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Liver Sieve Research Group Publications

Major Reviews

  • Fraser, R., Day, W. A. and Fernando, N. S. (1986). Review: The liver sinusoidal cells. Their role in disorders of the liver, lipoprotein metabolism and atherogenesis. Pathology 18:5-11
  • Fraser R., Dobbs B. R. and Rogers G. W. T. (1995). Special Article : The role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherogenesis and cirrhosis. Hepatology 21:863-874. Transcribed onto Bulletin Disk by the Sheffield Academic Press (SUBIS)
  • Le Couteur, D. G., Cogger, V. C., McCuskey, R. S., de Cabo, R., Smedsrod, B., Sorensen, K. K., Warren, A., Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium are a mechanism for dyslipidaemia. Annals New York Academy of Science (invited review) 1114: 79-87 (2007)
  • Le Couteur, D. G., Warren, A., Cogger, V. C., Smedsrod, B., Sorenson, K. K., de Cabo, R., Fraser R., McCuskey, R. S. (2008). Old age and the hepatic sinusoid. Anatomical Record (Hoboken). (invited review) 291:672-83
  • Fraser,R., Cogger, V.C., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S.N., Le Couteur, D.G. (2012). Review: The liver sieve and atherosclerosis. Pathology 44: 181-186

 

Other publications are grouped under the following topics

  1. Chylomicrons - size and composition from different amounts and types of dietary fat
  2. Liver sieve and it's function regulating the uptake of chylomicrons and other colloids, including viruses, by the liver
  3. Atherosclerosis, cholesterol and post-prandial and metabolic hyperlipidaemia
  4. Hepatic diseases caused by the liver sieve
  5. Effects of ageing on the liver sieve
  6. Effects of drugs, hormones, oxidants and toxins on the liver sieve
  7. Immunity and tolerance control by the liver sieve

Chylomicrons, Size and Composition

  • Zilversmit, D. B., Courtice, F. C. and Fraser, R. (1967). Cholesterol transport in thoracic duct lymph of the rabbit. J. Atheroscl. Res. 7:319-329
  • Fraser, R., Cliff, W. J. and Courtice, F. C. (1968). The effect of dietary fat load on the size and composition of chylomicrons in thoracic duct lymph. Q. Jl. Exp. Physiol. 53:390-8.*
  • Fraser, R. and Courtice, F. C. (1969). The transport of cholesterol in thoracic duct lymph of animals fed cholesterol with varying triglyceride loads. Aust. J. Exp. Biol. Med. Sci. 47: 723-732
  • Fraser R. (1970). Size and lipid composition of chylomicrons of different Svedberg units of flotation. J. Lipid. Res. 11:60-5*
  • Fraser, R., Du Bien, L., Musil, F., Fosslien, E. and Wissler, R. (1972). Transport of cholesterol in thoracic duct lymph and serum of Rhesus monkeys fed cholesterol with various food fats. Atherosclerosis 16:203-216*
  • Fraser R. (1974). The role of dietary triglycerides in cholesterol metabolism. Atherosclerosis 19:327-336*
  • Fischer-Dzoga, K., Fraser, R. and Wissler, R. W. (1976). Stimulation of proliferation in stationary primary cultures of monkey and rabbit aortic smooth muscle cell. I. Effects of lipoprotein fractions of hyperlipemic serum and lymph. Exp. Mol. Path. 24:346 -359
  • Fraser, R., Vesselinovitch, D. and Wissler, R. W. (1976). New interpretations of lipoproteins and arterial lesions of cholesterol-fed rabbits. Pathology 8:57-68*
  • Bosanquet, A. G., Bickerstaffe, R. and Fraser R. (1978). A new large chylomicron remnant from cholesterol-fed rabbits. Aust. J. Exp. Biol. Med. Sci. 56:157-169
  • Gooden, J. M., Fraser, R., Bosanquet, A. G. and Bickerstaffe, R. (1979). Size of lipoproteins in intestinal lymph of sheep and suckling lambs. Aust. J. Biol. Sci. 32:533-42
  • Bosanquet, A. G., Bickerstaffe, R. and Fraser, R. (1980). Analytical ultra centrifugation of lipoproteins: A method for determining the concentration of lipoproteins and their size distribution. Biochemical Society Transactions 8:598-599
  • Bosanquet, A. G., Munster, D., Bickerstaffe, R. and Fraser, R. (1980). A comparison of the Sf0 to 1000 plasma lipoproteins from rabbits fed cholesterol and humans with type III hyperlipoproteinaemia. Int. J. Biochem. 12:473-77
  • Bosanquet, A. G., Bickerstaffe, R., Viney, M. and Fraser, R. (1980). Lipoprotein size distributions from the analytical ultra centrifugation of serum and lymph lipoprotein samples. Med. Biol. Eng. Comp. 18:772-78
  • Wardell, M. R., Brennan, S. O., Fraser, R., Carrell, R. W., Janus, E. D. (1987). Molecular abnormality of Apolipoprotein E in type III hyperlipoproteinaemia. J. Clin. Invest 80:483-90*

