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Does retromer control epithelial polarity and ion channel delivery to the cell surface?

A postgraduate research opportunity at the University of Otago.

Details

Close date
Friday, 8 December 2017
Academic background
Health Sciences
Host campus
Dunedin
On-campus or via distance?
On-campus
Qualification
PhD
Department
Physiology
Supervisors
Associate Professor Fiona McDonald, Dr Kirk Hamilton

Overview

To achieve the optimal balance of intracellular and extracellular ion concentrations the numbers of ion channels situated at the cell surface are tightly regulated. Retromer is a recently described intracellular complex that controls whether cell surface proteins are recycled to the cell surface or degraded. In this project we will determine if two epithelial ion channels are regulated by retromer, and whether the polar distribution of these ion channels in epithelia are altered when retromer is disabled. The results will have implications for further understanding of electrolyte balance and blood pressure control.

Contact

Associate Professor Fiona McDonald
Email   fiona.mcdonald@otago.ac.nz