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Research Associate Professor Miriam T. Rademaker

Miriam Rademaker

BSc(Cant) PhD(Otago)

Email: miriam.rademaker@otago.ac.nz

Department of Medicine
University of Otago, Christchurch
P.O. Box 4345
Christchurch
New Zealand

Current Roles

  • Research Associate Professor, Department of Medicine
  • Co-Director, Physiology Division, Christchurch Heart Institute
  • Principle Investigator of physiological based studies
  • Member of Faculty of the Christchurch School of Medicine
  • Member of The Canterbury Medical Research Society

Research Interests

Research focus is on the integrated cardiovascular, endocrine and renal control of pressure/volume homeostasis.

Particular emphasis is placed on the role that key vasoactive hormones (the natriuretic peptides, adrenomedullin, endothelin and the renin-angiotensin-aldosterone system) play in the pathophysiology of circulatory diseases such as hypertension, myocardial infarction and heart failure, and ways of manipulating these systems in order to prevent and treat these diseases.

In the last couple of years interest has widened to include the urocortin family of peptides, which we have demonstrated for the first time to have beneficial effects in heart failure - and may therefore have therapeutic potential in this disease.

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Publications

Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2005). Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: Beneficial effects in heart failure. Circulation, 112, 3624-3632. doi: 10.1161/CIRCULATIONAHA.105.561308

Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Cooper, G. J., Coy, D. H., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Circulation, 96(6), 1983-1990.

Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2006). Urocortin 3: Haemodynamic, hormonal, and renal effects in expermental heart failure. European Heart Journal, 27(17), 2088-2098.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Endogenous urocortins reduce vascular tone and renin-aldosterone / endothelin activity in experimental heart failure. European Heart Journal, 26(19), 2046-2054. doi: 10.1093/eurheartj/ehi227

Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C. M. J., Lainchbury, J. G., Nicholls, M. G., Richards, A. M., & Vale, W. W. (2002). Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: Comparison with normal sheep. JACC, 40(8), 1495-1505.

Journal - Research Article

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2013). Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure. Circulation: Heart Failure, 6(4), 825-832. doi: 10.1161/circheartfailure.112.000205

Patel, K., Rademaker, M. T., Kirkpatrick, C. M. J., Charles, C. J., Fisher, S., Yandle, T. G., & Richards, A. M. (2012). Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep. British Journal of Pharmacology, 166(6), 1916-1925. doi: 10.1111/j.1476-5381.2012.01904.x

Rademaker, M. T., Yandle, T. G., Ellmers, L. J., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circulation: Heart Failure, 5, 645-652. doi: 10.1161/circheartfailure.112.967059

Rademaker, M. T., Charles, C. J., Melton, I. C., Richards, A. M., Frampton, C. M., Siou, J., … Troughton, R. W. (2011). Monitoring of heart failure: Comparison of left atrial pressure with intrathoracic impedance and natriuretic peptide measurements in an experimental model of ovine heart failure. Clinical Science, 120(5), 207-217. doi: 10.1042/CS20100388

Rademaker, M. T., Charles, C. J., Ellmers, L. J., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2011). Prolonged urocortin 2 administration in experimental heart failure: Sustained hemodynamic, endocrine, and renal effects. Hypertension, 57, 1136-1144. doi: 10.1161/HYPERTENSIONAHA.111.173203

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2009). Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. Circulation: Heart Failure, 2(6), 532-540. doi: 10.1161/CIRCHEARTFAILURE.109.861336

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Hemodynamic, hormonal, and renal actions of adrenomedullin 2 in experimental heart failure. Circulation: Heart Failure, 1, 134-142. doi: 10.1161/circheartfailure.107.755504

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Urocortin 2 combined with angiotensin-converting enzyme inhibition in experimental heart failure. Clinical Science, 114(10), 635-642. doi: 10.1042/CS20070364

Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 2 infusion in healthy humans: Hemodynamic, neurohormonal, and renal responses. JACC, 49(4), 461-471.

Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, M. (2007). Urocortin 2 infusion in human heart failure. European Heart Journal, 28(21), 2589-2597.

Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2006). Urocortin 3: Haemodynamic, hormonal, and renal effects in expermental heart failure. European Heart Journal, 27(17), 2088-2098.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure. European Heart Journal, 26, 2055-2062. doi: 10.1093/eurheartj/ehi351

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Endogenous urocortins reduce vascular tone and renin-aldosterone / endothelin activity in experimental heart failure. European Heart Journal, 26(19), 2046-2054. doi: 10.1093/eurheartj/ehi227

Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2005). Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: Beneficial effects in heart failure. Circulation, 112, 3624-3632. doi: 10.1161/CIRCULATIONAHA.105.561308

Rademaker, M. T., & Richards, A. M. (2005). Cardiac natriuretic peptides for cardiac health. Clinical Science, 108, 23-36. doi: 10.1042/CS20040253

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (2004). Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure. Clinical Science, 106, 569-576.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure. Clinical Science, 102(6), 653-660.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure. Hypertension, 39(1), 93-98.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C. M. J., Lainchbury, J. G., Nicholls, M. G., Richards, A. M., & Vale, W. W. (2002). Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: Comparison with normal sheep. JACC, 40(8), 1495-1505.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Long-Term adrenomedullin administration in experimental heart failure. Hypertension, 40(5), 667-672.

Troughton, R. W., Rademaker, M. T., Powell, J. D., Yandle, T. G., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (2000). Beneficial renal and hemodynamic effects of omapatrilat in mild and severe heart failure. Hypertension, 36(4), 523-530.

Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Cooper, G. J., Coy, D. H., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Circulation, 96(6), 1983-1990.

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