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Liver Sieve

  • Fraser, R., Bosanquet, A. G. and Day, W. A. (1977). Filtration of chylomicrons and their remnants by the liver. In Proceedings of the IVth International Symposium on Atherosclerosis, Tokyo, August, 1976 in Schettler, F, Goto, Y., Hata, Y., Klose, G, Springer-Verlag, Berlin, Heidelberg, New York. 218
  • Fraser, R., Bosanquet, A. G. and Day, W. A. (1978). The filtration of chylomicrons by the liver may influence cholesterol metabolism and atherosclerosis. Atherosclerosis 29:113-123*
  • Fraser, R., Bowler, L. M., Day, W. A., Dobbs, B., Johnson, H. D. and Lee, D. (1980). High perfusion pressure damages the sieving ability of sinusoidal endothelium in rat livers. Br. J. Exp. Path. 61:222-8*
  • Wisse, E., Van Direndonck, J. H., De Zanger, R. B., Fraser, R., McCuskey, R. S. (1980). On the role of liver endothelial filter in the transport of particulate fat (chylomicrons and their remnants) to parenchymal cells and the influence of certain hormones on the endothelial fenestrae. In Communications of Live Cells, In Proceedings of the 27th Falk Symposium, ed. Popper, H. MTP Press, England 195-200
  • Wright, P. L., Clemett, J. A., Smith, K. F., Day, W. A. and Fraser, R. (1983). Hepatic sinusoidal endothelium in goats. Aust. J. Exp. Biol. Med. Sci. 61:739-741
  • Wright, P. L., Smith, K. F., Day, W. A., Fraser, R. (1983). Hepatic sinusoidal endothelium in sheep. An ultrastructural reinvestigation. Anat. Rec. 206:385-390
  • Wright, P. L., Smith, K. F., Day, W. A. and Fraser, R. (1983). Small liver fenestrae may explain the susceptibility of rabbits to atherosclerosis. Arteriosclerosis 3:344-348*
  • Fraser, R., Heslop, V. R., Murray, F. E. M. and Day, W. A. (1986). Ultrastructural studies of the portal transport of fat in chickens. Br. J. Exp. Path. 67:783-91*
  • Fraser, R., Clark, S. A., Day, W.A. and Murray, F. E. M. (1988). Nicotine decreases the porosity of the rat liver sieve - a possible mechanism for hypercholesterolaemia. Br. J. Exp. Path. 69:345-350*
  • Clark, S. A., Angus, H. B. A., Cook, H. B., George, P. M., Oxner, R. B. G., Fraser, R. (1988). Defenestration of the hepatic sinusoids in an alcoholic leads to hyperlipoproteinaemia. Hypothesis in Lancet ii 1225-1227*
  • Clark, S. A., Angus, H. B. A., Cook, H. B., George, P. M., Oxner, R .B. G., and Fraser, R. (1990) (reporting the 1988 paper). Defenestration of the hepatic sinusoids in an alcoholic leads to hyperlipoproteinaemia. Hepatology Elsewhere section, Hepatology 11:148-149
  • Fraser, R, Clark, S. A. (1989). The microcirculation of the liver. In Progress in Microcirculation Research, Proceedings of the Fifth Australian and New Zealand Symposium on the Microcirculation. Perry, M. A., Garlick, D. G (eds), Sydney. University of NSW Press, 149-151
  • Rogers, G., Dobbs, B., Fraser, R. (1991) Defenestration of hepatic sinusoids and decreased dietary cholesterol uptake by the livers of dimethylnitrosamine (DMS) treated rats. In Progress in Microcirculation Research. In Proceedings of the Sixth Australian and New Zealand Symposium. Perry, M. A., Garlick, D. G eds. University of New South Wales 95
  • Rogers, G. W. T., Dobbs, B. R., and Fraser, R. (1992). Decreased hepatic uptake of cholesterol and retinol in the dimethylnitrosamine rat model of cirrhosis. Liver 12:326-329*
