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BBiomedSc(Hons) projects completed at the University of Otago, Christchurch

Centre for Free Radical Research

Project  Primary supervisor
Investigating the pro-apoptotic properties of portimine Professor Mark Hampton
Inactivation of a thiol-dependent enzyme by urate hydroperoxide Professor Tony Kettle
Measurement of mitochondrial dysfunction in humans Dr Andree Pearson
Involvement of mitochondria and peroxiredoxin in TNF-mediated necroptosis Professor Mark Hampton
The effect of cell metabolism on epigenetic processes in cancer cells Professor Margreet Vissers
Functional consequences of lowering mitochondrial peroxiredoxin 3 expression Professor Mark Hampton
Neutrophil activation in inflammatory bowel disease Professor Richard Gearry
Inhibiting the pro-inflammatory cytokine MIF Professor Mark Hampton
Assessing a blood biomarker of lung infection Professor Christine Winterbourn

Gene Structure and Function Laboratory

Project  Primary supervisor
Diagnostic applications of a Nanopore sequencing device Professor Martin Kennedy
Impact of G-quadruplex structures and DNA methylation on allelic drop-out during in vitro amplification of imprinted genes Professor Martin Kennedy
Establishment and validation of a telomere length assay Professor Martin Kennedy
Does promoter variation in the USP46 gene influence antidepressant response? Professor Martin Kennedy

Inflammation Research Group

Project Primary supervisor
Hydrogen sulfide: Investigation into the effects of different H2S donors on the upregulation of inflammatory cytokines Professor Madhav Bhatia

The Infection Group

Project Primary supervisor
A novel strategy to prevent bacterial biofilm formation using methylthioadenosine-nucleosidase inhibitors Professor Steve Chambers
Detecting 2-aminoacetophenone and pyocyanin from clinical strains of Pseudomonas aeruginosa Dr Amy Scott-Thomas

Mackenzie Cancer Research Group

Project Primary supervisor
The influence of exercise and hyperlipidaemia on breast cancer Assoc Professor Gabi Dachs
Development of a metabolic syndrome model of breast cancer Assoc Professor Gabi Dachs
Does fat provide energy for breast tumour cell invasion and metastasis? Dr Margaret Currie
Exploring molecular links between obesity and breast cancer Dr Logan Walker
Evaluating molecular markers of breast tumour progression Dr Logan Walker
Gene transfer to restore vitamin C synthesis in human cell line Assoc Professor Gabi Dachs
Immune suppression and cutaneous squamous cell carcinoma tumour biology Dr Margaret Currie
Myeloid-serived suppressor cells, tumour angiogenesis and cancer progression Dr Margaret Currie

Molecular Pathology

Project Primary supervisor
Development of an assay for interferon beta bioavailability in relapsing-remitting MS patients Professor Steve Brennan

Christchurch Heart Institute

Project Primary supervisor
Evaluation of The Four-and-a-half LIM 2 (FHL2) Single Polypeptide As A Potential Biomarker of Cardio-Renal Syndrome (CRS) Assoc Professor Chris Pemberton