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Professor John Evans

John Evans

Research Professor

MSc PhD

Tel 64 3 364 1698

Email john.evans@otago.ac.nz

Professor John Evans is studying gynaecological cancers in collaboration with Peter Sykes. These investigations aim to understand cancers and develop new treatments.

Another set of studies investigates the regulation of the ovulatory cycle. This research is aimed at developing methods of fertility modulation.

Previous investigations of the peptides in cells lining blood vessels have provided new information on vascular disease.

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Publications

Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2017). Cell-like features imprinted in the physical nano- and micro-topography of the environment modify the responses to anti-cancer drugs of endometrial cancer cells. Biofabrication, 9(1), 015017. doi: 10.1088/1758-5090/aa5c9a

Murray, L. M., Nock, V., Evans, J. J., & Alkaisi, M. M. (2016). The use of substrate materials and topography to modify growth patterns and rates of differentiation of muscle cells. Journal of Biomedical Materials Research Part A, 104A, 1638-1645. doi: 10.1002/jbm.a.35696

Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2015). The characteristics of Ishikawa endometrial cancer cells are modified by substrate topography with cell-like features and the polymer surface. International Journal of Nanomedicine, 10, 4883-4895. doi: 10.2147/ijn.s86336

Hogg, S. J., Evans, J. J., Sykes, P. H., & Chitcholtan, K. (2015). A method to investigate the anti-metabolic activity of anti-cancer agents on ovarian cancer cells cultured in a 96-well high throughput format. Journal of Ovarian Research, 8, 43. doi: 10.1186/s13048-015-0172-0

Mutreja, I., Woodfield, T. B. F., Sperling, S., Nock, V., Evans, J. J., & Alkaisi, M. M. (2015). Positive and negative bioimprinted polymeric substrates: New platforms for cell culture. Biofabrication, 7, 025002. doi: 10.1088/1758-5090/7/2/025002

Journal - Research Article

Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2017). Cell-like features imprinted in the physical nano- and micro-topography of the environment modify the responses to anti-cancer drugs of endometrial cancer cells. Biofabrication, 9(1), 015017. doi: 10.1088/1758-5090/aa5c9a

Murray, L. M., Nock, V., Evans, J. J., & Alkaisi, M. M. (2016). The use of substrate materials and topography to modify growth patterns and rates of differentiation of muscle cells. Journal of Biomedical Materials Research Part A, 104A, 1638-1645. doi: 10.1002/jbm.a.35696

Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2015). The characteristics of Ishikawa endometrial cancer cells are modified by substrate topography with cell-like features and the polymer surface. International Journal of Nanomedicine, 10, 4883-4895. doi: 10.2147/ijn.s86336

Mutreja, I., Woodfield, T. B. F., Sperling, S., Nock, V., Evans, J. J., & Alkaisi, M. M. (2015). Positive and negative bioimprinted polymeric substrates: New platforms for cell culture. Biofabrication, 7, 025002. doi: 10.1088/1758-5090/7/2/025002

Hogg, S. J., Evans, J. J., Sykes, P. H., & Chitcholtan, K. (2015). A method to investigate the anti-metabolic activity of anti-cancer agents on ovarian cancer cells cultured in a 96-well high throughput format. Journal of Ovarian Research, 8, 43. doi: 10.1186/s13048-015-0172-0

Yoshida, A., Chitcholtan, K., Evans, J. J., Uemura, S., & Beasley, S. W. (2014). Provision of optimal conditions for in vitro differentiation into peristaltic smooth muscle from a murine induced pluripotent stem cell line. JSM Regenerative Medicine & Bioengineering, 2(1), 1011.

Murray, L. M., Nock, V., Evans, J. J., & Alkaisi, M. M. (2014). Bioimprinted polymer platforms for cell culture using soft lithography. Journal of Nanobiotechnology, 12, 60. doi: 10.1186/s12951-014-0060-6

Evans, G. E., Martínez-Conejero, J. A., Phillipson, G. T. M., Sykes, P. H., Sin, I. L., Lam, E. Y. N., … Evans, J. J. (2014). In the secretory endometria of women, luminal epithelia exhibit gene and protein expressions that differ from those of glandular epithelia. Fertility & Sterility, 102(1), 307-317. doi: 10.1016/j.fertnstert.2014.04.005

Evans, J. J., Wilkinson, T. M., & Wall, D. J. N. (2013). A two-pathway mathematical model of the LH response to GnRH that predicts self-priming. International Journal of Endocrinology, 2013, 410348. doi: 10.1155/2013/410348

Chitcholtan, K., Asselin, E., Parent, S., Sykes, P. H., & Evans, J. J. (2013). Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer. Experimental Cell Research, 319(1), 75-87. doi: 10.1016/j.yexcr.2012.09.012

Evans, G. E., Martínez-Conejero, J. A., Phillipson, G. T. M., Simón, C., McNoe, L. A., Sykes, P. H., … Evans, J. J. (2012). Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. Fertility & Sterility, 97(6), 1365-1373. doi: 10.1016/j.fertnstert.2012.03.007