  • Fraser, R., Rogers, G. W. T., Bowler, L. M., Day, W. A., Dobbs, B. R., Baxter, J. N. (1992). Defenestration and Vitamin A status in a rat model of cirrhosis. In Cells of the Hepatic Sinusoid, Volume 3, Proceedings of the Fifth International Symposium of Cells of the Hepatic Sinusoid, Tucson, USA 1991 eds. Wisse, E., Knook, D. L,. McCuskey R. S., Kupffer Cell Foundation, The Netherlands, Leiden 195-198
  • Dobbs, B. R., Rogers, G. W. T., Xing, H. and Fraser, R. (1994). Endotoxin-induced defenestration of the hepatic sinusoidal endothelium: a factor in the pathogenesis of cirrhosis? Liver 14:230-233*
  • Fraser, R., Rogers, G. W. T., Sutton, L. E, Dobbs, B. R. (1995). Single dose models of defenestration: tools to explore mechanisms, modulation and measurement of hepatic sinusoidal porosity. In Cells of the Hepatic Sinusoids, Volume 5, Proceedings of the Seventh International Symposium of Cells of the Hepatic Sinusoid, Kyoto, Japan eds. Wisse, E., Knook, D. L. Wake, Y. Leiden, Kupffer Cell Foundation 263-266
  • Dobbs, B. R., Rogers, G. W. T., Fraser, R. (1997). Reduction of the hepatoxicity of dimethyl nitrosamine by gadolinium chloride, In Cells of the Hepatic Sinusoids. Volume 6 in Proceedings of the Eighth International Symposium on Cells of the Hepatic Sinusoids. Bordeaux, France, Eds Wisse, E., Knook, D. L., Balaboud, C. Leiden, Kupffer Cell Foundation 308-309
  • Jamieson, H. A., Day W. A., Dobbs, B. R., Rogers, G. W. T., Fraser, R. (1998). Is Fatty Liver of Diabetes, like that of Alcoholism, Related to an Increased Porosity of the Liver Sieve? In Cells of the Hepatic Sinusoids, Volume 7, Proceedings of the Ninth International Symposium on Cells of the Hepatic Sinusoid, Christchurch, New Zealand, 27 September – 1 October eds. Wisse, E., Knook, R., De Zanger, R. B., Fraser R. The Kupffer Cell Foundation, Leiden, The Netherlands 96-98*
  • Jamieson, H. A., Dobbs, B. R., Day, W. A., Rogers, G. W. T., Fraser, R. (2003). The liver in diabetes: are the ultrastructural changes similar to those seen in alcoholism? In Cells of the Hepatic Sinusoids, Volume 3, Proceedings of the Tenth International Symposium on Cells of the Hepatic Sinusoids, Southampton, U.K. Wisse, E., Knook, D. L., De Zanger, R. B., Arthur, M. J. P. The Kupffer Cell Foundation, Leiden,The Netherlands 123-124
  • Braet, F., Fraser, R., McCuskey R. S. (2003). Thirty-five years of liver sinusoidal cells: Eddie Wisse in retirement [A tribute]. Hepatology, 38:156-158
  • Cogger, V. C., Hilmer, S. N., Sullivan, D. S., Muller, M., Fraser, R., Le Couteur, D. G. 2006. Surfactants and hyperlipidaemia. The liver sieve is a link. Atherosclerosis 189:273-281*
  • Jamieson, H. A., Cogger, V.C., Twigg, S. M., McLennan, S. V., Warren, A., Cheluvappa, R., Hilmer, S. N., Fraser, R., de Cabo, R., Le Couteur D. G.. (2007). The effect of type 1 diabetes mellitus on the liver sinusoidal endothelium. Diabetologia 50:1969-1976*
  • Jamieson, H.A., Hilmer, S.N., Cogger, V.C., Warren, A., Cheluvappa, R., Abernethy, D.R., Everitt, A.V., Fraser, R., de Cabo, R., Le Couteur, D.G. (2007). Caloric restriction reduces age related pseudocapillarization ot the hepatic sinusoid. Exp Gerontol 42:374-8
  • Jamieson, H.A., Cogger, H.A., Twigg, S.M., McLennan, S.V., Warren, A., Cheluvappa, R., Hilmer, S.N., Fraser, R., de Cabo, R., Le Couteur, D.G. (2007) Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia 50:1969-76

