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Professor A. Mark Richards

Mark Richards

MD(Otago) PhD(Otago) FRACP

Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand

Email mark.richards@cdhb.health.nz

Current Roles

Research Interests

  • Neurohormonal physiology and pathophysiology in cardiovascular health and disease
  • Heart Failure
  • Acute Coronary Syndromes
  • Hypertension
  • Vasoactive Hormones
  • The Cardiac Natriuretic Peptides

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Publications

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2013). Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure. Circulation: Heart Failure, 6(4), 825-832. doi: 10.1161/circheartfailure.112.000205

Richards, M., Di Somma, S., Mueller, C., Nowak, R., Peacock, W. F., Ponikowski, P., … Maisel, A. (2013). Atrial fibrillation impairs the diagnostic performance of cardiac natriuretic peptides in dyspneic patients: Results from the BACH Study (Biomarkers in ACute Heart Failure). JACC: Heart Failure, 1(3), 192-199. doi: 10.1016/j.jchf.2013.02.004

Santhanakrishnan, R., Ng, T. P., Cameron, V. A., Gamble, G. D., Ling, L. H., Sim, D., … Troughton, R., Richards, A. M., … Lam, C. S. P. (2013). The Singapore heart failure outcomes and phenotypes (SHOP) study and prospective evaluation of outcome in patients with heart failure with preserved left ventricular ejection fraction (PEOPLE) study: Rationale and design. Journal of Cardiac Failure, 19(3), 156-162. doi: 10.1016/j.cardfail.2013.01.007

Rademaker, M. T., Yandle, T. G., Ellmers, L. J., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circulation: Heart Failure, 5, 645-652. doi: 10.1161/circheartfailure.112.967059

Than, M., Cullen, L., Reid, C. M., Lim, S. H., Aldous, S., Ardagh, M. W., … George, P. M., & Richards, A. M. (2011). A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): A prospective observational validation study. Lancet, 377(9771), 1077-1084. doi: 10.1016/S0140-6736(11)60310-3

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

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Journal - Research Article

Santhanakrishnan, R., Ng, T. P., Cameron, V. A., Gamble, G. D., Ling, L. H., Sim, D., … Troughton, R., Richards, A. M., … Lam, C. S. P. (2013). The Singapore heart failure outcomes and phenotypes (SHOP) study and prospective evaluation of outcome in patients with heart failure with preserved left ventricular ejection fraction (PEOPLE) study: Rationale and design. Journal of Cardiac Failure, 19(3), 156-162. doi: 10.1016/j.cardfail.2013.01.007

Richards, M., Di Somma, S., Mueller, C., Nowak, R., Peacock, W. F., Ponikowski, P., … Maisel, A. (2013). Atrial fibrillation impairs the diagnostic performance of cardiac natriuretic peptides in dyspneic patients: Results from the BACH Study (Biomarkers in ACute Heart Failure). JACC: Heart Failure, 1(3), 192-199. doi: 10.1016/j.jchf.2013.02.004

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2013). Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure. Circulation: Heart Failure, 6(4), 825-832. doi: 10.1161/circheartfailure.112.000205

Patel, K., Rademaker, M. T., Kirkpatrick, C. M. J., Charles, C. J., Fisher, S., Yandle, T. G., & Richards, A. M. (2012). Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep. British Journal of Pharmacology, 166(6), 1916-1925. doi: 10.1111/j.1476-5381.2012.01904.x

Pemberton, C. J., Siriwardena, M., Kleffmann, T., Ruygrok, P., Palmer, S. C., Yandle, T. G., & Richards, A. M. (2012). First identification of circulating Prepro-A-Type natriuretic peptide (PreproANP) signal peptide fragments in humans: Initial assessment as cardiovascular biomarkers. Clinical Chemistry, 58(4), 757-767. doi: 10.1373/clinchem.2011.176990

Than, M., Cullen, L., Aldous, S., Parsonage, W. A., Reid, C. M., Greenslade, J., … Ardagh, M. W., Troughton, R., … Richards, A. M. (2012). 2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: The ADAPT trial. JACC, 59(23), 2091-2098. doi: 10.1016/j.jacc.2012.02.035

Rademaker, M. T., Yandle, T. G., Ellmers, L. J., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circulation: Heart Failure, 5, 645-652. doi: 10.1161/circheartfailure.112.967059

Rusinaru, D., Tribouilloy, C., Berry, C., Richards, A. M., Whalley, G. A., Earle, N., … on behalf of the MAGGIC Investigators. (2012). Relationship of serum sodium concentration to mortality in a wide spectrum of heart failure patients with preserved and with reduced ejection fraction: An individual patient data meta-analysis. European Journal of Heart Failure, 14(10), 1139-1146. doi: 10.1093/eurjhf/hfs099

Than, M., Cullen, L., Reid, C. M., Lim, S. H., Aldous, S., Ardagh, M. W., … George, P. M., & Richards, A. M. (2011). A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): A prospective observational validation study. Lancet, 377(9771), 1077-1084. doi: 10.1016/S0140-6736(11)60310-3

