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DSM staff profile

Associate Professor Greg Jones

PositionResearch Associate Professor
DepartmentDepartment of Surgical Sciences (DSM)
QualificationsBSc PhD(Otago)
Research summaryVascular disease genetics, biomarker discovery, and histopathology

Research

Dr Jones' research group has a broad range of interests in the field of vascular biology, including population genetics, cardiovascular disease biomarkers, and vascular connective tissue biology. The group's research has a strong clinical emphasis, particularly in the areas of aortic aneurysm, coronary and peripheral arterial disease and varicose veins.

The Vascular Research Group has four main areas of research focus:

  • Genes associated with the initiation and progression of vascular diseases
  • Identifying circulating biomarkers to assess vascular disease risk
  • The early structural and molecular features of human arterial disease
  • The pathobiology of lower limb venous disease, including varicose veins, venous ulcers and post-operative recurrence
  • The techniques used in the Vascular Research Group include whole genome scanning, microRNA and mRNA microarray, proteomics, immunohistochemistry, cell culture, and functional assays.

The group is currently funded by the Health Research Council of New Zealand.

Publications

Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., … Phillips, L. V., Williams, M. J. A., Wei, W., … Thomson, I., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., … van Rij, A., … Bown, M. J. (2017). Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. Circulation Research, 120, 341-353. doi: 10.1161/circresaha.116.308765

Jones, G. T., Hill, B. G., Curtis, N., Kabir, T. D., Wong, L. E., Tilyard, M. W., Williams, M. J. A., & van Rij, A. M. (2016). Comparison of three targeted approaches to screening for abdominal aortic aneurysm based on cardiovascular risk. British Journal of Surgery, 103(9), 1139-1146. doi: 10.1002/bjs.10224

Jones, G. T., Phillips, V., Williams, M. J. A., van Rij, A. M., & Kabir, T. D. (2016). Two C-C family chemokines, eotaxin and RANTES, are novel independent plasma biomarkers for abdominal aortic aneurysm. Journal of the American Heart Association, 5(5), e002993. doi: 10.1161/jaha.115.002993

Jones, G. T., Bown, M. J., Gretarsdottir, S., Romaine, S. P. R., Helgadottir, A., Yu, G., … Jin, C., … Phillips, L. V., Williams, M. J. A., Topless, R., Merriman, T. R., … Lewis, D. R., … van Rij, A. M. (2013). A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Human Molecular Genetics, 22(14), 2941-2947. doi: 10.1093/hmg/ddt141

Jones, G. T. (2011). The pathohistology of abdominal aortic aneurysm. In R. T. Grundmann (Ed.), Diagnosis, screening and treatment of abdominal, thoracoabdominal and thoracic aortic aneurysms. (pp. 53-74). Rijeka, Croatia: InTech Europe. doi: 10.5772/746

Chapter in Book - Research

Jones, G. T. (2014). Matrix metalloproteinases in biologic samples. In G. S. Makowski (Ed.), Advances in clinical chemistry (Vol. 65). (pp. 199-219). Elsevier. doi: 10.1016/B978-0-12-800141-7.00007-3

Jones, G. T. (2011). The pathohistology of abdominal aortic aneurysm. In R. T. Grundmann (Ed.), Diagnosis, screening and treatment of abdominal, thoracoabdominal and thoracic aortic aneurysms. (pp. 53-74). Rijeka, Croatia: InTech Europe. doi: 10.5772/746

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Journal - Research Article

Khashram, M., Thomson, I. A., Jones, G. T., & Roake, J. A. (2017). Abdominal aortic aneurysm repair in New Zealand: A validation of the Australasian Vascular Audit. ANZ Journal of Surgery, 87(5), 394-398. doi: 10.1111/ans.13702

Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., … Phillips, L. V., Williams, M. J. A., Wei, W., … Thomson, I., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., … van Rij, A., … Bown, M. J. (2017). Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. Circulation Research, 120, 341-353. doi: 10.1161/circresaha.116.308765

Khashram, M., Williman, J. A., Hider, P. N., Jones, G. T., & Roake, J. A. (2016). Systematic review and meta-analysis of factors influencing survival following abdominal aortic aneurysm repair. European Journal of Vascular & Endovascular Surgery, 51(2), 203-215. doi: 10.1016/j.ejvs.2015.09.007

Jones, G. T., Phillips, V., Williams, M. J. A., van Rij, A. M., & Kabir, T. D. (2016). Two C-C family chemokines, eotaxin and RANTES, are novel independent plasma biomarkers for abdominal aortic aneurysm. Journal of the American Heart Association, 5(5), e002993. doi: 10.1161/jaha.115.002993

