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Contact Details

Phone
64 3 474 0999 ext 58079
Email
michael.williams@otago.ac.nz
Position
Clinical Professor
Department
Department of Medicine (Dunedin)
Qualifications
MD FRACP FACC
Research summary
Cardiology
Teaching
Integration of cardiac investigations into clinical practice.
Clinical
  • Echocardiography.
  • Interventional cardiology.
  • General cardiology.

Research

Michael Williams' research interests include studying the effect of lifestyle factors and diet on arterial function and the development of arterial disease. He has investigated the influence of physical fitness on measures of arterial inflammation and the risk of developing chest pain and heart attack in later life. His other clinical research has focussed on understanding the biology of restenosis in stents inserted in patients' heart arteries to open blockages. Studies of cardiovascular genetics have contributed to international collaborative research and the identification of novel genetic markers of arterial disease. Michael's current investigations include the regulation of gene expression on the development of narrowing and stiffening of cardiac valves with the aim of developing therapies to delay or prevent the requirement for surgical valve replacement. He is presently Chair of the Medicine Department Peer Review Committee.

Publications

Moore, M. K., Jones, G. T., Whalley, G., Prendergast, B., Williams, M. J. A., & Coffey, S. (2023). Outcomes of patients with early calcific aortic valve disease detected by clinically indicated echocardiography. European Heart Journal: Cardiovascular Imaging. Advance online publication. doi: 10.1093/ehjci/jead259

Roxburgh, B. H., Campbell, H. A., Cotter, J. D., Reymann, U., Williams, M. J. A., Gwynne-Jones, D., & Thomas, K. N. (2023). Upper-limb high-intensity interval training or passive heat therapy to optimise cardiorespiratory fitness prior to total hip or knee arthroplasty: A randomised controlled trial. Arthritis Care & Research, 25238. Advance online publication. doi: 10.1002/acr.25238

Siddiqui, H., Deo, N., Rutledge, M. T., Williams, M. J. A., Redpath, G. M. I., & McCormick, S. P. A. (2023). Plasminogen receptors promote lipoprotein(a) uptake by enhancing surface binding and facilitating macropinocytosis. Arteriosclerosis, Thrombosis, & Vascular Biology. Advance online publication. doi: 10.1161/atvbaha.123.319344

Kerr, A. J., Choi, Y., Williams, M. J. A., Stewart, R. A. H., White, H. D., Devlin, G., … Adamson, P. D., Fairley, S., … Poppe, K. (2023). Paired risk scores to predict ischaemic and bleeding risk twenty-eight days to one year after an acute coronary syndrome. Heart, 109(24), 1827-1836. doi: 10.1136/heartjnl-2023-322830

Roxburgh, B. H., Campbell, H. A., Cotter, J. D., Reymann, U., Williams, M. J. A., Gwynne-Jones, D., & Thomas, K. N. (2023). Acute and adaptive cardiovascular and metabolic effects of passive heat therapy or high-intensity interval training in patients with severe lower-limb osteoarthritis. Physiological Reports, 11, e15699. doi: 10.14814/phy2.15699

Williams, M. J. A. (2004). The importance of echocardiography to the interventionalist. In I. P. Kay, M. Sabaté & M. A. Costa (Eds.), Cardiac catheterization and percutaneous interventions. (pp. 407-416). London: Taylor & Francis.

Chapter in Book - Research

Swope, J. A., Kasabov, N. K., & Williams, M. J. A. (2000). Neuro-fuzzy modelling of heart rate signals and applications to diagnostics. In P. S. Szczepaniak, P. J. G. Lisboa & J. Kacprzyk (Eds.), Fuzzy Systems in Medicine. (pp. 519-542). Heidelberg: Physica Verlag.

Chapter in Book - Research

Barrett-Young, A., Ambler, A., Cheyne, K., Guiney, H., Kokaua, J., Tham, Y. C., Williams, M. J. A., Wilson, G. A., … Poulton, R. (2023). Childhood social isolation as a predictor of retinal neuronal thickness in middle age: A lifecourse birth cohort study. Psychosomatic Medicine. Advance online publication. doi: 10.1097/psy.0000000000001177

Journal - Research Article

Kerr, A. J., Choi, Y., Williams, M. J. A., Stewart, R. A. H., White, H. D., Devlin, G., … Adamson, P. D., Fairley, S., … Poppe, K. (2023). Paired risk scores to predict ischaemic and bleeding risk twenty-eight days to one year after an acute coronary syndrome. Heart, 109(24), 1827-1836. doi: 10.1136/heartjnl-2023-322830

Journal - Research Article

Moore, M. K., Jones, G. T., Whalley, G., Prendergast, B., Williams, M. J. A., & Coffey, S. (2023). Outcomes of patients with early calcific aortic valve disease detected by clinically indicated echocardiography. European Heart Journal: Cardiovascular Imaging. Advance online publication. doi: 10.1093/ehjci/jead259

