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Health Sciences profile

Associate Professor Joel Tyndall

PositionAssociate Dean (Marketing, Communication and Engagement)
QualificationsBSc(Hons)(Monash) PhD(Qld)
Research summaryDrug design and discovery
TeachingMedicinal Chemistry

Research

Drug design and discovery using computational techniques. Drug discovery in the areas of inflammatory disorders, cancer, fungal, bacterial, and viral infections targeting enzymes and GPCRs. Techniques include virtual screening, structural biology, enzymatic, and cellular assays.

Associate Professor Tyndall on PubMed

Publications

Sagatova, A. A., Keniya, M. V., Wilson, R. K., Tyndall, J. D. A., & Monk, B. C. (2016). Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase. Scientific Reports, 6, 26213. doi: 10.1038/srep26213

Sagatova, A. A., Keniya, M. V., Wilson, R. K., Monk, B. C., & Tyndall, J. D. A. (2015). Structural insights into binding of the antifungal drug fluconazole to Saccharomyces cerevisiae lanosterol 14α-demethylase. Antimicrobial Agents & Chemotherapy, 59(8), 4982-4989. doi: 10.1128/aac.00925-15

Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012

Monk, B. C., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., O'Connell, III, J. D., Cannon, R. D., … Stroud, R. M. (2014). Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. PNAS, 111(10), 3865-3870. doi: 10.1073/pnas.1324245111

Awasthi, A., Woolley, A. G., Lecomte, F. J., Hung, N., Baguley, B. C., Wilbanks, S. M., Jeffs, A. R., & Tyndall, J. D. A. (2013). Variable expression of GLIPR1 correlates with invasive potential in melanoma cells. Frontiers in Oncology, 3, 225. doi: 10.3389/fonc.2013.00225

Chapter in Book - Research

Marsh, J., Gloeckl, S., Tyndall, J., & Huston, W. M. (2011). The role of HtrA as a chaperone and protease in bacterial pathogenesis. In L. V. Berhardt (Ed.), Advances in Medicine and Biology (Vol. 27). (pp. 87-121). New York: Nova Science.

Tyndall, J. D. A., Kelso, M. J., & Ranson, M. (2010). Inhibitors of the plasminogen activation system: Promising new agents for suppressing breast cancer metastasis. In Atta-ur-Rahman & M. I. Choudhary (Eds.), Frontiers in anti-cancer drug discovery (Vol. 1). (pp. 55-78). Bentham Science.

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Journal - Research Article

Sagatova, A. A., Keniya, M. V., Wilson, R. K., Tyndall, J. D. A., & Monk, B. C. (2016). Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase. Scientific Reports, 6, 26213. doi: 10.1038/srep26213

Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012

Sagatova, A. A., Keniya, M. V., Wilson, R. K., Monk, B. C., & Tyndall, J. D. A. (2015). Structural insights into binding of the antifungal drug fluconazole to Saccharomyces cerevisiae lanosterol 14α-demethylase. Antimicrobial Agents & Chemotherapy, 59(8), 4982-4989. doi: 10.1128/aac.00925-15

Monk, B. C., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., O'Connell, III, J. D., Cannon, R. D., … Stroud, R. M. (2014). Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. PNAS, 111(10), 3865-3870. doi: 10.1073/pnas.1324245111

Dickerhof, N., Magon, N. J., Tyndall, J. D. A., Kettle, A. J., & Hampton, M. B. (2014). Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase (MPO)-dependant oxidation of epicatechins. Biochemical Journal, 462(2), 303-314. doi: 10.1042/BJ20140612

Keniya, M. V., Cannon, R. D., Nguyễn, Ấ., Tyndall, J. D. A., & Monk, B. C. (2013). Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae. FEMS Yeast Research, 13(3), 302-311. doi: 10.1111/1567-1364.12035

Vellas, S. K., Lewis, J. E. M., Shankar, M., Sagatova, A., Tyndall, J. D. A., Monk, B. C., Fitchett, C. M., Hanton, L. R., & Crowley, J. D. (2013). [Fe2L3]4+ cylinders derived from bis(bidentate) 2-pyridyl-1,2,3-triazole "Click" ligands: Synthesis, structures and exploration of biological activity. Molecules, 18(6), 6383-6407. doi: 10.3390/molecules18066383

