Dr Judith McKenzie, Our people, University of Otago, Christchurch

Haematology Research Group Leader

MSc(Oxon) PhD(Otago) Email judy.mckenzie@otago.ac.nz

Tel 64 3 364 0579

Publications

Hock, B. D., Goddard, L., MacPherson, S. A., Strother, M., Gibbs, D., Pearson, J. F., & McKenzie, J. L. (2023). Levels and in vitro functional effects of circulating anti-hinge antibodies in melanoma patients receiving the immune checkpoint inhibitor pembrolizumab. PLoS ONE, 18(9), e0290793. doi: 10.1371/journal.pone.0290793 Journal - Research Article

Sulit, A. K., Daigneault, M., Allen-Vercoe, E., Silander, O. K., Hock, B., McKenzie, J., Pearson, J., Frizelle, F. A., Schmeier, S., & Purcell, R. (2023). Bacterial lipopolysaccharide modulates immune response in the colorectal tumor microenvironment. npj Biofilms & Microbiomes, 9, 59. doi: 10.1038/s41522-023-00429-w Journal - Research Article

Sulit, A., Daigneault, M., Allen-Vercoe, E., Silander, O., Hock, B., McKenzie, J., Pearson, J., Frizelle, F., … Purcell, R. (2022). Lipopolysaccharide from colorectal cancer-associated bacteria influence cytokine production in immune cells. Colorectal Disease, 24(Suppl. 1), (pp. 55-56). doi: 10.1111/codi.16048 Conference Contribution - Published proceedings: Abstract

Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukaemia. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 183). Retrieved from https://www.faobmb2021.org Conference Contribution - Published proceedings: Abstract

2023

Journal - Research Article

2022

Conference Contribution - Published proceedings: Abstract

2021

Journal - Research Article

Conference Contribution - Published proceedings: Abstract

2020

Journal - Research Article

Hock, B. D., McKenzie, J. L., Strother, M., Goddard, L., Butt, L., & Currie, M. J. (2020). Functional effects of immune complexes formed between pembrolizumab and patient-generated anti-drug antibodies. Cancer Immunology, Immunotherapy, 69(12), 2453-2464. doi: 10.1007/s00262-020-02636-2

2019

Journal - Research Article

Hock, B. D., Smith, S. M., McEntyre, C. J., McKenzie, J. L., Sies, C., & Keating, P. E. (2019). Development of a competitive binding homogeneous mobility shift assay for the quantification of adalimumab levels in patient serum. Journal of Immunological Methods, 474, 112672. doi: 10.1016/j.jim.2019.112672

Tang, J. S., Bozonet, S. M., McKenzie, J. L., Anderson, R. F., Melton, L. D., & Vissers, M. C. M. (2019). Physiological concentrations of blueberry-derived phenolic acids reduce monocyte adhesion to human endothelial cells. Molecular Nutrition & Food Research, 63, 1900478. doi: 10.1002/mnfr.201900478

Hock, B. D., Mulholland, K. S., Ganly, P., McKenzie, J. L., Pearson, J. F., & MacPherson, S. A. (2019). Impact of increased access to novel agents on the survival of multiple myeloma patients treated at a single New Zealand centre. Internal Medicine Journal, 49, 598-606. doi: 10.1111/imj.14155

Journal - Research Other

Purcell, R. V., Hock, B. D., Gardner, J., Goddard, L., MacPherson, S. A., & McKenzie, J. L. (2019). Analysis of human papillomavirus infection and leukaemic infiltrate in cutaneous squamous cell carcinoma from patients with chronic lymphocytic leukaemia. British Journal of Haematology, 186(4), e67-e71. doi: 10.1111/bjh.15907

2018

Journal - Research Article

Hock, B. D., McKenzie, J. L., Goddard, L., Smith, S. M., McEntyre, C. J., & Keating, P. E. (2018). Discrimination of anti-drug antibodies with neutralizing capacity in infliximab-and adalimumab-treated patients: Comparison of the homogeneous mobility shift assay and the affinity capture and elution assay. Therapeutic Drug Monitoring, 40(6), 705-715. doi: 10.1097/FTD.0000000000000553

