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Regenerative medicine

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CReaTE
Christchurch Regenerative Medicine and Tissue Engineering Group

Tissue Engineering (TE) and Regenerative Medicine (RM) combine a patient’s own cells with biodegradable scaffolds and growth factors. These therapies may offer considerable advantages over current surgical interventions used to repair or regenerate damaged tissues following trauma or disease.

The CReaTE group consists of a multidisciplinary research team led by Dr Tim Woodfield, and is working at the interface of cell-biology, biomaterials science and engineering.

Using advanced 3D scaffolds and in-vitro culture techniques, combined with adult human stem cells, our group is attempting to identify the complex cellular environments controlling tissue growth in 3D. We are also researching their application in translating cell-based therapies to the clinic.

The group is focusing on three main areas of research involving:

  • tissue engineering & regenerative medicine
  • advanced scaffold design
  • bio-manufacturing and orthopaedic medical devices (see below).

The key application areas are in articular cartilage repair and nerve regeneration, as well as clinical orthopaedic medical device research related to spine and total joint arthroplasty interventions.

 

Research Focus

Tissue Engineering & Regenerative Medicine

  • Articular cartilage repair from clinically relevant human cell sources
  • Novel methods to enhance mesenchymal stem cell differentiation and tissue quality
  • In vitro 3D culture models for mimicking native tissue organisation in vivo
  • CT imaging of cartilage and engineered tissues
  • Guided cell growth for neural/spinal cord regeneration

Advanced scaffold design and bio-manufacturing

  • Solid free-form fabrication of porous scaffolds
  • 3D plotting and tissue assembly
  • 3D extracellular matrix (ECM) hydrogel models to control cell function
  • Pore architecture optimisation and modelling

Orthopaedic medical devices

  • Novel metal alloys for bone interfacing implants
  • Medical device design
  • Total joint replacement and clinical outcomes (NZ National Joint Registry) 

 

Lead researchers

The team consists of mechanical engineers, clinicians, process engineers, mathematicians, and surgeons.

Full and part-time staff

  • Assoc Prof Tim Woodfield (Orthopaedics, University of Otago, Christchurch)
  • Prof Anthony Butler (Bioengineering, University of Otago, Christchurch)
  • Assoc Prof Nigel Anderson (Radiology, University of Otago, Christchurch)
  • Peter Hilton (Bioengineering, University of Otago, Christchurch)
  • Deborah McMahon (Orthopaedics, University of Otago, Christchurch)

Postdocs and Research Assistants

  • Dr Khoon Lim (University of Otago, CReaTE, Research Fellow)
  • Dr Leigh Elmers (University of Otago, CReaTE, Research Fellow)
  • Dr Isha Mutreja (University of Otago, Postdoctoral Fellow)
  • Seamus Tredinnick (University of Otago, Orthopeadics, Assistant Research Fellow)

Students

  • Jessika Wise (University of Otago, CReaTE, PhD)
  • Josie Shum (University of Otago, CReaTE, PhD)
  • Pau Atienza (University of Otago, CReaTE, PhD)
  • Cesar Alcala (University of Otago, CReaTE, PhD)
  • Jun Li (University of Otago, CReaTE MBIE Ti Implant, PhD)
  • Gabriella Brown (University of Otago, CReaTE Rutherford Scholarship, PhD)
  • Jonathon Parrish (University of Otago, CReaTE, PhD)
  • Naveen Mekhileri (University of Otago, CReaTE, PhD)
  • Mohsen Ramyar (University of Otago, MARS/CReaTE, PhD)
  • Sandra Kieser (University of Otago, Orthopaedics, MSc)
  • Alasdair Soja (University of Otago, EnzTec MBIE Ti Implant, MSc)
  • William Linkhorn (University of Otago, CReaTE, MSc)

Visiting students

Recent students

  • Catherine Chia (University of Otago, CReaTE)
  • Jonas Anten (Utrecht University, Netherlands)
  • Kishore Rajendran (University of Otago, MARS/CReaTE, PhD)
  • Stefanie Sperling (Germany, MSc)
  • Caroline Lobker (University of Twente, Netherlands, MSc)
  • Eva Aigner (Technical University of Applied Sciences Vienna, Austria
  • Anthony Chan (University of Otago, CMRF)

Collaborators

Industrial partners

 

 Media

Publications

The Centre for Bioengineering supports a number of research projects, enabling researchers to attend conferences and present their work to an international audience.