Journal - Research Article

Roxburgh, B. H., Campbell, H. A., Cotter, J. D., Reymann, U., Williams, M. J. A., Gwynne-Jones, D., & Thomas, K. N. (2023). Acute and adaptive cardiovascular and metabolic effects of passive heat therapy or high-intensity interval training in patients with severe lower-limb osteoarthritis. Physiological Reports, 11, e15699. doi: 10.14814/phy2.15699

Journal - Research Article

Roxburgh, B. H., Campbell, H. A., Cotter, J. D., Reymann, U., Williams, M. J. A., Gwynne-Jones, D., & Thomas, K. N. (2023). Upper-limb high-intensity interval training or passive heat therapy to optimise cardiorespiratory fitness prior to total hip or knee arthroplasty: A randomised controlled trial. Arthritis Care & Research, 25238. Advance online publication. doi: 10.1002/acr.25238

Journal - Research Article

Siddiqui, H., Deo, N., Rutledge, M. T., Williams, M. J. A., Redpath, G. M. I., & McCormick, S. P. A. (2023). Plasminogen receptors promote lipoprotein(a) uptake by enhancing surface binding and facilitating macropinocytosis. Arteriosclerosis, Thrombosis, & Vascular Biology. Advance online publication. doi: 10.1161/atvbaha.123.319344

Journal - Research Article

Ghosh, N., Fenton, S., van Hout, I., Jones, G. T., Coffey, S., Williams, M. J. A., Sugunesegran, R., Parry, D., … Schwenke, D. O., Chatterjee, A., & Katare, R. (2022). Therapeutic knockdown of miR-320 improves deteriorated cardiac function in a pre-clinical model of non-ischemic diabetic heart disease. Molecular Therapy: Nucleic Acids, 29, 330-342. doi: 10.1016/j.omtn.2022.07.007

Journal - Research Article

McLeod, P., Coffey, S., Sneddon, K., Williams, M., Kerr, A., & Pemberton, J. (2022). Clinically acquired high sensitivity cardiac troponin T is a poor predictor of reduced left ventricular ejection fraction after ST elevation myocardial infarction: A national cohort study–ANZACS-QI 65. Heart, Lung & Circulation, 31, 1513-1523. doi: 10.1016/j.hlc.2022.07.014

Journal - Research Article

Aitken-Buck, H. M., Krause, J., van Hout, I., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., … Jones, P. P., & Lamberts, R. R. (2021). Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility. American Journal of Physiology: Heart & Circulatory Physiology, 321, H162-H174. doi: 10.1152/ajpheart.00184.2021

Journal - Research Article

Coffey, S., Dixit, P., Saw, E. L., Babakr, A. A., van Hout, I., Galvin, I. F., Saxena, P., Bunton, R. W., Davis, P. J., Lamberts, R. R., Katare, R., & Williams, M. J. A. (2021). Thiamine increases resident endoglin positive cardiac progenitor cells and atrial contractile force in humans: A randomised controlled trial. International Journal of Cardiology, 341, 70-73. doi: 10.1016/j.ijcard.2021.08.039

Journal - Research Article

Ho, C. Y.-C., Lee, M., El-Jack, S., Barr, P., Simmonds, M., Devlin, G., Adamson, P. D., Williams, M., & Kerr, A. J. (2021). How common are non-acute coronary syndrome (ACS) diagnoses in patients with suspected ACS investigated with coronary angiography in New Zealand? (ANZACS-QI 58). New Zealand Medical Journal, 134(1537), 43-55. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Pasupathy, S., Lindahl, B., Litwin, P., Tavella, R., Williams, M. J. A., Air, T., … Beltrame, J. F. (2021). Survival in patients with suspected myocardial infarction with nonobstructive coronary arteries: A comprehensive systematic review and meta-analysis from the MINOCA Global Collaboration. Circulation: Cardiovascular Quality & Outcomes, 14(11), e007880. doi: 10.1161/circoutcomes.121.007880

Journal - Research Article

Purvis, N., Kumari, S., Chandrasekera, D., Bellae Papannarao, J., Gandhi, S., van Hout, I., Coffey, S., Bunton, R., Sugunesegran, R., Parry, D., Davis, P., Williams, M. J. A., Bahn, A., & Katare, R. (2021). Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells. Diabetologia, 64, 1422-1435. doi: 10.1007/s00125-021-05405-7

Journal - Research Article

Roxburgh, B. H., Campbell, H. A., Cotter, J. D., Reymann, U., Williams, M. J. A., Gwynne-Jones, D., & Thomas, K. N. (2021). Cardiopulmonary exercise testing in severe osteoarthritis: A crossover comparison of four exercise modalities. Anaesthesia, 76, 72-81. doi: 10.1111/anae.15162