Khashram, M., Hider, P. N., Williman, J. A., Jones, G. T., & Roake, J. A. (2016). Does the diameter of abdominal aortic aneurysm influence late survival following abdominal aortic aneurysm repair? A systematic review and meta-analysis. Vascular, 24(6), 658-667. doi: 10.1177/1708538116650580

Nioi, P., Sigurdsson, A., Thorleifsson, G., Helgason, H., Agustsdottir, A. B., Norddahl, G. L., … Williams, M. J. A., van Rij, A. M., Jones, G. T., … Stefansson, K. (2016). Variant ASGR1 associated with a reduced risk of coronary artery disease. New England Journal of Medicine, 374, 2131-2141. doi: 10.1056/NEJMoa1508419

Jones, G. T., Hill, B. G., Curtis, N., Kabir, T. D., Wong, L. E., Tilyard, M. W., Williams, M. J. A., & van Rij, A. M. (2016). Comparison of three targeted approaches to screening for abdominal aortic aneurysm based on cardiovascular risk. British Journal of Surgery, 103(9), 1139-1146. doi: 10.1002/bjs.10224

Jin, C., Phillips, L. V., Williams, M. J. A., van Rij, A. M., & Jones, G. T. (2014). Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease. SpringerPlus, 3, 635. doi: 10.1186/2193-1801-3-635

Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2013). Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function. International Journal of Cardiology, 167(4), 1242-1246. doi: 10.1016/j.ijcard.2012.03.147

Tarr, G. P., Williams, M. J. A., Wilkins, G. T., Chen, V. H. T., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2013). Intra-individual changes of active matrix metalloproteinase-9 are associated with clinical in-stent restenosis of bare metal stents. Cardiology, 124(1), 28-35. doi: 10.1159/000345591

Jones, G. T., Bown, M. J., Gretarsdottir, S., Romaine, S. P. R., Helgadottir, A., Yu, G., … Jin, C., … Phillips, L. V., Williams, M. J. A., Topless, R., Merriman, T. R., … Lewis, D. R., … van Rij, A. M. (2013). A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Human Molecular Genetics, 22(14), 2941-2947. doi: 10.1093/hmg/ddt141

Dennis, N. A., Jones, G. T., Chong, Y. H., van Rij, A. M., & McLennan, I. S. (2013). Serum anti-Müllerian hormone (AMH) levels correlate with infrarenal aortic diameter in healthy older men: Is AMH a cardiovascular hormone? Journal of Endocrinology, 219, 13-20. doi: 10.1530/joe-13-0125

Bradley, D. T., Hughes, A. E., Badger, S. A., Jones, G. T., Harrison, S. C., Wright, B. J., … van Rij, A., … Bown, M. J. (2013). A variant in LDLR is associated with abdominal aortic aneurysm. Circulation: Cardiovascular Genetics, 6, 498-504. doi: 10.1161/CIRCGENETICS.113.000165

Harrison, S. C., Smith, A. J. P., Jones, G. T., Swerdlow, D. I., Rampuri, R., Brown, M. J., … Humphries, S. E. (2013). Interleukin-6 receptor pathways in abdominal aortic aneurysm. European Heart Journal, 34(48), 3707-3716. doi: 10.1093/eurheartj/ehs354

Krysa, J., Jones, G. T., & van Rij, A. M. (2012). Evidence for a genetic role in varicose veins and chronic venous insufficiency. Phlebology, 27(7), 329-335. doi: 10.1258/phleb.2011.011030

Helgadottir, A., Gretarsdottir, S., Thorleifsson, G., Holm, H., Patel, R. S., Gudnason, T., Jones, G. T., van Rij, A. M., … Stefansson, H. (2012). Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. JACC, 60(8), 722-729. doi: 10.1016/j.jacc.2012.01.078

Schunkert, H., König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., … Jones, G. T., … van Rij, A. M., … for the CARDIoGRAM Constortium. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics, 43(4), 333-340. doi: 10.1038/ng.784

Roberts, R. L., van Rij, A. M., Phillips, L. V., Young, S., McCormick, S. P. A., Merriman, T. R., & Jones, G. T. (2011). Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms. Atherosclerosis, 218(1), 123-126. doi: 10.1016/j.atherosclerosis.2011.04.043

Vincent, J. R., Jones, G. T., Hill, G. B., & van Rij, A. M. (2011). Failure of microvenous valves in small superficial veins is a key to the skin changes of venous insufficiency. Journal of Vascular Surgery, 54(6, Suppl. ), 62S-69S.e3. doi: 10.1016/j.jvs.2011.06.085

