, G.J. Hooper. Quantitative Detection of Cartilage and Bone Tissue Quality via Spectral MARS-CT Imaging. 10th World Congress of the International Cartilage Repair Society (ICRS), Montreal, Canada, May12-15, 2012. Oral.
  19. Opie AMT, Butler APH, Bones PJ. Energy-resolved scatter estimation for micro-CT. Proc. SPIE 8506, Developments in X-Ray Tomography VIII, 850616 (October 17, 2012). DOI:10.1117/12.930319.
  20. Ronaldson JP, Butler AP, Anderson NG, Zainon R, Butler PH. The performance of MARS-CT using Medipix3 for spectral imaging of soft-tissue. IEEE Conference Publications: Nuclear Science Symposium and Medical Imaging Conference(NSS/MIC), 2011 IEEE, pgs 4002 – 4008. Valencia, Spain, 23 – 29 October 2011. DOI:10.1109/NSSMIC.2011.6153761
  21. H Chen, R Mukundan, A.P. Butler, Automatic Lung Segmentation in HRCT Images, Image and Vision Computing New Zealand, 2011. IVCNZ ''11. Noc Dec 2012.
  22. R Zainon, P Ronaldson, A.P. Butler and P.H. Butler. Establishing a linear basis for quantifying material composition using spectral CT, Rafidah, In Proceedings of 2011 International Conference on Biomedical Engineering and Biotechnology (BEB2011). IEEE.
  23. R Aamir, N G Anderson, A P H Butler, P H Butler, S P Lansley, R M Doesburg, M Walsh and J L Mohr, Characterization of Si and CdTe sensor layers in Medipix assemblies using a microfocus x-ray source, Conference  Record  of  the  2011  IEEE  NSS/MIC/RTSD. DOI 
  24. A.M.T. Opie and P.J. Bones. "Sensitivity to error of the truncated Hilbert transform technique for interior reconstruction", Proc. IEEE Intl. Conf. on Image Processing, Brussels, Belgium, Sept. 2011, pp. 421-424. http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=6116540
  25. R. Zainon, P. H. Butler, J. P. Ronaldson, A. P. Butler. Evaluating the performance of the MARS-CT3 spectral micro-CT scanner incorporating Medipix3, Accepted 2011 IEEE-NSS-MIC
  26. R Aamir, S P Lansley, N G Anderson, P H Butler, A P H Butler, R M Doesburg, J L Mohr, M F Walsh, S J Nik, R Zainon. Characterization of Si, CdTe and GaAs sensor layers on Medipix assemblies using microfocus x-ray sources. Accepted to 2011 IEEE-NSS-MIC
  27. M.F. Walsh, J.P. Ronaldson, J.L. Mohr, R.M. Doesburg, R. Ballabriga, A.P.H. Butler, P.H. Butler. Improving and characterising the threshold equalisation process for multi-chip Medipix3 cameras in single pixel mode. IEEE Conference Publications: Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2011 IEEE, pgs 1718 – 1721. Valencia, Spain, 23 – 29 October 2011. DOI:10.1109/NSSMIC.2011.6154667
  28. R Aamir, M F Walsh, S P Lansley, R M Doesburg, R Zainon, N J A, de Ruiter, P H Butler, and A P H Butler. Characterization of CdTe x-ray sensor layer on Medipix detector chips. Accepted for AMN5, 2011
  29. R Zainon, N Cook, AP Butler, SP Gieseg, NG Anderson, TM Buckenham, G Shelkov, L Tlustos, JA Roake, PH Butler. High resolution multi-energy CT imaging of atherosclerotic plaque. NZ Med J 2010; 23 (1319):97. http://www.nzma.org.nz/journal/123-1319/4254/
  30. P.J. Bones, A.P.H. Butler, J.P. Ronaldson and A.M.T. Opie, Development of a CT scanner based on the Medipix family of detectors in Developments in X-Ray Tomography VII, Proc. SPIE, v7804, (2010).DOI: 10.1117/12.862166
  31. D.R. Eaker, S.M. Jorgensen, A.P.H. Butler, E.L. Ritman. Tomographic Imaging of Coherent X-Ray Scatter Momentum Transfer Distribution Using Spectral X-Ray Detection and Polycapillary, Optic Proc. SPIE 7804, 78041O (2010); DOI:10.1117/12.861508
  32. Walker P, Butler AP, Cook NJ, Anderson NG. Spectroscopic (multi-energy) CT: The Future of Medical Imaging. Plastic and Reconstructive Surgery, 2010 Volume 125, Num 6 (supplement), 146B, p98.
  33. Ning Pan, Niels de Ruiter, Hong Liu, Raphael Grasset (2009), Improving the image quality of spectral CT volume rendering, Image and Vision Computing New Zealand, 2009. IVCNZ ''09. 24th International Conference, Issue 23-25 Nov. 2009, pp 203 - 208.