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Atherosclerosis and Cholesterol

  • Zilversmit, D. B., Courtice, F. C. and Fraser, R. (1967). Cholesterol transport in thoracic duct lymph of the rabbit. J. Atheroscl. Res. 7:319-329
  • Fraser, R., Cliff, W. J. and Courtice, F. C. (1968). The effect of dietary fat load on the size and composition of chylomicrons in thoracic duct lymph. Q. Jl. Exp. Physiol. 53:390-8.*
  • Fraser, R., Du Bien, L., Musil, F., Fosslien, E. and Wissler, R. (1972). Transport of cholesterol in thoracic duct lymph and serum of Rhesus monkeys fed cholesterol with various food fats. Atherosclerosis 16:203-216*
  • Fischer-Dzoga, K., Fraser, R. and Wissler, R. W. (1976). Stimulation of proliferation in stationary primary cultures of monkey and rabbit aortic smooth muscle cell. I. Effects of lipoprotein fractions of hyperlipemic serum and lymph. Exp. Mol. Path. 24:346 -359*
  • Fraser, R., Vesselinovitch, D. and Wissler, R. W. (1976). New interpretations of lipoproteins and arterial lesions of cholesterol-fed rabbits. Pathology 8:57-68*
  • Fraser, R., Bosanquet, A. G. and Day, W. A. (1978). The filtration of chylomicrons by the liver may influence cholesterol metabolism and atherosclerosis. Atherosclerosis 29:113-123*
  • Bosanquet, A. G., Bickerstaffe, R. and Fraser R. (1978). A new large chylomicron remnant from cholesterol-fed rabbits. Aust. J. Exp. Biol. Med. Sci. 56:157-169*
  • Bosanquet, A. G., Munster, D., Bickerstaffe, R. and Fraser, R. (1980). A comparison of the Sf0 to 1000 plasma lipoproteins from rabbits fed cholesterol and humans with type III hyperlipoproteinaemia. Int. J. Biochem. 12:473-77*
  • Wright, P. L., Smith, K. F., Day, W. A. and Fraser, R. (1983). Small liver fenestrae may explain the susceptibility of rabbits to atherosclerosis. Arteriosclerosis 3:344-348*
  • Fraser, R., Heslop, V. R., Murray, F. E. M. and Day, W. A. (1986). Ultrastructural studies of the portal transport of fat in chickens. Br. J. Exp. Path. 67:783-91*
  • Fraser, R., Day, W. A., Fernando N. S. Atherosclerosis and the liver sieve. (1986). In Cells of the Hepatic Sinusoid, Proceedings of the Third International Kupffer Cell Symposium, Strasbourg, France, 1985 vol 1. Kirn, A., Knook, D. G. Wisse, E (eds). The Kupffer Cell Foundation, Rijswijk, The Netherlands. 317-322
  • Wardell, M. R., Brennan, S. O., Fraser, R., Carrell, R. W., Janus, E. D. (1987). Molecular abnormality of Apolipoprotein E in type III hyperlipoproteinaemia. J. Clin. Invest 80:483-90*
  • Fraser, R., Clark, S. A., Day, W.A. and Murray, F. E. M. (1988). Nicotine decreases the porosity of the rat liver sieve - a possible mechanism for hypercholesterolaemia. Br. J. Exp. Path. 69:345-350*
  • Clark, S. A., Angus, H. B. A., Cook, H. B., George, P. M., Oxner, R. B. G., Fraser, R. (1988). Defenestration of the hepatic sinusoids in an alcoholic leads to hyperlipoproteinaemia. Hypothesis in Lancet ii 1225-1227*
  • Clark, S. A., Angus, H. B. A., Cook, H. B., George, P. M., Oxner, R .B. G., and Fraser, R. (1990) (reporting the 1988 paper). Defenestration of the hepatic sinusoids in an alcoholic leads to hyperlipoproteinaemia. Hepatology Elsewhere section, Hepatology 11:148-149
  • Fraser R, Clark, S. A., Bowler, L. M., Murray F. E. M., Day, W. A., Wakasugi J., Ishihara, M., Tomikawa M. (1989). The opposite effect of nicotine and pantethine on the liver sieve and lipoprotein metabolism. In Cells of the Hepatic Sinusoid, Volume 2, Proceedings of the Fourth International Kupffer Cell Symposium, Titisee, Germany 1988 eds Wisse, E., Knook, D. L., Decker, K. The Kupffer Cell Foundation, The Netherlands, Rijswijk, 335-338
  • Le Couteur, D G., Fraser, R., Cogger, V. C., McLean, A. J. (2002). Hepatic pseudocapillarisation and atherosclerosis in ageing. Lancet 359:1612-1615*
  • Fraser, R., (2002). The liver, in health and disease. New Zealand Pharmacy: 22: 36-40
  • Le Couter, D.G., Cogger, V.C., Hilmer, S.N., Muller, M., Harris, M., Sullivan, D.,McLean, A.J.,Fraser, R. Aging, atherosclerosis and the liver sieve. New Research in Atherosclerosis. Editor: Leon V Clark, pp 19-44, 2006, Inc Nova Science NY [ISBN 1-59454-942-7]
  • Le Couter, D.G., Cogger, V.C., Hilmer, S.N., Muller, M., Harris, M., Sullivan, D.,McLean, A.J.,Fraser, R. Aging, atherosclerosis and the liver sieve. Aging and the Elderly: Psychology, Sociology and Health. Editor: LO Randall, 2006, Inc Nova Science NY [ISBn 1-60021-190-9] [duplicate publication]
  • Cogger, V. C., Hilmer, S. N., Sullivan, D. S., Muller, M., Fraser, R., Le Couteur, D. G. 2006. Surfactants and hyperlipidaemia. The liver sieve is a link. Atherosclerosis 189:273-281*
  • Jamieson, H. A., Cogger, V.C., Twigg, S. M., McLennan, S. V., Warren, A., Cheluvappa, R., Hilmer, S. N., Fraser, R., de Cabo, R., Le Couteur D. G.. (2007). The effect of type 1 diabetes mellitus on the liver sinusoidal endothelium. Diabetologia 50:1969-1976*