Ibrahim, S. N., Murray, L., Evans, J. J., & Alkaisi, M. M. (2012). Trapping single cells: Comparison between sandwiched insulation with back contact (SIBC) and planar biochip. Materials Science Forum, 700, 188-194. doi: 10.4028/www.scientific.net/MSF.700.188

Evans, J. J., & Anderson, G. M. (2012). Balancing ovulation and anovulation: Integration of the reproductive and energy balance axes by neuropeptides. Human Reproduction Update, 18(3), 313-332. doi: 10.1093/humupd/dms004

Evans, G. E., Phillipson, G. T. M., Sin, I. L., Frampton, C. M. A., Kirker, J. A., Bigby, S. M., & Evans, J. J. (2012). Gene expression confirms a potentially receptive endometrium identified by histology in fertile women. Human Reproduction, 27(9), 2747-2755. doi: 10.1093/humrep/des233

Evans, J. J., Chitcholtan, K., Dann, J. M., Guilford, P., Harris, G., Lewis, L. K., Nagase, J., … Sykes, P. H. (2012). Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades. Gynecologic Oncology, 125(1), 214-219. doi: 10.1016/j.ygyno.2011.12.429

Chitcholtan, K., Sykes, P. H., & Evans, J. J. (2012). The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer. Journal of Translational Medicine, 10(1), 38-53. doi: 10.1186/1479-5876-10-38

Ibrahim, S. N., Murray, L., Nock, V., Evans, J. J., & Alkaisi, M. M. (2012). The quadrupole microelectrode design on a multilayer biochip for dielectrophoretic trapping of single cells. Microelectronic Engineering, 97, 369-374. doi: 10.1016/j.mee.2012.04.018

Yoshida, A., Chitcholtan, K., Evans, J. J., Nock, V., & Beasley, S. W. (2012). In vitro tissue engineering of smooth muscle sheets with peristalsis using a murine induced pluripotent stem cell line. Journal of Pediatric Surgery, 47(2), 329-335. doi: 10.1016/j.jpedsurg.2011.11.027

Evans, J. J., & Chitcholtan, K. (2011). Extracellular matrix proteins in the anterior pituitary gland. Open Neuroendocrinology Journal, 4, 111-119. doi: 10.2174/1876528901104010111

Nock, V., Murray, L., Samsuri, F., Alkaisi, M. M., & Evans, J. J. (2011). Microfluidic arrays for bioimprint of cancer cells. Microelectronic Engineering, 88(8), 1828-1831. doi: 10.1016/j.mee.2010.12.042

Samsuri, F., Alkaisi, M. M., Evans, J. J., Chitcholtan, K., & Mitchell, J. S. (2011). Detection of changes in cell membrane structures using the Bioimprint technique. Microelectronic Engineering, 88(8), 1871-1874. doi: 10.1016/j.mee.2010.12.069

Samsuri, F., Alkaisi, M. M., Mitchell, J. S., & Evans, J. J. (2010). Replication of cancer cells using soft lithography bioimprint technique. Microelectronic Engineering, 87, 699-703. doi: 10.1016/j.mee.2009.12.068

Nock, V., Murray, L., Samsuri, F., Alkaisi, M. M., & Evans, J. J. (2010). Microfluidics-assisted photo nanoimprint lithography for the formation of cellular bioimprints. Journal of Vacuum Science & Technology B: Microelectronics & Nanometer Structures, 28(6), C6K17-C6K22. doi: 10.1116/1.3501342

Pearson, L. J., Yandle, T. G., Nicholls, M. G., & Evans, J. J. (2009). Intermedin (Adrenomedullin-2): A potential protective role in human aortic endothelial cells. Cellular Physiology & Biochemistry, 23(1-3), 97-108.

Alkaisi, M. M., Muys, J. J., & Evans, J. J. (2009). Single cell imaging with AFM using Biochip/Bioimprint technology. International Journal of Nanotechnology, 6(3-4), 355-368. doi: 10.1504/IJNT.2009.022925

Anderson, G. M., Relf, H.-L., Rizwan, M. Z., & Evans, J. J. (2009). Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats. Endocrinology, 150(4), 1834-1840. doi: 10.1210/en.2008-1359

Samsuri, F., Mitchell, J. S., Alkaisi, M. M., & Evans, J. J. (2009). Formation of nanoscale bioimprints of muscle cells using UV-cured spin-coated polymers. Journal of Nanotechnology, 593410. doi: 10.1155/2009/593410

Samsuri, F., Mitchell, J. S., Alkaisi, M. M., & Evans, J. J. (2009). Replication of muscle cell using bioimprint. AIP Conference Proceedings, 1151, 71-74. doi: 10.1063/1.3203250

Dann, J. M., Sykes, P. H., Mason, D. R., & Evans, J. J. (2009). Regulation of Vascular Endothelial Growth Factor in endometrial tumour cells by resveratrol and EGCG. Gynecologic Oncology, 113(3), 374-378.

