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Professor Brian A. Darlow

Brian Darlow

MA MB BChir MD (Cantab) FRCP FRCPCH

Email brian.darlow@otago.ac.nz

Tel 64 3 364 0747

Brian Darlow trained in the United Kingdom and New Zealand, with a spell in Papua New Guinea.

He returned to the department as Senior Lecturer in 1982 and was appointed to the Chair of Paediatrics in 2001.

He is a clinical neonatologist and his research interests include free radical disease in the newborn and the epidemiology and outcome of complications of prematurity.

He is also consultant in charge of the paediatric diabetic clinic.

Interests outside of medicine include ornithology and tramping.

Brian Darlow is the CureKids Chair of Paediatric Research at the University of Otago, Christchurch.

NZ Very Low Birthweight study

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Publications

Kelly, L. E., Shah, P. S., Håkansson, S., Kusuda, S., Adams, M., Lee, S. K., … Darlow, B. A., … for the investigators of the International Network for Evaluating Outcomes (iNeo) of Neonates. (2017). Perinatal health services organization for preterm births: A multinational comparison. Journal of Perinatology. Advance online publication. doi: 10.1038/jp.2017.45

Askie, L. M., Darlow, B. A., Davis, P. G., Finer, N., Stenson, B., Vento, M., & Whyte, R. (2017). Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants. Cochrane Database of Systematic Reviews, 4, CD011190. doi: 10.1002/14651858.CD011190.pub2

Darlow, B. A., Lui, K., Kusuda, S., Reichman, B., Håkansson, S., Bassler, D., … on behalf of the International Network for Evaluating Outcomes of Neonates (iNeo). (2017). International variations and trends in the treatment for retinopathy of prematurity. British Journal of Ophthalmology. Advance online publication. doi: 10.1136/bjophthalmol-2016-310041

Boost-II Australia and United Kingdom Collaborative Groups, including Darlow, B. A. (2016). Outcomes of two trials of oxygen-saturation targets in preterm infants. New England Journal of Medicine, 374(8), 749-760. doi: 10.1056/NEJMoa1514212

Gilbert, C., Wormald, R., Fielder, A., Deorari, A., Zepeda-Romero, L. C., Quinn, G., … Darlow, B. (2016). Potential for a paradigm change in the detection of retinopathy of prematurity requiring treatment. Archives of Disease in Childhood: Fetal & Neonatal Edition, 101(1), F6-F9. doi: 10.1136/archdischild-2015-308704

Chapter in Book - Research

Darlow, B. (2012). The newborn infant: Stabilization and examination. In M. South & D. Isaacs (Eds.), Practical paediatrics. (7th ed.) (pp. 328-340). Edinburgh, UK: Churchill Livingstone.

Begg, E. J., Atkinson, H. C., & Darlow, B. A. (1997). Guide to drug usage in lactation. In T. M. Speight & N. H. G. Holford (Eds.), Avery's Drug Treatment: a Guide to the Properties, Choice, Therapeutic Use and Economic Value of Drugs in Disease Management, 4th edition. (pp. 1701-1723). Auckland: Adis Press.

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Chapter in Book - Other

Darlow, B. (2013). Neonatal Health. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 88-95). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Kelly, L. E., Shah, P. S., Håkansson, S., Kusuda, S., Adams, M., Lee, S. K., … Darlow, B. A., … for the investigators of the International Network for Evaluating Outcomes (iNeo) of Neonates. (2017). Perinatal health services organization for preterm births: A multinational comparison. Journal of Perinatology. Advance online publication. doi: 10.1038/jp.2017.45

Darlow, B. A., Lui, K., Kusuda, S., Reichman, B., Håkansson, S., Bassler, D., … on behalf of the International Network for Evaluating Outcomes of Neonates (iNeo). (2017). International variations and trends in the treatment for retinopathy of prematurity. British Journal of Ophthalmology. Advance online publication. doi: 10.1136/bjophthalmol-2016-310041

Askie, L. M., Darlow, B. A., Davis, P. G., Finer, N., Stenson, B., Vento, M., & Whyte, R. (2017). Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants. Cochrane Database of Systematic Reviews, 4, CD011190. doi: 10.1002/14651858.CD011190.pub2

Boost-II Australia and United Kingdom Collaborative Groups, including Darlow, B. A. (2016). Outcomes of two trials of oxygen-saturation targets in preterm infants. New England Journal of Medicine, 374(8), 749-760. doi: 10.1056/NEJMoa1514212

Gilbert, C., Wormald, R., Fielder, A., Deorari, A., Zepeda-Romero, L. C., Quinn, G., … Darlow, B. (2016). Potential for a paradigm change in the detection of retinopathy of prematurity requiring treatment. Archives of Disease in Childhood: Fetal & Neonatal Edition, 101(1), F6-F9. doi: 10.1136/archdischild-2015-308704