Journal - Research Article

Roxburgh, B. H., Campbell, H. A., Cotter, J. D., Reymann, U., Williams, M. J. A., Gwynne-Jones, D., & Thomas, K. N. (2021). The absolute and relative reliability of hand-held dynamometry in patients with severe lower-limb osteoarthritis scheduled for total joint replacement surgery. International Journal of Research in Exercise Physiology, 16(2), 81-91. Retrieved from https://ijrep.org

Journal - Research Article

Saw, E. L., Pearson, J. T., Schwenke, D. O., Munasinghe, P. E., Tsuchimochi, H., Rawal, S., Coffey, S., … Bunton, R., Van Hout, I., … Williams, M. J. A., … Fronius, M., & Katare, R. (2021). Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular Diabetology, 20, 50. doi: 10.1186/s12933-021-01231-8

Journal - Research Article

Williams, M. J. A., Lee, M., Alfadhel, M., & Kerr, A. J. (2021). Obesity and all cause mortality following acute coronary syndrome (ANZACS QI 53). Heart, Lung & Circulation, 30, 1854-1862. doi: 10.1016/j.hlc.2021.04.014

Journal - Research Article

Aitken-Buck, H. M., Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Jones, P. P., & Lamberts, R. R. (2020). Inotropic and lusitropic, but not arrhythmogenic, effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism, 319, E540-E547. doi: 10.1152/ajpendo.00202.2020

Journal - Research Article

Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Aitken-Buck, H. M., Sugunesegran, R., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Stiles, M. K., Jones, P. P., & Lamberts, R. R. (2020). Acute interaction between human epicardial adipose tissue and human atrial myocardium induce arrhythmic susceptibility. American Journal of Physiology: Endocrinology & Metabolism, 318, E164-E172. doi: 10.1152/ajpendo.00374.2019

Journal - Research Article

Chan, D. Z. L., Stewart, R. A. H., Kerr, A. J., Dicker, B., Kyle, C. V., Adamson, P. D., … Edmond, J., … Elliott, J. M., … Swain, A. H., … Williams, M. J. A., … Somaratne, J. B. (2020). The impact of a national COVID-19 lockdown on acute coronary syndrome hospitalisations in New Zealand (ANZACS-QI 55). Lancet Regional Health: Western Pacific, 5, 100056. doi: 10.1016/j.lanwpc.2020.100056

Journal - Research Article

Chandrasekera, D. N. K., Neale, J. P. H., van Hout, I., Rawal, S., Coffey, S., Jones, G. T., … Manning, P., Williams, M. J. A., & Katare, R. (2020). Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart. Apoptosis, 25(5-6), 388-399. doi: 10.1007/s10495-020-01609-1

Journal - Research Article

Hancox, R. J., Thomas, L., Williams, M. J. A., & Sears, M. R. (2020). Associations between lung and endothelial function in early middle age. Respirology, 25, 89-96. doi: 10.1111/resp.13556

Journal - Research Article

Jones, G. T., Drinkwater, B., Blake-Barlow, A., Hill, G. B., Williams, M. J. A., Krysa, J., van Rij, A. M., & Coffey, S. (2020). Both small and large infrarenal aortic size is associated with an increased prevalence of ischaemic heart disease. European Journal of Vascular & Endovascular Surgery, 60, 594-601. doi: 10.1016/j.ejvs.2020.06.025

Journal - Research Article

Jones, G. T., Marsman, J., Bhat, B., Phillips, V. L., Chatterjee, A., Rodger, E. J., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2020). DNA methylation profiling identifies a high effect genetic variant for lipoprotein(a) levels. Epigenetics, 15(9), 949-958. doi: 10.1080/15592294.2020.1739797

Journal - Research Article

Lal, S., Gray, A., Kim, E., Bunton, R. W., Davis, P., Galvin, I. F., & Williams, M. J. A. (2020). Frailty in elderly patients undergoing cardiac surgery increases hospital stay and 12-month readmission rate. Heart, Lung & Circulation, 29, 1187-1194. doi: 10.1016/j.hlc.2019.10.007

Journal - Research Article

Moharram, M. A., Aitken-Buck, H. M., Reijers, R., van Hout, I., Williams, M. J. A., Jones, P. P., Whalley, G. A., Lamberts, R. R., & Coffey, S. (2020). Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. New Zealand Medical Journal, 133(1516), 22-32. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Moharram, M. A., Wilson, L. C., Williams, M. J. A., & Coffey, S. (2020). Beat-to-beat blood pressure measurement using a cuffless device does not accurately reflect invasive blood pressure. International Journal of Cardiology Hypertension, 5, 100030. doi: 10.1016/j.ijchy.2020.100030

Journal - Research Article

Morgan, B. M., Brown, A. N., Deo, N., Harrop, T. W. R., Taiaroa, G., Mace, P. D., Wilbanks, S. M., Merriman, T. R., Williams, M. J. A., & McCormick, S. P. A. (2020). Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo(a) alleles. Journal of Lipid Research, 61, 432-444. doi: 10.1194/jlr.M094540