The following publications have resulted from the CReaTE project since the launch of the Centre for Bioengineering:

Books/Chapters

  1. Melchels F., Fedorovich N., Alblas J., Malda J., Woodfield T. Organ Printing. In “Comprehensive Biomaterials.” P Ducheyne, KE Healy, DE Hutmacher, DE Grainger  &  CJ Kirkpatrick eds. Elsevier: Oxford UK,  (2011). ISBN: 978-0-08-055302-3.
  2. Dalton P., Woodfield T., Lewis J., Hutmacher D. Scaffold Design and Fabrication. In "Tissue Engineering Textbook." van Blitterswijk CA, Thomsen P, Lindahl A, Hubbell J, Williams DF, Cancedda R, de Bruijn J and Sohier J, (Eds); Academic Press: London, (2008); 403-454. ISBN: 978-0-12-370869-4.
  3. Malda J., Woodfield T., Radisic M., Levenberg S., Oomens C., Baaijens F., Svalander P., Vunjak-Novakovic G. Cell Nutrition. In "Tissue Engineering Textbook." van Blitterswijk CA, Thomsen P, Lindahl A, Hubbell J, Williams DF, Cancedda R, de Bruijn J and Sohier J, (Eds); Academic Press: London, (2008); 327-362. ISBN: 978-0-12-370869-4.
  4. Woodfield T.Cartilage Tissue Engineering: Instructing Cell-based Tissue Repair Through Scaffold Design. PhD Thesis, University of Twente (2004): 1-220. ISBN: 90-365-2057-6.
  5. Woodfield T.Interfacial Shear Strength Criteria for Tissue-Engineered Cartilage Anchored to Porous Synthetic Scaffolds. MASc Thesis, University of Toronto (2000): 1-148. ISBN: 0-612-49768-2

