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Dr Gabi Dachs

Gabi Dachs

Senior Research Fellow

BSc, PhD(Cape Town)

Email gabi.dachs@otago.ac.nz

Education

I did my undergraduate and PhD studies in Cape Town, South Africa, followed by post-doctoral work at the MRC in Harwell, UK. Prior to joining the University of Otago in Christchurch, I worked as senior scientist at the Gray Cancer Institute in London, UK.

Research Interests

I am interested in why human tumours are difficult to treat, and in new ways of treating them.

My interests at present include:

  • Can we dampen the activity of the global transcription factor HIF-1 using vitamin C? Can we reduce tumour growth in mice using vitamin C? Can we increase vitamin C in cancer cells using gene therapy?
  • Why do obese cancer patients often fare worse than non-obese patients? Can we identify the molecular factors associated with obesity in cancer? What effect do these obesity-related factors have on chemotherapy?
  • Which human enzymes are responsible for the activation of novel anticancer prodrugs (in collaboration with Auckland Cancer Society Research Centre)? Can this knowledge guide clinical use of these agents?
  • Can we improve gene directed enzyme prodrug therapy combinations to target solid tumours or their vasculature?

Publications

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