Shah, P. S., Lui, K., Sjörs, G., Mirea, L., Reichman, B., Adams, M., … Darlow, B. A., … for the investigators of the International Network for Evaluating Outcomes (iNeo) of Neonates. (2016). Neonatal outcomes of very low birth weight and very preterm neonates: An international comparison. Journal of Pediatrics, 177, 144-152. doi: 10.1016/j.jpeds.2016.04.083

Harris, S. L., Austin, N. C., Battin, M., Broadbent, R., Horwood, J., Keenan, R., … Graham, P., Woodward, L. J., & Darlow, B. A. (2016). In-hospital morbidity and brain metrics of preterm neonates born 1998–2009. New Zealand Medical Journal, 129(1440), 94-107. Retrieved from https://www.nzma.org.nz/journal

Martin, L. J., Sjörs, G., Reichman, B., Darlow, B. A., Morisaki, N., Modi, N., … on behalf of the International Network for Evaluating Outcomes (iNeo) of Neonates Investigators. (2016). Country-specific vs. common birthweight-for-gestational age references to identify small for gestational age infants born at 24–28 weeks: An international study. Paediatric & Perinatal Epidemiology, 30(5), 450-461. doi: 10.1111/ppe.12298

Darlow, B. A., Graham, P. J., & Rojas-Reyes, M. X. (2016). Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants (Review). Cochrane Database of Systematic Reviews, 8, CD000501. doi: 10.1002/14651858.CD000501.pub4

Zahari, M., Lee, D. S., & Darlow, B. A. (2016). Algorithms that eliminate the effects of calibration artefact and trial-imposed offsets of Masimo oximeter in BOOST-NZ trial. Journal of Clinical Monitoring & Computing, 30, 669-678. doi: 10.1007/s10877-015-9752-1

Darlow, B. A., Voss, L., Lennon, D. R., & Grimwood, K. (2016). Early-onset neonatal group B streptococcus sepsis following national risk-based prevention guidelines. Australian & New Zealand Journal of Obstetrics & Gynaecology, 56, 69-74. doi: 10.1111/ajo.12378

Chawla, D., & Darlow, B. A. (2016). Anti-vascular endothelial growth factor preparations in the treatment of retinopathy of prematurity: Balancing risks and benefits. Indian Pediatrics, 53(Suppl. 2), S129-S136.

Gemmell, L., Martin, L., Murphy, K. E., Modi, N., Håkansson, S., Reichman, B., … Darlow, B. A., … for the International Network for Evaluating Outcomes (iNEO) of Neonates Investigators. (2016). Hypertensive disorders of pregnancy and outcomes of preterm infants of 24 to 28 weeks' gestation. Journal of Perinatology, 36, 1067-1072. doi: 10.1038/jp.2016.133

Hossain, S., Shah, P. S., Ye, X. Y., Darlow, B. A., Lee, S. K., Lui, K., on behalf of the Canadian Neonatal Network, and Australian and New Zealand Neonatal Network. (2016). Outborns or inborns: Where are the differences? A comparison study of very preterm neonatal intensive care unit infants cared for in Australia and New Zealand and in Canada. Neonatology, 109(1), 76-84. doi: 10.1159/000441272

Darlow, B. A. (2015). Retinopathy of prematurity: New developments bring concern and hope. Journal of Paediatrics & Child Health, 51(8), 765-770. doi: 10.1111/jpc.12860

Hossain, S., Shah, P. S., Ye, X. J., Darlow, B. A., Lee, S. K., Lui, K., on behalf of the Canadian Neonatal Network, and Australian and New Zealand Neonatal Network. (2015). Outcome comparison of very preterm infants cared for in the neonatal intensive care units in Australia and New Zealand and in Canada. Journal of Paediatrics & Child Health, 51, 881-888. doi: 10.1111/jpc.12863

Tan, Z., Chong, C., Darlow, B., & Dai, S. (2015). Visual impairment due to retinopathy of prematurity (ROP) in New Zealand: A 22-year review. British Journal of Ophthalmology, 99, 801-806. doi: 10.1136/bjophthalmol-2014-305913

Darlow, B. A., & Morley, C. J. (2015). Oxygen saturation targeting and bronchopulmonary dysplasia. Clinics in Perinatology, 42(4), 807-823. doi: 10.1016/j.clp.2015.08.008

Guillén, U., Weiss, E. M., Munson, D., Maton, P., Jefferies, A., Norman, M., … Darlow, B., & Kirpalani, H. (2015). Guidelines for the management of extremely premature deliveries: A systematic review. Pediatrics, 136(2), 343-350. doi: 10.1542/peds.2015-0542

