Principal Investigator
PhD (Otago) MSc(Hons) (Canterbury)Email mark.hampton@otago.ac.nz
Tel +64 3 378 6225
Mark Hampton is a professor at the Department of Pathology and Biomedical Science on the University of Otago, Christchurch campus, and director of Mātai Hāora - Centre for Redox Biology and Medicine .
He completed his undergraduate and PhD studies in New Zealand before taking up postdoctoral positions at the Karolinksa Institute in Sweden and Harvard in the USA. He subsequently returned to the University of Otago where he was promoted to a professorial role in 2013.
Research interests
Oxidants (also called reactive oxygen species or free radicals) are continuously generated in our body, and we rely on sophisticated antioxidant systems to prevent them from causing damage. However, oxidants also have beneficial roles. They can act as signalling molecules that regulate a number of life and death pathways in cells, and they are generated by the immune system to fight microbes. Prof Hampton's research is focused on how understanding how cells sense and respond to oxidants, and how these pathways might be modulated to prevent and treat human disease.
In the early stages of Professor Hampton's career he investigated the role that neutrophil oxidants play in killing phagocytosed microbes. His interests then broadened to the impact of these oxidants on neighbouring cells during inflammation, and the controlled generation of oxidants by other cells during normal metabolism.
Professor Hampton's current projects include investigations of the ability of oxidants generated by the innate immune system to regulate epigenetic and cell death pathways; how the disruption of redox homeostasis can promote the killing of cancer cells and pathogenic microbes; and how oxidative stress is associated with the biological processes underlying human ageing.
Affiliations
Inaugural Professorial Lecture
Funded By
Publications
Swaminathan, A., Borichevsky, G. M., Frampton, C. M., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2024). Comparison of fecal calprotectin and myeloperoxidase in predicting outcomes in inflammatory bowel disease. Inflammatory Bowel Diseases. Advance online publication. doi: 10.1093/ibd/izae032 Journal - Research Article
Shearer, H., Currie, M., Agnew, H., Trappetti, C., Stull, F., Pace, P., … Hampton, M., … Dickerhof, N. (2023). Sensitising Streptococcus pneumoniae to the immune-derived oxidant hypothiocyanous acid. Free Radical Biology & Medicine, 208(Suppl. 1), 96. doi: 10.1016/j.freeradbiomed.2023.10.110 Conference Contribution - Published proceedings: Abstract
Meotti, F., de Souza, L. F., Dempsey, B., Silva, R., Pinz, M., Cruz, L., Pace, P., Hampton, M., & Winterbourn, C. (2023). Peroxiredoxin 2 interacts with granule stress proteins in proliferative leukemic myeloid cells. Free Radical Biology & Medicine, 208(Suppl. 1), 38. doi: 10.1016/j.freeradbiomed.2023.10.053 Conference Contribution - Published proceedings: Abstract
Ledgerwood, E., King-Hudson, T.-R., Pearson, A., Dunstan-Harrison, C., & Hampton, M. (2023). Peroxiredoxins as markers of redox homeostasis in studies of human ageing. Free Radical Biology & Medicine, 208(Suppl. 1), 113. doi: 10.1016/j.freeradbiomed.2023.10.127 Conference Contribution - Published proceedings: Abstract
Shearer, H. L., Pace, P. E., Smith, L. M., Fineran, P. C., Matthews, A. J., Camilli, A., Dickerhof, N., & Hampton, M. B. (2023). Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening. Journal of Bacteriology. Advance online publication. doi: 10.1128/jb.00208-23 Journal - Research Article
Peeters, W. M., Gram, M., Dias, G. J., Vissers, M. C. M., Hampton, M. B., Dickerhof, N., Bekhit, A. E., … Bayer, S., … Sheard, P. W., Danielson, K. M., … Cornwall, J., & Rowlands, D. S. (2023). Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes. Redox Biology, 67, 102918. doi: 10.1016/j.redox.2023.102918 Journal - Research Article
Seddon, A., Das, A., Hampton, M., & Stevens, A. (2023). Understanding how immune oxidants can drive epigenetic change. Proceedings of the European Society of Human Genetics (ESHG) European Human Genetics Hybrid Conference. P21.003.C. Retrieved from https://www.eshg.org/home Conference Contribution - Published proceedings: Abstract
Bozonet, S. M., Magon, N. J., Schwartfeger, A. J., Konigstorfer, A., Heath, S. G., Vissers, M. C. M., … Göbl, C., … Hampton, M. B. (2023). Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. Journal of Biological Chemistry, 104792. Advance online publication. doi: 10.1016/j.jbc.2023.104792 Journal - Research Article
Shearer, H. L., Loi, V. V., Weiland, P., Bange, G., Altegoer, F., Hampton, M. B., … Dickerhof, N. (2023). MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus. Molecular Microbiology. Advance online publication. doi: 10.1111/mmi.15035 Journal - Research Article
Hampton, M. B., & Dickerhof, N. (2023). Inside the phagosome: A bacterial perspective. Immunological Reviews. Advance online publication. doi: 10.1111/imr.13182 Journal - Research Other
Taylor, M. F., Black, M. A., Hampton, M. B., & Ledgerwood, E. C. (2023). Insights into H2O2-induced signaling in Jurkat cells from analysis of gene expression. Free Radical Research. Advance online publication. doi: 10.1080/10715762.2023.2165073 Journal - Research Article
Seddon, A. R., Das, A. B., Hampton, M. B., & Stevens, A. J. (2023). Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress. Human Molecular Genetics, 32(4), 632-648. doi: 10.1093/hmg/ddac232 Journal - Research Article
Hampton, M., Kettle, T., Gladyshev, V., & Sly, P. (2022, December). Where are oxidative footprints leading us? Panel discussion at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M., Winterbourn, C., Dick, T., & Murphy, M. (2022, December). What are redox signals telling us? Panel discussion at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M. (2022, October). Redox biology comes of age. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation]. Other Research Output
Hampton, M. B. (2022). Redox signalling comes of age. Proceedings of the ComBio Conference. (pp. 86). Retrieved from https://combio.org.au/combio2022/ Conference Contribution - Published proceedings: Abstract
Ashby, L. V., Dickerhof, N., Springer, R., Hampton, M. B., & Kettle, A. J. (2022, August). Bacterial resistance to oxidants in neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Shearer, H. L., Parker, H. A., Pace, P. E., Hampton, M. B., & Dickerhof, N. (2022, August). Sensitising Streptococcus pneumoniae to oxidative stress. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Dickerhof, N., Parker, H. A., Hampton, M. B., & Kettle, A. J. (2022, August). Gauging the exposure of bacteria to toxic oxidants inside neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Featherston, T., Khor, C., Paumann-Page, M., & Hampton, M. (2022, August). Reprogrammed antioxidant defences in metastatic melanoma cells. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Pace, P. E., Peskin, A. V., Winterbourn, C. C., & Hampton, M. B. (2022, August). Disrupting the oligomeric structure of peroxiredoxins in cancer cells using CRISPR. Poster session presented at the CRISPR Technologies Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Shearer, H. L., Pace, P. E., Paton, J. C., Hampton, M. B., & Dickerhof, N. (2022). A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid. Journal of Biological Chemistry, 298(9), 102359. doi: 10.1016/j.jbc.2022.102359 Journal - Research Article
Swaminathan, A., Borichevsky, G. M., Edwards, T. S., Hirschfeld, E., Mules, T. C., Frampton, C. M. A., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2022). Faecal myeloperoxidase as a biomarker of endoscopic activity in inflammatory bowel disease. Journal of Crohn's & Colitis, 16, 1862-1873. doi: 10.1093/ecco-jcc/jjac098 Journal - Research Article
Hampton, M. (2022, July). Redox biology and immunology: Exploring new connections. Plenary presentation at the New Zealand Branch of the Australian and New Zealand Society for Immunology (NZASI) Conference, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Ashby, L. V., Springer, R., Loi, V. V., Antelmann, H., Hampton, M. B., Kettle, A. J., & Dickerhof, N. (2022). Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes. Journal of Leukocyte Biology, 112, 591-605. doi: 10.1002/jlb.4hi1021-538rr Journal - Research Article
Smyth, L. C. D., Murray, H. C., Hill, M., van Leeuwen, E., Highet, B., Magon, N. J., … Mathiesen, S. N., Mockett, B., … Clarkson, A. N., … Abraham, W. C., Hughes, S. M., … Kettle, A. J., … Hampton, M. B. (2022). Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease. Acta Neuropathologicca Communications, 10, 38. doi: 10.1186/s40478-022-01347-2 Journal - Research Article
van Leeuwen, E., Hampton, M. B., & Smyth, L. C. D. (2022). Hypothiocyanous acid disrupts the barrier function of brain endothelial cells. Antioxidants, 11, 608. doi: 10.3390/antiox11040608 Journal - Research Article
Shearer, H. L., Kaldor, C. D., Hua, H., Kettle, A. J., Parker, H. A., & Hampton, M. B. (2022). Resistance of Streptococcus pneumoniae to hypothiocyanous acid generated by host peroxidases. Infection & Immunity, 90(3), e00530-21. doi: 10.1128/iai.00530-21 Journal - Research Article