Greer, A. W., McKenzie, J. L., McAnulty, R. W., Huntley, J. F., & McNeilly, T. N. (2018). Immune development and performance characteristics of Romney sheep selected for either resistance or resilience to gastrointestinal nematodes. Veterinary Parasitology, 250, 60-67. doi: 10.1016/j.vetpar.2017.12.013

2017

Journal - Research Article

Hock, B. D., MacPherson, S. A., & McKenzie, J. L. (2017). Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells. PLoS ONE, 12(3), e0172858. doi: 10.1371/journal.pone.0172858

Journal - Research Other

Hock, B. D., McKenzie, J. L., & Keenan, J. I. (2017). Helicobacter pylori outer membrane vesicles inhibit human T cell responses via induction of monocyte COX-2 expression [Short communication]. Pathogens & Disease, 75(4), ftx034. doi: 10.1093/femspd/ftx034

Conference Contribution - Verbal presentation and other Conference outputs

Currie, M., Hock, B., McKenzie, J., Miller, A., Simcock, J., Mackenzie, K., Seddon, A., & Kennedy, B. (2017, July). Functional and prognostic significance of neutrophil subpopulations in cutaneous squamous cell carcinoma. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

2016

Journal - Research Article

Hock, B. D., McIntosh, N. D., McKenzie, J. L., Pearson, J. F., Simcock, J. W., & MacPherson, S. A. (2016). Incidence of cutaneous squamous cell carcinoma in a New Zealand population of chronic lymphocytic leukaemia patients. Internal Medicine Journal, 46(12), 1414-1421. doi: 10.1111/imj.13261

Seddon, A., Hock, B., Miller, A., Frei, L., Pearson, J., McKenzie, J., Simcock, J., & Currie, M. (2016). Cutaneous squamous cell carcinomas with markers of increased metastatic risk are associated with elevated numbers of neutrophils and/or granulocytic myeloid derived suppressor cells. Journal of Dermatological Science, 83(2), 124-130. doi: 10.1016/j.jdermsci.2016.04.013

2015

Journal - Research Article

Hock, B. D., McKenzie, J. L., Cross, N. B., & Currie, M. J. (2015). Dynamic changes in myeloid derived suppressor cell subsets following renal transplant: A prospective study. Transplant Immunology, 32(3), 164-171. doi: 10.1016/j.trim.2015.05.001

Conference Contribution - Published proceedings: Abstract

Seddon, A. R., Hock, B. D., Miller, A. P., Frei, L. P., Pearson, J. F., McKenzie, J. L., Simcock, J. W., & Currie, M. J. (2015). Neutrophils in cutaneous squamous cell carcinoma: Potential prognostic markers? New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Hock, B. D., McKenzie, J. L., & Keenan, J. I. (2015, November). Helicobacter pylori outer membrane vesicles modulate human immune responses. Poster session presented at the 18th International Conference on Campylobacter, Helicobacter, and Related Organisms (CHRO), Rotorua, New Zealand.

2014

Journal - Research Article

Hock, B. D., MacPherson, S. A., Fernyhough, L. J., & McKenzie, J. L. (2014). Chronic lymphocytic leukemia cells become both activated and immunosuppressive following interaction with CD3 and CD28 stimulated PBMC. Leukemia Research, 38(10), 1217-1223. doi: 10.1016/j.leukres.2014.06.004

2013

Journal - Research Article

Hock, B. D., Fernyhough, L. J., Gough, S. M., & McKenzie, J. L. (2013). Clinical significance of plasma levels of soluble CD40 in patients with chronic lymphocytic leukemia. Open Journal of Blood Diseases, 3(1), 1-5. doi: 10.4236/ojbd.2013.31001

Journal - Research Other

Hock, B. D., & McKenzie, J. L. (2013). Suppression of CD3/CD28 antibody stimulated responses by human granulocytic myeloid-derived suppressor cells: Fact or artefact? Immunology Letters, 152(2), 151-152. doi: 10.1016/j.imlet.2013.05.009

2012

Journal - Research Article

Hock, B. D., Taylor, K. G., Cross, N. B., Kettle, A. J., Hampton, M. B., & McKenzie, J. L. (2012). Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability. Immunology, 137(3), 249-258. doi: 10.1111/imm.12004