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Hepatic diseases caused by the liver sieve

  • Fraser, R., Bowler, L. M., Day, W. A., Dobbs, B., Johnson, H. D. and Lee, D. (1980). High perfusion pressure damages the sieving ability of sinusoidal endothelium in rat livers. Br. J. Exp. Path. 61:222-8*
  • Fraser, R., Bowler, L. M. and Day, W. A. (1980). Damage of rat liver sinusoidal endothelium by ethanol. In Pathology 12:371-6*
  • Rogers, G. W. T., Dobbs, B. R., and Fraser, R. (1992). Decreased hepatic uptake of cholesterol and retinol in the dimethylnitrosamine rat model of cirrhosis. Liver 12:326-329*
  • Fraser, R., Rogers, G. W. T., Bowler, L. M., Day, W. A., Dobbs, B. R., Baxter, J. N. (1992). Defenestration and Vitamin A status in a rat model of cirrhosis. In Cells of the Hepatic Sinusoid, Volume 3, Proceedings of the Fifth International Symposium of Cells of the Hepatic Sinusoid, Tucson, USA 1991 eds. Wisse, E., Knook, D. L,. McCuskey R. S., Kupffer Cell Foundation, The Netherlands, Leiden 195-198*
  • Dobbs, B. R., Rogers, G. W. T., Xing, H. and Fraser, R. (1994). Endotoxin-induced defenestration of the hepatic sinusoidal endothelium: a factor in the pathogenesis of cirrhosis? Liver 14:230-233*
  • Jamieson, H. A., Day W. A., Dobbs, B. R., Rogers, G. W. T., Fraser, R. (1998). Is Fatty Liver of Diabetes, like that of Alcoholism, Related to an Increased Porosity of the Liver Sieve? In Cells of the Hepatic Sinusoids, Volume 7, Proceedings of the Ninth International Symposium on Cells of the Hepatic Sinusoid, Christchurch, New Zealand, 27 September – 1 October eds. Wisse, E., Knook, R., De Zanger, R. B., Fraser R. The Kupffer Cell Foundation, Leiden, The Netherlands 96-98*
  • Le Couteur, D. G., Fraser, R., Hilmer, S., Rivory, L. P., McLean, A. J. (2005). The Hepatic Sinusoid in Ageing and Cirrhosis. Clin. Pharmacokinet 44(2):187-200*
  • Warren, A., Bertolino, P., Beneseler, V., Fraser, R., McCaughan, G., Le Couteur, D. G. (2007). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology 46:239-346*