Shearer, H. L., Paton, J. C., Hampton, M. B., & Dickerhof, N. (2022). Glutathione utilization protects Streptococcus pneumoniae against lactoperoxidase-derived hypothiocyanous acid. Free Radical Biology & Medicine, 179, 24-33. doi: 10.1016/j.freeradbiomed.2021.12.261 Journal - Research Article
Shearer, H. L., Hampton, M. B., & Dickerhof, N. (2022). Bactericidal activity of the oxidants derived from mammilian heme peroxidases. In C. L. Hawkins & W. M. Nauseef (Eds.), Mammalian heme peroxidases: Diverse roles in health and disease. (pp. 171-188). Boca Raton, FL: CRC Press. doi: 10.1201/9781003212287 Chapter in Book - Research
Featherston, T., Paumann-Page, M., Dickerhof, N., Kaldor, C., Winterbourn, C. C., & Hampton, M. B. (2021). Measuring and exploiting oxidative stress in metastatic melanoma. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 281). Retrieved from https://www.faobmb2021.org Conference Contribution - Published proceedings: Abstract
Borichevsky, G., Swaminathan, A., Edwards, T., Day, A., Hampton, M., Kettle, A., & Gearry, R. (2021). Faecal myeloperoxidase is a biomarker of endoscopically active inflammatory bowel disease. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 234). Retrieved from https://www.faobmb2021.org Conference Contribution - Published proceedings: Abstract
Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukaemia. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 183). Retrieved from https://www.faobmb2021.org Conference Contribution - Published proceedings: Abstract
Shearer, H. L., Parker, H. A., Paton, J., Camilli, A., Pace, P. E., Dickerhof, N., & Hampton, M. B. (2021). Sensitising Streptococcus pneumoniae to oxidative stress. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 145). Retrieved from https://www.faobmb2021.org Conference Contribution - Published proceedings: Abstract
Heath, S. G., Magon, N. J., Winterbourn, C. C., Hampton, M., Morris, V. K., & Göbl, C. (2021). Oxidation induced amyloid formation of the tumour suppressor protein p16. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 33). Retrieved from https://www.faobmb2021.org Conference Contribution - Published proceedings: Abstract
Paumann-Page, M., Meredith, S., Eccles, M., Hampton, M., & Winterbourn, C. (2021). Investigating the role of peroxidasin in cancer cell invasion. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 278). Retrieved from https://www.faobmb2021.org Conference Contribution - Published proceedings: Abstract
van Leeuwen, E., Smyth, L., Pace, P., & Hampton, M. (2021). Hypothiocyanous acid oxidizes collapsin response mediator protein 2 in brain pericytes. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 277). Retrieved from https://www.faobmb2021.org Conference Contribution - Published proceedings: Abstract
Taylor, M., Black, M., Hampton, M., & Ledgerwood, L. (2021). Transcriptional response of Jurkat T lymphoma cells to hydrogen peroxide. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 276). Retrieved from https://www.faobmb2021.org Conference Contribution - Published proceedings: Abstract
Kettle, A. J., Ashby, L. V., Das, A. B., Dickerhof, N., Hampton, M. B., & Winterbourn, C. C. (2021). What's so super about superoxide? Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 275). Retrieved from https://www.faobmb2021.org Conference Contribution - Published proceedings: Abstract
Parker, H. A., Forrester, L., Kaldor, C. D., Dickerhof, N., & Hampton, M. B. (2021). Antimicrobial activity of neutrophils against mycobacteria. Frontiers in Immunology, 12, 782495. doi: 10.3389/fimmu.2021.782495 Journal - Research Other
Parker, H. A., Jones, H. M., Kaldor, C. D., Hampton, M. B., & Winterbourn, C. C. (2021). Neutrophil NET formation with microbial stimuli requires late stage NADPH oxidase activity. Antioxidants, 10, 1791. doi: 10.3390/antiox10111791 Journal - Research Article
Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukemia. Frontiers in Oncology, 11, 709543. doi: 10.3389/fonc.2021.709543 Journal - Research Article
Pearson, A. G., Pullar, J. M., Cook, J., Spencer, E. S., Vissers, M. C. M., Carr, A. C., & Hampton, M. B. (2021). Peroxiredoxin 2 oxidation reveals hydrogen peroxide generation within erythrocytes during high-dose vitamin C administration. Redox Biology, 43, 101980. doi: 10.1016/j.redox.2021.101980 Journal - Research Article
Seddon, A. R., Liau, Y., Pace, P. E., Miller, A. L., Das, A. B., Kennedy, M. A., Hampton, M. B., & Stevens, A. J. (2021). Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells. Epigenetics & Chromatin, 14(1), 17. doi: 10.1186/s13072-021-00388-6 Journal - Research Article
Schindler, L., Smyth, L. C. D., Bernhagen, J., Hampton, M. B., & Dickerhof, N. (2021). Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils. Redox Biology, 41, 101946. doi: 10.1016/j.redox.2021.101946 Journal - Research Article
Parker, H. A., Dickerhof, N., Forrester, L., Ryburn, H., Smyth, L., Messens, J., Aung, H. L., Cook, G. M., Kettle, A. J., & Hampton, M. B. (2021). Mycobacterium smegmatis resists the bactericidal activity of hypochlorous acid produced in neutrophil phagosomes. Journal of Immunology, 206, 1901-1912. doi: 10.4049/jimmunol.2001084 Journal - Research Article
Schindler, L., Zwissler, L., Krammer, C., Hendgen-Cotta, U., Rassaf, T., Hampton, M. B., Dickerhof, N., & Bernhagen, J. (2021). Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells. Journal of Leukocyte Biology, 110, 893-905. doi: 10.1002/JLB.3A0420-242RRR Journal - Research Article
Das, A. B., Seddon, A. R., O'Connor, K. M., & Hampton, M. B. (2021). Regulation of the epigenetic landscape by immune cell oxidants. Free Radical Biology & Medicine, 170, 131-149. doi: 10.1016/j.freeradbiomed.2020.12.453 Journal - Research Article
Königstorfer, A., Ashby, L. V., Bollar, G. E., Billiot, C. E., Gray, M. J., Jakob, U., Hampton, M. B., & Winterbourn, C. C. (2021). Induction of the reactive chlorine-responsive transcription factor RclR in Escherichia coli following ingestion by neutrophils. Pathogens & Disease, 79, ftaa079. doi: 10.1093/femspd/ftaa079 Journal - Research Article
Mayyas, I. M., Weeks, R. J., Day, R. C., Magrath, H. E., O’Connor, K. M., Kardailsky, O., Hore, T. A., Hampton, M. B., & Morison, I. M. (2021). Hairpin-bisulfite sequencing of cells exposed to decitabine documents the process of DNA demethylation. Epigenetics, 16(11), 1251-1259. doi: 10.1080/15592294.2020.1861169 Journal - Research Article
Magon, N. J., Parker, H. A., Ashby, L. V., Springer, R. J., & Hampton, M. B. (2020). Analysis of neutrophil bactericidal activity. In M. T. Quinn & F. R. DeLeo (Eds.), Neutrophil: Methods and protocols: Methods in molecular biology (Vol. 2087). (3rd ed.) (pp. 149-164). New York, NY: Humana Press. doi: 10.1007/978-1-0716-0154-9_12 Chapter in Book - Research
Ashby, L. V., Springer, R., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2020). Evaluating the bactericidal action of hypochlorous acid in culture media [Short communication]. Free Radical Biology & Medicine, 159, 119-124. doi: 10.1016/j.freeradbiomed.2020.07.033 Journal - Research Other
Van Leeuwen, E., Hampton, M. B., & Smyth, L. C. D. (2020). Redox signalling and regulation of the blood-brain barrier. International Journal of Biochemistry & Cell Biology, 125, 105794. doi: 10.1016/j.biocel.2020.105794 Journal - Research Article
Pearson, A. G., Zawari, M., Pearson, J. F., & Hampton, M. B. (2020). Quantifying mitochondrial respiration in human lymphocytes and monocytes challenged with hydrogen peroxide. Free Radical Research, 54(4), 271-279. doi: 10.1080/10715762.2020.1753722 Journal - Research Article
O'Connor, K. M., Das, A. B., Winterbourn, C. C., & Hampton, M. B. (2020). Inhibition of DNA methylation in proliferating human lymphoma cells by immune cell oxidants. Journal of Biological Chemistry, 295(23), 7839-7848. doi: 10.1074/jbc.RA120.013092 Journal - Research Article
Meng, Y., Sheen, C. R., Magon, N. J., Hampton, M. B., & Dobson, R. C. J. (2020). Structure-function analyses of alkylhydroperoxidase D from Streptococcus pneumoniae reveal an unusual three-cysteine active site architecture. Journal of Biological Chemistry, 295(10), 2984-2999. doi: 10.1074/jbc.RA119.012226 Journal - Research Article
Das, A. B., Hampton, M. B., & Vissers, M. C. M. (2019, August-September). Creodes and cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Fischer, J., Eglinton, T., Frizelle, F., Pace, P., Pearson, A., & Hampton, M. (2019). Marker of oxidative stress as a novel predictor of response to neoadjuvant chemoradiotherapy for rectal cancer. ANZ Journal of Surgery, 89(Suppl. 1), (pp. 25). doi: 10.1111/ans.15180 Conference Contribution - Published proceedings: Abstract
Talla, U., Bozonet, S. M., Parker, H. A., Hampton, M. B., & Vissers, M. C. M. (2019). Prolonged exposure to hypoxia induces an autophagy-like cell survival program in human neutrophils. Journal of Leukocyte Biology, 106, 1367-1379. doi: 10.1002/jlb.4a0319-079rr Journal - Research Article
Dickerhof, N., Isles, V., Pattemore, P., Hampton, M. B., & Kettle, A. J. (2019). Exposure of Pseudomonas aeruginosa to bactericidal hypochlorous acid during neutrophil phagocytosis is compromised in cystic fibrosis. Journal of Biological Chemistry, 294(36), 13502-13514. doi: 10.1074/jbc.RA119.009934 Journal - Research Article
