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Health Sciences profile

Associate Professor Pat Cragg

PositionAssociate Professor
DepartmentDepartment of Physiology
QualificationsBSc (Hons) PhD (Brist)
Research summaryCardiorespiratory physiology

Research

  • Myocardial infarction: effect on sympathetic nerve activity and peripheral chemoreceptor activity.
  • Pulmonary endothelial dysfunction during pulmonary hypertension in obesity.
  • Control of breathing: function of chemoreceptors and lung receptors.
  • Cardiorespiratory and renal responses to high altitude.
  • Surfactant deficiency in the newborn: replacement strategies, lung mechanics & cardiorespiratory function.

Publications

Cook, R. F., Bussey, C. T., Mellor, K. M., Cragg, P. A., & Lamberts, R. R. (2017). β1-Adrenoceptor, but not β2-adrenoceptor, subtype regulates heart rate in type 2 diabetes rats in vivo. Experimental Physiology. Advance online publication. doi: 10.1113/ep086293

Ashley, Z., Schwenke, D. O., & Cragg, P. A. (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiologica, 214, 415-425. doi: 10.1111/apha.12527

Schwenke, D. O., Tokudome, T., Kishimoto, I., Horio, T., Cragg, P. A., Shirai, M., & Kangawa, K. (2012). One dose of ghrelin prevents the acute and sustained increase in cardiac sympathetic tone after myocardial infarction. Endocrinology, 153(5), 2436-2443. doi: 10.1210/en.2011-2057

Schwenke, D. O., Pearson, J. T., Kangawa, K., Cragg, P. A., & Shirai, M. (2010). Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats. Acta Physiologica, 200(3), 279-287. doi: 10.1111/j.1748-1716.2010.02142.x

Schwenke, D. O., Pearson, J. T., Shimochi, A., Kangawa, K., Tsuchimochi, H., Umetani, K., … Cragg, P. A. (2009). Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: Assessed using synchrotron radiation. Journal of Hypertension, 27(7), 1410-1419. doi: 10.1097/HJH.0b013e32832af6a1

Chapter in Book - Research

Cragg, P. A., & Schwenke, D. O. (1996). Role of carotid bodies in the guinea-pig. In P. Zapata, C. Eyzaguirre & R. W. Torrance (Eds.), Frontiers in Arterial Chemoreception. (pp. 377-381). New York: Plenum Press.

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Journal - Research Article

Cook, R. F., Bussey, C. T., Mellor, K. M., Cragg, P. A., & Lamberts, R. R. (2017). β1-Adrenoceptor, but not β2-adrenoceptor, subtype regulates heart rate in type 2 diabetes rats in vivo. Experimental Physiology. Advance online publication. doi: 10.1113/ep086293

Ashley, Z., Schwenke, D. O., & Cragg, P. A. (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiologica, 214, 415-425. doi: 10.1111/apha.12527

Schwenke, D. O., Tokudome, T., Kishimoto, I., Horio, T., Cragg, P. A., Shirai, M., & Kangawa, K. (2012). One dose of ghrelin prevents the acute and sustained increase in cardiac sympathetic tone after myocardial infarction. Endocrinology, 153(5), 2436-2443. doi: 10.1210/en.2011-2057

Schwenke, D. O., Pearson, J. T., Kangawa, K., Cragg, P. A., & Shirai, M. (2010). Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats. Acta Physiologica, 200(3), 279-287. doi: 10.1111/j.1748-1716.2010.02142.x

Schwenke, D. O., Pearson, J. T., Shimochi, A., Kangawa, K., Tsuchimochi, H., Umetani, K., … Cragg, P. A. (2009). Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: Assessed using synchrotron radiation. Journal of Hypertension, 27(7), 1410-1419. doi: 10.1097/HJH.0b013e32832af6a1

Schwenke, D. O., Tokudome, T., Kishimoto, I., Horio, T., Shirai, M., Cragg, P. A., & Kangawa, K. (2008). Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology, 149(10), 5172-5176.

Schwenke, D. O., Bolter, C. P., & Cragg, P. A. (2007). Are the carotid bodies of the guinea-pig functional? Comparative Biochemistry & Physiology Part A, 146(2), 180-188.

Ellyett, K. M., Cragg, P. A., & Broadbent, R. S. (2006). Effect of surfactant deficiency and surfactant replacement on airway patency in the piglet lung. Respiratory Physiology & Neurobiology, 150, 173-181.

Schwenke, D. O., & Cragg, P. A. (2004). Comparison of the depressive effects of four anesthetic regimens on ventilatory and cardiovascular variables in the guinea pig. Comparative Medicine, 54(1), 77-85.

Schwenke, D. O., & Cragg, P. A. (2000). Carotid bodies and the sigh reflex in the conscious and anaesthetised guinea-pig. Advances in Experimental Medicine & Biology, 475, 801-813.

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