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PHSL343 Cellular and Epithelial Physiology

The cellular and molecular basis of the mechanisms and regulation of epithelial transport and the effect of representative diseases on these processes.

Epithelia form remarkable barrier structures that regulate the entry and exit of substances into and out of the body. Control of these transport processes needs to be exquisite to avoid severe pathophysiology. How does too little chloride secretion cause cystic fibrosis, how does too much sodium uptake cause high blood pressure? What is the new dogma around glucose absorption in the intestine? How does an increase in urea cause gout? To develop treatment for these conditions understanding of the alterations at the cell and tissue level is essential.

Paper title Cellular and Epithelial Physiology
Paper code PHSL343
Subject Physiology
EFTS 0.1500
Points 18 points
Teaching period Second Semester
Domestic Tuition Fees (NZD) $1,018.05
International Tuition Fees (NZD) $4,500.00

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Prerequisite
PHSL 233
Schedule C
Science
Eligibility
One of five 300-level papers for Physiology majors.
Essential paper for Functional Human Biology majors.
Optional paper for Drugs and Human Health, Infection and Immunity, Molecular Basis of Health and Disease and Nutrition and Metabolism in Human Health majors.
Contact
andrew.bahn@otago.ac.nz
Teaching staff
Course Convener: Dr Andrew Bahn
Lecturers: Associate Professor Grant Butt and Associate Professor Fiona McDonald

Note: The teaching staff list will be updated. See the 'more information' link above for details.
Paper Structure
The paper will be taught as four modules, each of 6 lectures and 12 laboratory sessions. Lecture topics include:
  • Recent advances in our understanding of the cellular and molecular basis of absorption and secretion of fluid and electrolytes by epithelia
  • Protein trafficking in epithelial cells
  • Cell biology and physiology of diseases such as cystic fibrosis, Liddle's Syndrome, Nephrogenic Diabetes Insipidus and gout
In the laboratory course you will design, perform, interpret and present your own experiment in a guided process over the entire semester.

Assessment consists of internal assessment (including the presentation of a research poster and a written research proposal)and a 3-hour final exam. A mark of at least 45% in the final exam must be attained to pass the paper as a whole.

For further detail please refer to the undergraduate handbooks BSc PHSL or BBiomedSc FUHB, available to download.
Teaching Arrangements
You will attend two lectures each week and two 4-hour laboratory sessions every second week (alternating with PHSL 344).
Textbooks
Original research articles
Graduate Attributes Emphasised
Lifelong learning, Scholarship, Communication, Critical thinking, Ethics, Research, Self-motivation, Teamwork.
View more information about Otago's graduate attributes.
Learning Outcomes
  • Acquired deep knowledge and understanding of the physiology of epithelial body systems in normal and dysfunctional situations
  • Developed skills in a variety of physiological techniques
  • Developed oral and written scientific communication skills

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Timetable

Second Semester

Location
Dunedin
Teaching method
This paper is taught On Campus
Learning management system
Blackboard

Lecture

Stream Days Times Weeks
Attend
L1 Wednesday 09:00-09:50 28-34, 36-41
Thursday 09:00-09:50 28-34, 36-41

Practical

Stream Days Times Weeks
Attend
P1 Tuesday 14:00-17:50 29, 31, 33, 36, 38, 40
Wednesday 14:00-17:50 29, 31, 33, 36, 38, 40

The cellular and molecular basis of the mechanisms and regulation of epithelial transport and the effect of representative diseases on these processes.

Epithelia form remarkable barrier structures that regulate the entry and exit of substances into and out of the body. Control of these transport processes needs to be exquisite to avoid severe pathophysiology. How does too little chloride secretion cause cystic fibrosis, how does too much sodium uptake cause high blood pressure? What is the new dogma around glucose absorption in the intestine? How does an increase in urea cause gout? To develop treatment for these conditions understanding of the alterations at the cell and tissue level is essential.

Paper title Cellular and Epithelial Physiology
Paper code PHSL343
Subject Physiology
EFTS 0.1500
Points 18 points
Teaching period Second Semester
Domestic Tuition Fees (NZD) $1,038.45
International Tuition Fees (NZD) $4,680.00

^ Top of page

Prerequisite
PHSL 233
Schedule C
Science
Eligibility
One of five 300-level papers for Physiology majors.
Essential paper for Functional Human Biology majors.
Optional paper for Drugs and Human Health, Infection and Immunity, Molecular Basis of Health and Disease and Nutrition and Metabolism in Human Health majors.
Contact
andrew.bahn@otago.ac.nz
Teaching staff
Course Convener: Dr Andrew Bahn
Lecturers: Associate Professor Grant Butt and Associate Professor Fiona McDonald

Note: The teaching staff list will be updated. See the 'more information' link above for details.
Paper Structure
The paper will be taught as four modules, each of 6 lectures and 12 laboratory sessions. Lecture topics include:
  • Recent advances in our understanding of the cellular and molecular basis of absorption and secretion of fluid and electrolytes by epithelia
  • Protein trafficking in epithelial cells
  • Cell biology and physiology of diseases such as cystic fibrosis, Liddle's Syndrome, Nephrogenic Diabetes Insipidus and gout
In the laboratory course you will design, perform, interpret and present your own experiment in a guided process over the entire semester.

Assessment consists of internal assessment (including the presentation of a research poster and a written research proposal)and a 3-hour final exam. A mark of at least 45% in the final exam must be attained to pass the paper as a whole.

For further detail please refer to the undergraduate handbooks BSc PHSL or BBiomedSc FUHB, available to download.
Teaching Arrangements
You will attend two lectures each week and two 4-hour laboratory sessions every second week (alternating with PHSL 344).
Textbooks
Original research articles.
Graduate Attributes Emphasised
Lifelong learning, Scholarship, Communication, Critical thinking, Ethics, Research, Self-motivation, Teamwork.
View more information about Otago's graduate attributes.
Learning Outcomes
  • Acquired deep knowledge and understanding of the physiology of epithelial body systems in normal and dysfunctional situations
  • Developed skills in a variety of physiological techniques
  • Developed oral and written scientific communication skills

^ Top of page

Timetable

Second Semester

Location
Dunedin
Teaching method
This paper is taught On Campus
Learning management system
Blackboard

Lecture

Stream Days Times Weeks
Attend
L1 Wednesday 09:00-09:50 28-34, 36-41
Thursday 09:00-09:50 28-34, 36-41

Practical

Stream Days Times Weeks
Attend
P1 Tuesday 14:00-17:50 29, 31, 33, 36, 38, 40
Wednesday 14:00-17:50 29, 31, 33, 36, 38, 40