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Dr Michael J. Epton

Michael Epton

BM BS BMedSci(Hons) MRCP(UK) FRACP PhD

Email michael.epton@cdhb.health.nz

Canterbury Respiratory Research Group
40 Stewart St
Christchurch
New Zealand

Current Roles

  • 2016 - Present
    Adjunct Professor, Departments of Geography, and Communication Disorders, University of Canterbury, Christchurch, New Zealand
  • November 2014 - Present
    Investigator (Christchurch Clinical Studies Trust, New Zealand)
  • February 2010 - Present
    Community Respiratory Physician, Canterbury Initiative, Christchurch, New Zealand
  • January 2009 - Present
    Consultant Physician, Department of Respiratory Medicine, Christchurch Hospital, New Zealand
  • July 2002 - Present
    Director, The Canterbury Respiratory Research Group, Christchurch, New Zealand

Research Interests

  • Asthma, allergy and airway inflammation
  • Air Pollution and airway inflammation
  • COPD
  • Alpha-1 anti-trypsin deficiency
  • Beta agonist pharmacogenetics
  • Exhaled Breath Condensate

Top 10 Publications

  • Darlow BA, Horwood LJ, Woodward LJ, Elliott JM, Troughton RW, Elder MJ, Epton MJ, Stanton JD, Swanney MP, Keenan R, Melzer TR, McKelvey VA, Levin K, Meeks MG, Espiner EA, Cameron VA, Martin J. The New Zealand 1986 very low birth weight cohort as young adults: mapping the road ahead. BMC Pediatr. 2015 Aug 5;15:90
  • Storer M, Curry K, Squire M, Kingham S, Epton M. Breath testing and personal exposure--SIFT-MS detection of breath acetonitrile for exposure monitoring. J Breath Res. 2015 May 26;9(3):036006
  • Frith PA, Thompson PJ, Ratnavadivel R, Chang CL, Bremner P, Day P, Frenzel C, Kurstjens N; Glisten Study Group. Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study, a randomised controlled trial. Thorax. 2015 Jun;70(6):519-27.
  • Epton MJ, Stanton JD, McGeoch GR, Shand BI, Swanney MP. The development of a community-based spirometry service in the Canterbury region of New Zealand: observations on new service delivery. NPJ Prim Care Respir Med. 2015 Mar 5;25:15003.
  • Magnussen H, Disse B, Rodriguez-Roisin R, Kirsten A, Watz H, Tetzlaff K, Towse L, Finnigan H, Dahl R, Decramer M, Chanez P, Wouters EF, Calverley PM; WISDOM Investigators. Withdrawal of inhaled glucocorticoids and exacerbations of COPD. N Engl J Med. 2014 Oct 2;371(14):1285-94
  • Storer M., Salmond J., Dirks K.N., Kingham, S., Epton, M. Mobile selected ion flow tube mass spectrometry (SIFT-MS) devices and their use for pollution exposure monitoring in breath and ambient air-pilot study. Journal of Breath Research 2014;8(3).
  • Maze M.J., Slow S., Cumins A.M., Boon K., Goulter P., Podmore R.G., Anderson T.P., Barratt K., Young S.A., Pithie A.D., Epton M.J., Werno A.M., Chambers S.T., Murdoch D.R. Enhanced detection of Legionnaires' disease by PCR testing of induced sputum and throat swabs. European Respiratory Journal 2014;43(2):644-646.
  • Scott-Thomas A., Epton M., Chambers S. Validating a breath collection and analysis system for the new tuberculosis breath test. Journal of Breath Research 2013;7(3)
  • Sturney S.C., Storer M.K., Shaw G.M., Shaw D.E., Epton M.J. Off-line breath acetone analysis in critical illness. Journal of Breath Research 2013;7(3)
  • Scott-Thomas A., Syhre M., Epton, M., Murdoch D.R., Chambers S.T. Assessment of potential causes of falsely positive Mycobacterium tuberculosis breath test. Tuberculosis 2013;93(3):312-317
  • Dummer J., Storer M., Sturney S., Scott-Thomas A., Chambers S., Swanney M., Epton E. Quantification of hydrogen cyanide (HCN) in breath using selected ion flow tube mass spectrometry - HCN is not a biomarker of Pseudomonas in chronic suppurative lung disease. Journal of Breath Research 2013;7(1). doi:10.1088/1752-7155/7/1/017105

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Publications

Epton, M. (2016, August). Secondary care perspective. Verbal presentation at the South General Practice Conference & Medical Exhibition (GP CME), Christchurch, New Zealand.