Gloeckl, S., Ong, V. A., Patel, P., Tyndall, J. D. A., Timms, P., Beagley, K. W., … Huston, W. M. (2013). Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis. Molecular Microbiology, 89(4), 676-689. doi: 10.1111/mmi.12306

Shankar, M., Wilbanks, S. M., Nakatani, Y., Monk, B. C., & Tyndall, J. D. A. (2013). Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata. Acta Crystallographica Section D, 69(8), 1580-1586. doi: 10.1107/S0907444913010949

Awasthi, A., Woolley, A. G., Lecomte, F. J., Hung, N., Baguley, B. C., Wilbanks, S. M., Jeffs, A. R., & Tyndall, J. D. A. (2013). Variable expression of GLIPR1 correlates with invasive potential in melanoma cells. Frontiers in Oncology, 3, 225. doi: 10.3389/fonc.2013.00225

Rawal, M. K., Khan, M. F., Kapoor, K., Goyal, N., Sen, S., Saxena, A. K., … Tyndall, J. D. A., Monk, B. C., Cannon, R. D., … Prasad, R. (2013). Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains. Journal of Biological Chemistry, 288(34), 24480-24493. doi: 10.1074/jbc.M113.488353

Marsh, J. W., Lott, W. B., Tyndall, J. D. A., & Huston, W. M. (2013). Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand β5. Cellular & Molecular Biology Letters, 18(4), 522-537. doi: 10.2478/s11658-013-0103-2

Niimi, K., Harding, D. R. K., Holmes, A. R., Lamping, E., Niimi, M., Tyndall, J. D. A., Cannon, R. D., & Monk, B. C. (2012). Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor. Molecular Microbiology, 85(4), 747-767. doi: 10.1111/j.1365-2958.2012.08140.x

Tyndall, J. D. A., Lue, H., Rutledge, M. T., Bernhagen, J., Hampton, M. B., & Wilbanks, S. M. (2012). Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate. Acta Crystallographica Section F, 68(9), 999-1002. doi: 10.1107/s1744309112030552

Matthews, H., Ranson, M., Tyndall, J. D. A., & Kelso, M. J. (2011). Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA). Bioorganic & Medicinal Chemistry Letters, 21(22), 6760-6766. doi: 10.1016/j.bmcl.2011.09.044

Huston, W. M., Tyndall, J. D. A., Lott, W. B., Stansfield, S. H., & Timms, P. (2011). Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis. PLoS ONE, 6(9), e24547. doi: 10.1371/journal.pone.0024547

Beggs, K. T., Tyndall, J. D. A., & Mercer, A. R. (2011). Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship. PLoS ONE, 6(11), e26809. doi: 10.1371/journal.pone.0026809

Ruiz-Gómez, G., Tyndall, J. D. A., Pfeiffer, B., Abbenante, G., & Fairlie, D. P. (2010). Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemical Reviews, 110, PR1-PR41. doi: 10.1021/cr900344w

Sawant, P. M., Tyndall, J. D. A., Holland, P. T., Peake, B. M., Mountfort, D. O., & Kerr, D. S. (2010). In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F. Neuropharmacology, 59, 129-138. doi: 10.1016/j.neuropharm.2010.03.019

Nisa, S., Blokpoel, M. C. J., Robertson, B. D., Tyndall, J. D. A., Lun, S., Bishai, W. R., & O'Toole, R. (2010). Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery. Journal of Antimicrobial Chemotherapy, 65(11), 2347-2358. doi: 10.1093/jac/dkq311

Madala, P. K., Tyndall, J. D. A., Nall, T., & Fairlie, D. P. (2010). Update 1 of: Proteases universally recognize beta strands in their active sites. Chemical Reviews, 110(6), PR1-PR31. doi: 10.1021/cr900368a

Loughlin, W. A., Tyndall, J. D. A., Glenn, M. P., Hill, T. A., & Fairlie, D. P. (2010). Update 1 of: Beta-strand mimetics. Chemical Reviews, 110(6), PR32-PR69. doi: 10.1021/cr900395y

Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J. D. A., Niimi, K., Holmes, A. R., Niimi, M., & Cannon, R. D. (2009). Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrobial Agents & Chemotherapy, 53(2), 354-369. doi: 10.1128/AAC.01095-08

Westphal, D., Ledgerwood, E. C., Tyndall, J. D. A., Hibma, M. H., Ueda, N., Fleming, S. B., & Mercer, A. A. (2009). The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis, 14(11), 1317-1330. doi: 10.1007/s10495-009-0403-1

Fry, B. G., Roelants, K., Champagne, D. E., Scheib, H., Tyndall, J. D. A., ..., & Rodríguez de la Vega, R. C. (2009). The toxicogenomic multiverse: Convergent recruitment of proteins into animal venoms. Annual Review of Genomics & Human Genetics, 10, 483-511. doi: 10.1146/annurev.genom.9.081307.164356

Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2009). Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. Journal of Biological Chemistry, 284(47), 32425-32433. doi: 10.1074/jbc.M109.047092

Ashton, J. C., Wright, J. L., McPartland, J. M., & Tyndall, J. D. A. (2008). Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current Medicinal Chemistry, 15, 1428-1443.

Tyndall, J. D. A., Pattenden, L. K., Reid, R. C., Hu, S.-H., Alewood, D., Alewood, P. F., … Martin, J. L. (2008). Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease: Implications for the catalytic mechanism. Biochemistry, 47, 3736-3744.

Tyndall, J. D. A., Kelso, M. J., Clingan, P., & Ranson, M. (2008). Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer. Recent Patents on Anti-Cancer Drug Discovery, 3(1), 1-13.

Pearl, E. J., Tyndall, J. D. A., Poulter, R. T. M., & Wilbanks, S. M. (2007). Sequence requirements for splicing by the Cne PRP8 intein. FEBS Letters, 581, 3000-3004.

Sobhani, A. M., Amini, S. R., Tyndall, J. D. A., Azizi, E., Daneshtalab, M., & Khalaj, A. (2006). A theory of mode of action of azolylalkylquinolines as DNA binding agents using automated flexible ligand docking. Journal of Molecular Graphics & Modelling, 25, 459-469.

Kahnberg, P., Lucke, A. J., Glenn, M. P., Boyle, G. M., Tyndall, J. D. A., Parsons, P. G., & Fairlie, D. P. (2006). Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from α-aminosuberic acid. Journal of Medicinal Chemistry, 49, 7611-7622.

Tyndall, J. D. A., & Sandilya, R. (2005). GPCR agonists and antagonists in the clinic. Medicinal Chemistry, 1, 405-421.

Gee, C. L., Nourse, A., Hsin, A.-Y., Wu, Q., Tyndall, J. D., Grunewald, G. L., … Martin, J. L. (2005). Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active. Biochimica et Biophysica Acta: Proteins & Proteomics, 1750, 82-92.

Chappell, K. J., Nall, T. A., Stoermer, M. J., Fang, N.-X., Tyndall, J. D. A., Fairlie, D. P., & Young, P. R. (2005). Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions. Journal of Biological Chemistry, 280(4), 2896-2903.

Higginbottom, A., Cain, S. A., Woodruff, T. M., Proctor, L. M., Madala, P. K., Tyndall, J. D. A., … Monk, P. N. (2005). Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. Journal of Biological Chemistry, 280(18), 17831-17840.

Tyndall, J. D. A., Pfeiffer, B., Abbenante, G., & Fairlie, D. P. (2005). Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemistry Review, 105, 793-826.

Tyndall, J. D. A., Nall, T., & Fairlie, D. P. (2005). Proteases universally recognize beta strands in their active sites. Chemistry Review, 105, 973-999.

Gee, C. L., Tyndall, J. D. A., Grunewald, G. L., Wu, Q., McLeish, M. J., & Martin, J. L. (2005). Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: Implications for catalysis. Biochemistry, 44, 16875-16885.

Wu, Q., Gee, C. L., Lin, F., Tyndall, J. D., Martin, J. L., Grunewald, G. L., & McLeish, M. J. (2005). Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. Journal of Medicinal Chemistry, 48(23), 7243-7252.