Journal - Research Article

Wang, T. K. M., Kasargod, C., Chan, D., Cicovic, S., Dimalapang, E., Webster, M., … Smyth, D., Williams, M., … Somaratne, J. (2020). Diagnostic coronary angiography and percutaneous coronary intervention practices in New Zealand: The All New Zealand Acute Coronary Syndrome-Quality Improvement CathPCI Registry 3-year study (ANZACS- QI 37). International Journal of Cardiology, 312, 37-41. doi: 10.1016/j.ijcard.2020.02.063

Journal - Research Article

Aitken-Buck, H. M., Moharram, M., Babakr, A. A., Reijers, R., Van Hout, I., Fomison-Nurse, I. C., Sugunesegran, R., … Bunton, R. W., Williams, M. J. A., … Jones, P. P., Coffey, S., & Lamberts, R. R. (2019). Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index. Adipocyte, 8(1), 412-420. doi: 10.1080/21623945.2019.1701387

Journal - Research Article

Ellis, C. J., Gamble, G. D., Williams, M. J. A., Matsis, P., Elliott, J. M., Devlin, G., Mann, S., … for the Regional Cardiac Society NZ ACS Audit Group, including Richards, M., & Nixon, G. (2019). All-cause mortality following an acute coronary syndrome: 12-year follow-up of the comprehensive 2002 New Zealand Acute Coronary Syndrome Audit. Heart, Lung & Circulation, 28(2), 245-256. doi: 10.1016/j.hlc.2017.10.015

Journal - Research Article

Jones, G. T., Sandiford, P., Hill, G. B., Williams, M. J. A., Khashram, M., Tilyard, M. W., Hammond-Tooke, G. D., Krysa, J., & van Rij, A. M. (2019). Correcting for body surface area identifies the true prevalence of abdominal aortic aneurysm in screened women. European Journal of Vascular & Endovascular Surgery, 57(2), 221-228. doi: 10.1016/j.ejvs.2018.08.048

Journal - Research Article

Kerr, A. J., Lee, M., Grey, C., Pegg, T. J., Fisher, N. G., White, H. H., … Williams, M. J. A., Smyth, D., … on behalf of the ANZACS-QI investigators. (2019). Acute reperfusion for ST-elevation myocardial infarction in New Zealand (2015-2017): Patient and system delay (ANZACS-QI 29). New Zealand Medical Journal, 132(1498), 41-59. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Kerr, A. J., Lee, M., Jiang, Y., Grey, C., Wells, S., Williams, M., … on behalf of the ANZACS-QI Investigators. (2019). High level of capture of coronary intervention and associated acute coronary syndromes in the all New Zealand acute coronary syndrome quality improvement cardiac registry and excellent agreement with national administrative datasets (ANZACS-QI 25). New Zealand Medical Journal, 132(1492), 19-29. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Rawal, S., Nagesh, P. T., Coffey, S., Van Hout, I., Galvin, I. F., Bunton, R. W., Davis, P., Williams, M. J. A., & Katare, R. (2019). Early dysregulation of cardiac-specific microRNA-208a is linked to maladaptive cardiac remodelling in diabetic myocardium. Cardiovascular Diabetology, 18, 13. doi: 10.1186/s12933-019-0814-4

Journal - Research Article

Williams, M. J. A., Barr, P. R., Lee, M., Poppe, K. K., & Kerr, A. J. (2019). Outcome after myocardial infarction without obstructive coronary artery disease. Heart, 105(7), 524-530. doi: 10.1136/heartjnl-2018-313665

Journal - Research Article

Fomison-Nurse, I., Saw, E. E. L., Gandhi, S., Munasinghe, P. E., Van Hout, I., Williams, M. J. A., Galvin, I., Bunton, R., Davis, P., Cameron, V., & Katare, R. (2018). Diabetes induces the activation of pro-ageing miR-34a in the heart, but has differential effects on cardiomyocytes and cardiac progenitor cells. Cell Death & Differentiation, 25, 1336-1349. doi: 10.1038/s41418-017-0047-6

Journal - Research Article

Shearer, D. M., Thomson, W. M., Cameron, C. M., Ramrakha, S., Wilson, G., Wong, T. Y., Williams, M. J. A., McLean, R., Theodore, R., & Poulton, R. (2018). Periodontitis and multiple markers of cardiometabolic risk in the fourth decade: A cohort study. Community Dentistry & Oral Epidemiology, 46(6), 615-623. doi: 10.1111/cdoe.12414

Journal - Research Article

Elliott, J. M., Wang, T. K. M., Gamble, G., Williams, M., Matsis, P., Troughton, R., … Mann, S., Richards, M., … Ellis, C. (2017). A decade of improvement in the management of New Zealand ST-elevation myocardial infarction (STEMI) patients: Results from the New Zealand Acute Coronary Syndrome (ACS) Audit Group national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 130(1453), 17-28. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., … Phillips, L. V., Williams, M. J. A., Wei, W., … Thomson, I. A., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., … van Rij, A., … Bown, M. J. (2017). Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. Circulation Research, 120, 341-353. doi: 10.1161/circresaha.116.308765