Darlow, B. A., Horwood, L. J., Woodward, L. J., Elliott, J. M., Troughton, R. W., Elder, M. J., Epton, M. J., Stanton, J. D., Swanney, M., Keenan, R., Melzer, T. R., McKelvey, V. A., Levin, K., Meeks, M. G., Espiner, E. A., Cameron, V. A., & Martin, J. (2015). The New Zealand 1986 very low birth weight cohort as young adults: Mapping the road ahead. BMC Pediatrics, 15, 90. doi: 10.1186/s12887-015-0413-9

Dummer, J., Storer, M., Swanney, M. P., Frampton, C., & Epton, M. (2015). Analysis of hydrogen sulfide in breath. American Journal of Respiratory & Critical Care Medicine, 191(Meetings Abstracts). Retrieved from http://www.atsjournals.org/series/ajrccm-conference

Chen, D., Curtis, J., Braithwaite, L., van der Pol, S., Epton, M., & Mulligan, H. (2015). Is the one-minute sit-to-stand test an appropriate replacement for the six-minute walk test in community pulmonary rehabilitation programmes? Physiotherapy, 101(Suppl. 1), (pp. e222). doi: 10.1016/j.physio.2015.03.392

Maze, M. J., Slow, S., Cumins, A.-M., Boon, K., Goulter, P., Podmore, R. G., … Pithie, A. D., Epton, M. J., Werno, A. M., Chambers, S. T., & Murdoch, D. R. (2014). Enhanced detection of Legionnaires' disease by PCR testing of induced sputum and throat swabs. European Respiratory Journal, 43(2), 644-646. doi: 10.1183/09031936.00191913

Journal - Research Article

Scott-Thomas, A., Syhre, M., Epton, M., Murdoch, D. R., & Chambers, S. T. (2013). Assessment of potential causes of falsely positive Mycobacterium tuberculosis breath test. Tuberculosis, 93(3), 312-317. doi: 10.1016/j.tube.2013.01.005

Storer, M., Dummer, J., Sturney, S., & Epton, M. (2013). Validating SIFT-MS analysis of volatiles in breath. Current Analytical Chemistry, 9(4), 576-583. doi: 10.2174/15734110113099990022

Dummer, J., Storer, M., Sturney, S., Scott-Thomas, A., Chambers, S., Swanney, M., & Epton, M. (2013). Quantification of hydrogen cyanide (HCN) in breath using selected ion flow tube mass spectrometry: HCN is not a biomarker of Pseudomonas in chronic suppurative lung disease. Journal of Breath Research, 7(1), 017105. doi: 10.1088/1752-7155/7/1/017105

Scott-Thomas, A., Epton, M., & Chambers, S. (2013). Validating a breath collection and analysis system for the new tuberculosis breath test. Journal of Breath Research, 7(3), 037108. doi: 10.1088/1752-7155/7/3/037108

Crane, J., Lampshire, P., Wickens, K., Epton, M., Siebers, R., Ingham, T., Pattemore, P., Town, I., and the Year Six New Zealand Asthma and Allergy Cohort Study Group, (NZAACS6) . (2012). Asthma, atopy and exhaled nitric oxide in a cohort of 6-yr-old New Zealand children. Pediatric Allergy & Immunology, 23(1), 59-64. doi: 10.1111/j.1399-3038.2011.01227.x

