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Health Sciences profile

Dr Harold Bernhardt

PositionResearch Fellow
DepartmentsDepartment of Anatomy, Department of Biochemistry
QualificationsPhD
Research summaryOrigins of Life

Research

My research focuses on the origin and early evolution of life, specifically in relation to the RNA world hypothesis, which proposes that RNA once played the dominant role in biological catalysis and replication. I have recently been awarded a Marsden Fast Start to study the possible prebiotic chemical evolution of RNA by spontaneous or non-enzymatic reactions.

Publications

Bernhardt, H. S., & Sandwick, R. K. (2014). Purine biosynthetic intermediate-containing ribose-phosphate polymers as evolutionary precursors to RNA. Journal of Molecular Evolution, 79(3), 91-104. doi: 10.1007/s00239-014-9640-1

Bernhardt, H. S. (2012). The RNA world hypothesis: The worst theory of the early evolution of life (except for all the others). Biology Direct, 7, 23. doi: 10.1186/1745-6150-7-23

Bernhardt, H. S., & Tate, W. P. (2012). Primordial soup or vinaigrette: Did the RNA world evolve at acidic pH? Biology Direct, 7(4). doi: 10.1186/1745-6150-7-4

Bernhardt, H. S., & Tate, W. P. (2010). The transition from noncoded to coded protein synthesis: Did coding mRNAs arise from stability-enhancing binding partners to tRNA? Biology Direct, 5, 16. doi: 10.1186/1745-6150-5-16

Bernhardt, H. S., & Tate, W. P. (2008). Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code. Biology Direct, 3, 53. doi: 10.1186/1745-6150-3-53

Journal - Research Article

Bernhardt, H. S., & Patrick, W. M. (2014). Genetic code evolution started with the incorporation of glycine, followed by other small hydrophilic amino acids. Journal of Molecular Evolution, 78(6), 307-309. doi: 10.1007/s00239-014-9627-y

Bernhardt, H. S., & Sandwick, R. K. (2014). Purine biosynthetic intermediate-containing ribose-phosphate polymers as evolutionary precursors to RNA. Journal of Molecular Evolution, 79(3), 91-104. doi: 10.1007/s00239-014-9640-1

Bernhardt, H. S. (2012). The RNA world hypothesis: The worst theory of the early evolution of life (except for all the others). Biology Direct, 7, 23. doi: 10.1186/1745-6150-7-23

Bernhardt, H. S., & Tate, W. P. (2012). Primordial soup or vinaigrette: Did the RNA world evolve at acidic pH? Biology Direct, 7(4). doi: 10.1186/1745-6150-7-4

Bernhardt, H. S., & Tate, W. P. (2010). The transition from noncoded to coded protein synthesis: Did coding mRNAs arise from stability-enhancing binding partners to tRNA? Biology Direct, 5, 16. doi: 10.1186/1745-6150-5-16

Bernhardt, H. S., & Tate, W. P. (2008). Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code. Biology Direct, 3, 53. doi: 10.1186/1745-6150-3-53

Bernhardt, H. S., & Tate, W. P. (2008). Self-assembling transfer RNA has potential for nanoparticle arrays. Current Applied Physics, 8(3-4), 380-382. doi: 10.1016/j.cap.2007.10.035

More publications...