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DSM staff profile

Dr Erin Macaulay

PositionResearch Fellow
DepartmentDepartment of Pathology (DSM)
QualificationsBSc(Hons) PhD
Research summaryEpigenetics in the human placenta and early human development
Teaching

Lab Supervisor for the Epigenetics module of the Genetics 313 laboratory (2009–present).

Memberships
  • Associate Investigator and member, Gravida: National Centre for Growth and Development, a New Zealand Government Centre of Research Excellence (CoRE), 01/05/06 - present.
  • Member, Australian and New Zealand Placental Research Association (ANZPRA), 01/08/11 - present.
  • Elected member, Phi Beta Kappa (prestigious national academic honour society where selection is based on exceptionally high academic performance), inducted 05/2005, lifetime member.

Research

The focus of my research is on epigenetics in the human placenta and epigenetic mechanisms that regulate early human development. I study the unique epigenetic profile of the placenta (compared to somatic tissues) and the lineage-specific epigenetic modifications that direct early human development.

My research also seeks to discover meaningful epigenetic aberrations that lead to abnormal placental development and function, with a particular focus on pre-eclampsia (a dangerous condition of pregnancy that is associated with abnormal placental development).

Publications

Chatterjee, A., Macaulay, E. C., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., Devenish, C. J., & Morison, I. M. (2016). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Genes Genomes Genetics, 6, 1911-1921. doi: 10.1534/g3.116.030379

Macaulay, E. C., & Bloomfield, F. H. (2016). Unravelling the link between the placental epigenome and pregnancy outcomes. Biology of Reproduction, 94(4), 82. doi: 10.1095/biolreprod.116.139915

Macaulay, E. C., Roberts, H. E., Cheng, X., Jeffs, A. R., Baguley, B. C., & Morison, I. M. (2014). Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene. PLoS ONE, 9(4), e95840. doi: 10.1371/journal.pone.0095840

Macaulay, E. C., Donovan, E. L., Leask, M. P., Bloomfield, F. H., Vickers, M. H., Dearden, P. K., … and on behalf of the Gravida International College Summit Team. (2014). The importance of early life in childhood obesity and related diseases: A report from the 2014 Gravida Strategic Summit. Journal of Developmental Origins of Health & Disease, 5(6), 398-407. doi: 10.1017/S2040174414000488

Slatter, T. L., Tan, X., Yuen, Y. C., Gunningham, S., Ma, S. S., Daly, E., Packer, S., Devenish, C., Royds, J. A., & Hung, N. A. (2012). The alternative lengthening of telomeres pathway operates in non-neoplastic human cells. Journal of Pathology, 226(3), 509-518. doi: 10.1002/path.2981

Journal - Research Article

Chatterjee, A., Macaulay, E. C., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., Devenish, C. J., & Morison, I. M. (2016). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Genes Genomes Genetics, 6, 1911-1921. doi: 10.1534/g3.116.030379

Macaulay, E. C., Roberts, H. E., Cheng, X., Jeffs, A. R., Baguley, B. C., & Morison, I. M. (2014). Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene. PLoS ONE, 9(4), e95840. doi: 10.1371/journal.pone.0095840

Slatter, T. L., Tan, X., Yuen, Y. C., Gunningham, S., Ma, S. S., Daly, E., Packer, S., Devenish, C., Royds, J. A., & Hung, N. A. (2012). The alternative lengthening of telomeres pathway operates in non-neoplastic human cells. Journal of Pathology, 226(3), 509-518. doi: 10.1002/path.2981

Macaulay, E. C., Weeks, R. J., Andrews, S., & Morison, I. M. (2011). Hypomethylation of functional retrotransposon-derived genes in the human placenta. Mammalian Genome, 22, 722-735. doi: 10.1007/s00335-011-9355-1

Botta, P., Radcliffe, R. A., Carta, M., Mameli, M., Daly, E., Floyd, K. L., … Valenzuela, C. F. (2007). Modulation of GABAA receptors in cerebellar granule neurons by ethanol: A review of genetic and electrophysiological studies. Alcohol, 41, 187-199. doi: 10.1016/j.alcohol.2007.04.004

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Journal - Research Other

Macaulay, E. C., & Bloomfield, F. H. (2016). Unravelling the link between the placental epigenome and pregnancy outcomes. Biology of Reproduction, 94(4), 82. doi: 10.1095/biolreprod.116.139915

Macaulay, E. C., Donovan, E. L., Leask, M. P., Bloomfield, F. H., Vickers, M. H., Dearden, P. K., … and on behalf of the Gravida International College Summit Team. (2014). The importance of early life in childhood obesity and related diseases: A report from the 2014 Gravida Strategic Summit. Journal of Developmental Origins of Health & Disease, 5(6), 398-407. doi: 10.1017/S2040174414000488

Abad, C., Antczak, D. F., Carvalho, J., Chamley, L. W., Chen, Q., Daher, S., … Daly, E., … Lash, G. E. (2011). IFPA Meeting 2010 Workshop Report I: Immunology; ion transport; Epigenetics; Vascular reactivity; Epitheliochorial placentation; Proteomics. Placenta, 32(Suppl. 2), S81-S89. doi: 10.1016/j.placenta.2010.12.019

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