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Effects of Ageing

  • Le Couteur, D G., Fraser, R., Cogger, V. C., McLean, A. J. (2002). Hepatic pseudocapillarisation and atherosclerosis in ageing. Lancet 359:1612-1615*
  • Hilmer, S. N., Warren, A., Cogger, V. C., Fraser, R., McLean, A. J., Sullivan, D., Le Couteur D. G. (2003). The effect of ageing on the immunohistochemistry of apolipoprotein E in the liver. Experimental Gerontology 39:53-57
  • Cogger, V. C., Warren, A., Fraser, R., Ngu, M., McLean, A. J., Le Couteur, D. G. (2003). Hepatic sinusoidal pseudoapillarization with ageing in the non-human primate. Experimental Gerontology 38:1101-1107
  • Cogger, V. C., Fraser, R., Le Couteur, D. G. (2003). Liver dysfunction and heart failure. American Journal of Cardiology [letter] 91:1399*
  • Cogger, V. C., Muller, M., Fraser, R., McLean A. J., Le Couteur, D. G. (2004). The effects of tertButylhydroperoxide on the hepatic sinusoid. Journal of Hepatology 41:370-376*
  • Cogger, V. C., Muller, M., Khan, J., Fraser, R., McLean, A. J., Le Couteur, D. G. (2004) The effects of oxidative stress on the liver sieve. Journal of Hepatology 41:370-376, [front cover image]*
  • Warren, A., Bertolino, P., Cogger, V. C., McLean, A. J., Fraser, R., Le Couteur, D. G. (2005). Hepatic pseudocapillarisation in aged mice. Experimental Gerontology 40:807-812
  • Hilmer, S. N., Cogger, V. C., Fraser, R., McLean, A. J., Sullivan, D. R., Le Couteur D. G. (2005). Age-related changes in hepatic sinusoidal endothelium impede lipoprotein transfer. Hepatology 42(6):1349-1354, (Editorial, Front cover)*
  • Le Couteur, D. G., Fraser, R., Hilmer, S., Rivory, L. P., McLean, A. J. (2005). The Hepatic Sinusoid in Ageing and Cirrhosis. Clin. Pharmacokinet 44(2):187-200
  • Le Couteur, D. G., Cogger, V. C., McCuskey, R. S., de Cabo, R., Smedsrod, B., Sorensen, K. K., Warren, A., Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium are a mechanism for dyslipidaemia. Annals New York Academy of Science (invited review in press)
  • Le Couteur, D. G., Warren, A., Cogger, V. C., Smedsrod, B., Sorenson, K. K., de Cabo, R., Fraser R., McCuskey, R. S. (2007). Old age and the hepatic sinusoid. Anatomical Record (invited review in press)
  • Jamieson, H. A., Hilmer, S. N. ,Cogger, V. C., Warren, A., Cheluvappa, R., Abernethey, D. R., Everitt, A. V., Fraser, R., de Cabo, R., Le Couteur, D. G. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid Experimental Gerontology 42:374-8*
  • Jamieson, H.A., Hilmer, S.N., Cogger, V.C., Warren, A., Cheluvappa, R., Abernethy, D.R., Everitt, A.V., Fraser, R., de Cabo, R., Le Couteur, D.G. (2007). Caloric restriction reduces age related pseudocapillarization ot the hepatic sinusoid. Exp Gerontol 42:374-8
  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V.C., Hilmer, S.N., McCuskey, R.S., Fraser, R., Le Couteur, D.G. (2008)Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation 15:191-202

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Effects of Drugs, Hormones, Oxidants and Toxins

