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Profile

Associate Professor Ros Kemp

PositionAssociate Professor
DepartmentDepartment of Microbiology and Immunology
QualificationsBSc(Hons) PhD
Research summaryApplied and molecular immunology, cancer immunobiology, vaccines – immunology and technology

Research

My research focuses on T cells as mediators of anti-tumour immunity and inflammation. Specifically, we study the role of inflammation and the unique features of different subsets of T cells and myeloid cells, focussing on cancer and gut-specific immune responses; and how these cell subsets are involved in patient outcome.

We are currently looking at T cell and myeloid cell subsets in colorectal cancer and inflammatory bowel disease to improve diagnosis, prognosis and treatment. We are generating site-specific T cell memory using novel slow release vaccines and analysing the molecular signalling pathways required to maintain these populations.

Publications

Girardin, A., McCall, J., Black, M. A., Edwards, F., Phillips, V., Taylor, E. S., Reeve, A. E., & Kemp, R. A. (2013). Inflammatory and regulatory T cells contribute to a unique immune microenvironment in tumor tissue of colorectal cancer patients. International Journal of Cancer, 132(8), 1842-1850. doi: 10.1002/ijc.27855

Highton, A. J., Kojarunchitt, T., Girardin, A., Hook, S., & Kemp, R. A. (2015). Chitosan hydrogel vaccine generates protective CD8 T cell memory against mouse melanoma. Immunology & Cell Biology, 93, 634-640. doi: 10.1038/icb.2015.14

Kemp, R. A., Pearson, C. F., Cornish, G. H., & Seddon, B. P. (2010). Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activation. Immunology & Cell Biology, 88, 213-219. doi: 10.1038/icb.2009.95

Kemp, R. A., Black, M. A., McCall, J., Yoon, H.-S., Phillips, V., Anjomshoaa, A., & Reeve, A. E. (2011). T cell subpopulations in lymph nodes may not be predictive of patient outcome in colorectal cancer. Journal of Experimental & Clinical Cancer Research, 30, 78. doi: 10.1186/1756-9966-30-78

Neumann, S., Burkert, K., Kemp, R., Rades, T., Dunbar, P. R., & Hook, S. (2014). Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunology & Cell Biology, 92, 535-542. doi: 10.1038/icb.2014.21

Journal - Research Article

Ward-Hartstonge, K. A., McCall, J. L., McCulloch, T. R., Kamps, A.-K., Girardin, A., Cretney, E., Munro, F. M., & Kemp, R. A. (2017). Inclusion of BLIMP-1+ effector regulatory T cells improves the Immunoscore in a cohort of New Zealand colorectal cancer patients: A pilot study. Cancer Immunology, Immunotherapy, 66(4), 515-522. doi: 10.1007/s00262-016-1951-1

Norton, S. E., Dunn, E. T. J., McCall, J. L., Munro, F., & Kemp, R. A. (2016). Gut macrophage phenotype is dependent on the tumor microenvironment in colorectal cancer. Clinical & Translational Immunology, 5(4), e76. doi: 10.1038/cti.2016.21

Dunn, E. T. J., Taylor, E. S., Stebbings, S., Schultz, M., Butt, A. G., & Kemp, R. A. (2016). Distinct immune signatures in the colon of Crohn's disease and ankylosing spondylitis patients in the absence of inflammation. Immunology & Cell Biology, 94(5), 421-429. doi: 10.1038/icb.2015.112

Taylor, E. S., McCall, J. L., Girardin, A., Munro, F. M., Black, M. A., & Kemp, R. A. (2016). Functional impairment of infiltrating T cells in human colorectal cancer. OncoImmunology, 5(11), e1234573. doi: 10.1080/2162402X.2016.1234573

Highton, A. J., Kojarunchitt, T., Girardin, A., Hook, S., & Kemp, R. A. (2015). Chitosan hydrogel vaccine generates protective CD8 T cell memory against mouse melanoma. Immunology & Cell Biology, 93, 634-640. doi: 10.1038/icb.2015.14

Neumann, S., Burkert, K., Kemp, R., Rades, T., Dunbar, P. R., & Hook, S. (2014). Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunology & Cell Biology, 92, 535-542. doi: 10.1038/icb.2014.21

Girardin, A., McCall, J., Black, M. A., Edwards, F., Phillips, V., Taylor, E. S., Reeve, A. E., & Kemp, R. A. (2013). Inflammatory and regulatory T cells contribute to a unique immune microenvironment in tumor tissue of colorectal cancer patients. International Journal of Cancer, 132(8), 1842-1850. doi: 10.1002/ijc.27855

Gordon, S., Young, K., Wilson, R., Rizwan, S., Kemp, R., Rades, T., & Hook, S. (2012). Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems. Journal of Liposome Research, 22(3), 193-204. doi: 10.3109/08982104.2011.637502

Kemp, R. A., Black, M. A., McCall, J., Yoon, H.-S., Phillips, V., Anjomshoaa, A., & Reeve, A. E. (2011). T cell subpopulations in lymph nodes may not be predictive of patient outcome in colorectal cancer. Journal of Experimental & Clinical Cancer Research, 30, 78. doi: 10.1186/1756-9966-30-78

Kemp, R. A., Pearson, C. F., Cornish, G. H., & Seddon, B. P. (2010). Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activation. Immunology & Cell Biology, 88, 213-219. doi: 10.1038/icb.2009.95

Bouwer, A. L., Netter, P., Kemp, R. A., & McLellan, A. D. (2010). A defined serum-free medium useful for monitoring anti-melanoma responses induced by dendritic cell immunotherapy. Journal of Immunological Methods, 352, 178-181. doi: 10.1016/j.jim.2009.11.001

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