A postgraduate research opportunity at the University of Otago.
- Close date
- Friday, 23 February 2018
- Academic background
- Sciences, Health Sciences
- Host campus
- On-campus or via distance?
- Pathology (UOC)
- Dr Margaret Currie, Dr Elisabeth Phillips
In breast cancer, many obese patients have worse outcomes and shorter survival following chemotherapy, but the reasons remain unclear. Recent publications, and our own studies, have shown that breast cancer cells that are cultured with breast adipocytes (fat cells) become more invasive and more resistant to radiation therapy and chemotherapy drugs.
To begin to understand how fat cells are promoting breast cancer cell invasion and resistance to therapy, we have used discovery mass spectrometry to identify proteins and peptides secreted by cancer associated adipocytes (CAA). In addition, we have identified breast cancer cell proteins and peptides that are up- and down-regulated by CAA and their secreted products.
We are looking for a BBiomedSc (Hons) to join our established team, to investigate key signalling pathways involved in this breast cancer cell response to cancer associated adipocytes. The student will learn cell culture and various techniques for analysing proteins (e.g Western analysis and targeted inhibition of key signalling molecules).
Preferred student expertise
An enthusiastic science student with an interest in cancer biology who has some previous laboratory experience.
This project is one of the many available for the 2018 intake of BBiomedSc(Hons) at the University of Otago, Christchurch campus.
- Visit the University of Otago, Christchurch website for more information about the Honours programme.
- Visit the Mackenzie Cancer Research Group website
- Visit Dr Margaret Currie's staff profile
- Visit Dr Elisabeth Phillips' staff profile
ContactDr Margaret Currie
Tel 64 3 364 0544