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Associate Professor Peter Sykes

Peter SykesMBChB(Bristol) FRANZCOG DGO

Email peter.sykes@otago.ac.nz

Peter joined the Department in 1998 and was appointed Head of Department in 2009 until December 2015.

He completed his undergraduate training in the United Kingdom and specialised in Obstetrics and Gynaecology in New Zealand.

He subsequently completed his sub-specialty training in gynaecological oncology in Melbourne and his interests include gynaecological oncology and advanced preinvasive disease of the genital tract.

Peter is a keen outdoor sports person and enjoys tramping, mountain climbing and surfing.

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Publications

Taghavi, K., Morell, S., Lamb, J., MacNab, H., Innes, C., Coffey, K., Williman, J., Simcock, B., & Sykes, P. (2017). Initial observation of CIN2 does not appear to reduce quality of life in women under 25 years of age. Australian & New Zealand Journal of Obstetrics & Gynaecology. Advance online publication. doi: 10.1111/ajo.12633

Jamieson, A., Sykes, P., Eva, L., Bergzoll, C., & Simcock, B. (2017). Subtypes of stage IV ovarian cancer; response to treatment and patterns of disease recurrence. Gynecologic Oncology. Advance online publication. doi: 10.1016/j.ygyno.2017.05.023

Lindemann, K., Kok, P.-S., Stockler, M., Sykes, P., & Brand, A. (2017). Enhanced recovery after surgery for suspected ovarian malignancy: A survey of perioperative practice among gynecologic oncologists in Australia and New Zealand to inform a clinical trial. International Journal of Gynecological Cancer, 27(5), 1046-1050. doi: 10.1097/igc.0000000000000982

Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2017). Cell-like features imprinted in the physical nano- and micro-topography of the environment modify the responses to anti-cancer drugs of endometrial cancer cells. Biofabrication, 9(1), 015017. doi: 10.1088/1758-5090/aa5c9a

Raja, A. Y., Moghiesh, M., Kumar, D., Sykes, P., Butler, A. P., & Anderson, N. (2017). Effect of of size and concentration of gold nanoparticles on spectral CT imaging of cancer cells. Proceedings of the 8th International Conference on Advanced Materials and Nanotechnology (AMN8). (pp. 105). Retrieved from http://confer.co.nz/amn8/

Chapter in Book - Other

Sykes, P. (2013). Obstetrics and Gynaecology. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 33-37). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Taghavi, K., Morell, S., Lamb, J., MacNab, H., Innes, C., Coffey, K., Williman, J., Simcock, B., & Sykes, P. (2017). Initial observation of CIN2 does not appear to reduce quality of life in women under 25 years of age. Australian & New Zealand Journal of Obstetrics & Gynaecology. Advance online publication. doi: 10.1111/ajo.12633

Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2017). Cell-like features imprinted in the physical nano- and micro-topography of the environment modify the responses to anti-cancer drugs of endometrial cancer cells. Biofabrication, 9(1), 015017. doi: 10.1088/1758-5090/aa5c9a

Lindemann, K., Kok, P.-S., Stockler, M., Sykes, P., & Brand, A. (2017). Enhanced recovery after surgery for suspected ovarian malignancy: A survey of perioperative practice among gynecologic oncologists in Australia and New Zealand to inform a clinical trial. International Journal of Gynecological Cancer, 27(5), 1046-1050. doi: 10.1097/igc.0000000000000982

Jamieson, A., Sykes, P., Eva, L., Bergzoll, C., & Simcock, B. (2017). Subtypes of stage IV ovarian cancer; response to treatment and patterns of disease recurrence. Gynecologic Oncology. Advance online publication. doi: 10.1016/j.ygyno.2017.05.023

Kumar, D., Mutreja, I., & Sykes, P. (2016). Seed mediated synthesis of highly mono-dispersed gold nanoparticles in the presence of hydroquinone. Nanotechnology, 27, 355601. doi: 10.1088/0957-4484/27/35/355601

Stravens, M., Short, J., Johnson, K., Simcock, B., Shand, B., McGeoch, G., & Sykes, P. (2016). Management of postmenopausal bleeding by general practitioners in a community setting: An observational study. New Zealand Medical Journal, 129(1434), 59-68. Retrieved from http://www.nzma.org.nz/journal