  • Fraser, R., Bowler, L. M. and Day, W. A. (1980). Damage of rat liver sinusoidal endothelium by ethanol. In Pathology 12:371-6*
  • Wisse, E., Van Dierendonck, J. H., De Zanger, R. B., Fraser, R., McCuskey, R. S. (1980). On the role of liver endothelial filter in the transport of particulate fat (chylomicrons and their remnants) to parenchymal cells and the influence of certain hormones on the endothelial fenestrae. In Communications of Live Cells, In Proceedings of the 27th Falk Symposium, ed. Popper, H. MTP Press, England 195-200 (refers to serotonin)*
  • Fraser, R., Clark, S. A., Day, W.A. and Murray, F. E. M. (1988). Nicotine decreases the porosity of the rat liver sieve - a possible mechanism for hypercholesterolaemia. Br. J. Exp. Path. 69:345-350*
  • Clark, S. A., Angus, H. B. A., Cook, H. B., George, P. M., Oxner, R. B. G., Fraser, R. (1988). Defenestration of the hepatic sinusoids in an alcoholic leads to hyperlipoproteinaemia. Hypothesis in Lancet ii 1225-1227*
  • Fraser, R, Clark, S. A. (1989). The microcirculation of the liver. In Progress in Microcirculation Research, Proceedings of the Fifth Australian and New Zealand Symposium on the Microcirculation. Perry, M. A., Garlick, D. G (eds), Sydney. University of NSW Press, 149-151
  • Rogers, G. W. T., Dobbs, B. R., and Fraser, R. (1992). Decreased hepatic uptake of cholesterol and retinol in the dimethylnitrosamine rat model of cirrhosis. Liver 12:326-329*
  • Tamba-Lebbie B, Rogers GWT, Dobbs BR, Fraser R (1993). Defenestration of the sinusoidal endothelium of the liver of the dimethylnitrosamine fed rat is a reversible process. In Cells of the Hepatic Sinusoids, Vol. 4. Eds. Wisse E, Knook DL, Leiden, Kupffer Cell Foundation 179-181.*
  • Dobbs, B. R., Rogers, G. W. T., Xing, H. and Fraser, R. (1994). Endotoxin-induced defenestration of the hepatic sinusoidal endothelium: a factor in the pathogenesis of cirrhosis? Liver 14:230-233*
  • Cogger, V. C., Fraser, R., Le Couteur, D. G. (2003). Liver dysfunction and heart failure. American Journal of Cardiology [letter] 91:1399
  • Cogger, V. C., Muller, M., Fraser, R., McLean A. J., Le Couteur, D. G. (2004). The effects of tertButylhydroperoxide on the hepatic sinusoid. Journal of Hepatology 41:370-376*
  • Cogger, V. C., Muller, M., Khan, J., Fraser, R., McLean, A. J., Le Couteur, D. G. (2004) The effects of oxidative stress on the liver sieve. Journal of Hepatology 41:370-376, [front cover image]*
  • Cogger, V. C., Hilmer, S. N., Sullivan, D. S., Muller, M., Fraser, R., Le Couteur, D. G. 2006. Surfactants and hyperlipidaemia. The liver sieve is a link. Atherosclerosis 189:273-281*
  • Jamieson, H.A., Hilmer, S.N., Cogger, V.C., Warren, A., Cheluvappa, R., Abernethy, D.R., Everitt, A.V., Fraser, R., de Cabo, R., Le Couteur, D.G. (2007). Caloric restriction reduces age related pseudocapillarization ot the hepatic sinusoid. Exp Gerontol 42:374-8

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Immunity and Tolerance

  • Fraser, R., Le Couteur, D. G., Warren, A., Cogger, V. C., Bertolino, P., Smith, M. (2003). The liver sieve and gene therapy. Blood 101:3338-3339, [letter]*
  • Warren, A., Le Couteur, D. G., Fraser, R., Bowen, D. G., McCaughan, G. W., Bertolino, P. T. (2006). T lymphocytes interact with hepatocytes through fenestrations in liver sinusoidal endothelial cells. Hepatology 44:1182-1190. [Editorial, Highlights, Front Cover]*
  • Warren, A., Bertolino, P., Beneseler, V., Fraser, R., McCaughan, G., Le Couteur, D. G. (2007). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology 46:239-346*

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* To the best of our knowledge these papers contain important original concepts