Refereed Journals 

  1. B S Schon, G J Hooper, T B F Woodfield. Modular Tissue Assembly Strategies for Biofabrication of Engineered Cartilage. Annals of Biomedical Engineering, Apr 2016 (DOI: 10.1007/s10439-016-1609-3).
  2. Jürgen Groll, Thomas Boland, Torsten Blunk, Jason A Burdick, Dong-Woo Cho, Paul D Dalton, Brian Derby, Gabor Forgacs, Qing Li, Vladimir A Mironov, Lorenzo Moroni, Makoto Nakamura ,Wenmiao Shu, Shoji Takeuchi, Giovanni Vozzi, Tim B F Woodfield, Tao Xu, James J Yoo, Jos Malda. Biofabrication: Reappraising the definition of an evolving field. Biofabrication 8(1):013001, Jan 2016 (DOI: 10.1088/1758-5090/8/1/013001).
  3. Fei Chen, Gernot Hochleitner, Tim Woodfield, Juergen Groll, Paul D Dalton, Brian G Amsden. Additive Manufacturing of a Photo-Cross-Linkable Polymer via Direct Melt Electrospinning Writing For Producing High Strength Structures. Biomacromolecules 11/2015; 17(1), Nov 2015 (DOI: 10.1021/acs.biomac.5b01316).
  4. E. Selvarajah, G. Hooper, K. Grabowski, C. Frampton, T. B. F. Woodfield, G. Inglis. The rates of wear of X3 highly cross-linked polyethylene at five years when coupled with a 36 mm diameter ceramic femoral head in young patients. Bone and Joint Journal 97-B(11):1470-1474, Nov 2015 (DOI: 10.1302/0301-620X.97B11.35736).
  5. Joanne Nunnerley, Jennifer Dunn, Kathryn McPherson, Gary Hooper, Tim Woodfield. Return to work for severely injured survivors of the Christchurch earthquake: Influences in the first 2 years. Disability and Rehabilitation 38(10):1-7, Jul 2015 (DOI: 10.3109/09638288.2015.1070299).
  6. Joanne Nunnerley, Jennifer Dunn, Kathryn McPherson, Gary Hooper, Tim Woodfield. Participation and Quality of Life Outcomes Among Individuals with Earthquake-Related Physical Disability: A Systematic Review. Journal of rehabilitation medicine: official journal of the UEMS European Board of Physical and Rehabilitation Medicine 04/2015; 47(5), Apr 2015 (DOI: 10.2340/16501977-1965).
  7. Isha Mutreja, T. B. F. Woodfield , S. Sperling, Volker Nock, John J. Evans, Maan Alkaisi. Positive and negative bioimprinted polymeric substrates: New platforms for cell culture. Biofabrication 04/2015; 7(2):025002, Apr 2015 (DOI: 10.1088/1758-5090/7/2/025002).
  8. Karsten Schrobback, Travis Jacob Klein, Tim B F Woodfield. The Importance of Connexin Hemichannels During Chondroprogenitor Cell Differentiation in Hydrogel Versus Microtissue Culture Models. Tissue Engineering Part A 02/2015; 21(11-12), Feb 2015 (DOI: 10.1089/ten.TEA.2014.0691).
  9. R. Aamir, A.P.H. Butler, P.H. Butler, N.G. Anderson, T. Woodfield, et al. (2014). MARS spectral molecular imaging of lamb tissue: data collection and image analysis. J Instrumentation (JINST). 9 (Article in press, doi:10.1088/1748-0221/9/02/P02005).
  10. K. Rajendran, A. P. H. Butler, P. H. Butler, S. T. Bell, N. G. Anderson, T. B. F. Woodfield, et al. (2014). Reducing beam hardening effects and metal artefacts in spectral CT using Medipix3RX. JINST; 9 (doi:10.1088/1748-0221/9/03/P03015).
  11. Walker J, Shadanbaz S, Woodfield TBF, Staiger MP, Dias GJ. (2014). Magnesium biomaterials for orthopedic application: A review from a biological perspective. J Biomed Matls Res-B (Article in press: DOI: 10.1002/jbm.b.33113).
  12. Walker J, Shadanbaz S, Woodfield TBF, Staiger MP, Dias GJ. (2014). The in vitro and in vivo evaluation of the biocompatibility of Mg alloys. Biomed Matls; 9(1).
  13. Shadanbaz S, Walker J, Woodfield TBF, Staiger MP, Dias GJ. Monetite and brushite coated magnesium: In vivo and in vitro models for degradation analysis. J Materials Science: Materials in Medicine 2014; 25(1): 173-183.
  14. Selvarajah, E., Woodfield, T., Devane, P., Hooper, G.J. (2013). Measurement of early wear rates with X3 Polyethylene and 36mm femoral heads in young patients - a prospective study with two year follow up. Current Orthopaedic Practice; 24(6): 641-646.
  15. Schuurman W, Harimulijo EB, Woodfield T, van Weeren PR, Dhert W, Malda J. Three-dimensional Assembly of Tissue Engineered Cartilage Constructs Results in Cartilaginous Tissue Formation without Retainment of Zonal Characteristics. J Tissue Engineering & Regenerative Medicine (in press).