Tino, A. B., Chitcholtan, K., Sykes, P. H., & Garrill, A. (2016). Resveratrol and acetyl-resveratrol modulate activity of VEGF and IL-8 in ovarian cancer cell aggregates via attenuation of the NF-κB protein. Journal of Ovarian Research, 9(1), 84. doi: 10.1186/s13048-016-0293-0

Hassan, W., Chitcholtan, K., Sykes, P., & Garrill, A. (2016). A combination of two receptor tyrosine kinase inhibitors, canertinib and PHA665752 comprises ovarian cancer cell growth in 3D cell models. Oncology & Therapy, 4(2), 257-274. doi: 10.1007/s40487-016-0031-1

Hogg, S. J., Chitcholtan, K., Hassan, W., Sykes, P. H., & Garrill, A. (2015). Resveratrol, acetyl-resveratrol, and polydatin exhibit antigrowth activity against 3D cell aggregates of the SKOV-3 and OVCAR-8 ovarian cancer cell lines. Obstetrics & Gynecology International, 2015, 279591. doi: 10.1155/2015/279591

Wilkinson, T. M., Sykes, P. H. H., Simcock, B., & Petrich, S. (2015). Recurrence of high-grade cervical abnormalities following conservative management of cervical intraepithelial neoplasia grade 2. American Journal of Obstetrics & Gynecology, 212(6), 769.e1-769.e7. doi: 10.1016/j.ajog.2015.01.010

Hogg, S. J., Evans, J. J., Sykes, P. H., & Chitcholtan, K. (2015). A method to investigate the anti-metabolic activity of anti-cancer agents on ovarian cancer cells cultured in a 96-well high throughput format. Journal of Ovarian Research, 8, 43. doi: 10.1186/s13048-015-0172-0

Slatter, T. L., Hsia, H., Samaranayaka, A., Sykes, P., Clow, W., Devenish, C. J., … Royds, J. A., … Hung, N. A. (2015). Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma. Journal of Pathology: Clinical Research, 1(2), 95-105. doi: 10.1002/cjp2.11

Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2015). The characteristics of Ishikawa endometrial cancer cells are modified by substrate topography with cell-like features and the polymer surface. International Journal of Nanomedicine, 10, 4883-4895. doi: 10.2147/ijn.s86336

Taghavi, K., Sykes, P., Innes, C., Gibbs, D., Hunter, L. A., McBurnie, W., & Simcock, B. (2015). Wrong place at the wrong time: A case of cervical embryonal rhabdomyosarcoma in pregnancy [Case report]. Gynecologic Oncology Reports, 12, 77-79. doi: 10.1016/j.gore.2015.04.001

Amant, F., Floquet, A., Friedlander, M., Kristensen, G., Mahner, S., Nam, E. J., … Sykes, P., … Seddon, B. (2014). Gynecological Cancer InterGroup (GCIG) consensus review for endometrial stromal sarcoma. International Journal of Gynecological Cancer, 24(9, Suppl. 3), S67-S72. doi: 10.1097/igc.0000000000000205

Evans, G. E., Martínez-Conejero, J. A., Phillipson, G. T. M., Sykes, P. H., Sin, I. L., Lam, E. Y. N., … Evans, J. J. (2014). In the secretory endometria of women, luminal epithelia exhibit gene and protein expressions that differ from those of glandular epithelia. Fertility & Sterility, 102(1), 307-317. doi: 10.1016/j.fertnstert.2014.04.005

Sykes, P., Gopala, K., Tan, A. L., Kenwright, D., Petrich, S., Molijn, A., & Chen, J. (2014). Type distribution of human papillomavirus among adult women diagnosed with invasive cervical cancer (stage 1b or higher) in New Zealand. BMC Infectious Diseases, 14, 374. doi: 10.1186/1471-2334-14-374

Lawton, B., Filoche, S. K., Rose, S. B., Stanley, J., Garrett, S., Robson, B., Brown, S., & Sykes, P. (2014). Uterine cancer: Exploring access to services in the public health system. Australian & New Zealand Journal of Obstetrics & Gynaecology, 54(5), 457-461. doi: 10.1111/ajo.12237

Chitcholtan, K., Asselin, E., Parent, S., Sykes, P. H., & Evans, J. J. (2013). Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer. Experimental Cell Research, 319(1), 75-87. doi: 10.1016/j.yexcr.2012.09.012

Kang, M. Y., Sykes, P., Herbison, P., & Petrich, S. (2013). Retrospective analysis on timeframes of referral, diagnosis and treatment of patients with endometrial carcinomas in Dunedin Hospital, 2008–2011. New Zealand Medical Journal, 126(1384). Retrieved from http://www.nzma.org.nz/journal

