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Health Sciences profile

Associate Professor Sarah Young

PositionAssociate Professor
DepartmentDepartment of Pathology (DSM)
QualificationsBSc(Hons) PhD
Research summaryImmune therapies for disease

Research

Sarah gained her PhD in Immunology in 2000 and subsequently worked for the Imperial Cancer Research Fund and Cancer Research UK, before returning to New Zealand.

Sarah's research focuses on immune therapies for cancer and implementing the best strategy for activating anti-tumour immune responses in the host. The therapies investigated include vaccines, such as a virus-like particle, adenovirus and a bacterial ghost, and T cell-based therapies. All therapies aim to activate the Th1 arm of the immune response and projects are designed around this.

We have a range of projects associated with our vaccines such as determining how dendritic cells take up and process our vaccines through to the vaccines' ability to activate T cells and induce a memory response. We also have projects focussed on T cell adoptive therapy for tumours, in particular CD4 T cell therapy.

These research projects use a variety of immunological techniques, such as flow cytometry, bead arrays, cell sorting, and confocal microscopy.

Aside from research, Sarah is also a member of the Lotteries Health Assessing Committee and is the deputy convener of the O-Zone group at the University of Otago (a group of early-to-mid-career researchers who have been awarded Early Career Awards for Distinction in Research).

In 2008 she was also awarded the prestigious Sir Charles Hercus Fellowship by the Health Research Council.

Publications

Kramer, K., Shields, N. J., Poppe, V., Young, S. L., & Walker, G. F. (2017). Intracellular cleavable CpG oligodeoxynucleotide-antigen conjugate enhances anti-tumor immunity. Molecular Therapy, 25(1), 62-70. doi: 10.1016/j.ymthe.2016.10.001

Donaldson, B., Al-Barwani, F., Pelham, S. J., Young, K., Ward, V. K., & Young, S. L. (2017). Multi-target chimaeric VLP as a therapeutic vaccine in a model of colorectal cancer. Journal of ImmunoTherapy of Cancer, 5, 69. doi: 10.1186/s40425-017-0270-1

Li, K., Donaldson, B., Young, V., Ward, V., Jackson, C., Baird, M., & Young, S. (2017). Adoptive cell therapy with CD4+ T helper 1 cells and CD8+ cytotoxic T cells enhances complete rejection of an established tumour, leading to generation of endogenous memory responses to non-targeted tumour epitopes. Clinical & Translational Immunology, 6, e160. doi: 10.1038/cti.2017.37

Grant, M. L., Shields, N., Neumann, S., Kramer, K., Bonato, A., Jackson, C., Baird, M. A., & Young, S. L. (2017). Combining dendritic cells and B cells for presentation of oxidised tumour antigens to CD8+ T cells. Clinical & Translational Immunology, 6, e149. doi: 10.1038/cti.2017.28

Kramer, K., Young, S. L., & Walker, G. F. (2017). Comparative study of 5′- and 3′-linked CpG–antigen conjugates for the induction of cellular immune responses. ACS Omega, 2(1), 227-235. doi: 10.1021/acsomega.6b00368

Chapter in Book - Research

Donaldson, B., Al-Barwani, F., Young, V., Scullion, S., Ward, V., & Young, S. (2015). Virus-like particles, a versatile subunit vaccine platform. In C. Foged, T. Rades, Y. Perrie & S. Hook (Eds.), Subunit vaccine delivery. (pp. 159-180). New York: Springer. doi: 10.1007/978-1-4939-1417-3

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Journal - Research Article

Kramer, K., Shields, N. J., Poppe, V., Young, S. L., & Walker, G. F. (2017). Intracellular cleavable CpG oligodeoxynucleotide-antigen conjugate enhances anti-tumor immunity. Molecular Therapy, 25(1), 62-70. doi: 10.1016/j.ymthe.2016.10.001

Kramer, K., Young, S. L., & Walker, G. F. (2017). Comparative study of 5′- and 3′-linked CpG–antigen conjugates for the induction of cellular immune responses. ACS Omega, 2(1), 227-235. doi: 10.1021/acsomega.6b00368

Grant, M. L., Shields, N., Neumann, S., Kramer, K., Bonato, A., Jackson, C., Baird, M. A., & Young, S. L. (2017). Combining dendritic cells and B cells for presentation of oxidised tumour antigens to CD8+ T cells. Clinical & Translational Immunology, 6, e149. doi: 10.1038/cti.2017.28

Li, K., Donaldson, B., Young, V., Ward, V., Jackson, C., Baird, M., & Young, S. (2017). Adoptive cell therapy with CD4+ T helper 1 cells and CD8+ cytotoxic T cells enhances complete rejection of an established tumour, leading to generation of endogenous memory responses to non-targeted tumour epitopes. Clinical & Translational Immunology, 6, e160. doi: 10.1038/cti.2017.37