Gilbert, C., Darlow, B., Zin, A., Sivasubramaniam, S., Shah, S., Gianini, N., … Lopes Moreira, M. E. (2014). Educating neonatal nurses in Brazil: A before-and-after study with interrupted time series analysis. Neonatology, 106(3), 201-208. doi: 10.1159/000362532

Shah, P. S., Lee, S. K., Lui, K., Sjörs, G., Mori, R., Reichman, B., … Darlow, B., … on behalf of the International Network for Evaluating Outcomes of Neonates (iNeo). (2014). The International Network for Evaluating Outcomes of very low birth weight, very preterm neonates (iNeo): A protocol for collaborative comparisons of international health services for quality improvement in neonatal care. BMC Pediatrics, 14(1), 110. doi: 10.1186/1471-2431-14-110

Darlow, B. A., Marschner, S. L., Donoghoe, M., Battin, M. R., Broadbent, R. S., Elder, M. J., Hewson, M. P., … Graham, P., McNeill, N. J., … on behalf of the Benefits Of Oxygen Saturation Targeting-New Zealand (BOOST-NZ) Collaborative Group. (2014). Randomized controlled trial of oxygen saturation targets in very preterm infants: Two year outcomes. Journal of Pediatrics, 165(1), 30-35. doi: 10.1016/j.jpeds.2014.01.017

Mulder, R. T., Carter, J. D., Frampton, C. M. A., & Darlow, B. A. (2014). Good two-year outcome for parents whose infants were admitted to a neonatal intensive care unit. Psychosomatics, 55(6), 613-620. doi: 10.1016/j.psym.2013.12.007

Reid, R. A., Prickett, T. C. R., Pullar, B. E., Darlow, B. A., Gullam, J. E., & Espiner, E. A. (2014). C-type natriuretic peptide in complicated pregnancy: Increased secretion precedes adverse events. Journal of Clinical Endocrinology & Metabolism, 99(4), 1470-1478. doi: 10.1210/jc.2013-3758

Porter, J. A., MacKenzie, K., Darlow, B., & Day, A. S. (2014). Looking for coeliac disease in children with type 1 diabetes mellitus. Journal of Paediatrics & Child Health, 50(10), 811-816. doi: 10.1111/jpc.12643

Austin, N., Darlow, B. A., & McGuire, W. (2013). Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants (Review). Cochrane Database of Systematic Reviews, 3, CD003478. doi: 10.1002/14651858.CD003478.pub4

Darlow, B. A., Ells, A. L., Gilbert, C. E., Gole, G. A., & Quinn, G. E. (2013). Are we there yet? Bevacizumab therapy for retinopathy of prematurity. Archives of Disease in Childhood: Fetal & Neonatal Edition, 98, F170-F174. doi: 10.1136/archdischild-2011-301148

Jacobs, S. E., Tobin, J. M., Opie, G. F., Donath, S., Tabrizi, S. N., Pirotta, M., … for the ProPrems Study Group, including Darlow, B. A. (2013). Probiotic effects on late-onset sepsis in very preterm infants: A randomized controlled trial. Pediatrics, 132(6), 1055-1062. doi: 10.1542/peds.2013-1339

Darlow, B. A., Horwood, L. J., Pere-Bracken, H. M., & Woodward, L. J. (2013). Psychosocial outcomes of young adults born very low birth weight. Pediatrics, 132(6), e1521-e1528. doi: 10.1542/peds.2013-2024

Boost II United Kingdom, Australia, and New Zealand Collaborative Groups, including Darlow, B. A., Broadbent, R., & Hewson, M. (2013). Oxygen saturation and outcomes in preterm infants. New England Journal of Medicine, 368, 2094-2104. doi: 10.1056/NEJMoa1302298

Martin, A. J., Darlow, B. A., Salt, A., Hague, W., Sebastian, L., McNeill, N., & Tarnow-Mordi, W. (2013). Performance of the Parent Report of Children's Abilities-Revised (PARCA-R) versus the Bayley Scales of Infant Development III. Archives of Disease in Childhood, 98(12), 955-958. doi: 10.1136/archdischild-2012-303288

Darlow, B. A., Gilbert, C. E., & Quiroga, A. M. (2013). Setting up and improving retinopathy of prematurity programs: Interaction of neonatology, nursing, and ophthalmology. Clinics in Perinatology, 40(2), 215-227. doi: 10.1016/j.clp.2013.02.006