Journal - Research Article

Kerr, A. J., Williams, M., White, H., Grey, C., Jiang, Y., Nunn, C., on behalf of the ANZACS-QI investigators. (2017). 30-day mortality aft er percutaneous coronary intervention in New Zealand public hospitals (ANZACS-QI 18). New Zealand Medical Journal, 130(1459), 54-63. Retrieved from http://www.nzma.org.nz/journal

Journal - Research Article

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916

Journal - Research Article

Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2017). Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovascular Research, 113(1), 90-101. doi: 10.1093/cvr/cvw235

Journal - Research Article

Sharma, M., Redpath, G. M., Williams, M. J. A., & McCormick, S. P. A. (2017). Recycling of apolipoprotein(a) after PlgRKT-mediated endocytosis of lipoprotein(a). Circulation Research, 120(7), 1091-1102. doi: 10.1161/circresaha.116.310272

Journal - Research Article

Williams, M. J. A., Milne, B. J., Ambler, A., Theodore, R., Ramrakha, S., Caspi, A., Moffitt, T. E., & Poulton, R. (2017). Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife. International Journal of Obesity, 41, 1355-1360. doi: 10.1038/ijo.2017.108

Journal - Research Article

Wilson, L. C., Peebles, K. C., Hoye, N. A., Manning, P., Sheat, C., Williams, M. J. A., Wilkins, G. T., Wilson, G. A., & Baldi, J. C. (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports, 5(8), e13248. doi: 10.14814/phy2.13248

Journal - Research Article

Barr, P., Smyth, D., Harding, S. A., El-Jack, S., Williams, M. J. A., Devlin, G., … on behalf of the ANZACS-QI Investigators. (2016). Variation in arterial access for invasive coronary procedures in New Zealand: A national analysis (ANZACS-QI 5). Heart, Lung & Circulation, 25, 451-458. doi: 10.1016/j.hlc.2015.10.009

Journal - Research Article

Coffey, S., Cox, B., & Williams, M. J. A. (2016). Changing causes of heart valve disease mortality in New Zealand from 1988 to 2007. New Zealand Medical Journal, 129(1428), 55-64. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Coffey, S., Williams, M. J. A., Phillips, L. V., Galvin, I. F., Bunton, R. W., & Jones, G. T. (2016). Integrated microRNA and messenger RNA analysis in aortic stenosis. Scientific Reports, 6, 36904. doi: 10.1038/srep36904

Journal - Research Article

Devlin, G., Williams, M., Elliott, J., White, H., French, J., Gamble, G., Matsis, P., Troughton, R., Richards, M., & Ellis, C. (2016). Management of non ST-elevation acute coronary syndrome patients in New Zealand: A longitudinal analysis: Results from the New Zealand Acute Coronary Syndrome national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 129(1428), 9-15. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Jones, G. T., Hill, B. G., Curtis, N., Kabir, T. D., Wong, L. E., Tilyard, M. W., Williams, M. J. A., & van Rij, A. M. (2016). Comparison of three targeted approaches to screening for abdominal aortic aneurysm based on cardiovascular risk. British Journal of Surgery, 103(9), 1139-1146. doi: 10.1002/bjs.10224

Journal - Research Article

Jones, G. T., Phillips, V., Williams, M. J. A., van Rij, A. M., & Kabir, T. D. (2016). Two C-C family chemokines, eotaxin and RANTES, are novel independent plasma biomarkers for abdominal aortic aneurysm. Journal of the American Heart Association, 5(5), e002993. doi: 10.1161/jaha.115.002993

Journal - Research Article

Kerr, A. J., Williams, M. J. A., Harding, S., White, H., Doughty, R. N., Nunn, C., … on behalf of the ANZACS-QI Investigators. (2016). The All New Zealand Acute Coronary Syndrome Quality Improvement programme: Implementation, methodology and cohorts (ANZACS-QI 9). New Zealand Medical Journal, 129(1439), 23-36. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Mandic, S., Stevens, E., Hodge, C., Brown, C., Walker, R., Body, D., … Nye, E. R., & Williams, M. J. A. (2016). Long-term effects of cardiac rehabilitation in elderly individuals with stable coronary artery disease. Disability & Rehabilitation, 38(9), 837-843. doi: 10.3109/09638288.2015.1061611

Journal - Research Article

Nioi, P., Sigurdsson, A., Thorleifsson, G., Helgason, H., Agustsdottir, A. B., Norddahl, G. L., … Williams, M. J. A., van Rij, A. M., Jones, G. T., … Stefansson, K. (2016). Variant ASGR1 associated with a reduced risk of coronary artery disease. New England Journal of Medicine, 374, 2131-2141. doi: 10.1056/NEJMoa1508419

