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LOADD Study - Lifestyle Over and Above Drugs in Diabetes

Until recently 'lifestyle therapy' (appropriate diet and exercise) was the cornerstone of treatment for type 2 diabetes (T2DM). Drugs to lower high blood glucose, reduce raised blood pressure, and to treat abnormal blood lipid levels are more widely prescribed than previously, and the importance of lifestyle may have been overlooked. This research aims to examine the extent to which an intensive dietary intervention can further improve glucose, blood pressure and lipids levels, over and above the effects of recommended drugs. Patients with established T2DM on appropriate diabetes and cardiovascular medication will be randomised to receive either intensive evidence based dietary advice or 'usual' dietary advice. All participants will continue to receive their usual medical care. Surrogate markers of clinical endpoints will be measured. Establishing such benefit could influence clinical practice and outcome for people with T2DM.

Funding:

The Southern Trust
Health Research Council of New Zealand

Publications:

Coppell KJ, Kataoka M, Williams SM, Chisholm AW, Vorgers SM, Mann JI. Nutritional intervention in patients with type 2 diabetes who are hyperglycaemic despite optimised drug treatment—Lifestyle Over and Above Drugs in Diabetes (LOADD) study: randomised controlled trial. BMJ. 2010; 341(c3337).
View abstract at BMJ website

Clinical Trials information:

This study is registered at http://www.clinicaltrials.gov with the identifier: NCT00124553

Media coverage: