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Professor Robin Fraser

Robin FraserEmeritus Professor

ONZM, BSc, MB BS(Syd), PhD(ANU), MD(Otago), FRCPA

Email robin.fraser@otago.ac.nz

Background and research interests

After graduating in Medicine at the University of Sydney and three years at the Royal Prince Alfred Hospital Professor Robin Fraser began his medical career as a country doctor in Australia.

Professor Fraser's  interest in medical research led him to gain his PhD in the field of lipoprotein metabolism from the Australian National University. He took a post-doc at the University of Chicago before becoming a Senior Lecturer at the University of Sydney.

He took an appointment as an Associate Professor at the Christchurch School of Medicine and Health Sciences in 1974.

He is now Emeritus Professor but keeps his interest in the liver sieve as visiting professor to the University of Sydney. This work is directed by Professor David Le Couteur (Centre for Education and Research on Ageing at Concord Hospital and the ANZAC Institute of Medical Research). Professor Fraser is a collaborator and an advisor to this exciting work.

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Publications

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521

Badiei, A., Chambers, S. T., Gaddam, R. R., Fraser, R., & Bhatia, M. (2016). Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis. Applied Microbiology & Biotechnology, 100(1), 337-346. doi: 10.1007/s00253-015-6989-z

Cogger, V. C., Mohamad, M., Solon-Biet, S., Senior, A. M., Warren, A., O'Reilly, J. N., … Fraser, R., … Le Couteur, D. G. (2016). Dietary macronutrients and the aging liver sinusoidal endothelial cell. American Journal of Physiology: Heart & Circulatory Physiology, 310, H1064-H1070. doi: 10.1152/ajpheart.00949.2015

Mohamad, M., Mitchell, S. J., Wu, L. E., White, M. Y., Cordwell, S. J., Mach, J., … Fraser, R., … Cogger, V. C. (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell, 15(4), 706-715. doi: 10.1111/acel.124819

Edited Book - Research

Wisse, E., Knook, D. L., de Zander, R., & Fraser, R. (Eds.). (1998). Cells of the hepatic sinusoids. Volume 7. Leiden: The Kupffer Cell Foundation, 310p.

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Chapter in Book - Research

Svistunenko, D., Zykova, S. N., Cogger, V. C., Warren, A., Fraser, R., Smedsrød, B., … Le Couteur, D. G. (2011). Pseudocapillarization and the aging liver. In L. D. DeLeve & G. Garcia-Tsao (Eds.), Vascular liver disease: Mechanisms and management. (pp. 41-50). New York: Springer. doi: 10.1007/978-1-4419-8327-5_3

Le Couteur, D. G., Cogger, V. C., Hilmer, S. N., Muller, M., Harris, M., Sullivan, D., … Fraser, R. (2006). Aging, atherosclerosis and the liver sieve. In L. V. Clark (Ed.), New research on atherosclerosis. (pp. 19-44). New York: Nova Science.

Jamieson, H. A., Dobbs, B. R., Day, W. A., Rogers, G. W. T., & Fraser, R. (2001). The liver sieve in diabetes: Are the ultrastructural changes similar to those seen in alcoholism? In E. Wisse, D. L. Knook, R. De Zanger & M. P. J. Arthur (Eds.), Cells of the hepatic sinusoid (vol. 8). (pp. 123-124). Netherlands: The Kupffer Cell Foundation.

Jamieson, H. A., Day, W. A., Dobbs, B. R., Rogers, G. W. T., & Fraser, R. (1999). Is the fatty liver of diabetes like that of alcohol related to an increased porosity of the liver sieve? In E. Wisse, D. L. Knook, R. deZanger & R. Fraser (Eds.), Cells of Hepatic Sinusoid Volume 7. (pp. 96-98). Leiden: The Kupffer Cell Foundation.

Dobbs, B. R., Fraser, R., & Rogers, G. W. T. (1997). Reduction of the hepatotoxicity of dimethyl-nitrosamine with gadolinium chloride. In E. Wisse, D. L. Knook & C. Balabaud (Eds.), Cells of the hepatic sinusoids. Volume 6. (pp. 308-309). Leiden: The Kupffer Cell FOundation.

Dobbs, B. R., Rogers, G. R., & Fraser, R. (1995). Reduction of the hepatotoxicity of dimethylnitrosamine with gadolinium chloride. In E. Wisse, D. L. Knook & K. Wake (Eds.), Cells of the Hepatic Sinusoid, vol.5. (pp. 308-309). Leiden: Kupffer Cell Foundation.