Peters, E. E. M., Towler, K. L., Mason, D. R., & Evans, J. J. (2009). Effects of galanin and leptin on gonadotropin-releasing hormone-stimulated luteinizing hormone release from the pituitary. Neuroendocrinology, 89(1), 18-26.

Pearson, L. J., Yandle, T. G., Nicholls, M. G., & Evans, J. J. (2008). Regulation of endothelin-1 release from human endothelial cells by sex steroids and angiotensin-II. Peptides, 29(6), 1057-1061.

Savigny, P., Evans, J., & McGrath, K. M. (2007). Cell membrane structures during exocytosis. Endocrinology, 148(8), 3863-3874. doi: 10.1210/en.2006-1644

Muys, J. J., Alkaisi, M. M., Melville, D. O. S., Nagase, J., Sykes, P., Parguez, G. M., & Evans, J. J. (2006). Cellular transfer and AFM imaging of cancer cells using Bioimprint. Journal of Nanobiotechnology, 4. Retrieved from http://www.jnanobiotechnology.com/content/4/1/1

Muys, J. J., Alkaisi, M. M., & Evans, J. J. (2006). Bioimprint: Nanoscale analysis by replication of cellular topography using soft lithography. Journal of Biomedical Nanotechnology, 2(1), 1-5.

Muys, J. J., Alkaisi, M. M., & Evans, J. J. (2006). Cellular replication and atomic force microscope imaging using a UV-Bioimprint technique. Nanomedicine, 2, 169-176.

Pearson, L. J., Rait, C., Nicholls, M. G., Yandle, T. G., & Evans, J. J. (2006). Regulation of adrenomedullin release from human endothelial cells by sex steroids and angiotensin-II. Journal of Endocrinology, 191(1), 171-177.

Muys, J., Alkaisi, M. M., Evans, J. J., & Nagase, J. (2005). Biochip: Cellular analysis by atomic force microscopy using dielectrophoretic manipulation. Japanese Journal of Applied Physics, 44(7B), 5717-5723.

Abbas, M. M., Evans, J. J., Sykes, P. H., & Benny, P. S. (2004). Modulation of vascular endothelial growth factor and thymidine phosphorylase in normal human endometrial stromal cells. Fertility & Sterility, 82(Suppl. 3), 1048-1053.

Evans, J. J., Reid, R. A., Wakeman, S., Croft, L. B., & Benny, P. S. (2003). Evidence that oxytocin is a physiological component of LH regulation in non-pregnant women. Human Reproduction, 18(7), 1428-1431.

Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2003). Endothelin-1 directly modulates its own secretion: Studies utilising the cell immunoblot technique. Regulatory Peptides, 113, 149-153.

Abbas, M. M., Evans, J. J., Sin, I. L., Gooneratne, A., Hill, A., & Benny, P. S. (2003). Vascular endothelial growth factor and leptin: Regulation in human cumulus cells and in follicles. Acta Obstetricia et Gynecologica Scandinavica, 82(11), 997-1003.

Evans, J. J. (2002). Peptides interact in gonadotrophin regulation. Archives of Physiology & Biochemistry, 110, 154-161.

Cameron, V. A., Autelitano, D. J., Evans, J. J., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Adrenomedullin expression in rat uterus is correlated with plasma estradiol. American Journal of Physiology: Endocrinology & Metabolism, 282, E139-E146.

Hamill, J., Maoate, K., Beasley, S. W., Corbett, R., & Evans, J. (2002). Familial parathyroid carcinoma in a child. Journal of Paediatrics & Child Health, 38(3), 314-317.

Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2002). Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. Journal of Endocrinology, 175, 225-232.

Evans, J. J. (2002). The anterior pituitary gland is mysterious, alluring and useful. Archives of Physiology & Biochemistry, 110, 3-8.

Evans, J. J., Pragg, F. L., & Mason, D. R. (2001). Release of luteinizing hormone from the anterior pituitary gland in vitro can be concurrently regulated by at least three peptides: Gonadotropin-releasing hormone, oxytocin and neuropeptide Y. Neuroendocrinology, 73, 408-416.

Evans, J. J. (2000). Oxytocin - a luteinising hormone regulating peptide. Obstetrics & Gynaecology Communications, 2, 17-22.

Abbas, M. M., & Evans, J. J. (2000). Regulation of c-fos protein in gonadotrope cells by oxytocin and gonadotropin-releasing hormome. Neuroendocrinology, 71, 292-300.

Evans, J. J., & Janmohamed, S. (1999). In vitro basal and GnRH-stimulated secretion of gonadotropins reflects long-lasting modulatory effects, and peripheral levels are not predicted by pituitary responsiveness to GnRH. European Journal of Endocrinology, 141, 512-520.

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