  16. Schrobback K, Wrobel J, Hutmacher DW, Woodfield T, Klein TJ (2013). Stage-specific embryonic antigen-4 (SSEA-4) is not a marker for chondrogenic and osteogenic potential in cultured chondrocytes and mesenchymal progenitor cells. Tissue Engineering Part A. (in press) ahead of print. doi:10.1089/ten.tea.2012.0496.
  17. Murray LM, Nock V, Alkaisi MM, Lee JJM, Woodfield TBF (2012). Fabrication of polymeric substrates with micro- and nanoscale topography bioimprinted at progressive cell morphologies. Journal of Vacuum Science & Technology B; 30(6).
  18. Nguyen T, Waterman J, Staiger M, Woodfield T. (2012) Controlling corrosion rate of pure Mg with rough surface finish via biomimetic coating systems. Corrosion Engineering Science & Technology, 47(5): 358-364.
  19. J. Waterman, N. Birbilis, G. Dias, T. Woodfield, M.P. Staiger (2012) Improving the in vitro corrosion resistance of biomimetic calcium phosphate coatings for Mg substrates using a calcium hydroxide layer. Corrosion Engineering Science & Technology , 47(5): 340-345.
  20. Emans, P.J., E.J.P. Jansen, D. van Iersel, T.J.M. Welting, T.B.F. Woodfield, S.K. Bulstra, J. Riesle, L.W. van Rhijn, and R. Kuijer (2012). Tissue-engineered constructs: The effect of scaffold architecture in osteochondral repair. J Tissue Engineering & Regenerative Medicine, (published online: 21 MAR 2012, DOI: 10.1002/term.1477).
  21. T.L. Nguyen, A. Blanquet, G. Dias, M.P. Staiger, T.B.F. Woodfield. (2012) On the role of surface roughness in the corrosion of pure magnesium in vitro. Journal of Biomedical Materials Research - Part B, 100(5): 1310-1318.
  22. Walker J, Shadanbaz S, Kirkland NT, Stace E, Woodfield T, Staiger MP, Dias GJ (2012). Magnesium alloys: Predicting in vivo corrosion with in vitro immersion testing. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 100(4) , pp. 1134-1141
  23. G.J. Hooper, A.R. Maxwell, B. Wilkinson, J. Mathew, T.B.F. Woodfield, I.D. Penny, P.J. Burn, and C. Frampton (2012). The early radiological results of the uncemented Oxford medial compartment knee replacement. Journal of Bone and Joint Surgery. British Volume, 94(3): p. 334-8.
  24. Schon, B., van der Ven, M., Schrobback, K., Stroebel, S., Woodfield, T. Validation of a high-throughput approach for mass-production of pellets for 3D Tissue Assembly. Cell & Tissue Res (in press). DOI: 10.1007/s00441-011-1311-6.
  25. NT Kirkland, J Waterman, N Birbilis, G Dias, TBF Woodfield, RM Hartshorne, MP Staiger (2011). Buffer-regulated biocorrosion of pure magnesium. Journal of Materials Science - Materials in Medicine (in press). DOI: 10.1007/s10856-011-4517-y. IF: 2.325.
  26. Emans PJ, Jansen EJP, van Iersel D, Welting TJM, Woodfield TBF, Bulstra SK, Riesle J, van Rhijn LW, Kuijer R. (2011). Tissue engineered constructs; the effect of scaffold architecture in osteochondral repair. Journal of Tissue Engineering & Regenerative Medicine (in press). IF: 3.534
  27. J. Waterman, A. Pietak, N. Birbilis, T. Woodfield, G. Dias, M.P. Staiger (2011). Corrosion Resistance of Biomimetic Calcium Phosphate Coatings on Magnesium due to Varying Pretreatment Time. Materials Science & Engineering B. 176(20): p1756-1760. IF: 1.560
  28. T. Nguyen, M. Staiger, G. Dias, T. Woodfield (2011).  A Novel Manufacturing Route for Fabrication of Topologically-Ordered Porous Magnesium Scaffolds. Advanced Engineering Materials. 13(9): p872-881. IF: 1.738.
  29. N. T. Kirkland, I. Kolbeinsson, T. Woodfield, G. J. Dias, and M. P. Staiger (2011). Synthesis and properties of topologically-ordered porous magnesium. Materials Science & Engineering B. 176(20): p1666–1672. IF: 1.560
  30. M.P. Staiger, N.T. Kirkland, I. Kolbeinsson, T. Nguyen, G.J. Dias, and T. Woodfield (2010). Synthesis of topologically-ordered open-cell porous magnesium. Materials Letters 63 (23) p2572-2574. IF: 2.117
  31. N.T. Kirkland, N. Birbilis, T. Woodfield, G.J. Dias, and M.P. Staiger (2010). In vitro dissolution of magnesium-calcium binary alloys: Clarifying the unique role of calcium additions in bioresorbable magnesium implant alloys. Journal of Biomedical Materials Research Part B, 95(1); p91-100. IF: 2.220