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Journal - Research Article

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521

Mohamad, M., Mitchell, S. J., Wu, L. E., White, M. Y., Cordwell, S. J., Mach, J., … Fraser, R., … Cogger, V. C. (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell, 15(4), 706-715. doi: 10.1111/acel.124819

Cogger, V. C., Mohamad, M., Solon-Biet, S., Senior, A. M., Warren, A., O'Reilly, J. N., … Fraser, R., … Le Couteur, D. G. (2016). Dietary macronutrients and the aging liver sinusoidal endothelial cell. American Journal of Physiology: Heart & Circulatory Physiology, 310, H1064-H1070. doi: 10.1152/ajpheart.00949.2015

Badiei, A., Chambers, S. T., Gaddam, R. R., Fraser, R., & Bhatia, M. (2016). Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis. Applied Microbiology & Biotechnology, 100(1), 337-346. doi: 10.1007/s00253-015-6989-z

Cogger, V. C., Roessner, U., Warren, A., Fraser, R., & Le Couteur, D. G. (2013). A sieve-raft hypothesis for the regulation of endothelial fenestrations. Computational & Structural Biotechnology Journal, 8(11), e201308003. doi: 10.5936/csbj.201308003

Fraser, R., Cogger, V. C., Dobbs, B., Jamieson, H., Warren, A., ..., & Le Couteur, D. G. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. doi: 10.1097/PAT.0b013e328351bcc8

Warren, A., Cogger, V. C., Fraser, R., DeLeve, L. D., McCuskey, R. S., & Le Couteur, D. G. (2011). The effects of old age on hepatic stellate cells. Current Gerontology & Geriatrics Research, 2011, 439835. doi: 10.1155/2011/439835

O'Reilly, J. N., Cogger, V. C., Fraser, R., & Le Couteur, D. G. (2010). The effect of feeding and fasting on fenestrations in the liver sinusoidal endothelial cell. Pathology, 42(3), 255-258. doi: 10.3109/00313021003636469

Le Couteur, D. G., Warren, A., Cogger, V. C., Smedsrød, B., Sørensen, K. K., de Cabo, R., Fraser, R., & McCuskey, R. S. (2008). Old age and the hepatic sinusoid. Anatomical Record, 291, 672-683. doi: 10.1002/ar.20661

Warren, A., Chaberek, S., Ostrowski, K., Cogger, V. C., Hilmer, S. N., McCuskey, R. S., Fraser, R., & Le Couteur, D. G. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. doi: 10.1080/10739680701600856

Jamieson, H. A., Hilmer, S. N., Cogger, V. C., Warren, A., Cheluvappa, R., Abernethy, D. R., … Fraser, R., … Le Couteur, D. G. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378.

Jamieson, H. A., Cogger, V. C., Twigg, S. M., McLennan, S. V., Warren, A., Cheluvappa, R., … Fraser, R., … Le Couteur, D. G. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia, 50, 1969-1976.

Warren, A., Bertolino, P., Benseler, V., Fraser, R., McCaughan, G. W., & Le Couteur, D. G. (2007). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246.

Le Couteur, D. G., Cogger, V. C., McCuskey, R. S., de Cabo, R., Smedsrød, B., Sorensen, K. K., … Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium: A mechanism for dyslipidemia. Annals of the New York Academy of Sciences, 1114, 79-87.

Slow, S., Vasudevamurthy, M., Fraser, R., McEntyre, C., Lever, M., Chambers, S., & George, P. (2007). Dimethylthetin treatment causes diffuse alveolar lung damage: A pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD). Experimental & Toxicologic Pathology, 58, 285-290.

Warren, A., Le Couteur, D. G., Fraser, R., Bowen, D. G., McCaughan, G. W., & Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190.

Cogger, V. C., Hilmer, S. N., Sullivan, D., Muller, M., Fraser, R., & Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281.

Le Couteur, D. G., Fraser, R., Hilmer, S., Rivory, L. P., & McLean, A. J. (2005). The hepatic sinusoid in aging and cirrhosis [Major review]. Clinical Pharmacokinetics, 44(2), 187-200.

Warren, A., Bertolino, P., Cogger, V. C., McLean, A. J., Fraser, R., & Le Couteur, D. G. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40, 807-812.

Hilmer, S. N., Cogger, V. C., Fraser, R., McLean, A. J., Sullivan, D., & Le Couteur, D. G. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42, 1349-1354.

Cogger, V. C., Muller, M., Fraser, R., McLean, A. J., Khan, J., & Le Couteur, D. G. (2004). The effects of oxidative stress on the liver sieve. Journal of Hepatology, 41, 370-376.

Hilmer, S. N., Warren, A., Cogger, V. C., Fraser, R., McLean, A. J., Sullivan, D., & Le Couteur, D. G. (2004). The effect of aging on the immunohistochemistry of apolipoprotein E in the liver. Experimental Gerontology, 39(1), 53-57. doi: 10.1016/j.exger.2003.09.016

Keenan, J. I., Peterson, R. A., Fraser, R., Frampton, C. M., Walmsley, T. A., Allardyce, R. A., & Roake, J. A. (2004). The effect of Helicobacter pylori infection and dietary iron deficiency on host iron homeostasis: A study in mice. Helicobacter, 9(6), 643-650.

Braet, F., Fraser, R., & McCuskey, R. S. (2003). Thirty-five years of liver sinusoidal cells: Eddie Wisse in retirement [A tribute]. Hepatology, 38, 156-158.

