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Professor Richard W. Troughton

Richard Troughton

MB ChB(Auck) PhD(Otago) FRACP

Email richard.troughton@cdhb.health.nz

Department of Medicine
University of Otago, Christchurch
P.O. Box 4345
Christchurch
New Zealand

Current Roles

  • Professor in Medicine
  • Cardiologist

Research Interests

  • Neurohormonal control of cardiovascular and renal function
  • Heart Failure
  • Echocardiography
  • Left Ventricular Diastolic Function
  • Novel monitoring devices for heart failure

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Publications

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine. Advance online publication. doi: 10.7326/m16-2562

Elliott, J. M., Wang, T. K. M., Gamble, G., Williams, M., Matsis, P., Troughton, R., … Mann, S., Richards, M., … Ellis, C. (2017). A decade of improvement in the management of New Zealand ST-elevation myocardial infarction (STEMI) patients: Results from the New Zealand Acute Coronary Syndrome (ACS) Audit Group national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 130(1453), 17-28. Retrieved from https://www.nzma.org.nz/journal

Ibrihim, I., Kuan, W. S., Frampton, C., Troughton, R., Liew, O. W., Chong, J. P. C., … Pemberton, C. J., … Richards, A. M. (2017). Superior performance of N-terminal pro brain natriuretic peptide for diagnosis of acute decompensated heart failure in an Asian compared with a Western setting. European Journal of Heart Failure, 19(2), 209-217. doi: 10.1002/ejhf.612

Laribi, S., Pemberton, C. J., Kirwan, L., Nouira, S., Turkdogan, K., Yilmaz, M. B., Troughton, R. W., … Richards, M., … on behalf of the GREAT (Global Research on Acute Conditions Team) Network. (2017). Mortality and acute exacerbation of COPD: A pilot study on the influence of myocardial injury. European Respiratory Journal, 49(6), 1700096. doi: 10.1183/13993003.00096-2017

Chapter in Book - Research

Chan, W., & Troughton, R. (2014). Pulmonary hypertension and cardiac resynchronization therapy: Evaluation prior to implantation and response to therapy. In C.-M. Yu, D. L. Hayes & A. Auricchio (Eds.), Cases in cardiac resynchronization therapy. (pp. 295-300). Philadelphia, PA: Saunders.

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Troughton, R. W. (2010). Dilated cardiomyopathy. In M. J. Garcia (Ed.), Noninvasive cardiovascular imaging: A multimodality approach. (pp. 465-477). Philadelphia, PA: Lippincott Williams & Wilkins.

Troughton, R. W., Ritzema-Carter, J., & Nicholls, M. G. (2008). Role of neurohormones. In A. L. Klein & M. J. Garcia (Eds.), Diastology: Clinical approach to diastolic heart failure. (pp. 345-366). Philadelphia, PA: Saunders.

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

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Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Troughton, R., Lin, S., & Wong, J. (2004). Prosthetic heart valves. In Manual of Cardiovascular Medicine. (2nd ed.) (pp. 236-248). Philadelphia: Lippincott Williams and Wilkins.

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

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Journal - Research Article

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Ibrihim, I., Kuan, W. S., Frampton, C., Troughton, R., Liew, O. W., Chong, J. P. C., … Pemberton, C. J., … Richards, A. M. (2017). Superior performance of N-terminal pro brain natriuretic peptide for diagnosis of acute decompensated heart failure in an Asian compared with a Western setting. European Journal of Heart Failure, 19(2), 209-217. doi: 10.1002/ejhf.612

Elliott, J. M., Wang, T. K. M., Gamble, G., Williams, M., Matsis, P., Troughton, R., … Mann, S., Richards, M., … Ellis, C. (2017). A decade of improvement in the management of New Zealand ST-elevation myocardial infarction (STEMI) patients: Results from the New Zealand Acute Coronary Syndrome (ACS) Audit Group national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 130(1453), 17-28. Retrieved from https://www.nzma.org.nz/journal

Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine. Advance online publication. doi: 10.7326/m16-2562

Young, J. M., Pickering, J. W., George, P. M., Aldous, S. J., Wallace, J., Frampton, C. M., Troughton, R. W., Richards, A. M., … Than, M. P. (2016). Heart Fatty Acid Binding Protein and cardiac troponin: Development of an optimal rule-out strategy for acute myocardial infarction. BMC Emergency Medicine, 16(1), 34. doi: 10.1186/s12873-016-0089-y