Hock, B. D., Mackenzie, K. A., Cross, N. B., Taylor, K. G., Currie, M. J., Robinson, B. A., Simcock, J. W., & McKenzie, J. L. (2012). Renal transplant recipients have elevated frequencies of circulating myeloid-derived suppressor cells. Nephrology Dialysis Transplantation, 27(1), 402-410. doi: 10.1093/ndt/gfr264

2011

Journal - Research Article

Glubb, D. M., Gearry, R. B., Barclay, M. L., Roberts, R. L., Pearson, J., Keenan, J. I., McKenzie, J., & Bentley, R. W. (2011). NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease. World Journal of Gastroenterology, 17(23), 2829-2837. doi: 10.3748/wjg.v17.i23.2829

Geertsema, L., Lucas, S. J. E., Cotter, J. D., Hock, B., McKenzie, J., & Fernyhough, L. J. (2011). The cardiovascular risk factor, soluble CD40 ligand (CD154), but not soluble CD40, is lowered by ultra-endurance exercise in athletes. British Journal of Sports Medicine, 45(1), 42-45. doi: 10.1136/bjsm.2008.051896

2010

Journal - Research Article

Hock, B. D., McKenzie, J. L., McArthur, L., Tansley, S., Taylor, K. G., & Fernyhough, L. J. (2010). CD38 as a prognostic marker in chronic lymphocytic leukaemia at a single New Zealand centre: Patient survival in comparison to age and sex matched population data. Internal Medicine Journal, 40(12), 842-849. doi: 10.1111/j.1445-5994.2009.02135.x

Conference Contribution - Published proceedings: Abstract

Wilkinson, T. J., Tweed, M. J., McKenzie, J., Ali, A., Rudland, J., & Egan, A. (2010). Conditional pass facilitates action on professionalism and aligns assessment to learning. Proceedings of the 14th Ottawa Conference: Assessment of Competence in Medicine and the Healthcare Professions. (pp. 189-190). Retrieved from http://www.ottawaconference.org/images/stories/Ottawa_Conference_2010_Abstracts.5.10_1.pdf

2009

Journal - Research Article

Hock, B. D., Fernyhough, L. J., Gough, S. M., Steinkasserer, A., Cox, A. G., & McKenzie, J. L. (2009). Release and clinical significance of soluble CD83 in chronic lymphocytic leukemia. Leukemia Research, 33(8), 1089-1095. doi: 10.1016/j.leukres.2009.01.001

Conference Contribution - Published proceedings: Abstract

Marshall, C. J., Mocatta, T., McKenzie, J., Kettle, A., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. R. (2009). Acute systemic and local neutrophil and monocyte degranulation prior to primary percutaneous coronary intervention in ST elevation myocardial infarction. JACC, 53(10, Suppl. 1), (pp. A307-A308). [Abstract]

2008

Conference Contribution - Published proceedings: Abstract

Marshall, C., Mocatta, T., McKenzie, J., Kettle, A., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. (2008). Increased systemic and local neutrophil and monocyte degranulation in patients undergoing primary percutaneous coronary intervention for acute ST elevation myocardial infarction. Heart, Lung & Circulation, 17S, (pp. S106). doi: 10.1016/j.hlc.2008.05.255

Marshall, C., Mocatta, T., McKenzie, J., Kettle, A. J., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. R. (2008). Increased neutrophil and monocyte degranulation with release of intracellular leucocyte elastase and myeloperoxidase in acute ST elevation myocardial infarction. Heart, Lung & Circulation, 17S, (pp. S2). doi: 10.1016/j.hlc.2008.03.003

Conference Contribution - Verbal presentation and other Conference outputs

Moon, S.-Y., McKenzie, J., Jewell, U., Ganly, P., & Morris, C. (2008, August-September). Identification of novel CNVs in chronic lymphocytic leukaemia using array CGH. Verbal presentation at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

2007

Conference Contribution - Published proceedings: Abstract

Moon, S., McKenzie, J., Jewell, U., Ganly, P., & Morris, C. (2007). High-resolution genomic profiling of chronic lymphocytic leukaemia by array CGH. Chromosome Research. 15(Suppl. 1), (pp. 268). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Moon, S., McKenzie, J., Jewell, U., Ganly, P., & Morris, C. (2007, July). High-resolution genomic profiling of chronic lymphocytic leukaemia by array CGH. Verbal presentation at the 6th European Cytogenetics Conference (ECC), Istanbul, Turkey.

