Senior Lecturer, Department of Biochemistry
Craig's research is focused on cold adaptations; specifically, organisms that live in cold places. Most of the world's organisms tolerate freeze-thaw cycles—some freeze, others super cool; all have strategies to cope with sub-zero temperatures.
In particular, Craig's work centres on:
- What pathways are important in cold tolerance?
- How do proteins protect against freezing or ice damage?
- How do enzymes function at low temperatures?
- What other factors cause stress at low temperatures?
Craig's work also involves identifying proteins important in ice formation, and in identifying genes that are associated with freezing and thawing in an Antarctic nematode, Panagrolaimus davidi.
Craig teaches in GENE 411 Current Topics in Genetics.
Janko, K., Marshall, C. et al. Did glacial advances during the Pleistocene influence differently the demographic histories of benthic and pelagic Antarctic shelf fishes? - Inferences from intraspecific mitochondrial and nuclear DNA sequence diversity. Bmc Evolutionary Biology 7 (2007).
Kumble, K.D., Marshall, C. et al. Characterization of a family of ice-active proteins from the Ryegrass, Lolium perenne. Cryobiology 57, 263-268 (2008).
Smith, T., Wharton, D.A. & Marshall, C.J. Cold tolerance of an Antarctic nematode that survives intracellular freezing: comparisons with other nematode species. Journal of Comparative Physiology B-Biochemical Systemic and Environmental Physiology 178, 93-100 (2008).
Wharton, D.A., Pow, B., Kristensen, M., Ramlov, H. & Marshall, C.J. ICE-active proteins and cryoprotectants from the New Zealand alpine cockroach, Celatoblatta quinquemaculata. Journal of Insect Physiology 55, 27-31 (2009).