Sykes, P., Vaughan, M., Chrystal, K., Ehrenberg, N., Hefford, M., Hutchings, S., … Ngan Kee, D. (2012). Providing care for women with gynaecological malignancy: The need for a coordinated national approach. New Zealand Medical Journal, 125(1360). Retrieved from http://www.nzma.org.nz/journal

Evans, G. E., Martínez-Conejero, J. A., Phillipson, G. T. M., Simón, C., McNoe, L. A., Sykes, P. H., … Evans, J. J. (2012). Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. Fertility & Sterility, 97(6), 1365-1373. doi: 10.1016/j.fertnstert.2012.03.007

Evans, J. J., Chitcholtan, K., Dann, J. M., Guilford, P., Harris, G., Lewis, L. K., Nagase, J., … Sykes, P. H. (2012). Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades. Gynecologic Oncology, 125(1), 214-219. doi: 10.1016/j.ygyno.2011.12.429

Chitcholtan, K., Sykes, P. H., & Evans, J. J. (2012). The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer. Journal of Translational Medicine, 10(1), 38-53. doi: 10.1186/1479-5876-10-38

Lawton, B. A., Rose, S. B., Pullon, S., Stanley, J., Garrett, S., Sykes, P., Cormack, D., Robson, B., Langdana, F., Cooper, A., & Filoche, S. K. (2012). The impact of outpatient booking systems on waiting times for investigation of suspected cancer: The case of post-menopausal bleeding. Clinical Ovarian & Other Gynecologic Cancer, 5(2), 87-93. doi: 10.1016/j.cogc.2013.06.001

Kondalsamy-Chennakesavan, S., Yu, C., Kattan, M. W., Leung, Y., Sykes, P., Nascimento, M., … Obermair, A. (2012). Nomograms to predict isolated loco-regional or distant recurrence among women with uterine cancer. Gynecologic Oncology, 125(3), 520-525. doi: 10.1016/j.ygyno.2012.02.022

McLeod, M., Cormack, D., Harris, R., Robson, B., Sykes, P., & Crengle, S. (2011). Achieving equitable outcomes for Māori women with cervical cancer in New Zealand: Health provider views. New Zealand Medical Journal, 124(1334). Retrieved from http://journal.nzma.org.nz/journal/124-1334/4661/content.pdf

Obermair, A., Mileshkin, L., Bolz, K., Kondalsamy-Chennakesavan, S., Cheuk, R., Vasey, P., … Sykes, P., & Janda, M. (2011). Prospective, non-randomized phase 2 clinical trial of carboplatin plus paclitaxel with sequential radical pelvic radiotherapy for uterine papillary serous carcinoma. Gynecologic Oncology, 120(2), 179-184. doi: 10.1016/j.ygyno.2010.10.039

McAllum, B., Sykes, P. H. H., Sadler, L., MacNab, H., Simcock, B. J., & Mekhail, A. K. (2011). Is the treatment of CIN 2 always necessary in women under 25? American Journal of Obstetrics & Gynecology, 205(5), 478.e1-478.e7. doi: 10.1016/j.ajog.2011.06.069

McLeod, M., Harris, R., Purdie, G., Cormack, D., Robson, B., Sykes, P., Crengle, S., Iupati, D., & Walker, N. (2010). Improving survival disparities in cervical cancer between Māori and non-Māori women in New Zealand: A National Retrospective Cohort Study. Australian & New Zealand Journal of Public Health, 34(2), 193-199. doi: 10.1111/j.1753-6405.2010.00506.x

Janda, M., Gebski, V., Brand, A., Hogg, R., Jobling, T. W., Land, R., … Sykes, P., … Obermair, A. (2010). Quality of life after total laparoscopic hysterectomy versus total abdominal hysterectomy for stage I endometrial cancer (LACE): A randomised trial. Lancet Oncology, 11(8), 772-780. doi: 10.1016/S1470-2045(10)70145-5

Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2010). Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer. Cancer Research, 70(14), 5749-5758. doi: 10.1158/0008-5472.CAN-10-0263

Smart, O. C., Sykes, P., McNab, H., & Jennings, L. (2010). Testing for high risk human papilloma virus in the initial follow-up of women treated for high-grade squamous intraepithelial lesions. Australian & New Zealand Journal of Obstetrics & Gynaecology, 50(2), 164-167. doi: 10.1111/j.1479-828X.2009.01132.x

Priest, P., Sadler, L., Sykes, P., Marshall, R., Peters, J., & Crengle, S. (2010). Determinants of inequalities in cervical cancer stage at diagnosis and survival in New Zealand. Cancer Causes & Control, 21, 209-214. doi: 10.1007/s10552-009-9451-7

Dann, J. M., Sykes, P. H., Mason, D. R., & Evans, J. J. (2009). Regulation of Vascular Endothelial Growth Factor in endometrial tumour cells by resveratrol and EGCG. Gynecologic Oncology, 113(3), 374-378.