Journal - Research Article

Rawal, S., Parshu Ram, T., Coffey, S., Williams, M. J. A., Saxena, P., Bunton, R. W., Galvin, I. F., & Katare, R. (2016). Differential expression pattern of cardiovascular microRNAs in the human type-2 diabetic heart with normal ejection fraction. International Journal of Cardiology, 202, 40-43. doi: 10.1016/j.ijcard.2015.08.161

Journal - Research Article

Thomas, K. N., Cotter, J. D., Williams, M. J. A., & van Rij, A. M. (2016). Diagnosis, incidence, and clinical implications of perioperative myocardial injury in vascular surgery. Vascular & Endovascular Surgery, 50(4), 247-255. doi: 10.1177/1538574416637441

Journal - Research Article

Thomas, K. N., Cotter, J. D., Williams, M. J. A., & van Rij, A. M. (2016). Repeated episodes of remote ischemic preconditioning for the prevention of myocardial injury in vascular surgery. Vascular & Endovascular Surgery, 50(3), 140-146. doi: 10.1177/1538574416639150

Journal - Research Article

van 't Hof, F. N. G., Ruigrok, Y. M., Lee, C. H., Ripke, S., Anderson, G., de Andrade, M., … Jones, G. T., … van Rij, A. M., … Vascular Research Consortium of New Zealand, including Phillips, L. V., Hill, G. B., Williams, M. J. A., Thomson, I. A., Krysa, J., Wilkins, G. T., Merriman, T. R., Lewis, D. R., … de Bakker, P. I. W. (2016). Shared genetic risk factors of intracranial, abdominal, and thoracic aneurysms. Journal of the American Heart Association, 5(7), e002603. doi: 10.1161/jaha.115.002603

Journal - Research Article

Williams, M. J. A., Harding, S. A., Devlin, G., Nunn, C., El-Jack, S., Scott, T., … on behalf of the ANZACS-QI Investigators, including Matsis, P., Smyth, D., Blake, J., Elliott, J., Lainchbury, J., Bridgman, P., Troughton, R., Wilkins, G., Green, B., Edmond, J., & Milburn, K. (2016). National variation in coronary angiography rates and timing after an acute coronary syndrome in New Zealand (ANZACS-QI 6). New Zealand Medical Journal, 129(1428), 65-77. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Journal - Research Article

Coffey, S., Williams, M. J. A., Phillips, L. V., & Jones, G. T. (2015). Circulating microRNA profiling needs further refinement before clinical use in patients with aortic stenosis. Journal of the American Heart Association, 4(8), e002150. doi: 10.1161/jaha.115.002150

Journal - Research Article

Ellis, C., Hammett, C., Ranasinghe, I., French, J., Briffa, T., Devlin, G., Elliott, J., … Williams, M., Troughton, R., … on behalf of Bi-National Acute Coronary Syndromes (ACS) 'SNAPSHOT' Audit Group. (2015). Comparison of the management and in-hospital outcomes of acute coronary syndrome patients in Australia and New Zealand: Results from the binational SNAPSHOT acute coronary syndrome 2012 audit. Internal Medicine Journal, 45(5), 497-509. doi: 10.1111/imj.12739

Journal - Research Article

Horwood, H., Williams, M. J. A., & Mandic, S. (2015). Examining motivations and barriers for attending maintenance community-based cardiac rehabilitation using the Health-Belief Model. Heart, Lung & Circulation, 24, 980-987. doi: 10.1016/j.hlc.2015.03.023

Journal - Research Article

Majeed, K., Hamer, A. W., White, S. C., Pegg, T. J., Wilkins, G. T., Williams, S. M., … Williams, M. J. A. (2015). Prevalence of abdominal aortic aneurysm in patients referred for transthoracic echocardiography. Internal Medicine Journal, 45(1), 32-39. doi: 10.1111/imj.12592

Journal - Research Article

Mandic, S., Body, D., Barclay, L., Walker, R., Nye, E. R., Grace, S. L., & Williams, M. J. A. (2015). Community-based cardiac rehabilitation maintenance programs: Use and effects. Heart, Lung & Circulation, 24, 710-718. doi: 10.1016/j.hlc.2015.01.014

Journal - Research Article

Sharma, M., Von Zychlinski-Kleffmann, A., Porteous, C. M., Jones, G. T., Williams, M. J. A., & McCormick, S. P. A. (2015). Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids. Journal of Lipid Research, 56, 1318-1328. doi: 10.1194/jlr.M056150

Journal - Research Article

Theodore, R. F., Broadbent, J., Nagin, D., Ambler, A., Hogan, S., Ramrakha, S., … Williams, M. J. A., Harrington, H., Moffitt, T. E., … Milne, B., & Poulton, R. (2015). Childhood to early-midlife systolic blood pressure trajectories: Early-life predictors, effect modifiers, and adult cardiovascular outcomes. Hypertension, 66, 1108-1115. doi: 10.1161/HYPERTENSIONAHA.115.05831