Maisel, A., Mueller, C., Nowak, R., ..., Richards, M., ..., & Anker, S. D. (2011). Midregion prohormone adrenomedullin and prognosis in patients presenting with acute dyspnea: Results from the BACH (Biomarkers in Acute Heart Failure) Trial. JACC, 58(10), 1057-1067. doi: 10.1016/j.jacc.2011.06.006

Ellis, K. L., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Skelton, L., Thomson, J. A., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2011). Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in established coronary artery disease. Circulation: Cardiovascular Genetics, 4(6), 636-646. doi: 10.1161/circgenetics.111.960336

Lainchbury, J. G., Troughton, R. W., Strangman, K. M., Frampton, C. M., Pilbrow, A., Yandle, T. G., … Nicholls, M. G., & Richards, A. M. (2010). N-terminal pro-B-type natriuretic peptide-guided treatment for chronic heart failure: Results from the BATTLESCARRED (NT-proBNP-assisted treatment to lessen serial cardiac readmissions and death) trial. JACC, 55(1), 53-60. doi: 10.1016/j.jacc.2009.02.095

Ellis, K. L., Pilbrow, A. P., Frampton, C. M., Doughty, R. N., Whalley, G. A., Ellis, C. J., Palmer, B. R., Skelton, L., Yandle, T. G., Palmer, S. C., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2010). A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality. Circulation: Cardiovascular Genetics, 3(3), 286-293. doi: 10.1161/circgenetics.109.917443

Ritzema, J., Troughton, R., Melton, I., Crozier, I., Doughty, R., Krum, H., … Richards, M., … Frampton, C. M., … on behalf of the Hemodynamically Guided Home Self-Therapy in Severe Heart Failure Patients (HOMEOSTASIS) Study Group. (2010). Physician-directed patient self-management of left atrial pressure in advanced chronic heart failure. Circulation, 121, 1086-1095. doi: 10.1161/CIRCULATIONAHA.108.800490

Hildebrandt, P., Collinson, P. O., Doughty, R. N., Fuat, A., Gaze, D. C., Gustafsson, F., … Richards, M. (2010). Age-dependent values of N-terminal pro-B-type natriuretic peptide are superior to a single cut-point for ruling out suspected systolic dysfunction in primary care. European Heart Journal, 31(15), 1881-1889. doi: 10.1093/eurheartj/ehq163

Palmer, S. C., Yandle, T. G., Frampton, C. M., Troughton, R. W., Nicholls, M. G., & Richards, A. M. (2009). Renal and cardiac function for long-term (10 year) risk stratification after myocardial infarction. European Heart Journal, 30, 1486-1494. doi: 10.1093/eurheartj/ehp132

Wright, S. P., Doughty, R. N., Frampton, C. M., Gamble, G. D., Yandle, T. G., & Richards, A. M. (2009). Plasma urocortin 1 in human heart failure. Circulation: Heart Failure, 2(5), 465-471. doi: 10.1161/circheartfailure.108.840207

The ONTARGET Investigators, including Richards, A. M., & Troughton, R. W. (2008). Telmisartan, Ramipral, or both in patients at high risk for vascular events. New England Journal of Medicine, 358(15), 1547-1559.

Molyneux, S. L., Florkowski, C. M., George, P. M., Pilbrow, A. P., Frampton, C. M., Lever, M., & Richards, A. M. (2008). Coenzyme Q10: An independent predictor of mortality in chronic heart failure. JACC, 52(18), 1435-1441. doi: 10.1016/j.jacc.2008.07.044

Hillock, R. J., Frampton, C. M., Yandle, T. G., Troughton, R. W., Lainchbury, J. G., & Richards, A. M. (2008). B-type natriuretic peptide infusions in acute myocardial infarction. Heart, 94(5), 617-622. doi: 10.1136/hrt.2006.110239

Whalley, G. A., Wright, S. P., Pearl, A., Gamble, G. D., Walsh, H. J., Richards, M., & Doughty, R. N. (2008). Prognostic role of echocardiography and brain natriuretic peptide in symptomatic breathless patients in the community. European Heart Journal, 29(4), 509-516. doi: 10.1093/eurheartj/ehm647

Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Yandle, T. G., Skelton, L., Nicholls, M. G., & Richards, A. M. (2008). Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction. European Heart Journal, 29, 2489-2496. doi: 10.1093/eurheartj/ehn383

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Conference Contribution - Published proceedings: Full paper

Martinez-Rumayor, A., Richards, A. M., Burnett, J. C., & Januzzi, Jr, J. L. (2008). Biology of the natriuretic peptides. American Journal of Cardiology. 101(3, Suppl. 1), (pp. 3A-8A). doi: 10.1016/j.amjcard.2007.11.012

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Conference Contribution - Poster Presentation (not in published proceedings)

Ellis, K. L., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2011, August). Genomic risk variants at 1p13.3, 1q41 and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in patients with established coronary artery disease. Poster session presented at the European Society of Cardiology (ESC) Congress, Paris, France.

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