Dutertre, S., Nicke, A., Tyndall, J. D. A., & Lewis, R. J. (2004). Determination of α-conotoxin binding modes on neuronal nicotinic acetylcholine receptors. Journal of Molecular Recognition, 17, 339-347.

March, D. R., Proctor, L. M., Stoermer, M. J., Sbaglia, R., Abbenante, G., Reid, R. C., … Tyndall, J. D. A., … Fairlie, D. P. (2004). Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes: Relationships between structures and activity. Molecular Pharmacology, 65(4), 868-879.

Reid, R. C., Pattenden, L. K., Tyndall, J. D. A., Martin, J. L., Walsh, T., & Fairlie, D. P. (2004). Countering cooperative effects in protease inhibitors using constrained β-strand-mimicking templates in focused combinatorial libraries. Journal of Medicinal Chemistry, 47, 1641-1651.

Loughlin, W. A., Tyndall, J. D. A., Glenn, M. P., & Fairlie, D. P. (2004). Beta-strand mimetics. Chemical Reviews, 104, 6085-6117.

van den Brenk, A. L., Tyndall, J. D. A., Cusack, R. M., Jones, A., Fairlie, D. P., Gahan, L. R., & Hanson, G. R. (2004). Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: Influence of anion and solvent. Journal of Inorganic Biochemistry, 98, 1857-1866.

Nall, T. A., Chappell, K. J., Stoermer, M. J., Fang, N.-X., Tyndall, J. D. A., Young, P. R., & Fairlie, D. P. (2004). Enzymatic characterization and homology model of a catalytically active recombinant West Nile Virus NS3 protease. Journal of Biological Chemistry, 279(47), 48535-48542.

Milne, T. J., Abbenante, G., Tyndall, J. D. A., Halliday, J., & Lewis, R. J. (2003). Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. Journal of Biological Chemistry, 278(33), 31105-31110.

Glenn, M. P., Kelso, M. J., Tyndall, J. D. A., & Fairlie, D. P. (2003). Conformationally homogeneous cyclic tetrapeptides: Useful new three-dimensional scaffolds. Journal of the American Chemical Society, 125(3), 640-641.

Lucke, A. J., Tyndall, J. D. A., Singh, Y., & Fairlie, D. P. (2003). Designing supramolecular structures from models of cyclic peptide scaffolds with heterocyclic constraints. Journal of Molecular Graphics & Modelling, 21, 341-355.

Hansford, K. A., Reid, R. C., Clark, C. I., Tyndall, J. D. A., Whitehouse, M. W., Guthrie, T., … Fairlie, D. P. (2003). D-tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. ChemBioChem, 4(2-3), 181-185.

Tyndall, J. D. A., Sinchaikul, S., Fothergill-Gilmore, L. A., Taylor, P., & Walkinshaw, M. D. (2002). Crystal structure of a thermostable lipase from Bacillus stearothermophilus P1. Journal of Molecular Biology, 323, 859-869.

Glenn, M. P., Pattenden, L. K., Reid, R. C., Tyssen, D. P., Tyndall, J. D. A., Birch, C. J., & Fairlie, D. P. (2002). β-strand mimicking macrocyclic amino acids: Templates for protease inhibitors with antiviral activity. Journal of Medicinal Chemistry, 45, 371-381.

Sinchaikul, S., Tyndall, J. D. A., Fothergill-Gilmore, L. A., Taylor, P., Phutrakul, S., Chen, S.-T., & Walkinshaw, M. D. (2002). Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable lipase from Bacillus stearothermophilus P1. Acta Crystallographica Section D, D58, 182-185.

Tyndall, J. D. A., & Fairlie, D. P. (2001). Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases. Current Medicinal Chemistry, 8(8), 893-907.

Tyndall, J. D. A., Reid, R. C., Tyssen, D. P., Jardine, D. K., Todd, B., Passmore, M., … Fairlie, D. P. (2000). Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease. Journal of Medicinal Chemistry, 43, 3495-3504.

Fairlie, D. P., Tyndall, J. D. A., Reid, R. C., Wong, A. K., Abbenante, G., Scanlon, M. J., … Burkett, B. A. (2000). Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing. Journal of Medicinal Chemistry, 43, 1271-1281.

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