Donaldson, B., Al-Barwani, F., Pelham, S. J., Young, K., Ward, V. K., & Young, S. L. (2017). Multi-target chimaeric VLP as a therapeutic vaccine in a model of colorectal cancer. Journal of ImmunoTherapy of Cancer, 5, 69. doi: 10.1186/s40425-017-0270-1

Li, K., Baird, M., Yang, J., Jackson, C., Ronchese, F., & Young, S. (2016). Conditions for the generation of cytotoxic CD4+ Th cells that enhance CD8+ CTL-mediated tumor regression. Clinical & Translational Immunology, 5(8), e95. doi: 10.1038/cti.2016.46

Jemon, K., Leong, C.-M., Ly, K., Young, S. L., McLellan, A. D., & Hibma, M. H. (2016). Suppression of the CD8 T cell response by human papillomavirus type 16 E7 occurs in Langerhans cell-depleted mice. Scientific Reports, 6, 34789. doi: 10.1038/srep34789

Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. (2015). Bridging small molecules to modified bacterial microparticles using a disulphide linkage: MIS416 as a cargo delivery system. PLoS ONE, 10(12), e0145403. doi: 10.1371/journal.pone.0145403

Al-Barwani, F., Young, S. L., Baird, M. A., Larsen, D. S., & Ward, V. K. (2014). Mannosylation of virus-like particles enhances internalization by antigen presenting cells. PLoS ONE, 9(8), e104523. doi: 10.1371/journal.pone.0104523

Al Barwani, F., Donaldson, B., Pelham, S. J., Young, S. L., & Ward, V. K. (2014). Antigen delivery by virus-like particles for immunotherapeutic vaccination. Therapeutic Delivery, 5(11), 1223-1240. doi: 10.4155/TDE.14.74

Kim, D. W., Young, S. L., Grattan, D. R., & Jasoni, C. L. (2014). Obesity during pregnancy disrupts placental morphology, cell proliferation, and inflammation in a sex-specific manner across gestation in the mouse. Biology of Reproduction, 90(6), 130. doi: 10.1095/biolreprod.113.117259

Li, K., Peers-Adams, A., Win, S. J., Scullion, S., Wilson, M., Young, V. L., Jennings, P., Ward, V. K., Baird, M. A., & Young, S. L. (2013). Antigen incorporated in virus-like particles is delivered to specific dendritic cell subsets that induce an effective antitumor immune response in vivo. Journal of Immunotherapy, 36(1), 11-19. doi: 10.1097/CJI.0b013e3182787f5e

Jemon, K., Young, V., Wilson, M., McKee, S., Ward, V., Baird, M., Young, S., & Hibma, M. (2013). An enhanced heterologous virus-like particle for human papillomavirus type 16 tumour immunotherapy. PLoS ONE, 8(6), e66866. doi: 10.1371/journal.pone.0066866

Tang, R., Li, K., Wilson, M., Both, G. W., Taylor, J. A., & Young, S. L. (2012). Potent antietumor immunity in mice induced by vaccination with an ovine Atadenovirus vector. Journal of Immunotherapy, 35(1), 32-41. doi: 10.1097/CJI.0b013e318238a115

Win, S. J., McMillan, D. G. G., Errington-Mais, F., Ward, V. K., Young, S. L., Baird, M. A., & Melcher, A. A. (2012). Enhancing the immunogenicity of tumour lysate-loaded dendritic cell vaccines by conjugation to virus-like particles. British Journal of Cancer, 106, 92-98. doi: 10.1038/bjc.2011.538

McKee, S. J., Young, V. L., Clow, F., Hayman, C. M., Baird, M. A., Hermans, I. F., Young, S. L., & Ward, V. K. (2012). Virus-like particles and α-galactosylceramide form a self-adjuvanting composite particle that elicits anti-tumor responses. Journal of Controlled Release, 159(3), 338-345. doi: 10.1016/j.jconrel.2012.02.015

Win, S. J., Ward, V. K., Dunbar, P. R., Young, S. L., & Baird, M. A. (2011). Cross-presentation of epitopes on virus-like particles via the MHC I receptor recycling pathway. Immunology & Cell Biology, 89, 681-688. doi: 10.1038/icb.2010.161

Roberts, R. L., van Rij, A. M., Phillips, L. V., Young, S., McCormick, S. P. A., Merriman, T. R., & Jones, G. T. (2011). Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms. Atherosclerosis, 218(1), 123-126. doi: 10.1016/j.atherosclerosis.2011.04.043

Lateef, Z., Baird, M. A., Wise, L. M., Young, S., Mercer, A. A., & Fleming, S. B. (2010). The chemokine binding protein encoded by the poxvirus orf virus inhibits recruitment of dendritic cells to sites of skin inflammation and migration to peripheral lymph nodes. Cellular Microbiology, 12(5), 665-676. doi: 10.1111/j.1462-5822.2009.01425.x

Buchan, G. S., Lee, R., Wilson, M., Slobbe, L., Buddle, B. M., & Young, S. L. (2010). Strains of Mycobacterium avium differentially activate human dendritic cells. Immunology & Cell Biology, 88(1), 95-98. doi: 10.1038/icb.2009.51