Prickett, T. C. R., Hector-Taylor, J., Olney, R. C., Darlow, B. A., & Espiner, E. A. (2013). Acute inflammation in young children inhibits C-type natriuretic peptide. Pediatric Research, 74(2), 191-195. doi: 10.1038/pr.2013.92

Cheong, J. L. Y., Coleman, L., Hunt, R. W., Lee, K. J., Doyle, L. W., Inder, T. E., … for the Infant Cooling Evaluation Collaboration, including Darlow, B. A. (2012). Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: Substudy of a randomized trial. Archives of Pediatrics & Adolescent Medicine, 166(7), 634-640. doi: 10.1001/archpediatrics.2012.284

Hickey, L., Jacobs, S. E., Garland, S. M., on behalf of the ProPrems Study Group, including Darlow, B. A. (2012). Probiotics in neonatology. Journal of Paediatrics & Child Health, 48(9), 777-783. doi: 10.1111/j.1440-1754.2012.02508.x

Martin, A. J., Darlow, B. A., Salt, A., Hague, W., Sebastian, L., Mann, K., … on behalf of the INIS Trial Collaborative Group. (2012). Identification of infants with major cognitive delay using parental report. Developmental Medicine & Child Neurology, 54(3), 254-259. doi: 10.1111/j.1469-8749.2011.04161.x

Darlow, B. A., Phillips, A. A., & Dickson, N. P. (2011). New Zealand surveillance of neonatal vitamin K deficiency bleeding (VKDB): 1998-2008. Journal of Paediatrics & Child Health, 47(7), 460-464. doi: 10.1111/j.1440-1754.2010.01995.x

Darlow, B. A., & Graham, P. J. (2011). Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birthweight infants (Review). Cochrane Database of Systematic Reviews, 10, CD000501. doi: 10.1002/14651858.CD000501.pub3

MacDonald, A., Scarrott, C. J., Lee, D., Darlow, B., Reale, M., & Russell, G. (2011). A flexible extreme value mixture model. Computational Statistics & Data Analysis, 55(6), 2137-2157. doi: 10.1016/j.csda.2011.01.005

Askie, L. M., Brocklehurst, P., Darlow, B. A., Finer, N., Schmidt, B., Tarnow-Mordi, W., the NeOProM Collaborative Group. (2011). NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol. BMC Pediatrics, 11, 6. doi: 10.1186/1471-2431-11-6

Lee, D. S., Zahari, M., Russell, G., Darlow, B. A., Scarrott, C. J., & Reale, M. (2011). An exploratory investigation of some statistical summaries of oximeter oxygen saturation data from preterm babies. ISRN Pediatrics, 2011, 296418. doi: 10.5402/2011/296418

Harwood, D. T., Darlow, B. A., Cheah, F. C., McNeill, N., Graham, P., & Winterbourn, C. C. (2011). Biomarkers of neutrophil-mediated glutathione and protein oxidation in tracheal aspirates from preterm infants: Association with bacterial infection. Pediatric Research, 69(1), 28-33. doi: 10.1203/PDR.0b013e3181ff2378

Jacobs, S. E., Morley, C. J., Inder, T. E., Stewart, M. J., Smith, K. R., McNamara, P. J., … Darlow, B. A., … for the Infant Cooling Evaluation Collaboration. (2011). Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: A randomized controlled trial. Archives of Pediatrics & Adolescent Medicine, 165(8), 692-700. doi: 10.1001/archpediatrics.2011.43

Vella-Brincat, J. W. A., Begg, E. J., Robertshawe, B. J., Lynn, A. M., Borrie, T. L., & Darlow, B. A. (2011). Are gentamicin and/or vancomycin associated with ototoxicity in the neonate? A retrospective audit. Neonatology, 100, 186-193. doi: 10.1159/000324857

Miller, L. J., Willis, J. A., Pearce, J., Barnett, R., Darlow, B. A., & Scott, R. S. (2011). Urban-rural variation in childhood type 1 diabetes incidence in Canterbury, New Zealand, 1980 to 2004. Health & Place, 17(1), 248-256. doi: 10.1016/j.healthplace.2010.10.010

Brocklehurst, P., Farrell, B., King, A., Juszczak, E., Darlow, B. A., Haque, K., … on behalf of the INIS Trial Collaborative Group. (2011). Treatment of neonatal sepsis with intravenous immune globulin. New England Journal of Medicine, 365(13), 1201-1211. doi: 10.1056/NEJMoa1100441

Zin, A. A., Lopes Moreira, M. E., Bunce, C., Darlow, B. A., & Gilbert, C. E. (2010). Retinopathy of prematurity in 7 neonatal units in Rio de Janeiro: Screening criteria and workload implications. Pediatrics, 126(2), e410-e417. doi: 10.1542/peds.2010-0090

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