Dr Richard Gearry
Dr Richard Gearry is a Senior Lecturer in the Department of Medicine, University of Otago, Christchurch and a Consultant Gastroenterologist at Christchurch Hospital. His research focuses on luminal Gastroenterology including the genetics of inflammatory bowel disease (Crohn's disease and ulcerative colitis) and the pharmacogenetics of thiopurine drugs. He collaborates widely with groups within the University of Otago, New Zealand and internationally.
Recent Publications
Bentley, R.W., Gearry, R.B. et al. Incidence of Mycobacterium avium subspecies paratuberculosis in a population-based cohort of patients with Crohn's disease and control subjects. American Journal of Gastroenterology 103, 1168-1172 (2008).
Gardiner, S.J., Gearry, R.B., Burt, M.J., Ding, S.L. & Barclay, M.L. Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides. European Journal of Gastroenterology & Hepatology 20, 1238-1242 (2008).
Gearry, R.B., Tarrant, K.M., Shirley, P.M., Frampton, C.M. & Barclay, M.L. Perianal disease predicts changes in Crohn's disease phenotype-results of a population-based study of inflammatory bowel disease phenotype. Journal of Gastroenterology and Hepatology 23, A178-A178 (2008).
Leong, R.W.L., Gearry, R.B. & Sparrow, M.P. Thiopurine hepatotoxicity in inflammatory bowel disease: the role for adding allopurinol. Expert Opinion on Drug Safety 7, 607-616 (2008).
Ngu, J.H., Bechly, K., Gearry, R.B. & Stedman, C.A. EPIDEMIOLOGY OF AUTOIMMUNE HEPATITIS IN CANTERBURY, NEW ZEALAND: A RETROSPECTIVE POPULATION BASED SURVEY. in 59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases 1763 (San Francisco, CA, 2008).
Roberts, R.L., Gearry, R.B. et al. Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity. Pharmacogenetics and Genomics 18, 434-438 (2008).
Roberts, R.L., Gearry, R.B., Kennedy, M.A. & Barclay, M.L. Beyond TPMT: genetic influences on thiopurine drug responses in inflammatory bowel disease. Personalized Medicine 5, 233-248 (2008).
Roberts, R.L., Gearry, R.B. et al. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. Genes and Immunity 9, 561-565 (2008).
Tarrant, K.M., Barclay, M.L., Frampton, C.M.A. & Gearry, R.B. Perianal Disease Predicts Changes in Crohn's Disease Phenotype-Results of a Population-Based Study of Inflammatory Bowel Disease Phenotype. American Journal of Gastroenterology 103, 3082-3093 (2008).