de Souza, L. F., Pearson, A. G., Pace, P. E., Dafre, A. L., Hampton, M. B., Meotti, F. C., & Winterbourn, C. C. (2019). Peroxiredoxin expression and redox status in neutrophils and HL-60 cells. Free Radical Biology & Medicine, 135, 227-234. doi: 10.1016/j.freeradbiomed.2019.03.007 Journal - Research Article
Albrett, A. M., Ashby, L. V., Dickerhof, N., Hampton, M. B., Winterbourn, C. C., & Kettle, A. J. (2018). Detection of hypochlorous acid in neutrophil phagosomes with the probe R19S: Chlorinated product formation and real-time fluorescence. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 112-113). Retrieved from https://www.nzmsconference.org.nz Conference Contribution - Published proceedings: Abstract
Kaldor, C. D., Parker, H. A., & Hampton, M. B. (2018). Oxidant production by Streptococcus pneumoniae associated with neutrophil extracellular traps. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 108). Retrieved from https://www.nzmsconference.org.nz Conference Contribution - Published proceedings: Abstract
Parker, H. A., Jones, M. G., Kaldor, C. D., Hampton, M. B., & Winterbourn, C. C. (2018). Timing of reactive oxygen species involvement in formation of neutrophil extracellular traps. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 100). Retrieved from https://www.nzmsconference.org.nz Conference Contribution - Published proceedings: Abstract
Parker, H. A., Hampton, M. B., Rosado, L. A., Messens, J., & Kettle, A. J. (2018). Resistance of Mycobacterium smegmatis to oxygen-dependent killing by neutrophils. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 95-96). Retrieved from https://www.nzmsconference.org.nz Conference Contribution - Published proceedings: Abstract
Mayyas, I., Weeks, R., Hampton, M., Hore, T., & Morison, I. (2018, August). Mechanisms of active DNA demethylation in somatic cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Fischer, J., Eglinton, T. W., Frizelle, F. A., & Hampton, M. B. (2018). Peroxiredoxins in colorectal cancer: Predictive biomarkers of radiation response and therapeutic targets to increase radiation sensitivity? Antioxidants, 7(10), 136. doi: 10.3390/antiox7100136 Journal - Research Other
Pace, P. E., Peskin, A. V., Konigstorfer, A., Jasoni, C. L., Winterbourn, C. C., & Hampton, M. B. (2018). Peroxiredoxin interaction with the cytoskeletal-regulatory protein CRMP2: Investigation of a putative redox relay. Free Radical Biology & Medicine, 129, 383-393. doi: 10.1016/j.freeradbiomed.2018.10.407 Journal - Research Article
Richards, S. J. G., Frizelle, F. A., Geddes, J. A., Eglinton, T. W., & Hampton, M. B. (2018). Frailty in surgical patients. International Journal of Colorectal Disease, 33(12), 1657-1666. doi: 10.1007/s00384-018-3163-y Journal - Research Article
Swan, J., Aitchison, A., Hampton, M., & Keenan, J. (2018, September). Asprin's role in preventing e-cadherin cleavage by the carcinogenic Bacteroides Fragilis toxin. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Kaldor, C., Parker, H., Cook, G., & Hampton, M. (2018, September). Streptococcus Pneumoniae adhered to neutrophil extracellular traps produce hydrogen peroxide which is converted into hypochlorous acid. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Springer, R., Ashby, L., Kettle, A., Winterbourn, C., & Hampton, M. (2018, September). Staphylococcus Aureus survival inside the neutrophil phagosome. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Vick, K., Kaur, G., Doroshow, J., Winterbourn, C., & Hampton, M. (2018). Peroxiredoxins as markers of oxidative stress in cancer cells. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/ Conference Contribution - Published proceedings: Abstract
Dagnell, M., Cheng, Q., Pace, P. E., Hampton, M. B., Winterbourn, C. C., & Arnér, E. S. J. (2018). Bicarbonate is required for hydrogen peroxide-dependent inactivation of PTP1B in presence of the Trx system and peroxiredoxin. Free Radical Biology & Medicine, 120(Suppl. 1), (pp. S36). doi: 10.1016/j.freeradbiomed.2018.04.123 Conference Contribution - Published proceedings: Abstract
Yewdall, N. A., Peskin, A. V., Hampton, M. B., Goldstone, D. C., Pearce, F. G., & Gerrard, J. A. (2018). Quaternary structure influences the peroxidase activity of peroxiredoxin 3. Biochemical & Biophysical Research Communications, 497(2), 558-563. doi: 10.1016/j.bbrc.2018.02.093 Journal - Research Article
Hampton, M. B. (2018). Hydrogen peroxide-dependent redox signaling: Basic concepts and unanswered questions. In M. C. M. Vissers, M. B. Hampton & A. J. Kettle (Eds.), Hydrogen peroxide metabolism in health and disease. (pp. 353-364). Boca Raton, FL: CRC Press. Chapter in Book - Research
Vissers, M. C. M., Hampton, M. B., & Kettle, A. J. (Eds.). (2018). Hydrogen peroxide metabolism in health and disease. Boca Raton, FL: CRC Press, 456p. Edited Book - Research
Hampton, M. B., Vick, K. A., Skoko, J. J., & Neumann, C. A. (2018). Peroxiredoxin involvement in the initiation and progression of human cancer. Antioxidants & Redox Signaling, 28(7), 591-608. doi: 10.1089/ars.2017.7422 Journal - Research Article
Mayyas, I., Weeks, R., Hampton, M., & Morison, I. (2017). Mechanisms of active DNA demethylation in somatic cells. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 770. Retrieved from http://gen2017.w.events4you.currinda.com Conference Contribution - Published proceedings: Abstract
Schindler, L., Dickerhof, N., Hampton, M. B., & Bernhagen, J. (2017). Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning. Redox Biology, 15, 135-142. doi: 10.1016/j.redox.2017.11.028 Journal - Research Article
Bozonet, S., Hampton, M., & Vissers, M. (2017, September). Hypothiocyanous acid protects endothelial cells from hypochlorous acid-mediated death. Poster session presented at the European Cell Death Organisation (ECDO)25gth Conference: Cell Death and Immunity in Disease: From Molecules to Translational Medicine, Leuven, Belgium. Conference Contribution - Poster Presentation (not in published proceedings)
Pearson, A. G., Zawari, M., & Hampton, M. B. (2017, September). Assessing mitochondrial activity and response to oxidative stress in human monocyte and lymphocytes. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
O'Connor, K. M., Konigstorfer, A., Zawari, M., Betz, A., Heath, S., Hildebrand, J. M., … Hampton, M. (2017, September). MLKL-dependent disruption of mitochondrial function and redox homeostasis during the initiation of TNF-mediated necroptosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Mayyas, I., Weeks, R., Hampton, M., & Morison, I. (2017, September). Mechanisms of active DNA demethylation in somatic cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Talla, U. R., Parker, H., Bozonet, S., Hampton, M., & Vissers, M. (2017, July). An altered cell death pathway for neutrophils in a hypoxic environment. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M. B., Dickerhof, N., Pace, P. E., & Bozonet, S. M. (2017, July). Redox signalling and the regulation of immune cell life and death. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Forbes, L. V., Konigstorfer, A., Gray, M. J., Jakob, U., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2017, July). Bacterial resistance to neutrophil-derived oxidants. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Pearson, A., Zawari, M., & Hampton, M. B. (2017, July). Assessment of mitochondrial metabolism in immune cells. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Hoskin, T. S., Dickerhof, N., Hampton, M. B., & Kettle, A. J. (2017, July). Calprotectin is sensitive to oxidants generated by myeloperoxidase. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Parker, H., Jones, M., Hampton, M., & Winterbourn, C. (2017, July). Oxidant-dependent steps in the formation of neutrophil extracellular traps. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Dagnell, M., Pace, P. E., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E. S. J., Hampton, M. B., & Winterbourn, C. C. (2017). Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure. Journal of Biological Chemistry, 292(35), 14371-14380. doi: 10.1074/jbc.M117.793745 Journal - Research Article
Spencer, E. S., O'Connor, K. M., & Hampton, M. B. (2017). Isothiocyanates trigger early disruption of mitochondrial function in cells overexpressing Bcl-2. Free Radical Biology & Medicine, 108(Suppl. 1), (pp. S51). doi: 10.1016/j.freeradbiomed.2017.04.185 Conference Contribution - Published proceedings: Abstract
Pearson, A. G., Moran, S. M., Zawari, M., & Hampton, M. B. (2016). Peroxiredoxins as markers of oxidative stress in circulating blood cells. Free Radical Biology & Medicine, 100(Suppl.), (pp. S106). doi: 10.1016/j.freeradbiomed.2016.10.270 Conference Contribution - Published proceedings: Abstract
Talla, U. R., Bozonet, S., Parker, H., Hampton, M., & Vissers, M. (2016). Inhibition of neutrophil apoptosis and initiation of an autophagy-like process in hypoxia and effects on neutrophil function. Free Radical Biology & Medicine, 100(Suppl.), (pp. S63). doi: 10.1016/j.freeradbiomed.2016.10.166 Conference Contribution - Published proceedings: Abstract
Pace, P., Peskin, A. V., Jasoni, C. L., Winterbourn, C., & Hampton, M. (2016). Interaction of peroxiredoxin 2 with collapsin response mediator protein 2. Free Radical Biology & Medicine, 100(Suppl.), (pp. S47). doi: 10.1016/j.freeradbiomed.2016.10.126 Conference Contribution - Published proceedings: Abstract