Young, S. L., Slobbe, L. J., Peacey, M., Gilbert, S. C., Buddle, B. M., de Lisle, G. W., & Buchan, G. S. (2010). Immunogenicity and protective efficacy of mycobacterial DNA vaccines incorporating plasmid-encoded cytokines against Mycobacterium bovis. Immunology & Cell Biology, 88(6), 651-657. doi: 10.1038/icb.2010.25

Peacey, M., Wilson, S., Perret, R., Ronchese, F., Ward, V. K., Young, V., Young, S. L., & Baird, M. A. (2008). Virus-like particles from rabbit hemorrhagic disease virus can induce an anti-tumor response. Vaccine, 26, 5334-5337. doi: 10.1016/j.vaccine.2008.07.074

Sutherland, T. J. T., Cowan, J. O., Young, S., Goulding, A., Grant, A. M., Williamson, A., Brassett, K., Herbison, G. P., & Taylor, D. R. (2008). The association between obesity and asthma: Interactions between systemic and airway inflammation. American Journal of Respiratory & Critical Care Medicine, 178, 469-475. doi: 10.1164/rccm.200802-301OC

Sherwin, C., Broadbent, R., Young, S., Worth, J., McCaffrey, F., Medlicott, N. J., & Reith, D. (2008). Utility of interleukin-12 and interleukin-10 in comparison with other cytokines and acute-phase reactants in the diagnosis of neonatal sepsis. American Journal of Perinatology, 25, 629-636. doi: 10.1055/s-0028-1090585

Williman, J., Young, S., Buchan, G., Slobbe, L., Wilson, M., Pang, P., … Baird, M. (2008). DNA fusion vaccines incorporating IL-23 or RANTES for use in immunization against influenza. Vaccine, 26, 5153-5158. doi: 10.1016/j.vaccine.2008.03.084

Young, S. L., Slobbe, L., Wilson, R., Buddle, B. M., de Lisle, G. W., & Buchan, G. S. (2007). Environmental strains of Mycobacterium avium interfere with immune responses associated with Mycobacterium bovis BCG vaccination. Infection & Immunity, 75(6), 2833-2840.

Young, S. L., Wilson, M., Wilson, S., Beagley, K. W., Ward, V., & Baird, M. A. (2006). Transcutaneous vaccination with virus-like particles. Vaccine, 24, 5406-5412. doi: 10.1016/j.vaccine.2006.03.052

Young, S. L., Simon, M. A., Baird, M. A., Tannock, G. W., Bibiloni, R., Spencely, K., Lane, J. M., Fitzharris, P., Crane, J., Town, I., … Woodcock, A. (2004). Bifidobacterial species differentially affect expression of cell surface markers and cytokines of dendritic cells harvested from cord blood. Clinical & Diagnostic Laboratory Immunology, 11(4), 686-690.

Young, S. L., Buchan, G. S., Slobbe, L. J., Williman, J. A., Wilson, M., Ward, V. K., … Baird, M. A. (2004). Novel vaccine formulations to enhance type 1 immune responses. Immunology, 555-563.

Baird, M., Wilson, R., Young, L., Williman, J., Young, S. L., Wilson, M., Slobbe, L., Lockhart, E., & Buchan, G. S. (2004). Bystander help within a polyepitope DNA vaccine improves immune responses to influenza antigens. Scandinavian Journal of Immunology, 60(4), 363-371.

Young, S. L., Murphy, M., Zhu, X. W., Harnden, P., O'Donnell, M. A., James, K., … Jackson, A. (2004). Cytokine-modified Mycobacterium smegmatis as a novel anticancer immunotherapy. International Journal of Cancer, 112, 653-660.

Mears, R., Craven, R. A., Hanrahan, S., Totty, N., Upton, C., Young, S. L., … Banks, R. E. (2004). Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Proteomics, 4, 4019-4031.

Young, S. L., O'Donnell, M., Lockhart, E., Buddle, B. M., Slobbe, L., Luo, Y., … Buchan, G. S. (2002). Manipulation of immune responses to Mycobacterium bovis by vaccination with IL-2- and IL-18-secreting recombinant bacillus Calmette Guerin. Immunology & Cell Biology, 80, 209-215.

Young, S. L., O'Donnell, M., & Buchan, G. S. (2002). IL-2-secreting recombinant bacillus Calmette Guerin can overcome a Type 2 immune response and corticosteroid-induced immunosuppression to elicit a Type 1 immune response. International Immunology, 14(7), 793-800.

Baird, M. A., Young, S. L., & Buchan, G. S. (2001). Improving vaccine formulation: Looking for the X factors. Modern Aspects of Immunobiology, 1(6), 256-258.

Buchan, G. S., Young, S. L., Lockhart, E., Wales, J. R., Faulkner, L., Slobbe, L., & Baird, M. A. (2000). Targeting early events in T cell activation to construct improved vaccines. Molecular Immunology, 37(9), 545-552.

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