Conference proceedings

  1. K. S. Lim, G. C. Brown, N. V. Mekhileri, B. S. Schon, G. J. Hooper, T. B. Woodfield. The Effect of Oxygen Inhibition in Biofabrication of Photocrosslinked Hydrogels. 4th TERMIS World Congress, Volume: 21, Sep 2015.
  2. G. Rodgers, E. Van Houten, R. Bianco, R. Besset, T. Woodfield. Topology Optimization of Porous Lattice Structures for Orthopaedic Implants. International Federation of Automatic Control (IFAC) Proceedings, 2014; (Accepted).
  3. Lang M, Chen X, Wang W, Woodfield TBF. Injection system for cellular assembly of 3D bio-tissue engineered constructs. Proceedings IEEE International Conference on Automation Science and Engineering, 2012; 291-296.
  4. Woodfield T, Schon B, Schrobback K, Hooper G. NEXT GENERATION CARTILAGE TISSUE ENGINEERING STRATEGIES BASED ON 3D TISSUE ASSEMBLY. Journal of Bone & Joint Surgery, British Volume 2012; 94-B (SUPP XLI): 123. IF: 2.832
  5. Woodfield T, Siegert A, Schon B, Schrobback K, Hooper. NOVEL IMAGING METHODS FOR DETECTING CARTILAGE TISSUE QUALITY VIA MARS-MICRO COMPUTED TOMOGRAPHY. Journal of Bone & Joint Surgery, British Volume 2012; 94-B (SUPP XLI): 122. IF: 2.832
  6. E. Selvarajah, G. Hooper, P. Devane, and T. Woodfield. WEAR RATES OF HIGHLY CROSS LINKED POLYETHYLENE IN TOTAL HIP ARTHROPLASTY USING 36MM HEADS – A MINIMUM 2 YEAR FOLLOW-UP STUDY. J Bone Joint Surg Br 2011 93-B: p381. IF: 2.351
  7. T. Woodfield, G. Hooper, G. Dias, and M. Staiger. BIODEGRADABLE METALS: A NEW CLASS OF ORTHOPAEDIC BIOMATERIALS. J Bone Joint Surg Br 2011 93-B: p382.
  8. Lang M, Wang W, Chen XQ, Woodfield T. Integrated system for 3D assembly of bio-scaffolds and cells. 2010 IEEE International Conference on Automation Science and Engineering, CASE 2010, 2010; p786-791.
  9. E. Selvarajah, G. Hooper, G. Inglis, T. Woodfield, and P. Devane. CROSS-LINKED POLYETHYLENE WEAR IN TOTAL HIP JOINT REPLACEMENTS WITH 36MM CERAMIC HEADS. J Bone Joint Surg Br Proceedings, Mar 2010; 92-B: p225. IF: 2.351
  10. T. Woodfield, G. Hooper, A Vincent, and V. Bell. EVALUATION OF KNEE JOINT PROPRIOCEPTION FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION – A 1-YEAR FOLLOW-UP. J Bone Joint Surg Br Proceedings, Mar 2010; 92-B: p226 - 227. IF: 2.351