Pemberton, C. J., Frampton, C. M., Aldous, S., Bailey, M., Young, J., Troughton, R., Than, M., & Richards, M. (2016). B-type natriuretic peptide signal peptide (BNPsp) in patients presenting with chest pain. Clinical Biochemistry, 49, 645-650. doi: 10.1016/j.clinbiochem.2016.02.015

Than, M. P., Pickering, J. W., Aldous, S. J., Cullen, L., Frampton, C. M. A., Peacock, W. F., … Richards, A. M., Ardagh, M. W., Deely, J. M., Florkowski, C. M., George, P., Hamilton, G. J., Jardine, D. L., Troughton, R. W., … Lord, S. J. (2016). Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: A pragmatic randomized controlled trial embedded within practice. Annals of Emergency Medicine, 68(1), 93-102. doi: 10.1016/j.annemergmed.2016.01.001

Williams, M. J. A., Harding, S. A., Devlin, G., Nunn, C., El-Jack, S., Scott, T., … on behalf of the ANZACS-QI Investigators, including Matsis, P., Smyth, D., Blake, J., Elliott, J., Lainchbury, J., Bridgman, P., Troughton, R., Wilkins, G., Green, B., Edmond, J., & Milburn, K. (2016). National variation in coronary angiography rates and timing after an acute coronary syndrome in New Zealand (ANZACS-QI 6). New Zealand Medical Journal, 129(1428), 65-77. Retrieved from https://www.nzma.org.nz/journal

Devlin, G., Williams, M., Elliott, J., White, H., French, J., Gamble, G., Matsis, P., Troughton, R., Richards, M., & Ellis, C. (2016). Management of non ST-elevation acute coronary syndrome patients in New Zealand: A longitudinal analysis: Results from the New Zealand Acute Coronary Syndrome national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 129(1428), 9-15. Retrieved from https://www.nzma.org.nz/journal

Pilbrow, A. P., Lewis, K. A., Perrin, M. H., Sweet, W. E., Moravec, C. S., Tang, W. H. W., … Troughton, R. W., & Cameron, V. A. (2016). Cardiac CRFR1 expression is elevated in human heart failure and modulated by genetic variation and alternative splicing. Endocrinology, 157(12), 4865-4874. doi: 10.1210/en.2016-1448

Ellis, C., Hammett, C., Ranasinghe, I., French, J., Briffa, T., Devlin, G., Elliott, J., … Williams, M., Troughton, R., … on behalf of Bi-National Acute Coronary Syndromes (ACS) 'SNAPSHOT' Audit Group. (2015). Comparison of the management and in-hospital outcomes of acute coronary syndrome patients in Australia and New Zealand: Results from the binational SNAPSHOT acute coronary syndrome 2012 audit. Internal Medicine Journal, 45(5), 497-509. doi: 10.1111/imj.12739

Chan, W. Y. W., Charles, C. J., Frampton, C. M., Richards, A. M., Crozier, I. G., Troughton, R. W., & Jardine, D. L. (2015). Human muscle sympathetic nerve responses to urocortin-2 in health and stable heart failure. Clinical & Experimental Pharmacology & Physiology, 42(9), 888-895. doi: 10.1111/1440-1681.12449

Tang, W. H. W., Dupont, M., Hernandez, A. F., Voors, A. A., Hsu, A. P., Felker, G. M., … Troughton, R. W., … Starling, R. C. (2015). Comparative assessment of short-term adverse events in acute heart failure with cystatin C and other estimates of renal function: Results from the ASCEND-HF trial. JACC: Heart Failure, 3(1), 40-49. doi: 10.1016/j.jchf.2014.06.014

Earle, N. J., Poppe, K. K., Pilbrow, A. P., Cameron, V. A., Troughton, R. W., Skinner, J. R., … Richards, A. M., & Doughty, R. N. (2015). Genetic markers of repolarization and arrhythmic events following acute coronary syndromes. American Heart Journal, 169(4), 579-586.e3. doi: 10.1016/j.ahj.2014.11.015

Porter, T. R., Shillcutt, S. K., Adams, M. S., Desjardins, G., Glas, K. E., Olson, J. J., & Troughton, R. W. (2015). Guidelines for the use of echocardiography as a monitor for therapeutic intervention in adults: A report from the American Society of Echocardiography. Journal of the American Society of Echocardiography, 28(1), 40-56. doi: 10.1016/j.echo.2014.09.009

Meller, B., Cullen, L., Parsonage, W. A., Greenslade, J. H., Aldous, S., Reichlin, T., … Troughton, R., Pemberton, C. J., Richards, A. M., … Than, M., & Mueller, C. (2015). Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients. International Journal of Cardiology, 184C, 208-215. doi: 10.1016/j.ijcard.2015.02.006

