Principles of medicinal chemistry and pharmacology that underpin drug pharmacokinetics and drug action. Chemical structure as a determinant of physicochemical properties and biological activity. Basic principles of pharmacology applied in the autonomic nervous system.
|Paper title||Introduction to Drug Action|
|Teaching period||Second Semester|
|Domestic Tuition Fees (NZD)||$745.37|
|International Tuition Fees (NZD)||$3,467.50|
- Limited to
- Teaching staff
- Associate Professor Joel Tyndall, Dr Allan Gamble, Mr David Schmierer, Professor Stephen Duffull and Pharmacology staff
- Paper Structure
- Three modules
- Teaching Arrangements
- Lectures, laboratories and tutorials
- Patrick, G. L. (2013) An Introduction to Medicinal Chemistry, 5th edn, Oxford University
Rang, Humphrey, and Dale, Maureen, and Ritter, James, and Flower, Rod, and Henderson, Graeme, (2011) Rang and Dale's Pharmacology, 7th edn, Churchill Livingston.
Lemke, T.L and Williams, D. A. (2013) Foye's Principles of Medicinal Chemistry 7th edn, Lippincott Williams and Wilkins.
- Graduate Attributes Emphasised
- Lifelong learning, Communication, Critical thinking, Cultural understanding, Ethics,
Information literacy, Research.
View more information about Otago's graduate attributes.
- Learning Outcomes
- Predict the acid-base properties and lipophilicity of drugs based on structural features
- Understand how structure and physicochemical properties of a drug influence drug transport following administration via various routes
- Recognise the reactions involved in the metabolism of drugs within the body and predict the metabolic pathway of drugs from their chemical structure
- Predict likely drug-protein interactions based on the functional groups present in a drug and identify the nature of the biological effect a molecule has at different types of drugs targets
- Recognise the methodologies used to identify and optimise drug leads and their access to drug targets
- Understand the basic principles of pharmacology as applied to the autonomic nervous system.
- Understand and be able to use pharmacological terminology
- Understand the different receptor classes targeted by drugs, including ionotropic, G-protein coupled, kinaselinked and nuclear receptors
- Use data from pharmacological experiments to draw conclusions about mechanisms of drug action
- Be able to create dose (EC50, etc.) response curves from pharmacological data and extrapolate pharmacological variables from them