2006

Journal - Research Article

Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Currie, M. J., McKenzie, J. L., Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2006). Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: Response to cytokines and natriuretic peptide receptor expression profiles. American Journal of Physiology: Heart & Circulatory Physiology, 291, H1952-H1958. doi: 10.1152/ajpheart.00764.2005

Hock, B. D., McKenzie, J. L., Patton, N. W., Drayson, M., Taylor, K., Wakeman, C., … Albitar, M. (2006). Circulating levels and clinical significance of soluble CD40 in patients with hematologic malignancies. Cancer, 106(10), 2148-2157.

Hock, B. D., Drayson, M., Patton, W. N., Taylor, K., Kerr, L., McKenzie, J. L., & on behalf of the Working Party on Leukaemia in Adults. (2006). Circulating levels and clinical significance of soluble CD86 in myeloma patients. British Journal of Haematology, 133, 165-172.

Hock, B. D., O'Donnell, J. L., Taylor, K., Steinkasserer, A., McKenzie, J. L., Rothwell, A. G., & Summers, K. L. (2006). Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients. Tissue Antigens, 67(1), 57-60. doi: 10.1111/j.1399-0039.2005.00524.x

Conference Contribution - Published proceedings: Abstract

Moon, S. Y., McKenzie, J., Walker, L., McDonald, M., Ganly, P., & Morris, C. M. (2006). High throughput screening of genomic copy number changes in chronic lymphocytic leukaemia using array comparative genomic hybridisation. In L. Griffiths (Ed.), Proceedings of the 11th International Congress of Human Genetics. (pp. 149). [Abstract]

2005

Journal - Research Article

Hock, B. D., Roberts, G., McKenzie, J. L., Gokhale, P., Salm, N., McLellan, A. D., Patton, N. W., & Roake, J. A. (2005). Exposure to the electrofusion process can increase the immunogenicity of human cells. Cancer Immunology, Immunotherapy, 54, 880-890.

2004

Journal - Research Article

Hock, B. D., Haring, L. F., Steinkasserer, A., Taylor, K. G., Patton, W. N., & McKenzie, J. L. (2004). The soluble form of CD83 is present at elevated levels in a number of hematological malignancies. Leukemia Research, 28, 237-241.

Hock, B. D., Starling, G. C., Patton, W. N., Salm, N., Bond, K., McArthur, L. T., & McKenzie, J. L. (2004). Identification of a circulating soluble form of CD80: Levels in patients with hematological malignancies. Leukemia & Lymphoma, 45(10), 2111-2118. doi: 10.1080/10428190410001712199

Conference Contribution - Published proceedings: Abstract

Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Palmer, B. R., Frampton, C. M., Gunningham, S. P., Currie, M. J., McKenzie, J. L., … Cameron, V. A. (2004). Cytokine induced changes in cultured cardiac fibroblasts: Cell morphology and natriuretic peptide receptor expression. Proceedings of the 12^th International Congress of Endocrinology. (pp. 145). [Abstract]

2003

Journal - Research Article

Hock, B. D., McKenzie, J., Patton, W. N., Haring, L., Yang, Y., Shen, Y., … Albitar, M. (2003). The clinical significance of soluble CD86 levels in patients with acute myeloid leukemia and myelodysplastic syndrome. Cancer, 98, 1681-1688.

Copland, M., Baird, M. A., Rades, T., McKenzie, J., Becker, B., Reck, F., … Davies, N. M. (2003). Liposomal delivery of antigen to human dendritic cells. Vaccine, 21, 883-890.

2001

Journal - Research Article

Hock, B. D., Kato, M., McKenzie, J., & Hart, D. N. J. (2001). A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera. International Immunology, 13(7), 959-967.

Summers, K. L., Hock, B. D., McKenzie, J. L., & Hart, D. N. J. (2001). Phenotypic characterization of five dendritic cell subsets in human tonsils. American Journal of Pathology, 159, 285-295.

1997

Journal - Research Article

Mannering, S. I., McKenzie, J. L., Fearnley, D. B., & Hart, D. N. J. (1997). HLA-DR1-restricted BCR-ABL (B3A2)-specific CD4(+) T lymphocytes respond to dentritic cells pulsed with B3A2 peptide and antigen-presenting cells exposed to B3A2 containing cell lysates. Blood, 90(1), 290-297.