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Professor David Murdoch

David Murdoch

Head of Department, Department of Pathology

MB ChB, MD (Otago), MSc (Lond), DTM&H (Liv), FRACP, FRCPA, FFSc(RCPA)

Email david.murdoch@otago.ac.nz 

Professor David Murdoch heads the Department of Pathology at the University of Otago, Christchurch.

He is a Senior Associate in the Department of International Health at Johns Hopkins School of Public Health, and a clinical microbiologist at Canterbury Health Laboratories.

Research Interests

David’s main research interests are the epidemiology, diagnosis and prevention of respiratory tract infections, pneumococcal disease, legionellosis, bloodstream infections, and the role of vitamin D in infectious diseases.

He has a particular interest in the microbial aetiology of pneumonia, and is the Laboratory Director of the Pneumonia Etiology Research for Child Health (PERCH) project which is focused on determining the causes of severe pneumonia in young children from developing countries. David has ongoing projects based in nine countries in Africa and Asia.

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Publications

Hamaluba, M., Kandasamy, R., Upreti, S. R., Subedi, G. R., Shrestha, S., Bhattarai, S., … Murdoch, D. R., … Pollard, A. J. (2015). Comparison of two-dose priming plus 9-month booster with a standard three-dose priming schedule for a ten-valent pneumococcal conjugate vaccine in Nepalese infants: A randomised, controlled, open-label, non-inferiority trial. Lancet Infectious Diseases, 15(4), 405-414. doi: 10.1016/s1473-3099(15)70007-1

Murdoch, D. R., Podmore, R. G., Anderson, T. P., Barratt, K., Maze, M. J., French, K. E., … Chambers, S. T., Werno, A. M. (2013). Impact of routine systematic polymerase chain reaction testing on case finding for Legionnaires' disease: A pre-post comparison study. Clinical Infectious Diseases, 57(9), 1275-1281. doi: 10.1093/cid/cit504

Murdoch, D. R., Slow, S., Chambers, S. T., Jennings, L. C., Stewart, A. W., Priest, P. C., Florkowski, C. M., … Scragg, R. (2012). Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: The vidaris randomized controlled trial. JAMA, 308(13), 1333-1339. doi: 10.1001/jama.2012.12505

Murdoch, D. R., Corey, G. R., Hoen, B., Miró, J. M., Fowler, , V. G., Jr, Bayer, A. S., … Chambers, S. T., … Raymond, N. J., … for the International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators. (2009). Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: The International Collaboration on Endocarditis-Prospective Cohort Study. Archives of Internal Medicine, 169(5), 463-473.

Ruuskanen, O., Lahti, E., Jennings, L. C., & Murdoch, D. R. (2011). Viral pneumonia. Lancet, 377, 1264-1275. doi: 10.1016/S0140-6736(10)61459-6

Journal - Research Article

Kandasamy, R., Gurung, M., Thapa, A., Ndimah, S., Adhikari, N., Murdoch, D. R., … Pollard, A. J. (2015). Multi-serotype pneumococcal nasopharyngeal carriage prevalence in vaccine naïve Nepalese children, assessed using molecular serotyping. PLoS ONE, 10(2), e0114286. doi: 10.1371/journal.pone.0114286

Hamaluba, M., Kandasamy, R., Upreti, S. R., Subedi, G. R., Shrestha, S., Bhattarai, S., … Murdoch, D. R., … Pollard, A. J. (2015). Comparison of two-dose priming plus 9-month booster with a standard three-dose priming schedule for a ten-valent pneumococcal conjugate vaccine in Nepalese infants: A randomised, controlled, open-label, non-inferiority trial. Lancet Infectious Diseases, 15(4), 405-414. doi: 10.1016/s1473-3099(15)70007-1

Slow, S., Priest, P. C., Chambers, S. T., Stewart, A. W., Jennings, L. C., Florkowski, C. M., … Murdoch, D. R. (2014). Effect of vitamin D3 supplementation on Staphylococcus aureus nasal carriage: A randomized, double-blind, placebo-controlled trial in healthy adults. Clinical Microbiology & Infection, 20(5), 453-458. doi: 10.1111/1469-0691.12350

Hanieh, S., Hamaluba, M., Kelly, D. F., Metz, J. A., Wyres, K. L., Fisher, R., … Werno, A. M., … Murdoch, D. R., … Pollard, A. J. (2014). Streptococcus pneumoniae carriage prevalence in Nepal: Evaluation of a method for delayed transport of samples from remote regions and implications for vaccine implementation. PLoS ONE, 9(6), e98739. doi: 10.1371/journal.pone.0098739