Posters and abstracts

  1. Schon B.S., Hooper G.J., Woodfield T. Probing cell-biomaterial and tissue-tissue interactions via 3D assembly of engineered cartilage microtissues. Combined 22nd Annual Conference of the Australasian Society for Biomaterials & Tissue Engineering and 5th Indo-Australian Conference on Biomaterials, Implants, Tissue Engineering and Drug Delivery Systems, Barossa Valley, Australia, 2-5 April 2013. (Oral).
  2. Tredinnick, S., Woodfield T. Osseointegration of preclinical electron beam melted titanium scaffolds. Combined 22nd Annual Conference of the Australasian Society for Biomaterials & Tissue Engineering and 5th Indo-Australian Conference on Biomaterials, Implants, Tissue Engineering and Drug Delivery Systems, 2-5 April 2013. (Oral).
  3. G. Rodgers, A. Fields, R. Shearer, J. Lau Young, G. Chase, J. Burn, G. Hooper, T. Woodfield. RESULTS OF IN-VITRO AND IN-VIVO ACOUSTIC EMISSION MONITORING OF TOTAL HIP REPLACEMENT IMPLANTS. New Zealand Orthopaedic Association Annual Conference. Oct 2012, Dunedin, New Zealand. Oral.
  4. Khan-Edmundson, A., Rodgers, G.W., Woodfield, T.B.F., Hooper, G.J., Chase, J.G. (2012) Tissue attenuation characteristics of acoustic emission signals for wear and degradation of total hip arthroplasty implants. 8th IFAC Symposium on Biological and Medical Systems (BMS12), Budapest, Hungary, 29-31 Aug 2012. 8, 1, 355-360.
  5. K. C. Chan, T. Führmann, T.D. Brown, P.D. Dalton, T.B.F. Woodfield. Utilising aligned melt electrospun fibres as guidance cues for neural cell growth in a 3D hydrogel microenvironment. 9th World Biomaterials Conference, Chengdu, China, June 1-5th 2012 (Oral).
  6. T. Nguyen, M. Staiger, G. Dias, T. Woodfield. Mechanical properties of topology optimised magnesium scaffolds: FEA prediction and compression testing. 9th World Biomaterials Conference, Chengdu, China, June 1-5th 2012 (Oral).
  7. J. Waterman, N. Birbilis, T. Woodfield, G.Dias, M. Staiger. Self-Healing Corrosion Resistant Coatings for Biodegradable Mg. 9th World Biomaterials Conference, Chengdu, China, June 1-5th 2012 (Oral).
  8. J. Walker, S. Shadanbaz, T. Woodfield, M. Staiger, G. Dias. Screening of Magnesium Alloys for Orthopaedic Application. 9th World Biomaterials Conference, Chengdu, China, June 1-5th 2012 (Oral).
  9. J. Walker, S. Shadanbaz, T. Woodfield, M. Staiger, G. Dias. Investigating Magnesium Alloys in vivo. 9th World Biomaterials Conference, Chengdu, China, June 1-5th 2012 (Poster).
  10. S. Shadanbaz, J. Walker, T. Woodfield, M. Staiger, G. Dias. In vivo and in vitro Assessment of Brushite and Monetite coated Magnesium: Biocompatibility and Corrosion Protection Analysis. 9th World Biomaterials Conference, Chengdu, China, June 1-5th 2012 (Oral).
  11. S. Shadanbaz, J. Walker, T. Woodfield, M. Staiger, G. Dias. A Novel in vitro Calcium Phosphate Coating Technique on Magnesium Substrates. 9th World Biomaterials Conference, Chengdu, China, June 1-5th 2012 (Poster).
  12. T. Woodfield, A. Siegert, B. Schon, A. Butler, G.J. Hooper. Quantitative Detection of Cartilage and Bone Tissue Quality via Spectral MARS-CT Imaging. 10th World Congress of the International Cartilage Repair Society (ICRS), Montreal, Canada, May12-15, 2012. Oral
  13. K. Schrobback, S. Stroebel, B. Schon, D.W. Hutmacher, T.J. Klein, T. Woodfield. The importance of cell-cell interactions during in vitro differentiation of human chondroprogenitor cells. 10th World Congress of the International Cartilage Repair Society (ICRS), Montreal, Canada, May12-15, 2012. Oral
  14. B. Schon, G.J. Hooper, T. Woodfield. 3D cartilage micro-tissue assembly: does eliminating cell-material interactions influence cell re-differentiation capacity? 10th World Congress of the International Cartilage Repair Society (ICRS), Montreal, Canada, May12-15, 2012. Poster
  15. T. Woodfield, A. Siegert, B. Schon, A. Butler, G.J. Hooper. Novel Imaging Methods for Detecting Cartilage Tissue Quality via MARS-Micro Computed Tomography. Combined Australia/NZ Orthopaedic Assn Conference, Oct 9-14, 2011. Oral