Dagnell, M., Pace, P., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E., Hampton, M., & Winterbourn, C. (2016). Thioredoxin reductase 1 directly protects protein tyrosine phosphatase 1B from inactivation by H2O2. Free Radical Biology & Medicine, 100(Suppl.), (pp. S47). doi: 10.1016/j.freeradbiomed.2016.10.125 Conference Contribution - Published proceedings: Abstract
Newman, T., Leeke, B., Carleton, C., Leask, M., Hampton, M., & Horsfield, J. (2016). How zebrafish can help understand craniofacial biology. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 16-17). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026 Conference Contribution - Published proceedings: Abstract
Cuddihy, S. L., Drake, S., Harwood, T., Selwood, A. I., McNabb, P. S., & Hampton, M. B. (2016). The marine cytotoxin portimine is a potent and selective inducer of apoptosis. Apoptosis, 21(12), 1447-1452. doi: 10.1007/s10495-016-1302-x Journal - Research Article
Bayer, S. B., Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2016). Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane. Free Radical Research, 50(12), 1329-1339. doi: 10.1080/10715762.2016.1241995 Journal - Research Article
Bolaños, J. P., Cadenas, E., Duchen, M. R., Hampton, M. B., Mann, G. E., & Murphy, M. P. (2016). Introduction to special issue on mitochondrial redox signaling in health and disease. Free Radical Biology & Medicine, 100, 1-4. doi: 10.1016/j.freeradbiomed.2016.08.004 Journal - Research Other
Yewdall, N. A., Venugopal, H., Desfosses, A., Abrishami, V., Yosaatmadja, Y., Hampton, M. B., … Radjainia, M. (2016). Structures of human peroxiredoxin 3 suggest self-chaperoning assembly that maintains catalytic state. Structure, 24(7), 1120-1129. doi: 10.1016/j.str.2016.04.013 Journal - Research Article
Winterbourn, C. C., Kettle, A. J., & Hampton, M. B. (2016). Reactive oxygen species and neutrophil function. Annual Review of Biochemistry, 85, 765-792. doi: 10.1146/annurev-biochem-060815-014442 Journal - Research Other
Hampton, M. B., & O'Connor, K. M. (2016). Peroxiredoxins and the regulation of cell death. Molecules & Cells, 39(1), 72-76. doi: 10.14348/molcells.2016.2351 Journal - Research Other
Poynton, R. A., Peskin, A. V., Haynes, A. C., Lowther, W. T., Hampton, M. B., & Winterbourn, C. C. (2016). Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation. Biochemical Journal, 473, 411-421. doi: 10.1042/bj20150572 Journal - Research Article
Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2015, September). Myeloperoxidase-derived oxidants render macrophage migration inhibitory factor (MIF) enzymatically inactive while retaining its immunologic function. Verbal presentation at the 9th International Human Peroxidase Meeting, Cologne, USA. Conference Contribution - Verbal presentation and other Conference outputs
Venugopal, H., Radjainia, M., Desfosses, A., Phillips, A. J., Yewdall, A. J., Hampton, M. B., … Mitra, A. K. (2015, August-September). High resolution cryo-electron microscopy structure of human peroxiredoxin-3 filament reveals the assembly of a putative chaperone. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Newman, T. A. C., Carleton, C. R., Leeke, B., Hampton, M. B., & Horsfield, J. A. (2015). Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biology, 6, 648-655. doi: 10.1016/j.redox.2015.10.010 Journal - Research Article
Dickerhof, N., Schindler, L., Bernhagen, J., Kettle, A. J., & Hampton, M. B. (2015). Macrophage migration inhibitory factor (MIF) Is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function. Free Radical Biology & Medicine, 89, 498-511. doi: 10.1016/j.freeradbiomed.2015.09.009 Journal - Research Article
Spencer, E., Dickerhof, N., Tyndall, J., Bernhagen, J., Kettle, A., & Hampton, M. (2015). Assessing inhibition of macrophage migration inhibitory factor by isothiocyanates. Free Radical Biology & Medicine, 86(Suppl. 1), (pp. S42-S43). doi: 10.1016/j.freeradbiomed.2015.07.145 Conference Contribution - Published proceedings: Abstract
Balasubramanain, D., Deng, A. X., Doudney, K., Hampton, M. B., & Kennedy, M. A. (2015). Valproic acid exposure leads to upregulation and increased promoter histone acetylation of sepiapterin reductase in a serotonergic cell line. Neuropharmacology, 99, 79-88. doi: 10.1016/j.neuropharm.2015.06.018 Journal - Research Article
Magon, N. J., Turner, R., Gearry, R. B., Hampton, M. B., Sly, P. D., & Kettle, A. J. (2015). Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis. Free Radical Biology & Medicine, 86, 133-144. doi: 10.1016/j.freeradbiomed.2015.05.022 Journal - Research Article
Radjainia, M., Venugopal, H., Desfosses, A., Phillips, A. M., Yewdall, N. A., Hampton, M. B., … Mitra, A. K. (2015). Cryo-electron microscopy structure of human peroxiredoxin-3 filament reveals the assembly of a putative chaperone. Structure, 23(5), 912-920. doi: 10.1016/j.str.2015.03.019 Journal - Research Article
Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012 Journal - Research Article
Wilkie-Grantham, R. P., Magon, N. J., Harwood, D. T., Kettle, A. J., Vissers, M. C., Winterbourn, C. C., & Hampton, M. B. (2015). Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils. Journal of Biological Chemistry, 290(15), 9896-9905. doi: 10.1074/jbc.M114.613422 Journal - Research Article
Bayer, S. B., Hampton, M. B., & Winterbourn, C. C. (2015). Accumulation of oxidized peroxiredoxin 2 in red blood cells and its prevention. Transfusion, 55(8), 1909-1918. doi: 10.1111/trf.13039 Journal - Research Article
Jodczyk, S., Pearson, J. F., Aitchison, A., Miller, A. L., Hampton, M. B., & Kennedy, M. A. (2015). Telomere length measurement on the Roche LightCycler 480 platform. Genetic Testing & Molecular Biomarkers, 19(2), 63-68. doi: 10.1089/gtmb.2014.0208 Journal - Research Article
Winterbourn, C. C., & Hampton, M. B. (2015). Signaling via a peroxiredoxin sensor. Nature Chemical Biology, 11(1), 5-6. doi: 10.1038/nchembio.1722 Journal - Research Other
Jodczyk, S., Pearson, J. F., Fergusson, D. M., Horwood, L. J., Spittlehouse, J. K., Joyce, P. R., Hampton, M. B., & Kennedy, M. A. (2014). No association between telomere length and exposure to life course stress or adversity in two longitudinal New Zealand cohorts. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 1325M. Retrieved from http://www.ashg.org/ Conference Contribution - Published proceedings: Abstract
Hampton, M. (2014, December). Mitochondrial redox changes during TNF-mediated necroptosis. Verbal presentation at the Society for Free Radical Research Australasia 22nd Annual Scientific Meeting, Melbourne, Australia. Conference Contribution - Verbal presentation and other Conference outputs
Tyndall, J. D. A., Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., & Hampton, M. B. (2014, August). Multiple binding modes of isothiocyanate inhibitors of macrophage migration inhibitory factor define design strategies. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Jodczyk, S., Pearson, J., Fergusson, D., Horwood, J., Spittlehouse, J., Joyce, P., Hampton, M., & Kennedy, M. (2014, September). No association between telomere length and exposure to life course stress in two longitudinal New Zealand cohorts. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Dickerhof, N., Magon, N. J., Tyndall, J. D. A., Kettle, A. J., & Hampton, M. B. (2014). Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependant oxidation of epicatechins. Biochemical Journal, 462(2), 303-314. doi: 10.1042/BJ20140612 Journal - Research Article
Jodczyk, S., Pearson, J. F., Fergusson, D. M., Horwood, L. J., Spittlehouse, J. K., Joyce, P. R., Hampton, M. B., & Kennedy, M. A. (2014). Association between telomere length and life stress in two New Zealand cohorts. New Zealand Medical Journal, 127(1396). Retrieved from http://www.nzma.org.nz/journal Conference Contribution - Published proceedings: Abstract
Tyndall, J. D. A., Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., & Hampton, M. B. (2014). Multiple binding modes of isothiocyanate inhibitors of macrophage migration inhibitory factor define structure activity relationships. Proceedings of the CRYSTAL29: 29th Biennial Conference of the Society of Crystallographers in Australia and New Zealand (SCANZ). (pp. 88). Retrieved from http://www.crystal29.com/ Conference Contribution - Published proceedings: Abstract
Parker, H. A., Magon, N. J., Green, J. N., Hampton, M. B., & Winterbourn, C. C. (2014). Analysis of neutrophil bactericidal activity. In M. T. Quinn & F. R. DeLeo (Eds.), Neutrophil methods and protocols: Methods in Molecular Biology (Vol. 1124). (2nd ed.) (pp. 291-306). New York, NY: Springer. doi: 10.1007/978-1-62703-845-4_19 Chapter in Book - Research
Poynton, R. A., & Hampton, M. B. (2014). Peroxiredoxins as biomarkers of oxidative stress. Biochimica et Biophysica Acta: General Subjects, 1840(2), 906-912. doi: 10.1016/j.bbagen.2013.08.001 Journal - Research Article