Tarr, G. P., Williams, M. J. A., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2011). Pro-MMP-9/TIMP-1 ratio correlates poorly with a direct assessment of MMP-9 activity. Clinical Biochemistry, 44(17-18), 1480-1482. doi: 10.1016/j.clinbiochem.2011.09.019

Bown, M. J., Jones, G. T., Harrison, S. C., Wright, B. J., Bumpstead, S., Baas, A. F., … CARDIoGRAM Consortium, GLOBAL BPgen Consortium, DIAGRAM Consortium, VRCNZ Consortium, … van Rij, A., … Samani, N. J. (2011). Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. American Journal of Human Genetics, 89(5), 619-627. doi: 10.1016/j.ajhg.2011.10.002

Thompson, A. R., Cooper, J. A., Jones, G. T., Drenos, F., van Bockxmeer, F. M., Biros, E., … van Rij, A. M., … Humphries, S. E. (2010). Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm. Atherosclerosis, 209, 367-373. doi: 10.1016/j.atherosclerosis.2009.09.073

Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J.-P. P. M., … van Rij, A. M., Williams, M. J. A., … Jones, G. T., … Stefansson, K. (2010). Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics, 42(8), 692-697. doi: 10.1038/ng.622

Thorgeirsson, T. E., Gudbjartsson, D. F., Surakka, I., Vink, J. M., Amin, N., Geller, F., … Jones, G. T., van Rij, A. M., … Stefansson, K. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature Genetics, 42(5), 448-453. doi: 10.1038/ng.573

Jones, G. T., Grant, M. W., Thomson, I. A., Hill, B. G., & van Rij, A. M. (2009). Characterization of a porcine model of chronic superficial varicose veins. Journal of Vascular Surgery, 49(6), 1554-1561. doi: 10.1016/j.jvs.2009.01.070

Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. M., … Williams, M. J. A., van Rij, A. M., Jones, G. T., … Stefansson, K. (2009). Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics, 41(3), 342-347. doi: 10.1038/ng.323

Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2009). Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis. Atherosclerosis, 207(2), 603-607. doi: 10.1016/j.atherosclerosis.2009.05.036

Chan, E. C., Jones, G. T., Dusting, G. J., Datla, S. R., & Jiang, F. (2009). Prevention of aortic elastic lamina defects by losartan in apolipoprotein E-deficient mouse. Clinical & Experimental Pharmacology & Physiology, 36(9), 919-924. doi: 10.1111/j.1440-1681.2009.05169.x

Jones, G. T., Thompson, A. R., van Bockxmeer, F. M., Hafez, H., Cooper, J. A., Golledge, J., … van Rij, A. M. (2008). Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts. Arteriosclerosis, Thrombosis, & Vascular Biology, 28, 764-770. doi: 10.1161/ATVBAHA.107.155564

Helgadottir, A., Thorleifsson, G., Magnusson, K. P., Grétarsdottir, S., Steinthorsdottir, V., Manolescu, A., Jones, G. T., … van Rij, A. M., … Stefansson, K. (2008). The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm [Letter]. Nature Genetics, 40(2), 217-224. doi: 10.1038/ng.72

Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., … Jones, G. T., … van Rij, A. M., … Stefansson, K. (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease [Letter]. Nature, 452, 638-642. doi: 10.1038/nature06846

Jones, G. T., van Rij, A. M., Cole, J., Williams, M. J. A., Bateman, E. H., Marcovina, S. M., Deng, M., & McCormick, S. P. A. (2007). Plasma lipoprotein(a) indicates risk for 4 distinct forms of vascular disease. Clinical Chemistry, 53(4), 679-685.

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Journal - Research Other

Kuivaniemi, H., Sakalihasan, N., Lederle, F. A., Jones, G. T., Defraigne, J.-O., Labropoulos, N., … Elefteriades, J. A. (2013). New insights into aortic disease: A report from the Third International Meeting on Aortic Diseases (IMAD3). Aorta, 1(1), 23-39. doi: 10.12945/j.aorta.2013.13.006

Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2011). Plasma active matrix metalloproteinase 9 associated to diastolic dysfunction in patients with coronary artery disease [Letter]. International Journal of Cardiology, 147(2), 336-338. doi: 10.1016/j.ijcard.2010.12.093

Jones, G. T., Deng, M., Hammond-Tooke, G. D., McCormick, S. P. A., & van Rij, A. M. (2009). Increased plasma lipoprotein(a) found in large-artery atherosclerotic, but not small-artery occlusive, stroke [Letter to the editor]. Clinical Chemistry, 55(10), 1888-1890. doi: 10.1373/clinchem.2009.126771

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