Tanpowpong, P., Ingham, T. R., Lampshire, P. K., Kirchberg, F. F., Epton, M. J., Crane, J., … and the New Zealand Asthma and Allergy Cohort Study Group, including Pattemore, P., Siebers, R., & Wickens, K. (2012). Coeliac disease and gluten avoidance in New Zealand children. Archives of Disease in Childhood, 97, 12-16. doi: 10.1136/archdischild-2011-300248

Chambers, S. T., Scott-Thomas, A., & Epton, M. (2012). Developments in novel breath tests for bacterial and fungal pulmonary infection. Current Opinion in Pulmonary Medicine, 18(3), 228-232. doi: 10.1097/MCP.0b013e328351f98b

Silvers, K. M., Frampton, C. M., Wickens, K., Pattemore, P. K., Ingham, T., Fishwick, D., Crane, J., Town, G. I., Epton, M. J., on behalf of the New Zealand Asthma and Allergy Cohort Study Group, including Duignan, M., Irvine, V., Lampshire, P., Leadbitter, P., & Siebers, R. (2012). Breastfeeding protects against current asthma up to 6 years of age. Journal of Pediatrics, 160(6), 991-996. doi: 10.1016/j.jpeds.2011.11.055

Thomson, C. D., Wickens, K., Miller, J., Ingham, T., Lampshire, P., Epton, M. J., Town, G. I., Pattemore, P., Crane, J., and the Year Six New Zealand Asthma and Allergy Cohort Study Group, (NZAACS6) including Siebers, R. (2012). Selenium status and allergic disease in a cohort of New Zealand Children. Clinical & Experimental Allergy, 42(4), 560-567. doi: 10.1111/j.1365-2222.2011.03924.x

Dummer, J., Storer, M., Swanney, M., McEwan, M., Scott-Thomas, A., Bhandari, S., Chambers, S., … Epton, M. (2011). Analysis of biogenic volatile organic compounds in human health and disease. Trends in Analytical Chemistry, 30(7), 960-967. doi: 10.1016/j.trac.2011.03.011

Wickens, K., Beasley, R., Town, I., Epton, M., Pattemore, P., Ingham, T., Crane, J., and the New Zealand Asthma and Allergy Cohort Study Group, including Duignan, M., Irvine, V., Lampshire, P., Leadbitter, P., & Siebers, R. (2011). The effects of early and late paracetamol exposure on asthma and atopy: A birth cohort. Clinical & Experimental Allergy, 41(3), 399-406. doi: 10.1111/j.1365-2222.2010.03610.x

Young, R. P., Hopkins, R. J., Whittington, C. F., Hay, B. A., Epton, M. J., & Gamble, G. D. (2011). Individual and cumulative effects of GWAS susceptibility loci in lung cancer: Associations after sub-phenotyping for COPD. PLoS ONE, 6(2), e16476. doi: 10.1371/journal.pone.0016476

Bhandari, S., Chambers, S., Pearson, J., Syhre, M., Epton, M., & Scott-Thomas, A. (2011). Determining the limits and confounders for the 2-pentyl furan breath test by gas chromatography/mass spectrometry. Journal of Chromatography B, 879(26), 2815-2820. doi: 10.1016/j.jchromb.2011.08.010

Storer, M., Dummer, J., Lunt, H., Scotter, J., McCartin, F., Cook, J., Swanney, M., … Epton, M. (2011). Measurement of breath acetone concentrations by selected ion flow tube mass spectrometry in type 2 diabetes. Journal of Breath Research, 5, 046011. doi: 10.1088/1752-7155/5/4/046011

Storer, M. K., Dummer, J. F., Cook, J., McEwan, M., & Epton, M. J. (2011). Increased concentrations of breath haloamines are not detectable in airways inflammation using SIFT-MS. Journal of Breath Research, 5(3). doi: 10.1088/1752-7155/5/3/037105

Fukuda, K., Hider, P. N., Epton, M. J., Jennings, L. C., & Kingham, S. (2011). Including viral infection data supports an association between particulate pollution and respiratory admissions. Australian & New Zealand Journal of Public Health, 35(2), 163-169. doi: 10.1111/j.1753-6405.2010.00620.x