Journal - Research Article

Coffey, S., Cox, B., & Williams, M. J. A. (2014). Lack of progress in valvular heart disease in the pre—transcatheter aortic valve replacement era: Increasing deaths and minimal change in mortality rate over the past three decades. American Heart Journal, 167(4), 562-567. doi: 10.1016/j.ahj.2013.12.030

Journal - Research Article

Coffey, S., Cox, B., & Williams, M. J. A. (2014). The prevalence, incidence, progression, and risks of aortic valve sclerosis: A systematic review and meta-analysis. JACC, 63(25), 2852-2861. doi: 10.1016/j.jacc.2014.04.018

Journal - Research Article

Francois, M. E., Baldi, J. C., Manning, P. J., Lucas, S. J. E., Hawley, J. A., Williams, M. J. A., & Cotter, J. D. (2014). ‘Exercise snacks’ before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia, 57(7), 1437-1445. doi: 10.1007/s00125-014-3244-6

Journal - Research Article

Jin, C., Phillips, L. V., Williams, M. J. A., van Rij, A. M., & Jones, G. T. (2014). Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease. SpringerPlus, 3, 635. doi: 10.1186/2193-1801-3-635

Journal - Research Article

Kader, T., Porteous, C. M., Williams, M. J. A., Gieseg, S. P., & McCormick, S. P. A. (2014). Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice. Atherosclerosis, 237(2), 725-733. doi: 10.1016/j.atherosclerosis.2014.10.101

Journal - Research Article

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Journal - Research Article

Moore, A., Shindikar, A., Fomison-Nurse, I., Riu, F., Munasinghe, P. E., Parshu Ram, T., Saxena, P., Coffey, S., Bunton, R. W., Galvin, I. F., Williams, M. J. A., … Katare, R. (2014). Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1. Cardiovascular Diabetology, 13, 68. doi: 10.1186/1475-2840-13-68

Journal - Research Article

von Zychilinski, A., Williams, M., McCormick, S., & Kleffmann, T. (2014). Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins. Journal of Proteomics, 106, 181-190. doi: 10.1016/j.jprot.2014.04.030

Journal - Research Article

Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2013). Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function. International Journal of Cardiology, 167(4), 1242-1246. doi: 10.1016/j.ijcard.2012.03.147

Journal - Research Article

Ellis, C., Gamble, G., Devlin, G., Elliott, J., Hamer, A., Williams, M., Matsis, P., Troughton, R., … for the New Zealand Acute Coronary Syndromes (NZACS) 'SNAPSHOT' Audit Group. (2013). The management of acute coronary syndrome patients across New Zealand in 2012: Results of a third comprehensive nationwide audit and observations of current interventional care. New Zealand Medical Journal, 126(1387). Retrieved from http://www.nzma.org.nz/journal

Journal - Research Article

Jones, G. T., Bown, M. J., Gretarsdottir, S., Romaine, S. P. R., Helgadottir, A., Yu, G., … Jin, C., … Phillips, L. V., Williams, M. J. A., Topless, R., Merriman, T. R., … Lewis, D. R., … van Rij, A. M. (2013). A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Human Molecular Genetics, 22(14), 2941-2947. doi: 10.1093/hmg/ddt141

Journal - Research Article

Mandic, S., Hodge, C., Stevens, E., Walker, R., Nye, E. R., Body, D., Barclay, L., & Williams, M. J. A. (2013). Effects of community-based cardiac rehabilitation on body composition and physical function in individuals with stable coronary artery disease: 1.6-year followup. BioMed Research International, 2013, 903604. doi: 10.1155/2013/903604

Journal - Research Article

Mandic, S., Walker, R., Stevens, E., Nye, E. R., Body, D., Barclay, L., & Williams, M. J. A. (2013). Estimating exercise capacity from walking tests in elderly individuals with stable coronary artery disease. Disability & Rehabilitation, 35(22), 1853-1858. doi: 10.3109/09638288.2012.759629

Journal - Research Article

Murrell, C. J., Cotter, J. D., Thomas, K. N., Lucas, S. J. E., Williams, M. J. A., & Ainslie, P. N. (2013). Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training. Age, 35(3), 905-920. doi: 10.1007/s11357-012-9414-x

Journal - Research Article

Sorrenson, B., Suetani, R. J., Williams, M. J. A., Bickley, V. M., George, P. M., Jones, G. T., & McCormick, S. P. A. (2013). Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate. Journal of Lipid Research, 54, 55-62. doi: 10.1194/jlr.M027193

Journal - Research Article

Tarr, G. P., Williams, M. J. A., Wilkins, G. T., Chen, V. H. T., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2013). Intra-individual changes of active matrix metalloproteinase-9 are associated with clinical in-stent restenosis of bare metal stents. Cardiology, 124(1), 28-35. doi: 10.1159/000345591