Posters and abstracts

  1. Healy J, Panta R.K, Aamir R, Rajendran K, de Ruiter N, Bateman C.J, Chernoglazov A, Walsh M, Bell S.T, Anderson N.G, Butler A.P.H, Butler P.H, Roak J, Gieseg S.P. Multienergy X-ray-CT identification of lipid cores and valcium mineralisation in excised carotid plaques. Australian Atherosclerosis Society and Australian Vascular Biology Society joint meeting 2016 – December 7-10, Grand Chancellor Hotel, Hobart, TAS (Joint ASM with HBPRCA and AVBS)
  2. Anderson NG, Woodfield T, Lobker C, Schon B, Rajendran K, Mogdiseh M, Raja A, Kumar D, Sykes P. 2015. Preclinical cancer imaging with MARS spectral CT and new nanocontrast agents In RANZCR NZ Branch Annual Meeting. Rotorua 31 Jul - 2 Aug, 2015
  3. Ronaldson JP, Zainon R, Sedayo A, Scott NJA, Butler APH, Butler PH, Anderson NG. Towards quantifying the composition of soft-tissues by spectral CT imaging with Medipix3. RSNA 2011 (97th Scientific Assembly and Annual Meeting of the Radiological Society of North America), Chicago, USA, 26 November - 2 December 2011. Abstract of Scientific Formal Presentation published in online meeting programme: http://rsna2011.rsna.org/search/search.cfm?action=add&filter=Author&value=122675 (accessed 11 April 2012).
  4. Butler APH. Spectroscopic CT Imaging Using Medipix3. Invited talk on clinical applications at the Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Valencia, 2011.
  5. A Butler, P Ronaldson, M Walsh, R Aamir, R Doesburg, N de Ruiter, N Scott, R Zainon, S Geiseg, T Woodfield,  A Siegert, J Mohr, N Anderson, P Butler. Development of a Medipix3 based spectral (multi-energy) CT for pre-clinical evaluation of biomarkers.  Accepted for the Royal Australia and New Zealand College of Radiologists Annual Scientific Meeting, Oct 2011. Melbourne, Australia, 6 – 9 October 2011. Available online at http://posterng.netkey.at/ranzcr/online_viewing/index.php?module=view_login&task (accessed 11 May 2012). doi: 10.1594/ranzcr2011/R-0090.
  6. A Butler, P Ronaldson, N Scott, R Zainon, P Butler, S Geiseg, T Janmale, N Anderson. Soft tissue imaging with the MARS spectral CT scanner.  Accepted for Queenstown Heart Meeting, August 2011.
  7. R Aamir, S P Lansley, R Zainon, M Fiederle, P H Butler, A P H Butler. Characterisation of x-ray sensor layers on Medipix detector chips.  in Proc. 5th International Conference on Advanced Materials and Nanotechnology. Wellington, New Zealand. 7-11th February 2011
  8. A Butler, N Anderson, R Ballabriga, S Jorgensen, P Butler. Spectral CT with photon counting detectors, Australasian Physical & Engineering Science in Medicine (2010) Vol.34 p 124
  9. S J Nik, J Meyer, R Watts Optimisation of material discrimination using spectral CT, Australasian Physical & Engineering Science in Medicine (2010) 34 : 123
  10. R S Thing, S J Nik, Bryn Currie, Tony Dale, J Meyer, R Watts A virtual spectral CT scanner, Australasian Physical & Engineering Science in Medicine (2010) 34 : 123 – 4
  11. R Zainon, N Cook, AP Butler, SP Gieseg, NG Anderson, TM Buckenham, G Shelkov, L Tlustos, JA Roake, PH Butler. High resolution multi-energy CT imaging of atherosclerotic plaque. Accepted for Clinical Meeting HRSC scientific presentations and will be published in New Zealand Medical Journal (NZMJ), 2010.
  12. R Zainon, NJ Cook, SP Gieseg, AP Butler, PH Butler. Imaging of excised plaques. Canterbury Health Research Poster Expo NZi3 Building, Creyke Road, University of Canterbury, NZ, 2010. (Best student poster).
  13. Doesburg, R.M.N., Clyne, M.N., van Leeuwen, D., Cook, N.J., Butler, P.H., Butler. A.P.H. (2009), Fast Ethernet Readout for Medipix Arrays with MARS-CT. Orlando, FL, USA: IEEE Nuclear Sciences Symposium, 25-31 Oct 2009.