Camargo, Jr, C. A., Ingham, T., Wickens, K., Thadhani, R., Silvers, K. M., Epton, M. J., Town, G. I., Pattemore, P. K., … Crane, J., and the New Zealand Asthma and Allergy Cohort Study Group, including Duignan, M., Irvine, V., Lampshire, P., Leadbitter, P., & Siebers, R. (2011). Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics, 127(1), e180-e187. doi: 10.1542/peds.2010-0442

Camargo, Jr, C. A., Ingham, T., Wickens, K., Thadhani, R. I., Silvers, K. M., Epton, M. J., Town, G. I., … Crane, J., and the New Zealand Asthma and Allergy Cohort Study Group, including Leadbitter, P., Pattemore, P., & Siebers, R. (2010). Vitamin D status of newborns in New Zealand. British Journal of Nutrition, 104(7), 1051-1057. doi: 10.1017/S0007114510001674

Young, R. P., Whittington, C. F., Hopkins, R. J., Hay, B. A., Epton, M. J., Black, P. N., & Gamble, G. D. (2010). Chromosome 4q31 locus in COPD is also associated with lung cancer. European Respiratory Journal, 36(6), 1375-1382. doi: 10.1183/09031936.00033310

Hu, W.-P., Langford, V. S., McEwan, M. J., Milligan, D. B., Storer, M. K., Dummer, J., & Epton, M. J. (2010). Monitoring chloramines and bromamines in a humid environment using selected ion flow tube mass spectrometry. Rapid Communications in Mass Spectrometry, 24(12), 1744-1748. doi: 10.1002/rcm.4570

Scott-Thomas, A. J., Syhre, M., Pattemore, P. K., Epton, M., Laing, R., Pearson, J., & Chambers, S. T. (2010). 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. BMC Pulmonary Medicine, 10, 56. doi: 10.1186/1471-2466-10-56

Dummer, J. F., . . ., Frampton, C. M., Scotter, J. M., Prisk, G., & Epton, M. J. (2010). Accurate, reproducible measurement of acetone concentration in breath using selected ion flow tube-mass spectrometry. Journal of Breath Research, 4, 046001. doi: 10.1088/1752-7155/4/4/046001

Young, R. P., Hopkins, R. J., Hay, B. A., Epton, M. J., Mills, G. D., Black, P. N., … Gamble, G. D. (2009). Lung cancer susceptibility model based on age, family history and genetic variants. PLoS ONE, 4(4), e5302. doi: 10.1371/journal.pone.0005302

Dummer, J. F., Epton, M. J., Cowan, J. O., Cook, J. M., Condliffe, R., Landhuis, C. E., Smith, A. D., & Taylor, D. R. (2009). Predicting corticosteroid response in chronic obstructive pulmonary disease using exhaled nitric oxide. American Journal of Respiratory & Critical Care Medicine, 180(9), 846-852. doi: 10.1164/rccm.200905-0685OC

Young, R. P., Hopkins, R. J., Hay, B. A., Epton, M. J., Mills, G. D., Black, P. N., … Gamble, G. D. (2009). A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. Postgraduate Medical Journal, 85(1008), 515-524. doi: 10.1136/pgmj.2008.077107

Epton, M. J., Ledingham, K., Dummer, J., Hu, W.-P., Rhodes, B., Senthilmohan, S. T., Scotter, J. M., Allardyce, R., Cook, J., & Swanney, M. P. (2009). Interference of chlorofluorocarbon (CFC)-containing inhalers with measurements of volatile compounds using selected ion flow tube mass spectrometry. Rapid Communications in Mass Spectrometry, 23(3), 443-447. doi: 10.1002/rcm.3875

Chambers, S. T., Syhre, M., Murdoch, D. R., McCartin, F. J., & Epton, M. J. (2009). Detection of 2-Pentylfuran in the breath of patients with Aspergillus fumigatus. Medical Mycology, 47(5), 468-476. doi: 10.1080/13693780802475212