Scragg, R., Slow, S., Stewart, A. W., Jennings, L. C., Chambers, S. T., Priest, P. C., Florkowski, C. M., … Murdoch, D. R. (2014). Long-term high-dose vitamin D3 supplementation and blood pressure in healthy adults: A randomized controlled trial. Hypertension, 64, 725-730. doi: 10.1161/hypertensionaha.114.03466

Slow, S., Florkowski, C. M., Chambers, S. T., Priest, P. C., Stewart, A. W., Jennings, L. C., … Murdoch, D. R. (2014). Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: Randomised controlled trial. BMJ, 349, g7260. doi: 10.1136/bmj.g7260

McAuliffe, G. N., Anderson, T. P., Stevens, M., Adams, J., Coleman, R., Mahagamasekera, P., … Jennings, L. C., Murdoch, D. R. (2013). Systematic application of multiplex PCR enhances the detection of bacteria, parasites, and viruses in stool samples. Journal of Infection, 67(2), 122-129. doi: 10.1016/j.jinf.2013.04.009

Chambers, S. T., Murdoch, D., Morris, A., Holland, D., Pappas, P., Almela, M., … Raymond, N., … and the International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators. (2013). HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort. PLoS ONE, 8(5), e63181. doi: 10.1371/journal.pone.0063181

Murdoch, D. R., Podmore, R. G., Anderson, T. P., Barratt, K., Maze, M. J., French, K. E., … Chambers, S. T., Werno, A. M. (2013). Impact of routine systematic polymerase chain reaction testing on case finding for Legionnaires' disease: A pre-post comparison study. Clinical Infectious Diseases, 57(9), 1275-1281. doi: 10.1093/cid/cit504

Hammitt, L. L., Kazungu, S., Morpeth, S. C., Gibson, D. G., Mvera, B., Brent, A. J., … Murdoch, D. R., … Scott, J. A. G. (2012). A preliminary study of pneumonia etiology among hospitalized children in Kenya. Clinical Infectious Diseases, 54(Suppl. 2), S190-S199. doi: 10.1093/cid/cir1071

Murdoch, D. R., O'Brien, K. L., Driscoll, A. J., Karron, R. A., Bhat, N., the Pneumonia Methods Working Group, and the PERCH Core Team. (2012). Laboratory methods for determining pneumonia etiology in children. Clinical Infectious Diseases, 54(Suppl. 2), S146-S152. doi: 10.1093/cid/cir1073

Werno, A. M., Anderson, T. P., & Murdoch, D. R. (2012). Association between pneumococcal load and disease severity in adults with pneumonia. Journal of Medical Microbiology, 61(8), 1129-1135. doi: 10.1099/jmm.0.044107-0

Murdoch, D. R., Slow, S., Chambers, S. T., Jennings, L. C., Stewart, A. W., Priest, P. C., Florkowski, C. M., … Scragg, R. (2012). Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: The vidaris randomized controlled trial. JAMA, 308(13), 1333-1339. doi: 10.1001/jama.2012.12505

Williams, E. J., Lewis, J., John, T., Hoe, J. C., Yu, L., Dongol, S., … Werno, A. M., Murdoch, D. R., … Pollard, A. J. (2011). Haemophilus influenzae type b carriage and novel bacterial population structure among children in urban Kathmandu, Nepal. Journal of Clinical Microbiology, 49(4), 1323-1330. doi: 10.1128/jcm.02200-10

Kelly, D. F., Thorson, S., Maskey, M., Mahat, S., Shrestha, U., Hamaluba, M., … Werno, A. M., … Murdoch, D. R., Pollard, A. J. (2011). The burden of vaccine-preventable invasive bacterial infections and pneumonia in children admitted to hospital in urban Nepal. International Journal of Infectious Diseases, 15(1), e17-e23. doi: 10.1016/j.ijid.2010.05.021

Malbruny, B., Werno, A. M., Murdoch, D. R., Leclercq, R., & Cattoir, V. (2011). Cross-resistance to lincosamides, streptogramins A, and pleuromutilins due to the lsa(C) gene in Streptococcus agalactiae UCN70. Antimicrobial Agents & Chemotherapy, 55(4), 1470-1474. doi: 10.1128/AAC.01068-10

Ruuskanen, O., Lahti, E., Jennings, L. C., & Murdoch, D. R. (2011). Viral pneumonia. Lancet, 377, 1264-1275. doi: 10.1016/S0140-6736(10)61459-6

Nienaber, J. C., Kuinkel, B. K. S., Clarke-Pearson, M., Lamlertthon, S., Park, L., Rude, T. H., … Murdoch, D. R., … for the International Collaboration on Endocarditis-Microbiology Investigators. (2011). Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins. Journal of Infectious Diseases, 204(5), 704-713. doi: 10.1093/infdis/jir389