Journal - Research Article

Nadarasa, K., & Williams, M. J. A. (2012). Single high oral dose amiodarone for cardioversion of recent onset atrial fibrillation. Heart, Lung & Circulation, 21(8), 444-448. doi: 10.1016/j.hlc.2012.03.015

Journal - Research Article

Nadarasa, K., Robertson, M. C., Wong, C.-K., Green, B. K. W., Chen, V. H. T., Wilkins, G. T., & Williams, M. J. A. (2012). Rapid cycle change to predominantly radial access coronary angiography and percutaneous coronary intervention: Effect on vascular access site complications. Catheterization & Cardiovascular Interventions, 79(4), 589-594. doi: 10.1002/ccd.23120

Journal - Research Article

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Cardiorespiratory and cerebrovascular responses to head-up tilt II: Influence of age, training status and acute exercise. Experimental Gerontology, 46(1), 1-8. doi: 10.1016/j.exger.2010.06.004

Journal - Research Article

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Cardiorespiratory and cerebrovascular responses to head-up tilt I: Influence of age and training status. Experimental Gerontology, 46(1), 9-17. doi: 10.1016/j.exger.2010.06.005

Journal - Research Article

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Syncope is unrelated to supine and postural hypotension following prolonged exercise. European Journal of Applied Physiology, 111(3), 469-476. doi: 10.1007/s00421-010-1671-8

Journal - Research Article

Sorrenson, B., Suetani, R. J., Bickley, V. M., George, P. M., Williams, M. J. A., Scott, R. S., & McCormick, S. P. A. (2011). An ABCA1 truncation shows no dominant negative effect in a familial hypoalphalipoproteinemia pedigree with three ABCA1 mutations. Biochemical & Biophysical Research Communications, 409(3), 400-405. doi: 10.1016/j.bbrc.2011.05.006

Journal - Research Article

Suetani, R. J., Sorrenson, B., Tyndall, J. D. A., Williams, M. J. A., & McCormick, S. P. A. (2011). Homology modeling and functional testing of an ABCA1 mutation causing Tangier disease. Atherosclerosis, 218(2), 404-410. doi: 10.1016/j.atherosclerosis.2011.06.019

Journal - Research Article

Tarr, G. P., Williams, M. J. A., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2011). Pro-MMP-9/TIMP-1 ratio correlates poorly with a direct assessment of MMP-9 activity. Clinical Biochemistry, 44(17-18), 1480-1482. doi: 10.1016/j.clinbiochem.2011.09.019

Journal - Research Article

Tarr, G. P., Williams, M. J. A., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2011). Seasonal variation and stability of matrix metalloproteinase-9 activity and tissue inhibitor of matrix metalloproteinase-1 with storage at -80 oC. Clinical Biochemistry, 44(16), 1346-1348. doi: 10.1016/j.clinbiochem.2011.08.1139

Journal - Research Article

von Zychlinski, A., Kleffmann, T., Williams, M. J. A., & McCormick, S. P. (2011). Proteomics of Lipoprotein(a) identifies a protein complement associated with response to wounding. Journal of Proteomics, 74, 2881-2891. doi: 10.1016/j.jprot.2011.07.008

Journal - Research Article

Ellis, C., Devlin, G., Elliott, J., Matsis, P., Williams, M., Gamble, G., … Richards, M., … for the New Zealand Acute Coronary Syndromes (NZACS) Audit Group. (2010). ACS patients in New Zealand experience significant delays to access cardiac investigations and revascularisation treatment especially when admitted to non-interventional centres: Results of the second comprehensive national audit of ACS patients. New Zealand Medical Journal, 123(1319). Retrieved from http://journal.nzma.org.nz/journal/123-1319/4237/content.pdf

Journal - Research Article

Ellis, C., Gamble, G., Hamer, A., Williams, M., Matsis, P., Elliott, J., … Richards, M., … for the New Zealand Acute Coronary Syndromes (NZACS) Audit Group. (2010). Patients admitted with an acute coronary syndrome in New Zealand in 2007: Results of a second comprehensive nationwide audit and a comparison with the first audit from 2002. New Zealand Medical Journal, 123(1319). Retrieved from http://journal.nzma.org.nz/journal/123-1319/4235/content.pdf

Journal - Research Article

Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J.-P. P. M., … van Rij, A. M., Williams, M. J. A., … Jones, G. T., … Stefansson, K. (2010). Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics, 42(8), 692-697. doi: 10.1038/ng.622

Journal - Research Article

Stewart, R. A. H., Kerr, A. J., Whalley, G. A., Legget, M. E., Zeng, I., Williams, M. J. A., Lainchbury, J., … Richards, M. A., … for the New Zealand Heart Valve Study Investigators. (2010). Left ventricular systolic and diastolic function assessed by tissue Doppler imaging and outcome in asymptomatic aortic stenosis. European Heart Journal, 31(18), 2216-2222. doi: 10.1093/eurheartj/ehq159

Journal - Research Article

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