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MICR335 Molecular Microbiology

The bacterial nucleoid and its influence on gene expression. Molecular mechanisms by which bacteria adapt to environmental change. Regulation of gene expression by proteins and small RNAs. Riboswitches. Bacterial RNA maturation.

Molecular Microbiology is highly relevant to all aspects of modern microbiology. MICR 335 will provide a fundamental knowledge of the mechanisms that bacteria use to sense their environment and adapt their gene expression to optimise their growth and survival. This paper emphasises general principles and illustrates their application with topical examples. Lectures are complemented by a laboratory course, which will help you develop skills in scientific record-keeping and reporting. A research project will provide hands-on experience with many of the skills and techniques that are used in a microbial genetics laboratory.

Paper title Molecular Microbiology
Paper code MICR335
Subject Microbiology
EFTS 0.1500
Points 18 points
Teaching period First Semester
Domestic Tuition Fees (NZD) $1,018.05
International Tuition Fees (NZD) $4,500.00

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Prerequisite
MICR 221 or GENE 221
Schedule C
Science
Eligibility
Appropriate for students majoring in Microbiology, Genetics, Biochemistry or Molecular Biotechnology
Contact
greg.cook@otago.ac.nz
Teaching staff
Convenor: Professor Gregory Cook
Other Lecturers: Professor Clive Ronson,Associate Professor Peter Fineran, Dr Jennifer Robson and Keil Hards
Paper Structure
The lecture course is divided into a number of modules, some of which change from year to year, reflecting topical issues in microbiology.

Modules for 2017 are:
  • General overview of genetic regulatory mechanisms (9 lectures)
  • Global regulation of respiration and molecular responses to oxidative stress (6 lectures)
  • Regulatory RNAs and CRISPR-Cas (6 lectures)
  • Gene regulation by toxin-antitoxin modules and stationary phase adaptation (4 lectures)

The lecture course is complemented by a laboratory course that aims to help students develop research skills relevant to molecular microbiology.

Assessment:
  • Internal assessment based on laboratory report 25% (due at the end of week 5 of the semester, one week after the final lab)
  • Assignment 5% (given out in week 3 of the semester, due 28 April))
  • A written three-hour final exam comprising four either/or essay questions: 70%


To pass the paper, you must achieve a minimum of 50% overall.
Teaching Arrangements
This is a first semester paper with two lectures per week. The laboratory course runs over the first 4 weeks of the first semester only. Small amounts of work will also be required on additional days to laboratories. However, there is considerable flexibility in these hours, with attendance compulsory only at one specific time. Other than that, students may leave the lab for other commitments, such as lectures, and are able to plan their experiments to fit in with these commitments.
Textbooks
Text books are not required for this paper.
Course readings are reviews and original papers from the literature. PDFs of these will be placed on Blackboard.
Graduate Attributes Emphasised
Critical thinking, Information literacy, Research.
View more information about Otago's graduate attributes.
Learning Outcomes
Demonstrate an in-depth knowledge of central concepts and current developments in molecular microbiology

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Timetable

First Semester

Location
Dunedin
Teaching method
This paper is taught On Campus
Learning management system
Blackboard

Lecture

Stream Days Times Weeks
Attend
L1 Monday 11:00-11:50 9-15, 17-22
Wednesday 11:00-11:50 9-15, 17-22

Practical

Stream Days Times Weeks
Attend
P1 Tuesday 14:00-17:50 9-12
Wednesday 09:00-10:50 9-12
Wednesday 12:00-17:50 9-12

The bacterial nucleoid and its influence on gene expression. Molecular mechanisms by which bacteria adapt to environmental change. Regulation of gene expression by proteins and small RNAs. Riboswitches. Bacterial RNA maturation.

Molecular Microbiology is highly relevant to all aspects of modern microbiology. MICR 335 will provide a fundamental knowledge of the mechanisms that bacteria use to sense their environment and adapt their gene expression to optimise their growth and survival. This paper emphasises general principles and illustrates their application with topical examples. Lectures are complemented by a laboratory course, which will help you develop skills in scientific record-keeping and reporting. A research project will provide hands-on experience with many of the skills and techniques that are used in a microbial genetics laboratory.

Paper title Molecular Microbiology
Paper code MICR335
Subject Microbiology
EFTS 0.1500
Points 18 points
Teaching period First Semester
Domestic Tuition Fees Tuition Fees for 2018 have not yet been set
International Tuition Fees Tuition Fees for international students are elsewhere on this website.

^ Top of page

Prerequisite
MICR 221 or GENE 221
Schedule C
Science
Eligibility
Appropriate for students majoring in Microbiology, Genetics, Biochemistry or Molecular Biotechnology.
Contact
greg.cook@otago.ac.nz
Teaching staff
Convenor: Professor Gregory Cook
Other Lecturers: Professor Clive Ronson,Associate Professor Peter Fineran, Dr Jennifer Robson and Dr Kiel Hards
Teaching Arrangements
This is a first semester paper with two lectures per week. The laboratory course runs over the first 4 weeks of the first semester only. Small amounts of work will also be required on additional days to laboratories. However, there is considerable flexibility in these hours, with attendance compulsory only at one specific time. Other than that, students may leave the lab for other commitments, such as lectures, and are able to plan their experiments to fit in with these commitments.
Paper Structure
The lecture course is divided into a number of modules, some of which change from year to year, reflecting topical issues in microbiology.

Modules for 2017 are:
  • General overview of genetic regulatory mechanisms (9 lectures)
  • Global regulation of respiration and molecular responses to oxidative stress (6 lectures)
  • Regulatory RNAs and CRISPR-Cas (6 lectures)
  • Gene regulation by toxin-antitoxin modules and stationary phase adaptation (4 lectures)
The lecture course is complemented by a laboratory course that aims to help students develop research skills relevant to molecular microbiology.

Assessment:
  • Internal assessment based on laboratory report 25% (due at the end of week 5 of the semester, one week after the final lab)
  • Assignment 5% (given out in week 3 of the semester, due 28 April))
  • A written three-hour final exam comprising four either/or essay questions: 70%
To pass the paper, you must achieve a minimum of 50% overall.
Textbooks
Text books are not required for this paper.
Course readings are reviews and original papers from the literature. PDFs of these will be placed on Blackboard.
Graduate Attributes Emphasised
Critical thinking, Information literacy, Research.
View more information about Otago's graduate attributes.
Learning Outcomes
Demonstrate an in-depth knowledge of central concepts and current developments in molecular microbiology.

^ Top of page

Timetable

First Semester

Location
Dunedin
Teaching method
This paper is taught On Campus
Learning management system
Blackboard

Lecture

Stream Days Times Weeks
Attend
L1 Monday 11:00-11:50 9-13, 15-22
Wednesday 11:00-11:50 9-13, 15-16, 18-22

Practical

Stream Days Times Weeks
Attend
P1 Tuesday 14:00-17:50 9-12
Wednesday 09:00-10:50 9-12
Wednesday 12:00-17:50 9-12