Brunner-La Rocca, H.-P., Eurlings, L., Richards, A. M., Januzzi, J. L., Pfisterer, M. E., Dahlström, U., … Frampton, C. M., Nicholls, M. G., & Troughton, R. W. (2015). Which heart failure patients profit from natriuretic peptide guided therapy? A meta-analysis from individual patient data of randomized trials. European Journal of Heart Failure, 17(12), 1252-1261. doi: 10.1002/ejhf.401

Whalley, G. A., Pitama, S., Troughton, R. W., Doughty, R. N., Gamble, G. D., Gillies, T., Wells, J. E., Faatoese, A., Huria, T., Richards, M., & Cameron, V. A. (2015). Higher prevalence of left ventricular hypertrophy in two Māori cohorts: Findings from the Hauora Manawa/Community Heart Study. Australian & New Zealand Journal of Public Health, 39(1), 26-31. doi: 10.1111/1753-6405.12300

Charles, C. J., Rademaker, M. T., Melton, I. C., Gutfinger, D., Eigler, N. L., Qu, F., & Troughton, R. W. (2015). Thoracic impedance measures tissue characteristics in the vicinity of the electrodes, not intervening lung water: Implications for heart failure monitoring. Journal of Clinical Monitoring & Computing, 29(1), 65-76. doi: 10.1007/s10877-014-9570-x

Pickering, J. W., Young, J. M., George, P., Aldous, S., Cullen, L., Greenslade, J. H., Richards, A. M., Troughton, R., Ardagh, M., Frampton, C. M., & Than, M. P. (2015). The utility of presentation and 4-hour high sensitivity troponin I to rule-out acute myocardial infarction in the emergency department. Clinical Biochemistry, 48(18), 1219-1224. doi: 10.1016/j.clinbiochem.2015.07.033

Lee, J., Young, J., Frampton, C. M., Aldous, S., Troughton, R. W., Than, M., Richards, A. M., & Pemberton, C. J. (2015). A novel troponin T peptide in humans: Assay, biochemistry and preliminary findings in acute coronary syndromes. International Journal of Cardiology, 190, 68-74. doi: 10.1016/j.ijcard.2015.04.145

Lee, J., Than, M., Aldous, S., Troughton, R., Richards, M., & Pemberton, C. J. (2015). CNP signal peptide in patients with cardiovascular disease. Frontiers in Cardiovascular Medicine, 2, 28. doi: 10.3389/fcvm.2015.00028

Rigolli, M., Rossi, A., Quintana, M., Klein, A. L., Yu, C.-M., Ghio, S., … Troughton, R. W., … on behalf of the MeRGE Collaborators. (2015). The prognostic impact of diastolic dysfunction in patients with chronic heart failure and post-acute myocardial infarction: Can age-stratified E/A ratio alone predict survival? International Journal of Cardiology, 181, 362-368. doi: 10.1016/j.ijcard.2014.12.051

Lever, M., George, P. M., Slow, S., Bellamy, D., Young, J. M., Ho, M., … Elmslie, J. L., … Troughton, R. W., Frampton, C. M., Richards, A. M., & Chambers, S. T. (2014). Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: An observational study. PLoS ONE, 9(12), e114969. doi: 10.1371/journal.pone.0114969

Troughton, R., Felker, G. M., & Januzzi, Jr, J. L. (2014). Natriuretic peptide-guided heart failure management. European Heart Journal, 35(1), 16-24. doi: 10.1093/eurheartj/eht463

Cullen, L., Aldous, S., Than, M., Greenslade, J. H., Tate, J. R., George, P. M., … Richards, A. M., Ungerer, J. P. J., Troughton, R. W., … Pemberton, C. J., Florkowski, C., … Parsonage, W. A. (2014). Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clinical Biochemistry, 47(6), 321-326. doi: 10.1016/j.clinbiochem.2013.11.019

Than, M., Flaws, D., Sanders, S., Doust, J., Glasziou, P., Kline, J., Aldous, S., Troughton, R., … Frampton, C., … Ardagh, M., … Cullen, L. (2014). Development and validation of the Emergency Department Assessment of Chest pain Score and 2 h accelerated diagnostic protocol. Emergency Medicine Australasia, 26, 34-44. doi: 10.1111/1742-6723.12164