Gommans, A. L., Tyndall, J. D. A., Hampton, M. B., & Wilbanks, S. M. (2013, February). Improved resolution of macrophage migration inhibitory factor complexed with phenethyl isothiocyanate. Verbal presentation at the 38th Lorne Conference on Protein Structure and Function, Lorne, Australia. Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M. (2013). New ways of thinking about and measuring oxidative stress. Proceedings of the Gravida Annual Science Symposium: How Can We Create a Better Future For All New Zealanders? Retrieved from http://www.gravida.org.nz/video/gravida-science-symposium-2013/ Conference Contribution - Published proceedings: Abstract
Magon, N. J., Turner, R., Dickerhof, N., Gearry, R., Hampton, M., Sly, P., & Kettle, A. (2013). Oxidation of methionine in calprotectin by neutrophils in the airways of children with cystic fibrosis. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S62-S63). doi: 10.1016/j.freeradbiomed.2013.10.535 Conference Contribution - Published proceedings: Abstract
Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013). Covalent modification of the pro-inflammatory cytokine MIF by dietary and endogenous electrophiles. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S35-S36). doi: 10.1016/j.freeradbiomed.2013.10.470 Conference Contribution - Published proceedings: Abstract
Peskin, A. V., Dickerhof, N., Paton, L. N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidation of human peroxiredoxin 2 and 3. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
O'Connor, K. M., & Hampton, M. B. (2013, August). Using the Seahorse Bioscience Extracellular Flux Analyzer to measure the consequences of oxidative stress on mitochondrial function. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Ejje, N., Deuss, F. A., Puskar, L., Hampton, M. B., & Giles, G. I. (2013, August). Analysis of the intracellular targets of auranofin drug action by Synchrotron Radiation Fourier Transform Infrared Spectroscopy. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Covalent modification of the pro-inflammatory cytokine MIF by dietary and endogenous electrophiles. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Vick, K. A., Betz, A., O'Connor, K. M., Hughes, S. M., Ledgerwood, E. C., & Hampton, M. B. (2013, August). Functional consequences of lowering mitochondrial peroxiredoxin 3 expression. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Spencer, E. S., Dale, E., Smith, R. A. J., Gamble, A. B., Tyndall, J. D. A., Rutledge, M. T., Wilbanks, S. M., Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Assessing inhibition of macrophage migration inhibitory factor by novel isothiocyanates. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Pujary, U. R., Hampton, M., Parker, H., & Vissers, M. (2013, August). Effect of hypoxia on neutrophil survival and function. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Poynton, R. A., Peskin, A. V., Dickerhof, N., Lowther, T. W., Betz, A., Winterbourn, C. C., & Hampton, M. B. (2013, August). Kinetics and biochemical properties of peroxiredoxin 3 hyperoxidation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Newman, T. A. C., Hampton, M. B., & Horsfield, J. A. (2013, August). The developmental consequences of oxidative stress. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2013, August). Oxidised calprotectin as a biomarker for inflammatory disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Bayer, S. B., Maghzal, G., Stocker, R., Hampton, M. B., & Winterbourn, C. C. (2013, August). Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Gommans, A., Hampton, M. B., Tyndall, J. D. A., & Wilbanks, S. M. (2013, August). Improved-resolution structure of macrophage migration inhibitory factor complexed with phenethyl isothiocyanate. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Falvey, J. D., Bentley, R. W., Merriman, T. R., Hampton, M. B., Barclay, M. L., Gearry, R. B., & Roberts, R. L. (2013). Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis. World Journal of Gastroenterology, 19(39), 6656-6664. doi: 10.3748/wjg.v19.i39.6656 Journal - Research Article
Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Biochemical Journal, 453, 475-485. doi: 10.1042/BJ20130030 Journal - Research Article
Bayer, S. B., Maghzal, G., Stocker, R., Hampton, M. B., & Winterbourn, C. C. (2013). Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation. FASEB Journal, 27(8), 3315-3322. doi: 10.1096/fj.13-227298 Journal - Research Article
Peskin, A. V., Dickerhof, N., Poynton, R. A., Paton, L. N., Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidation of peroxiredoxins 2 and 3: Rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine. Journal of Biological Chemistry, 288, 14170-14177. doi: 10.1074/jbc.M113.460881 Journal - Research Article
Hampton, M. (2013, February). Exploring nature's medicine chest. Verbal presentation at the Christchurch Medical School 40th Anniversary Celebrations, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Kumar, V., Kleffmann, T., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2013). Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry. Free Radical Biology & Medicine, 58, 109-117. doi: 10.1016/j.freeradbiomed.2013.01.021 Journal - Research Article
Pujary, U. R., Hampton, M., Winterbourn, C., & Vissers, M. (2012). Hypoxia extends neutrophil survival but does not necessarily retain cell function. Proceedings of the Oxygen Theme Meeting. (pp. 35). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf Conference Contribution - Published proceedings: Abstract
Pace, P., Peskin, A., Hampton, M., & Winterbourn, C. (2012). Hydrogen peroxide-dependent interaction of peroxiredoxin 2 with ERp46. Proceedings of the Oxygen Theme Meeting. (pp. 32). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf Conference Contribution - Published proceedings: Abstract
Spencer, E., Tyndall, J., Smith, R. A. J., & Hampton, M. (2012). Biological properties of isothiocyanates. Proceedings of the Oxygen Theme Meeting. (pp. 21). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf Conference Contribution - Published proceedings: Abstract
Newman, T., Hampton, M., & Horsfield, J. (2012). A developmental role for Peroxiredoxin 3. Proceedings of the Oxygen Theme Meeting. (pp. 15). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf Conference Contribution - Published proceedings: Abstract
Poynton, R., Peskin, A., Dickerhof, N., Paton, L., Winterbourn, C., & Hampton, M. (2012). Kinetics of peroxiredoxin 2 and 3 hyperoxidation. Proceedings of the Oxygen Theme Meeting. (pp. 14). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf Conference Contribution - Published proceedings: Abstract
Hampton, M. (2012). Peroxiredoxin 3 as a mitochondrial antioxidant and sensor and marker of mitochondrial oxidative stress. Proceedings of the Oxygen Theme Meeting. (pp. 13). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf Conference Contribution - Published proceedings: Abstract
Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2012). Oxidised calprotectin as a biomarker for inflammatory disease. Proceedings of the Oxygen Theme Meeting. (pp. 8). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf Conference Contribution - Published proceedings: Abstract
Newman, T., Hampton, M., & Horsfield, J. (2012, September). Peroxiredoxin 3 protects zebrafish development against mitochondrial oxidative stress. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Hampton, M., Bayer, S., Moran, S., Maghzal, G., Stocker, R., Choe, C. F., Lunt, H., Chambers, S., Peskin, A., & Winterbourn, C. (2012, November). Peroxiredoxins as biomarkers of oxidative stress. Verbal presentation at the Gravida Annual Science Symposium: What Makes the Best Start for a Healthy Life? Palmerston North, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Falvey, J. D., Hoskin, T., Meijer, B., Ashcroft, A., Hampton, M. B., Day, A. S., & Gearry, R. B. (2012). Disease assessment in Ulcerative Colitis (UC): Data from the Novel Biomarkers in Inflammatory Bowel Disease (NBIBD) project cohort. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal Conference Contribution - Published proceedings: Abstract
Falvey, J. D., Munday, J. S., Keenan, J. I., Dyer, A. E., Gearry, R. B., & Hampton, M. B. (2012). Clinical assessment of murine Dextran Sodium Sulphate (DSS) colitis: Prospective validation of a novel scoring tool. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal Conference Contribution - Published proceedings: Abstract
Falvey, J. D., Hoskin, T., Meijer, B., Ashcroft, A., Hampton, M. B., Day, A. S., & Gearry, R. B. (2012). Disease assessment in Crohn's disease (CD): Data from the Novel Biomarkers in Inflammatory Bowel Disease (NBIBD) project cohort. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal Conference Contribution - Published proceedings: Abstract
Balasubramanain, D., Hampton, M., & Kennedy, M. (2012, November). Effect of valproate on SPR gene expression in a serotonergic cell line. Verbal presentation at the 8th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Hock, B. D., Taylor, K. G., Cross, N. B., Kettle, A. J., Hampton, M. B., & McKenzie, J. L. (2012). Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability. Immunology, 137(3), 249-258. doi: 10.1111/imm.12004 Journal - Research Article
Pace, P. E., Peskin, A. V., Hampton, M. B., & Winterbourn, C. C. (2012). Hydrogen peroxide dependent interaction of peroxiredoxin 2 with ERp46. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S210). doi: 10.1016/j.freeradbiomed.2012.08.440 Conference Contribution - Published proceedings: Abstract