  16. T. Woodfield, B. Schon, K. Schrobback, G.J. Hooper. Next Generation Cartilage Tissue Engineering Strategies Based on 3D Tissue Assembly. Combined Australia/NZ Orthopaedic Assn Conference, Oct 9-14, 2011. Oral
  17. G. Rodgers, G. Chase, G.J. Hooper, T. Woodfield - SCREENING FOR EARLY WEAR OR FAILURE IN TOTAL HIP ARTHROPLASTY VIA ACOUSTIC EMISSION MONITORING. Combined Australia/NZ Orthopaedic Assn Conference, Oct 9-14, 2011. Poster
  18. Schon, B.S., Schrobback, K., Hooper, G., Woodfield, T.B.F. Next Generation Tissue Engineering Strategies Based on 3D Tissue Assembly. NZ Medical Sciences Conference, Queenstown, New Zealand, Aug 29-31, 2011. Oral
  19. T. Nguyen, M. Staiger, G. Dias, T. Woodfield. RELATIONSHIP BETWEEN SURFACE ROUGHNESS AND CORROSION RATE OF PURE MAGNESIUM BIOMATERIALS. 21st Annual Australasian Society for Biomaterials & Tissue Engineering, Queenstown, New Zealand, April 27-29, 2011; p:O34. Oral
  20. Schon, B.S., Schrobback, K., Woodfield, T.B.F. TOWARDS ASSEMBLING TISSUE-ENGINEERED ARTICULAR CARTILAGE: ARRANGING, VISUALISING AND TRACKING PELLET CULTURES. 21st Annual Australasian Society for Biomaterials & Tissue Engineering, Queenstown, New Zealand, April 27-29, 2011; p:OP1. Oral poster
  21. Chan, K.C., Dalton, P.D. and Woodfield, T.B.F. DEVELOPMENT OF A NOVEL CULTURE MODEL FOR ANALYSING CELLMATERIAL INTERACTIONS IN A 3D HYDROGEL MICROENVIRONMENT. 21st Annual Australasian Society for Biomaterials & Tissue Engineering, Queenstown, New Zealand, April 27-29, 2011; p:OP2. Oral poster
  22. Schrobback, K., Stroebel, S., Hutmacher, D.W., Klein, T.J. Woodfield, T. THE IMPORTANCE OF CELL-CELL INTERACTIONS DURING IN VITRO DIFFERENTIATION OF HUMAN CHONDROPROGENITOR CELLS. 21st Annual Australasian Society for Biomaterials & Tissue Engineering, Queenstown, New Zealand, April 27-29, 2011; p:OP4. Oral poster
  23. S. Shadanbaz, Walker, J, A. Pietak, M.P. Staiger, T. Woodfield, G.J. Dias. IN SITU CRYSTALLISATION, A NOVEL CALCIUM PHOSPHATE COATING TECHNIQUE ON PURE MAGNESIUM: IN VITRO CORROSSION PROTECTION ANALYSIS. 21st Annual Australasian Society for Biomaterials & Tissue Engineering, Queenstown, New Zealand, April 27-29, 2011; p:OP11. Oral poster
  24. Walker, J., Shadanbaz, S., Woodfield, T., Staiger, M., Schofield, J., Dias, G. THE DEVELOPMENT OF AN INTERMUSCULAR MODEL TO INVESTIGATE THE BIOCOMPATIBILITY OF MAGNESIUM ALLOYS. 21st Annual Australasian Society for Biomaterials & Tissue Engineering, Queenstown, New Zealand, April 27-29, 2011; p:OP12. Oral poster
  25. S. Tredinnick, G. Dias, G. Chase, T. Woodfield. IMPROVING THE OSSEOINTEGRATION OF TITANIUM WITH ELECTRON BEAM MELTING TECHNOLOGY. 21st Annual Australasian Society for Biomaterials & Tissue Engineering, Queenstown, New Zealand, April 27-29, 2011; p:POS5. Poster
  26. Rodgers, G.W., Hooper, G.J., Chase, J.G., Woodfield, T.B.F. ACOUSTIC EMISSION MONITORING OF IMPLANT MATERIALS FOLLOWING TOTAL HIP ARTHROPLASTY. 21st Annual Australasian Society for Biomaterials & Tissue Engineering, Queenstown, New Zealand, April 27-29, 2011; p:POS16. Poster
  27. Waterman, J., Kirkland, N., Hartshorn, R., Birbilis, N., Woodfield, T., Dias, G., Staiger, M.P. NMR STUDIES ON THE COMPLEX BEHAVIOUR OF MAGNESIUM AND HEPES FOR IN VITRO TESTING. 21st Annual Australasian Society for Biomaterials & Tissue Engineering, Queenstown, New Zealand, April 27-29, 2011; p:POS19. Poster
  28. S. Stroebel, J. Malda, T. Woodfield. A novel 3D tissue assembly approach for cartilage tissue engineering applications. 9th World Congress of the International Cartilage Repair Society (ICRS), Sitges / Barcelona, Spain, September 26 – 29, 2010; p161. Oral
  29. K. Schrobback, T. Woodfield, R. Crawford, D.W. Hutmacher, T. Klein. Stem cell surface marker SSEA-4 levels correlate with enhanced chondrogenic potential of cultured human osteoarthritic chondrocytes. 9th World Congress of the International Cartilage Repair Society (ICRS), Sitges / Barcelona, Spain, September 26 – 29, 2010; p161. Oral