Silvers, K. M., Frampton, C. M., Wickens, K., Epton, M. J., Pattemore, P. K., Ingham, T., … Crane, J., Town, G. I., and the New Zealand Asthma and Allergy Cohort Study Group, including Duignan, M., Irvine, V., Lampshire, P., Leadbitter, P., & Siebers, R. (2009). Breastfeeding protects against adverse respiratory outcomes at 15 months of age. Maternal & Child Nutrition, 5(3), 243-250. doi: 10.1111/j.1740-8709.2008.00169.x

Laugesen, M., Epton, M., Frampton, C. M. A., Glover, M., & Lea, R. A. (2009). Hand-rolled cigarette smoking patterns compared with factory-made cigarette smoking in New Zealand men. BMC Public Health, 9, 194. doi: 10.1186/1471-2458-9-194

Tashkin, D. P., Celli, B., Senn, S., Burkhart, D., Kesten, S., Menjoge, S., … UPLIFT Study Investigators, including Epton, M. (2008). A 4-year trial of tiotropium in chronic obstructive pulmonary disease. New England Journal of Medicine, 359(15), 1543-1554. doi: 10.1056/nejmoa0805800

Young, R. P., Hopkins, R. J., Hay, B. A., Epton, M. J., Black, P. N., & Gamble, G. D. (2008). Lung cancer gene associated with COPD: Triple whammy or possible confounding effect? European Respiratory Journal, 32(5), 1158-1164. doi: 10.1183/09031936.00093908

Epton, M. J., Dawson, R. D., Brooks, W. M., Kingham, S., Aberkane, T., Cavanagh, J. E., Frampton, C. M., Hewitt, T., Cook, J. M., … Brown, L. (2008). The effect of ambient air pollution on respiratory health of school children: A panel study. Environmental Health, 7. doi: 10.1186/1476-069X-7-16

Kingham, S., Durand, M., Harrison, J., Cavanagh, J., & Epton, M. (2008). Temporal variations in particulate exposure to wood smoke in a residential school environment. Atmospheric Environment, 42(19), 4619-4631.

Taylor, D. R., Jayaram, L., Asher, M. I., & Epton, M. J. (2008). ″As-required″ combination therapy with inhaled corticosteroids and long-acting beta-2 agonists for asthma: Current evidence and recommendations [Review article]. New Zealand Medical Journal, 121(1285). Retrieved from http://journal.nzma.org.nz/journal/121-1285/3346/content.pdf

Senthilmohan, S. T., Kettle, A. J., McEwan, M. J., Dummer, J., Edwards, S. J., Wilson, P. F., & Epton, M. J. (2008). Detection of monobromamine, monochloramine and dichloramine using selected ion flow tube mass spectrometry and their relevance as breath markers. Rapid Communications in Mass Spectrometry, 22(5), 677-681. doi: 10.1002/rcm.3418

Wickens, K., Ingham, T., Epton, M., Pattemore, P., Town, I., Fishwick, D., Crane, J., and the New Zealand Asthma and Allergy Cohort Study Group, including Duignan, M., Irvine, V., Lampshire, P., Leadbitter, P., & Siebers, R. (2008). The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: Confounding or causality? Clinical & Experimental Allergy, 38, 1318-1324. doi: 10.1111/j.1365-2222.2008.03024.x

Epton, M. J., Town, G. I., Ingham, T., Wickens, K., Fishwick, D., Crane, J., and the New Zealand Asthma and Allergy Cohort Study Group, including Duignan, M., Fitzharris, P., … Lampshire, P., Leadbitter, P., Nicholson, A., Pattemore, P., Siebers, R., Silvers, K. M., & Withell, K. (2007). The New Zealand Asthma and Allergy Cohort Study (NZA2CS): Assembly, demographics and investigations. BMC Public Health, 7, 26. doi: 10.1186/1471-2458-7-26

Cavanagh, J.-A. E., Brown, L., Trought, K., Kingham, S., & Epton, M. J. (2007). Elevated concentrations of 1-hydroxypyrene in schoolchildren during winter in Christchurch, New Zealand. Science of the Total Environment, 374, 51-59. doi: 10.1016/j.scitotenv.2006.11.042