Peskin, A. V., Dickerhof, N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2012). Kinetics of hyperoxidation of human peroxiredoxin 2. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S210-S211). doi: 10.1016/j.freeradbiomed.2012.08.441 Conference Contribution - Published proceedings: Abstract
Tyndall, J. D. A., Lue, H., Rutledge, M. T., Bernhagen, J., Hampton, M. B., & Wilbanks, S. M. (2012). Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate. Acta Crystallographica Section F, 68(9), 999-1002. doi: 10.1107/s1744309112030552 Journal - Research Article
Stacey, M. M., Cuddihy, S. L., Hampton, M. B., & Winterbourn, C. C. (2012). Protein thiol oxidation and formation of S-glutathionylated cyclophilin A in cells exposed to chloramines and hypochlorous acid. Archives of Biochemistry & Biophysics, 527(1), 45-54. doi: 10.1016/j.abb.2012.07.011 Journal - Research Article
Parker, H., Dragunow, M., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2012). Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. Journal of Leukocyte Biology, 92(4), 841-849. doi: 10.1189/jlb.1211601 Journal - Research Article
Keenan, J. I., Salm, N., Wallace, A. J., & Hampton, M. B. (2012). Using food to reduce H. pylori-associated inflammation. Phytotherapy Research, 26(11), 1620-1625. doi: 10.1002/ptr.4618 Journal - Research Article
Hampton, M. (2011, September). Peroxiredoxins as redox sensors and signalling proteins. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Falvey, J. D., Munday, J. S., Keenan, J. I., Gearry, R. B., & Hampton, M. B. (2011). Assessing the efficacy of isothiocyanates in experimental colitis. New Zealand Medical Journal, 124(1347). Retrieved from http://journal.nzma.org.nz/journal/124-1347/5015/content.pdf Conference Contribution - Published proceedings: Abstract
Tyndall, J. D. A., Dale, E. J., Spencer, E. S., Falvey, J. D., Smith, R. A. J., & Hampton, M. B. (2011, November-December). Isothiocyanate inhibitors of the proinflammatory cytokine macrophage migration inhibitory factor. Verbal presentation at the New Zealand Institute of Chemistry (NZIC) Conference, Hamilton, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Brown, K. K., & Hampton, M. B. (2011). Biological targets of isothiocyanates. Biochimica et Biophysica Acta: General Subjects, 1810(9), 888-894. doi: 10.1016/j.bbagen.2011.06.004 Journal - Research Article
Karton, A., Nagy, P., Betz, A., Peskin, A. V., Pace, P., O'Reilly, R. J., Hampton, M. B., … Winterbourn, C. C. (2011). Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide; a kinetic and computational study. Journal of Biological Chemistry, 286(20), 18048-18055. doi: 10.1074/jbc.M111.232355 Journal - Research Article
Cuddihy, S. L., Winterbourn, C. C., & Hampton, M. B. (2011). Assessment of redox changes to hydrogen peroxide-sensitive proteins during EGF signaling. Antioxidants & Redox Signaling, 15(1), 167-174. doi: 10.1089/ars.2010.3843 Journal - Research Article
Parker, H. A., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Oxidants, MPO and calcium in neutrophil extracellular trap formation. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2010, November-December). N-terminal proline of macrophage migration inhibitory factor as a biological target of isothiocyanates. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Davies, M. J., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Removal of amino acid, peptide and protein peroxide by reaction with peroxiredoxin 2 and peroxiredoxin 3. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Cellular interactions of peroxiredoxin 2. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Bernal, A. B., Vickers, M. H., Hampton, M. B., Poynton, R. A., & Sloboda, D. M. (2010). Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring. PLoS ONE, 5(12), e15558. doi: 10.1371/journal.pone.0015558 Journal - Research Article
Falvey, J. D., Bentley, R. W., Merriman, T. R., Hampton, M. B., Barclay, M. L., Gearry, R. B., & Roberts, R. L. (2010). Gene-gene interaction between Macrophage Migration Inhibitory Factor (MIF) and NOD2 alters susceptibility to ileal Crohn's disease. New Zealand Medical Journal, 123(1327). Retrieved from http://journal.nzma.org.nz/journal/123-1327/4492/content.pdf Conference Contribution - Published proceedings: Abstract
Cuddihy, S. L., Winterbourn, C. C., & Hampton, M. B. (2010). Redox proteomics of EGF signaling. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S128). doi: 10.1016/j.freeradbiomed.2010.10.350 Conference Contribution - Published proceedings: Abstract
Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2010). Oxidised calprotectin as a biomarker for inflammatory disease. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S169). doi: 10.1016/j.freeradbiomed.2010.10.479 Conference Contribution - Published proceedings: Abstract
Brown, K. K., & Hampton, M. B. (2010). N-terminal proline of macrophage migration inhibitory factor as a biological target of isothiocyanates. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S166). doi: 10.1016/j.freeradbiomed.2010.10.468 Conference Contribution - Published proceedings: Abstract
Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, M. J., & Winterbourn, C. C. (2010). Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3. Biochemical Journal, 432, 313-321. doi: 10.1042/BJ20101156 Journal - Research Article
Parker, H., Chitcholtan, K., Hampton, M. B., & Keenan, J. I. (2010). Uptake of Helicobacter pylori outer membrane vesicles by gastric epithelial cells. Infection & Immunity, 78(12), 5054-5061. doi: 10.1128/IAI.00299-10 Journal - Research Article
Poynton, R. A., Sloboda, D. M., Vickers, M. H., Winterbourn, C. C., & Hampton, M. B. (2010, September). Peroxiredoxin 3 and oxidative stress in mitochondria. Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Keenan, J. I., Salm, N., Hampton, M. B., & Wallace, A. J. (2010). Individual and combined effects of foods on Helicobacter pylori growth. Phytotherapy Research, 24(8), 1229-1233. doi: 10.1002/ptr.3167 Journal - Research Article
Requejo, R., Chouchani, E. T., Hurd, T. R., Menger, K. E., Hampton, M. B., & Murphy, M. P. (2010). Measuring mitochondrial protein thiol redox state. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Thiol redox transitions in cell signaling: Part B: Cellular localization and signaling (Vol. 474). (pp. 123-147). San Diego, CA: Academic Press. doi: 10.1016/S0076-6879(10)74004-0 Chapter in Book - Research
Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Measuring the redox state of cellular peroxiredoxins by immunoblotting. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Thiol redox transitions in cell signaling: Part B: Cellular localization and signaling (Vol. 474). (pp. 51-66). San Diego, CA: Academic Press. doi: 10.1016/S0076-6879(10)74004-0 Chapter in Book - Research
Brown, K. K., Cox, A. G., & Hampton, M. B. (2010). Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin. FEBS Letters, 584, 1257-1262. doi: 10.1016/j.febslet.2010.02.042 Journal - Research Article
Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. Biochemical Journal, 425(2), 313-325. doi: 10.1042/BJ20091541 Journal - Research Article
Pace, P., Hampton, M., & Winterbourn, C. (2009, December). Cellular interactions of peroxiredoxins. Poster session presented at the 5th Joint Meeting of the Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia. Conference Contribution - Poster Presentation (not in published proceedings)
Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2009). Peroxiredoxin 3 is a key regulator of mitochondrial hydrogen peroxide. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract] Conference Contribution - Published proceedings: Abstract
Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, M. J., & Winterbourn, C. C. (2009). Rapid removal of amino acid, peptide and protein peroxides. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S150-S151). [Abstract] Conference Contribution - Published proceedings: Abstract
Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2009). Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. Journal of Biological Chemistry, 284(47), 32425-32433. doi: 10.1074/jbc.M109.047092 Journal - Research Article
Cox, A. G., Peskin, A. V., Paton, L. N., Winterbourn, C. C., & Hampton, M. B. (2009). Redox potential and peroxide reactivity of human peroxiredoxin 3. Biochemistry, 48(27), 6495-6501. doi: 10.1021/bi900558g Journal - Research Article
Cox, A. G., Pearson, A. G., Pullar, J. M., Jönsson, T. J., Lowther, W. T., Winterbourn, C. C., & Hampton, M. B. (2009). Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins. Biochemical Journal, 421(1), 51-58. doi: 10.1042/BJ20090242 Journal - Research Article
Kumar, V., Kitaeff, N., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2009). Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Letters, 583(6), 997-1000. doi: 10.1016/j.febslet.2009.02.018 Journal - Research Article
Cuddihy, S. L., Baty, J. W., Brown, K. K., Winterbourn, C. C., & Hampton, M. B. (2009). Proteomic detection of oxidized and reduced thiol proteins in cultured cells. Methods in Molecular Biology, 519, 363-375. doi: 10.1007/978-1-59745-281-6_23 Journal - Research Article