Su, H. Y., & Sykes, P. H. (2009). Waiting times for gynaecological cancer surgery. New Zealand Medical Journal, 122(1305). Retrieved from http://journal.nzma.org.nz/journal/122-1305/3854/content.pdf

Sykes, P. H., Harker, D. Y., Miller, A., Whitehead, M., Neal, H., Wells, J. E., & Peddie, D. (2008). A randomised comparison of SurePath liquid-based cytology and conventional smear cytology in a colposcopy clinic setting. BJOG, 115(11), 1375-1381. doi: 10.1111/j.1471-0528.2008.01865.x

Jones, R. W., Coughlan, E. P., Reid, J. S., Sykes, P., Watson, P. D., & Cook, C. (2007). Human papilloma virus vaccines and their role in cancer prevention. New Zealand Medical Journal, 120(1266). Retrieved from http://journal.nzma.org.nz/journal/120-1266/2829/content.pdf

Muys, J. J., Alkaisi, M. M., Melville, D. O. S., Nagase, J., Sykes, P., Parguez, G. M., & Evans, J. J. (2006). Cellular transfer and AFM imaging of cancer cells using Bioimprint. Journal of Nanobiotechnology, 4. Retrieved from http://www.jnanobiotechnology.com/content/4/1/1

Watson, A. J., Smith, B. B., Whitehead, M. R., Sykes, P. H., & Frizelle, F. A. (2006). Malignant progression of anal intra-epithelial neoplasia. ANZ Journal of Surgery, 76(8), 715-717.

Sykes, P., Jennings, L., Harker, D., & Beynon, K. (2005). Human papilloma virus is detectable by the Hybrid Capture 2 test in cervical smear samples from women over 40 years of age with high-grade squamous intraepithelial lesions. Australian & New Zealand Journal of Obstetrics & Gynaecology, 45, 457-459.

Sadler, L., & Sykes, P. (2005). How little is known about cervical cancer in pregnancy? [Editorial]. Annals of Oncology, 16, 341-343.

Sykes, P. H., Reddy, J., & Peddie, D. J. (2005). Does regular cervical screening protect women from microinvasive squamous cell carcinoma of the cervix? A retrospective case-control study. BJOG, 112, 807-809.

Pather, S., Ford, M., Reid, R., & Sykes, P. (2005). Postpartum curettage: An audit of 200 cases. Australian & New Zealand Journal of Obstetrics & Gynaecology, 45, 368-371.

Sykes, P., Harker, D., & Peddie, D. (2005). Findings and outcome of teenage women referred for colposcopy at Christchurch Women's Hospital, New Zealand. New Zealand Medical Journal, 118(1211). Retrieved from http://journal.nzma.org.nz/journal/118-1211/1350/content.pdf

Jones, S., Sykes, P., Pather, S., & Peddie, D. (2004). Is there a role for colposcopy in the follow-up of treated low grade squamous intraepithelial lesions? Australian & New Zealand Journal of Obstetrics & Gynaecology, 44, 574-576.

Losco, G., Sykes, P., Anderson, N., Roberts, H., Fulton, J., & Fraser, H. (2004). Clinical utility of magnetic resonance imaging and the preoperative identification of low risk endometrial cancer. Australian & New Zealand Journal of Obstetrics & Gynaecology, 44, 419-422.

Abbas, M. M., Evans, J. J., Sykes, P. H., & Benny, P. S. (2004). Modulation of vascular endothelial growth factor and thymidine phosphorylase in normal human endometrial stromal cells. Fertility & Sterility, 82(Suppl. 3), 1048-1053.

Sykes, P., Allen, D., Cohen, C., Scurry, J., & Yeo, D. (2003). Does the density of lymphatic vascular space invasion affect the prognosis of stage Ib and IIA node negative carcinoma of the cervix? International Journal of Gynecological Cancer, 13, 313-316.

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