Other

  1. Ganet N, Anderson N, Beel S, Butler A, Butler P, Carbonez P, Cook N, Cotterill T, March S, Humar R, Laban J, Walker S, Yeabsley A, Damet J, Dosimetry for spectral molecular imaging of small animals with MARS-CThttp://hdl.handle.net/10092/11707

Thesis

PhD

Kishore Rajendran (UO)
"MARS spectral CT technology for orthopaedic applications "(2016)

Alexander Chernoglazov (UC)
"Tools for Visualising MARS Spectral CT Datasets" (2016)
http://hdl.handle.net/10092/11800

Raj Panta PhD (UO)
"Toward human MARS scanning: improving spectral performance for soft tissue imaging" (2015)
http://hdl.handle.net/10523/5836

Niels de Ruiter (UO)
"Algorithms to process data from the MARS molecular imaging system" (2015)

Chris Bateman (UO)
Methods for Material Discrimination in MARS Spectral Computed Tomography (2015)

Walsh, Michael Francis (UO)
"Spectral Computed Tomography Development" (2014)
http://otago.ourarchive.ac.nz/handle/10523/4658

Aamir Younis Raja (UC)
"Using MARS Spectral CT for Identifying Biomedical Nanoparticles" (2013)
httpp://hdl.handle.net/10092/8687

Alex M.T. Opie (UC)
"Contributions to spectral CT" (2013)
http://hdl.handle.net/10092/8532

Syen Nik (UC)
“Optimising the benefits of spectral x-ray imaging in material decomposition” (2013)
http://hdl.handle.net/10092/8398

Robert Doesburg (UC)
"The MARS Photon Processing Cameras for Spectral CT" (2012)
http://hdl.handle.net/10092/7327 

Anas Sedayo (UC)
"Clinical applications of the Medipix detector" (2012)
http://hdl.handle.net/10092/7229

Rafidah Zainon (UC)
"Spectral Micro-CT Imaging of Ex Vivo Atherosclerotic Plaque" (2012)
http://hdl.handle.net/10092/7165

Paul J Ronaldson (UOC)
"Quantitative soft-tissue imaging by spectral CT with Medipix3" (2012)
http://otago.lconz.ac.nz/vwebv/holdingsInfo?bibId=2438193


MSc

Gray Lu MSc (UC)
"Dosimetry for MARS" (2016)
http://hdl.handle.net/10092/12028

David Knight (UC)
"Algorithms for MARS spectral CT" (2015)
http://hdl.handle.net/10092/10422

Lieza Vanden Brooke (UC)
"Foil fluorescence in MARS spectral imaging" (2015)
http://hdl.handle.net/10092/11667

Daniel Kim (UC)
“Small animal irradiation using the MARS Spectral CT”
http://hdl.handle.net/10092/7948 

Nate Dikai Tang (UC)
"MARS Spectral CT: Image quality performance parameters using the Medipix3.0 detector"
http://hdl.handle.net/10092/7828

Niels de Ruiter (UC)
"GPU Accelerated Intermixing as a Framework for Interactively Visualizing Spectral CT Data"
http://hdl.handle.net/10092/5328 

Jochen Butzer (UC)
"MARS-CT: Biomedical Spectral X-ray Imaging with Medipix"
http://hdl.handle.net/10092/3863