Munro, A. R., Beasley, S. W., Pattemore, P. K., & Fraser, R. (2003). Fatal late onset necrotising enterocolitis in a term infant: Atypical Kawasaki disease or polyarteritis nodosa of infancy? Journal of Paediatrics & Child Health, 39, 555-557.

Cogger, V. C., Warren, A., Fraser, R., Ngu, M., McLean, A., & Le Couteur, D. G. (2003). Hepatic sinusoidal pseudocapillarization with aging in the non-human primate. Experimental Gerontology, 38, 1101-1107.

Le Couteur, D., Fraser, R., Cogger, V., & McLean, A. J. (2002). Hepatic pseudocapillarisation and atherosclerosis in ageing. Lancet, 359, 1612-1615.

Fraser, R. (2002). The liver, in health and disease. New Zealand Pharmacy, 22, 36-40.

Fraser, R. (2001). Undergraduate medical education. New Zealand Medical Journal, 114, 554-555.

Johnson, S. J., Toole, K., Fraser, R., Rogers, G., Dobbs, B. R., & Burt, A. D. (1996). Methylprednisolone does not inhibit the nonparenchymal cell responses to dimethylnitrosamine-induced liver injury. International Hepatology Communications, 4, 201-206.

Fraser, R., Rogers, G. R., Sutton, L. E., & Dobbs, B. R. (1995). Single dose models of defenestration: tools to explore mechanisms, modulation and measurement of hepatic sinusoidal porosity. Cells of the Hepatic Sinusoid, 5, 263-266.

Crump, J. A., Beard, M. E. J., Angus, H. B., Fraser, R., Hart, D., & Nicholls, M. G. (1995). Acute adrenal insufficiency: A new presentation of Castleman's disease [Case report]. Journal of Internal Medicine, 238, 81-84. doi: 10.1111/j.1365-2796.1995.tb00903.x

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Journal - Research Other

Fraser, R. (2010). Why teach human anatomy at Otago School of Medical Sciences? [Editorial]. New Zealand Medical Journal, 123(1312). Retrieved from http://journal.nzma.org.nz/journal/123-1312/4049/content.pdf

Cogger, V. C., Fraser, R., & Le Couteur, D. G. (2003). Liver dysfunction and heart failure. American Journal of Cardiology, 91(11), 1399.

Fraser, R., Le Couteur, D., Warren, A., Cogger, V., Bertolino, P., & Smith, M. (2003). The liver sieve and gene therapy [Letter to the editor]. Blood, 101(8), 3338.

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Conference Contribution - Published proceedings: Full paper

Fraser, R., Rogers, G. W. T., Sutton, L. E., & Dobbs, B. R. (1995). Are liver functions tests affected by the hepatic microcirculation? Progress in Microcirculation Research. Proceedings of the Eighth Australian and New Zealand Symposium. (pp. 21-22). Auckland: Uniprint, University of Auckland. [Full Paper]

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Conference Contribution - Published proceedings: Abstract

Gaddam, R. R., Fraser, R., Badiei, A., Cogger, V., Le Couteur, D., Ishii, I., & Bhatia, M. (2016). The effect of hydrogen sulfide synthesized by cystathionine-gamma-lyase on inflammation and liver sinusoidal endothelial cells in polymicrobial sepsis in mice. New Zealand Medical Journal, 129(1439), (pp. 88). Retrieved from http://www.nzma.org.nz/journal

Bhatia, M., Badiei, A., Gaddam, R., Fraser, R., & Chambers, S. (2015). Inhibition of hydrogen sulfide synthesis by gene silencing protects mice against caerulein-induced acute pancreatitis. Pancreatology, 15(3, Suppl.), (pp. S2). doi: 10.1016/j.pan.2015.05.048

Fraser, R., Bhatia, M., Gaddam, R. R., Jamieson, H. A., Dobbs, B. R., Wade, R. T., … Le Couteur, D. G. (2014). Arsenic containing water from Bangladeshi wells relates to local heart disease and stroke. Internationally, mining and exploratory fracking may lead to arsenical contamination of aquifers. Arsenical drinking-water, by closing the "liver sieve" causes dyslipidaemia and atherosclerosis? Proceedings of the 7th Annual Otago International Health Research Network (OIHRN) Conference. (pp. 9-10). Retrieved from http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/conference/index.html

Dale, G., Cogger, V., Fraser, R., & Le Couteur, D. (2008). The effect of block co-polymer on hepatotoxicity following paracetamol overdose. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Jamieson, H. A., Cogger, V. C., Hilmer, S., Le Couteur, D. G., & Fraser, R. (2006). Effects of aging on liver sinusoid caveolin-1 expression. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Cogger, V. C., Hilmer, S. N., Fraser, R., & Le Couteur, D. G. (2004). Defenestration of the liver sieve in a hyperlipidemic mouse model. Proceedings of the XII International Symposium on Cells of the Hepatic Sinusoid. (pp. O7). [Abstract]

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