Than, M., Aldous, S., Lord, S. J., Goodacre, S., Frampton, C. M. A., Troughton, R., George, P., Florkowski, C. M., Ardagh, M., Smyth, D., Jardine, D. L., … Young, J., Hamilton, G., Deely, J. M., … Richards, A. M. (2014). A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: A randomized clinical trial. JAMA Internal Medicine, 174(1), 51-58. doi: 10.1001/jamainternmed.2013.11362

Palmer, B. R., Slow, S., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Palmer, S. C., Troughton, R. W., Yandle, T. G., … Lever, M., George, P. M., Chambers, S. T., … Richards, A. M., & Cameron, V. A. (2014). Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. PLoS ONE, 9(3), e89029. doi: 10.1371/journal.pone.0089029

Troughton, R. W., Frampton, C. M., Brunner-La Rocca, H.-P., Pfisterer, M., Eurlings, L. W. M., Erntell, H., … Richards, A. M., … Nicholls, M. G. (2014). Effect of B-type natriuretic peptide-guided treatment of chronic heart failure on total mortality and hospitalization: An individual patient meta-analysis. European Heart Journal, 35, 1559-1567. doi: 10.1093/eurheartj/ehu090

Motoki, H., Borowski, A. G., Shrestha, K., Hu, B., Kusunose, K., Troughton, R. W., … Klein, A. L. (2014). Right ventricular global longitudinal strain provides prognostic value incremental to left ventricular ejection fraction in patients with heart failure. Journal of the American Society of Echocardiography, 27(7), 426-432. doi: 10.1016/j.echo.2014.02.007

Aldous, S., Richards, A. M., George, P. M., Cullen, L., Parsonage, W. A., Flaws, D., Florkowski, C. M., Troughton, R. W., … Than, M. (2014). Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction. International Journal of Cardiology, 177(1), 182-186. doi: 10.1016/j.ijcard.2014.09.026

Richards, A. M., Januzzi, Jr, J. L., & Troughton, R. W. (2014). Natriuretic peptides in heart failure with preserved ejection fraction. Heart Failure Clinics, 10(3), 453-470. doi: 10.1016/j.hfc.2014.04.006

Chan, C., Troughton, R., Elliott, J., Zarifeh, J., & Bridgman, P. (2014). One-year follow-up of the 2011 Christchurch Earthquake stress cardiomyopathy cases. New Zealand Medical Journal, 127(1396). Retrieved from http://www.nzma.org.nz/journal

Pilbrow, A. P., Cordeddu, L., Cameron, V. A., Frampton, C. M., Troughton, R. W., Doughty, R. N., … Yandle, T. G., Richards, A. M., & Foo, R. S.-Y. (2014). Circulating miR-323-3p and miR-652: Candidate markers for the presence and progression of acute coronary syndromes. International Journal of Cardiology, 176, 375-385. doi: 10.1016/j.ijcard.2014.07.068

Tang, W. H. W., Shrestha, K., Wang, Z., Troughton, R. W., Klein, A. L., & Hazen, S. L. (2013). Diminished global arginine bioavailability as a metabolic defect in chronic systolic heart failure. Journal of Cardiac Failure, 19(2), 87-93. doi: 10.1016/j.cardfail.2013.01.001

Ellis, K. L., Cameron, V. A., Troughton, R. W., Frampton, C. M., Ellmers, L. J., & Richards, A. M. (2013). Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients. European Journal of Heart Failure, 15(10), 1138-1147. doi: 10.1093/eurjhf/hft078

Schluter, P. J., Spittlehouse, J. K., Cameron, V. A., Chambers, S., Gearry, R., Jamieson, H. A., Kennedy, M., Lacey, C. J., Murdoch, D. R., Pearson, J., Porter, R. J., Richards, M., Skidmore, P. M. L., Troughton, R., Vierck, E., & Joyce, P. R. (2013). Canterbury Health, Ageing and Life Course (CHALICE) study: Rationale, design and methodology. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal

Chan, C., Elliott, J., Troughton, R., Frampton, C., Smyth, D., Crozier, I., & Bridgman, P. (2013). Acute myocardial infarction and stress cardiomyopathy following the Christchurch earthquakes. PLoS ONE, 8(7), e68504. doi: 10.1371/journal.pone.0068504

Cullen, L., Mueller, C., Parsonage, W. A., Wildi, K., Greenslade, J. H., Twerenbold, R., Aldous, S., … Troughton, R., … George, P., … Pemberton, C. J., Richards, A. M., … Florkowski, C., Deely, J. M., & Than, M. (2013). Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. JACC, 62(14), 1242-1249. doi: 10.1016/j.jacc.2013.02.078

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