Kiefer, T., Park, L., Tribouilloy, C., Cortes, C., Casillo, R., Chu, V., … Murdoch, D. R., … for the ICE-PCS Investigators. (2011). Association between valvular surgery and mortality among patients with infective endocarditis complicated by heart failure. JAMA, 306(20), 2239-2247. doi: 10.1001/jama.2011.1701

Holt, K. E., Baker, S., Dongol, S., Basnyat, B., Adhikari, N., Thorson, S., … Murdoch, D. R., … Dougan, G. (2010). High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children. BMC Infectious Diseases, 10, 144. doi: 10.1186/1471-2334-10-144

Huggan, P. J., Wells, J. E., Browne, M., Richardson, A., Murdoch, D. R., & Chambers, S. T. (2010). Population-based epidemiology of Staphylococcus aureus bloodstream infection in Canterbury, New Zealand. Internal Medicine Journal, 40(2), 117-125. doi: 10.1111/j.1445-5994.2009.01910.x

Murdoch, D. R., & Jennings, L. C. (2009). Association of respiratory virus activity and environmental factors with the incidence of invasive pneumococcal disease. Journal of Infection, 58(1), 37-46. doi: 10.1016/j.jinf.2008.10.011

Murdoch, D. R., Corey, G. R., Hoen, B., Miró, J. M., Fowler, , V. G., Jr, Bayer, A. S., … Chambers, S. T., … Raymond, N. J., … for the International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators. (2009). Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: The International Collaboration on Endocarditis-Prospective Cohort Study. Archives of Internal Medicine, 169(5), 463-473.

Williams, E. J., Thorson, S., Maskey, M., Mahat, S., Hamaluba, M., Dongol, S., Werno, A. M., … Murdoch, D. R. (2009). Hospital-based surveillance of invasive pneumococcal disease among young children in urban Nepal. Clinical Infectious Diseases, 48(Suppl. 2), S114-S122. doi: 10.1086/596488

Amodeo, M. R., Clulow, T., Lainchbury, J., Murdoch, D. R., Gallagher, K., Dyer, A., … Pithie, A. D., Chambers, S. T. (2009). Outpatient intravenous treatment for infective endocarditis: Safety, effectiveness and one-year outcomes. Journal of Infection, 59(6), 387-393. doi: 10.1016/j.jinf.2009.09.009

Bae, I.-G., Federspiel, J. J., Miró, J. M., Woods, C. W., Park, L., Rybak, M. J., … Murdoch, D. R., … for the International Collaboration on Endocarditis-Microbiology Investigators. (2009). Heterogeneous vancomycin-intermediate susceptibility phenotype in bloodstream methicillin-resistant Staphylococcus aureus isolates from an international cohort of patients with infective endocarditis: Prevalence, genotype, and clinical significance. Journal of Infectious Diseases, 200(9), 1355-1366. doi: 10.1086/606027

Jennings, L. C., Anderson, T. P., Beynon, K. A., Chua, A., Laing, R. T. R., Werno, A. M., … Chambers, S. T., Murdoch, D. R. (2008). Incidence and characteristics of viral community-acquired pneumonia in adults. Thorax, 63(1), 42-48. doi: 10.1136/thx.2006.075077

Durante-Mangoni, E., Bradley, S., Selton-Suty, C., Tripodi, M.-F., Barsic, B., Bouza, E., … Murdoch, D., … for the International Collaboration on Endocarditis Prospective Cohort Study Group. (2008). Current features of infective endocarditis in elderly patients: Results of the International Collaboration on Endocarditis Prospective Cohort Study. Archives of Internal Medicine, 168(19), 2095-2103.

Morpeth, S., Murdoch, D., Cabell, C. H., Karchmer, A. W., Pappas, P., Levine, D., … and the International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators. (2007). Non-HACEK gram-negative bacillus endocarditis. Annals of Internal Medicine, 147(12), 829-835.

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Journal - Research Other

Murdoch, D. R., & Chambers, S. T. (2009). Atypical pneumonia: Time to breathe new life into a useful term? Lancet Infectious Diseases, 9(8), 512-519. doi: 10.1016/S1473-3099(09)70148-3

Murdoch, D. R., O'Brien, K., Scott, J. A. G., Karron, R. A., Bhat, N., Driscoll, A. J., … Levine, O. S. (2009). Breathing new life into pneumonia diagnostics [Commentary]. Journal of Clinical Microbiology, 47(11), 3405-3408. doi: 10.1128/jcm.01685-09

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