  30. Woodfield T., van der Ven M., Stroebel S. Mass-scale fabrication of cell pellets for high throughput screening and 3D assembly of tissue engineered cartilage. Tissue Engineering & Regenerative Medicine International Society Asia Pacific (TERMIS-AP) Conference. Sydney, Australia, Sept 15-17, 2010; p51. Oral
  31. N. T. Kirkland, G. Dias, T. Woodfield, N. Birbilis, and M. P. Staiger. Toward Standardised In Vitro Performance Testing of Mg Alloys. European Society for Biomaterials, September 11-15, Tampere, Finland. Oral.
  32. N. T. Kirkland, J. Walker, G. Dias, T. Woodfield, N. Birbilis and M. P. Staiger. Losses in Mass and Yield Strength of Mg-based Biomaterials Due to Biodegradation Environment. European Society for Biomaterials, September 11-15, Tampere, Finland. Poster.
  33. N.T. Kirkland, N. Birbilis, G. Dias, T. Woodfield and M.P. Staiger. Predictive in vitro assessment of Mg-based biomaterials. 2nd Symposium on Biodegradable Metals. Maratea, Italy. Aug 31 – Sept 3, 2010, p28. Oral
  34. J. Walker, T. Woodfield, M. Staiger, G.J. Dias. The development of an in vitro immersion test to predict the in vivo corrosion of magnesium alloys. 2nd Symposium on Biodegradable Metals. Maratea, Italy. Aug 31 – Sept 3, 2010, p70. Oral
  35. S. Shadanbaz, A. Pietak, M. P. Staiger, T. Woodfield and G.J. Dias. A novel approach to coating pure magnesium with calcium phosphates using in-situ crystallisation: In vitro corrosion protection analysis. 2nd Symposium on Biodegradable Metals. Maratea, Italy. Aug 31 – Sept 3, 2010, p74. Oral
  36. T. Nguyen, M. Staiger, G. Dias, T. Woodfield. Manufacturing and characterising ordered porous magnesium scaffolds. 2nd Symposium on Biodegradable Metals. Maratea, Italy. Aug 31 – Sept 3, 2010, p84. Oral
  37. J. Waterman, M.P. Staiger, T. Woodfield, G. Dias. Corrosion protection of biomimetic calcium phosphate coatings on magnesium. 2nd Symposium on Biodegradable Metals. Maratea, Italy. Aug 31 – Sept 3, 2010, p91. Poster
  38. Stroebel, S., Malda, J., and Woodfield, T. A Novel 3D Tissue Assembly Approach for Cartilage Tissue Engineering Applications. 20th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), Brisbane, Australia. (2010, February). Oral
  39. Woodfield, T., Selvarajah, E., Devane, P., Hooper, G.J. Wear Rates of Highly Cross-Linked Polyethylene in Total Hip Arthroplasty Using 36mm Heads - A Minimum 2 Year Follow-up Study. 20th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), Brisbane, Australia. (2010, February). Oral
  40. Walker, J., Kirkland, N., Staiger, M., Woodfield, T, and Dias, G. Magnesium degradation: Comparison between in vitro and in vivo methodologies. 20th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), Brisbane, Australia. (2010, February). Oral
  41. Nguyen, T., Staiger, M., Dias, G., Woodfield, T. Manufacturing of ordered porous magnesium scaffolds. 20th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), Brisbane, Australia. (2010, February). Oral poster presentation (best poster award)
  42. Waterman, J., Shadanbaz, S., Dias, G., Woodfield, T., and Staiger, M.P. Controlling the degradation of magnesium biomaterials via biomimetic coatings. 20th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), Brisbane, Australia. (2010, February). Oral poster presentation
  43. Kirkland, N.T., Birbilis, N., Dias, G., Woodfield, T., and Staiger, M.P. Bio-corrosion behaviour of Mg-Ca binary alloys. 20th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), Brisbane, Australia. (2010, February). Oral poster presentation
  44. Waterman J., Dias G., Woodfield T. and Staiger M.P. Effects of magnesium alloy composition on biomimetic calcium phosphate coatings for orthopaedic implants. 2nd International Symposium on Surface and Interface of Biomaterials (ISSIB-II), University of Hong Kong, January 2010. Oral