Hampton, M. (2008, November). Mitochondrial peroxiredoxin 3 and the regulation of apoptosis. Poster session presented at the Society for Free Radical Research Australasia Conference, Melbourne, Australia. Conference Contribution - Poster Presentation (not in published proceedings)
Hampton, M. (2008, November). Mitochondrial peroxiredoxin 3 and the regulation of apoptosis. Verbal presentation at the Society for Free Radical Research Australasia Conference, Melbourne, Australia. Conference Contribution - Verbal presentation and other Conference outputs
Cox, A. G., & Hampton, M. B. (2008). Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. New Zealand Medical Journal, 121(1271). Retrieved from Oxidation of mitochondrial peroxiredoxin 3 during the initiation of http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf Conference Contribution - Published proceedings: Abstract
Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. (2008, November). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischemia-reperfusion injury. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Wilkie, R., Vissers, M. C. M., & Hampton, M. B. (2008). A functional NADPH oxidase promotes neutrophil apoptosis by a caspase-independent mechanism. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf Conference Contribution - Published proceedings: Abstract
Brown, K. M., Winterbourn, C. C., & Hampton, M. B. (2008). Impact of oxidative stress on DNA methylation. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf Conference Contribution - Published proceedings: Abstract
Brown, K. K., & Hampton, M. B. (2008). Pro-apoptotic isothiocyanates inactivate proteins involved in maintaining mitochondrial redox homeostasis. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf Conference Contribution - Published proceedings: Abstract
Chitcholtan, K., Hampton, M., & Keenan, J. (2008). Outer membrane vesicles (OMVs) of Helicobacter pylori alter cellular signalling pathways in human gastric epithelial cells. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf Conference Contribution - Published proceedings: Abstract
Cox, A. G., Brown, K. K., Arner, E. S. J., & Hampton, M. B. (2008). The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. Biochemical Pharmacology, 76(9), 1097-1109. doi: 10.1016/j.bcp.2008.08.021 Journal - Research Article
Chitcholtan, K., Hampton, M. B., & Keenan, J. I. (2008). Outer membrane vesicles enhance the carcinogenic potential of Helicobacter pylori. Carcinogenesis, 29(12), 2400-2405. doi: 10.1093/carcin/bgn218 Journal - Research Article
Cox, A. G., Pullar, J. M., Hughes, G., Ledgerwood, E. C., & Hampton, M. B. (2008). Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. Free Radical Biology & Medicine, 44(6), 1001-1009. doi: 10.1016/j.freeradbiomed.2007.11.017 Journal - Research Article
Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2008). Peroxiredoxin 2 and peroxide metabolism in the erythrocyte. Antioxidants & Redox Signaling, 10(9), 1621-1629. doi: 10.1089/ars.2008.2081 Journal - Research Article
Winterbourn, C. C., & Hampton, M. B. (2008). Thiol chemistry and specificity in redox signaling. Free Radical Biology & Medicine, 45(5), 549-561. doi: 10.1016/j.freeradbiomed.2008.05.004 Journal - Research Article
Thomson, S. J., Cox, A. G., Cuddihy, S. L., Pullar, J. M., & Hampton, M. B. (2008). Inhibition of receptor-mediated apoptosis upon Bcl-2 overexpression is not associated with increased antioxidant status. Biochemical & Biophysical Research Communications, 375(1), 145-150. doi: 10.1016/j.bbrc.2008.07.133 Journal - Research Article
Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. J. (2008). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury. Clinical Science, 114(4), 293-304. doi: 10.1042/CS20070229 Journal - Research Article
Cuddihy, S. L., Brown, K. K., Thomson, S. J., & Hampton, M. B. (2008). Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-XL. Cancer Letters, 271(2), 215-221. doi: 10.1016/j.canlet.2008.06.002 Journal - Research Article
Brown, K. K., Eriksson, S. E., Arnér, E. S. J., & Hampton, M. B. (2008). Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates. Free Radical Biology & Medicine, 45(4), 494-502. doi: 10.1016/j.freeradbiomed.2008.04.030 Journal - Research Article
Brown, K. M., Winterbourn, C. C., & Hampton, M. B. (2007, August). Impact of oxidative stress on DNA methylation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Cox, A. G., Pullar, J. M., Hughes, G., Ledgerwood, E. C., & Hampton, M. B. (2007). Mitochondrial peroxiredoxin 3 is oxidized during Fas and TNF-a mediated apoptosis. Proceedings of the American Association for Cancer Research (AACR) 98th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/ Conference Contribution - Published proceedings: Abstract
Salm, N., Hampton, M., Wallace, A. J., & Keenan, J. (2007). Broccoli sprouts inhibit the release of interleukin-8 from AGS cells co-cultured with Helicobacter pylori. Zoonoses and Public Health. 54(Suppl. 1), (pp. 97-98). [Abstract] Conference Contribution - Published proceedings: Abstract
Chitcholtan, K., Hampton, M., & Keenan, J. (2007). H. pylori outer membrane vesicles induce DNA damage in gastric epithelial cells. Zoonoses and Public Health. 54(Suppl. 1), (pp. 155). [Abstract] Conference Contribution - Published proceedings: Abstract
Davis, K. A., Chitcholtan, K., Hampton, M., & Keenan, J. I. (2007). Helicobacter pylori outer membrane vesicles induce cytoskeletal rearrangements and cell signaling events in gastric epithelial cells. Zoonoses and Public Health. 54(Suppl. 1), (pp. 151). [Abstract] Conference Contribution - Published proceedings: Abstract
Wilkie, R. P., Vissers, M. C. M., Dragunow, M., & Hampton, M. B. (2007). A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils. Infection & Immunity, 75(7), 3256-3263. Journal - Research Article
Kettle, A. J., Anderson, R. F., Hampton, M. B., & Winterbourn, C. C. (2007). Reactions of superoxide with myeloperoxidase. Biochemistry, 46, 4888-4897. Journal - Research Article
Cox, A. G., & Hampton, M. B. (2007). Bcl-2 over-expression promotes genomic instability by inhibiting apoptosis of cells exposed to hydrogen peroxide. Carcinogenesis, 28(10), 2166-2171. Journal - Research Article
Low, F. M., Hampton, M. B., Peskin, A. V., & Winterbourn, C. C. (2007). Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte. Blood, 109(6), 2611-2617. Journal - Research Article
Peskin, A. V., Low, F. M., Paton, L. N., Maghzal, G. J., Hampton, M. B., & Winterbourn, C. C. (2007). The high reactivity of peroxiredoxin 2 with H2O2 is not reflected in its reaction with other oxidants and thiol reagents. Journal of Biological Chemistry, 282(16), 11885-11892. Journal - Research Article
Green, J. N., Winterbourn, C. C., & Hampton, M. B. (2007). Analysis of neutrophil bactericidal activity. In M. T. Quinn, F. R. DeLeo & G. M. Bokoch (Eds.), Neutrophil methods and protocols. (pp. 319-332). Totowa, USA: Humana Press. Chapter in Book - Research
Brown, K. M., Reeve, A. E., Hampton, M. B., & Winterbourn, C. (2006). Sensitivity of methionine adenosyltransferase to oxidation: A critical enzyme for DNA methylation. Free Radical Research, 40(Suppl. 1), P15-6, (pp. S131). [Abstract] Conference Contribution - Published proceedings: Abstract
Wilkie, R., Vissers, M., & Hampton, M. (2006). Role of NADPH oxidase: Derived oxidants in neutrophil apoptosis. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf Conference Contribution - Published proceedings: Abstract
Thomson, S. J., Brown, K. K., Pullar, J. M., & Hampton, M. B. (2006). Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2. Cancer Research, 66(13), 6772-6777. Journal - Research Article
Winterbourn, C. C., Hampton, M. B., Livesey, J. H., & Kettle, A. J. (2006). Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: Implications for microbial killing. Journal of Biological Chemistry, 281(52), 39860-39869. Journal - Research Article
Hampton, M. B., Baty, J. W., & Winterbourn, C. C. (2006). Use of a proteomic technique to identify oxidant-sensitive thiol proteins in cultured cells. In I. Dalle-Donne, A. Scaloni & D. A. Butterfield (Eds.), Redox Proteomics: From protein modifications to cellular dysfunction and diseases. (pp. 253-265). Hoboken, NJ: John Wiley & Sons. Chapter in Book - Research
Pullar, J. M., Baty, J. W., Csordas, A., Winterbourn, C. C., & Hampton, M. B. (2005, December). Oxidation of thiol proteins in cultured cells: Comparison of H2O2 with receptor-mediated signalling. Verbal presentation at the 3rd Joint Meeting of the Society for Free Radical Research Australasia and Japan, Queensland, Australia. Conference Contribution - Verbal presentation and other Conference outputs
Parker, H., Ismail, S., Neal, S., Hampton, M., & Keenan, J. (2005). Association of Helicobacter pylori outer membrane vesicles with gastric epithelial cells. In V. Korolik, A. Lee, H. Mitchell, G. Mendz, B. Fry & P. Coloe (Eds.), Proceedings of the 13th International Workshop on Campylobacter, Helicobacter and Related Organisms. (pp. 72). [Abstract] Conference Contribution - Published proceedings: Abstract
Keenan, J., Peterson, R., Ismail, S., Hock, B., Frampton, C., & Hampton, M. (2005, September). Host iron deficiency alters the outcome of infection in Helicobacter pylori-infected mice. Verbal presentation at the 13th International Workshop on Campylobacter, Helicobacter and Related Organisms, Gold Coast, Australia. Conference Contribution - Verbal presentation and other Conference outputs
