Drug disposition and pharmacokinetic principles; pharmacokinetics and dose regimen optimisation; factors responsible for inter- and intra-subject variation.
|Paper title||Drug Disposition and Pharmacokinetics|
|Teaching period||First Semester|
|Domestic Tuition Fees (NZD)||$800.30|
|International Tuition Fees (NZD)||$3,796.00|
- Limited to
- Admission from successful completion of second-year programme or approved graduate entry
- Teaching staff
- Dr Dorothy Saville, Associate Professor Natalie Medlicott, Dr Arlene McDowell and Dr Hesham Al-Sallami
- Paper Structure
- 30 lectures
- Internal 30%
- Final 70%
- Teaching Arrangements
- Lectures, laboratories, CAL laboratories and workshops.
- Rowland, Malcolm and Tozer, Thomas, N., (2010) Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications, 4th edn,. Lippincott Williams and Wilkins.
- Graduate Attributes Emphasised
- Lifelong learning, Communication, Critical thinking, Cultural understanding, Ethics,
Information literacy, Research.
View more information about Otago's graduate attributes.
- Learning Outcomes
- After successfully completing this paper, students should be able to:
- Describe and discuss techniques by which drug disposition and pharmacokinetics may be investigated
- Describe and discuss drug and patient factors that influence pharmacokinetic profiles and parameters (the patient factors include age, genetics, pregnancy, disease, diet and other drugs) and the importance of these for therapeutic outcomes
- Outline the factors influencing drug bioavailability and be able to discuss issues related to lack of bioequivalence of oral dose forms and to discuss the effect of food and dietary components on oral bioavailability
- Describe and discuss mathematical modelling techniques used in pharmacokinetics and techniques for estimation of pharmacokinetic parameters; be able to simulate plasma-level profiles from single-dose and multi-dose administration
- Describe techniques by which known or estimated parameters of drugs can be used to optimise dose regimens or to assist in the development of alternative drug delivery systems
- Outline the implications of pharmacokinetic profiles for therapeutic drug monitoring procedures and interpretation
- Carry out simple laboratory projects, with attention to experimental design and data analysis, and prepare scientific reports relating to these
- Make simple pharmacokinetic calculations and dose regimen determinations