Sabel, C. E., Wilson, J. G., Kingham, S., Tisch, C., & Epton, M. (2007). Spatial implications of covariate adjustment on patterns of risk: Respiratory hospital admissions in Christchurch, New Zealand. Social Science & Medicine, 65, 43-59. doi: 10.1016/j.socscimed.2007.02.040

Brooks, W. M., Lash, H., Kettle, A. J., & Epton, M. J. (2006). Optimising hydrogen peroxide measurement in exhaled breath condensate. Redox Report, 11(2), 78-84.

Kingham, S., Durand, M., Aberkane, T., Harrison, J., Wilson, J. G., & Epton, M. (2006). Winter comparison of TEOM, MiniVol and DustTrak PM10 monitors in a woodsmoke environment. Atmospheric Environment, 40, 338-347.

McGeoch, G. R. B., Willsman, K. J., Dowson, C. A., Town, G. I., Frampton, C. M., McCartin, F. J., Cook, J. M., & Epton, M. J. (2006). Self-management plans in the primary care of patients with chronic obstructive pulmonary disease. Respirology, 11, 611-618.

Kelly, M. G., Frizelle, F. A., Thornley, P. T., Beckert, L., Epton, M., & Lynch, A. C. (2006). Inflammatory bowel disease and the lung: Is there a link between surgery and bronchiectasis? International Journal of Colorectal Disease, 21(8), 754-757.

Gillespie, J., Wickens, K., Siebers, R., Howden-Chapman, P., Town, I., Epton, M., Fitzharris, P., … Crane, J., and the New Zealand Asthma and Allergy Birth Cohort Study Group, including Ingham, T., Irvine, V., Lampshire, P., Leadbitter, P., & Silvers, K. M. (2006). Endotoxin exposure, wheezing, and rash in infancy in a New Zealand birth cohort. Journal of Allergy & Clinical Immunology, 118, 1265-1270. doi: 10.1016/j.jaci.2006.07.051

Taylor, D. R., Epton, M. J., Kennedy, M. A., Smith, A. D., Iles, S., Miller, A. L., Littlejohn, M. D., Cowan, J. O., Hewitt, T., Swanney, M. P., Brassett, K. P., & Herbison, G. P. (2005). Bronchodilator response in relation to β2-adrenoceptor haplotype in patients with asthma. American Journal of Respiratory & Critical Care Medicine, 172(6), 700-703.

Richards, D. A., Toop, L. J., Epton, M. J., McGeoch, G. R. B., Town, G. I., Wynn-Thomas, S. M. H., Dawson, R. D., Hlavac, M. C., Werno, A. M., & Abernethy, P. D. (2005). Home management of mild to moderately severe community-acquired pneumonia: A randomised controlled trial. Medical Journal of Australia, 183(5), 235-238.

Malainual, N., Hales, B. J., Epton, M. J., Smith, W.-A., & Thomas, W. R. (2004). T-cell responses to the allergens of the house dust mite. Allergy & Clinical Immunology International, Suppl. 1, 51-54.

Iles, S., Hodges, A. M., Darley, J. R., Frampton, C. M., Epton, M. J., Beckert, L. E. L., & Town, G. I. (2003). Clinical experience and pre-test probability scores in the diagnosis of pulmonary embolism. QJM, 96, 211-215.

Epton, M. J., Smith, W., Hales, B. J., Halzell, L., Thompson, P. J., & Thomas, W. R. (2002). Non-allergenic antigen in allergic sensitization: Responses to the mite ferritin heavy chain antigen by allergic and non-allergic subjects. Clinical & Experimental Allergy, 32(9), 1341-1347.

Epton, M. J., Hales, B. J., Thompson, P. J., & Thomas, W. R. (2002). T cell cytokine responses to outer membrane proteins of Haemophilus influenzae and the house dust mite allergens Der p 1 in allergic and non-allergic subjects. Clinical & Experimental Allergy, 32(11), 1589-1595.

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