Cheah, F. C., Hampton, M. B., Darlow, B. A., Winterbourn, C. C., & Vissers, M. C. M. (2005). Detection of apoptosis by caspase-3 activation in tracheal aspirate neurophils from premature infants: Relationship with NF-KB activation. Journal of Leukocyte Biology, 77, 432-437. Journal - Research Article
Baird, S. K., Reid, L., Hampton, M. B., & Gieseg, S. P. (2005). OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells. Biochimica et Biophysica Acta: Molecular Cell Reserch, 1745, 361-369. doi: 10.1016/j.bbamcr.2005.07.001 Journal - Research Article
Baty, J. W., Hampton, M. B., & Winterbourn, C. C. (2005). Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells. Biochemical Journal, 390(3), 785-795. Journal - Research Article
Keenan, J. I., Peterson, II, R. A., & Hampton, M. B. (2005). NADPH oxidase involvement in the pathology of Helicobacter pylori infection. Free Radical Biology & Medicine, 38, 1188-1196. Journal - Research Article
Thomson, S. J., Pullar, J. M., & Hampton, M. B. (2004, December). Phenethyl isothiocyanate triggers apoptosis in cells over-expressing Bcl-2. Poster session presented at the 13th Annual Conference of the Society for Free Radical Research (Australasia), Christchurch, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Keenan, J. I., Peterson, R. A., & Hampton, M. B. (2004). Role of neutrophil oxidants in the gastric pathology associated with Helicobacter pylori infection. Helicobacter. 9(5), (pp. 591-592). [Abstract] Conference Contribution - Published proceedings: Abstract
Pullar, J. M., Thomson, S. J., King, M. J., Turnbull, C. I., Midwinter, R. G., & Hampton, M. B. (2004). The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis. Carcinogenesis, 25(5), 765-772. Journal - Research Article
Vissers, M. C. M., & Hampton, M. B. (2004). The role of oxidants and vitamin C on neutrophil apoptosis and clearance. Biochemical Society Transactions. 32(3), (pp. 499-501). [Full Paper] Conference Contribution - Published proceedings: Full paper
Baird, S. K., Hampton, M. B., & Gieseg, S. P. (2004). Oxidized LDL triggers phosphatidylserine exposure in human monocyte cell lines by both caspase-dependent and -independent mechanisms. FEBS Letters, 578, 169-174. Journal - Research Article
Piuhola, J., Pemberton, C., Hampton, M., & Richards, M. (2004, June). Multiple cardiac effects of erythropoietin. Poster session presented at the 14th European Meeting on Hypertension, Paris. Conference Contribution - Poster Presentation (not in published proceedings)
Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hampton, M. B., & Vissers, M. C. (2004). NF-KAPPA B activation and apoptosis in lung neutrophils from infants with hyaline membrane disease. Pediatric Research. 56(3), (pp. 474). [Abstract] Conference Contribution - Published proceedings: Abstract
Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hampton, M. B., & Vissers, M. C. M. (2004). NF-KAPPA B activation and apoptosis in lung neutrophils from infants with hyaline membrane disease. Proceedings of the Perinatal Society of Australia and New Zealand: 8th Annual Congress. (pp. P133). Sydney, Australia: PSANZ. [Abstract] Conference Contribution - Published proceedings: Abstract
Ismail, S., Parker, H., Hampton, M. B., & Keenan, J. I. (2003). Helicobacter pylori outer membrane vesicles modulate proliferation and IL-8 production by gastric epithelial cells. International Journal of Medical Microbiology, 293(Suppl. 35), (pp. 116). [Abstract] Conference Contribution - Published proceedings: Abstract
Ismail, S., Hampton, M. B., & Keenan, J. I. (2003). Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells. Infection & Immunity, 71(10), 5670-5675. Journal - Research Article
Pullar, J. M., & Hampton, M. B. (2002). Diphenyleneiodonium triggers the efflux of glutathione from cultured cells. Free Radical Biology and Medicine. 33(Suppl. 1), (pp. S91-S92). [Abstract] Conference Contribution - Published proceedings: Abstract
Hampton, M. B., & Winterbourn, C. C. (2002). Redox regulation of neutrophil function. Antioxidants & Redox Signaling, 4(1), 1-3. Journal - Research Article
Pullar, J. M., & Hampton, M. B. (2002). Diphenyleneiodonium triggers the efflux of glutathione from cultured cells. Journal of Biological Chemistry, 277(22), 19402-19407. Journal - Research Article
Baty, J. W., Hampton, M. B., & Winterbourn, C. C. (2002). Detection of oxidant-sensitive thiol proteins by fluorescent labeling and two dimensional electrophoresis. Proteomics, 2, 1261-1266. Journal - Research Article
Chapman, A. L. P., Hampton, M. B., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2002). Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus. Journal of Biological Chemistry, 277(12), 9757-9762. Journal - Research Article
Hampton, M. B., Morgan, P., & Davies, M. (2002). Inactivation of cellular caspases by peptide-derived tryptophan and tyrosine peroxides. FEBS Letters, 527, 289-292. Journal - Research Article
Hampton, M. B., Stamenkovic, G., & Winterbourn, C. C. (2002). Interaction with substrate sensitises caspase-3 to inactivation by hydrogen peroxide. FEBS Letters, 517, 229-232. Journal - Research Article
Hampton, M. B., Vissers, M. C., Keenan, J. I., & Winterbourn, C. C. (2002). Oxidant-mediated phosphatidylserine exposure and macrophage uptake of activated neutrophils: possible impairment in chronic granulomatous disease. Journal of Leukocyte Biology, 71(5), 775-781. Journal - Research Article
Vissers, M. C. M., Lee, W. G., & Hampton, M. B. (2001). Regulation of apoptosis by vitamin C. Specific protection of the apoptotic machinery against exposure to chlorinated oxidants. Journal of Biological Chemistry, 276(50), 46835-46840. doi: 10.1074/jbc.M107664200 Journal - Research Article
Keenan, J. I., Hampton, M. B., & Allardyce, R. A. (2000). H. pylori proteases and the develpoment of gastric cancer. Gut. 47(Suppl. 1), (pp. A27). [Abstract] Conference Contribution - Published proceedings: Abstract
Winterbourn, C. C., van Dalen, C. J., Hampton, M. B., & Kettle, A. J. (2000). Reactions of myeloperoxidase and production of hypochlorous acid in neutrophil phagosomes. In P. E. Petrides & W. M. Nauseef (Eds.), The Peroxidase Multigene Family of Enzymes. (pp. 58-67). Berlin: Springer. Chapter in Book - Research
Vissers, M. C. M., Pullar, J. M., & Hampton, M. B. (1999). Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells. Biochemical Journal, 344, 443-449. Journal - Research Article
Stridh, H., Orrenius, S., & Hampton, M. B. (1999). Caspase involvement in the induction of apoptosis by the environmental toxicants tributylin and triphenyltin. Toxicology & Applied Pharmacology, 156, 141-146. Journal - Research Article
Hampton, M. B. (1999). Mitochondria: unravelling the secrets of life and death. Redox Report, 4, 137-139. Journal - Professional & Other Non-Research Articles
Hampton, M. B., & Winterbourn, C. C. (1999). Methods for quantifying phagocytosis and bacterial killing by human neutrophils. Journal of Immunological Methods, 232, 15-22. Journal - Research Article
Hampton, M. B., & Orrenius, S. (1998). Redox regulation of apoptotic cell death. BioFactors, 8, 1-5. Journal - Research Article
Hampton, M. B., Zhivotovsky, B., Burgess, D. H., Slater, A. F. G., & Orrenius, S. (1998). Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts. Biochemical Journal, 329, 95-99. Journal - Research Article
Hampton, M. B., & Orrenius, S. (1998). Redox regulation of apoptotic cell death in the immune system. Toxicology Letters, 102-103, 355-358. Journal - Research Article
Fadeel, B., Ahlin, A., Henter, J., Orrenius, S., & Hampton, M. B. (1998). Involvement of caspases in neutrophil apoptosis: Evidence for a regulatory role of reactive oxygen species. Blood, 92, 4808-4818. Journal - Research Article
Hampton, M. B., Fadeel, B., & Orrenius, S. (1998). Redox regulation of the caspases during apoptosis. Annals of the New York Academy of Sciences, 854, 328-335. Journal - Research Article
Stridh, H., Kimland, M., Jones, D. P., Orrenius, S., & Hampton, M. B. (1998). Cytochrome c release a cascade activation in hydrogen peroxide and tributyltin induced apoptosis. FEBS Letters, 429, 351-355. Journal - Research Article
Vollebregt, M., Hampton, M. B., & Winterbourn, C. C. (1998). Activation of NF-KB in human neutrophils during phagocytosis of bacteria independently of oxidant generation. FEBS Letters, 432, 40-44. Journal - Research Article
Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998). Inside the neutrophil phagosome: oxidants, myeloperoxidase and bacterial killing. Blood, 92, 3007-3017. Journal - Research Article
Hampton, M. B., & Orrenius, S. (1997). Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis. FEBS Letters, 414, 552-556. Journal - Research Article
Orrenius, S., Burgess, D. H., & Hampton, M. B. (1997). Mitochondria as the focus of apoptosis research. Cell Death & Differentiation, 4, 427-428. Journal - Research Other
Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1996). Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Straphuylococcus aureus by neutrophils. Infection & Immunity, 64(9), 3512-3517. Journal - Research Article