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The role of the Exocist complex in trafficking ion channels in polarised epithelia

A postgraduate research opportunity at the University of Otago.

Details

Close date
Friday, 8 December 2017
Academic background
Sciences, Health Sciences
Host campus
Dunedin
On-campus or via distance?
On-campus
Qualification
PhD
Department
Physiology
Supervisor
Dr Kirk Hamilton and Associate Professor Fiona McDonald

Overview

Proper trafficking of ion channels in epithelia is key to epithelial cell function. The Exocyst is a series of proteins that act as a complex and aids in tethering post-Golgi secretory vesicles for delivery of ion channels to the plasma membrane. The role of the Exocyst complex in trafficking ion channels still emerging. In this project, we will investigate the role of the Exocyst complex in the targeting of two epithelial ion channels to the appropriate membarne. This will be approached using a range of protein biochemistry, molecular biology, electrophysiological and imaging techniques. The implication of these results is to define novel trafficking partners of K+ and Na+ channels that may be used therapeutically in diseases.

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Contact

Dr Kirk Hamilton
Email   kirk.hamilton@otago.ac.nz