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Health Sciences profile

Associate Professor Rajesh Katare

PositionAssociate Professor
DepartmentDepartment of Physiology
QualificationsMBBS PhD
Research summaryCardiovascular disease; diabetes
Teaching
  • Teaching PHSL 232, ELM 2, PHSL 471
  • Convenor of PHSL 344
Memberships
  • Physiological Society of New Zealand
  • American Heart Association
  • Association of Physiologists of India
  • Pain at Otago
  • HeartOtago

Research

My research interests include:
  • Molecular mechanisms involved in the development of cardiovascular complications in diabetes.
  • Role of microRNAs in cardiovascular diseases.
  • Development of novel genetic and stem cell therapies for the treatment of ischemic and non-ischemic cardiovascular complications.

Projects include:

  • Pathological role of microRNAs in the development of diabetic cardiomyopathy.
  • Circulating microRNAs as potential biomarkers for early diagnosis of cardiovascular complications.
  • Gender differences in diabetic heart - why females are more prone to complications.
  • Investigating the role of suicidal autophagy in diabetic hearts.
  • Treatment of ischemic hearts with resident cardiac stem cells.
  • Development of engineered heart tissue using cardiac and mesenchymal stem cells.

Publications

Dixit, P., Donnelly, H., Edamatsu, M., Galvin, I., Bunton, R., & Katare, R. (2017). Progenitor cells from atria, ventricle and peripheral blood of the same patients exhibit functional differences associated with cardiac repair. International Journal of Cardiology, 228, 412-421. doi: 10.1016/j.ijcard.2016.11.178

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the type-2 diabetic human and mouse heart. Clinical Science. Advance online publication. doi: 10.1042/cs20160916

Sampath, K. K., Botnmark, E., Mani, R., Cotter, J. D., Katare, R., Munasinghe, P. E., & Tumilty, S. (2017). Neuro-endocrine response following a thoracic spinal manipulation in healthy men. Journal of Orthopaedic & Sports Physical Therapy. Advance online publication. doi: 10.2519/jospt.2017.7348

Satthenapalli, V. R., Lamberts, R. R., & Katare, R. G. (2017). Challenges in regenerating the diabetic heart: A comprehensive review. Stem Cells. Advance online publication. doi: 10.1002/stem.2661

Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2017). Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovascular Research, 113(1), 90-101. doi: 10.1093/cvr/cvw235

Journal - Research Article

Dixit, P., Donnelly, H., Edamatsu, M., Galvin, I., Bunton, R., & Katare, R. (2017). Progenitor cells from atria, ventricle and peripheral blood of the same patients exhibit functional differences associated with cardiac repair. International Journal of Cardiology, 228, 412-421. doi: 10.1016/j.ijcard.2016.11.178

Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2017). Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovascular Research, 113(1), 90-101. doi: 10.1093/cvr/cvw235

Satthenapalli, V. R., Lamberts, R. R., & Katare, R. G. (2017). Challenges in regenerating the diabetic heart: A comprehensive review. Stem Cells. Advance online publication. doi: 10.1002/stem.2661

Sampath, K. K., Botnmark, E., Mani, R., Cotter, J. D., Katare, R., Munasinghe, P. E., & Tumilty, S. (2017). Neuro-endocrine response following a thoracic spinal manipulation in healthy men. Journal of Orthopaedic & Sports Physical Therapy. Advance online publication. doi: 10.2519/jospt.2017.7348

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the type-2 diabetic human and mouse heart. Clinical Science. Advance online publication. doi: 10.1042/cs20160916

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R. R., … Katare, R. (2016). Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. International Journal of Cardiology, 202, 13-20. doi: 10.1016/j.ijcard.2015.08.111

Rawal, S., Parshu Ram, T., Coffey, S., Williams, M. J. A., Saxena, P., Bunton, R. W., Galvin, I. F., & Katare, R. (2016). Differential expression pattern of cardiovascular microRNAs in the human type-2 diabetic heart with normal ejection fraction. International Journal of Cardiology, 202, 40-43. doi: 10.1016/j.ijcard.2015.08.161

Katare, R., Rawal, S., Munasinghe, P. E., Tsuchimochi, H., Inagaki, T., Fujii, Y., Dixit, P., … Schwenke, D. O. (2016). Ghrelin promotes functional angiogenesis in a mouse model of critical limb ischemia through activation of proangiogenic microRNAs. Endocrinology, 157(2), 432-445. doi: 10.1210/en.2015-1799

Gubernator, M., Slater, S. C., Spencer, H. L., Spiteri, I., Sottoriva, A., Riu, F., … Katare, R., … Madeddu, P. (2015). Epigenetic profile of human adventitial progenitor cells correlates with therapeutic outcomes in a mouse model of limb ischemia. Arteriosclerosis, Thrombosis, & Vascular Biology, 35, 675-688. doi: 10.1161/ATVBAHA.114.304989

Aiba, T., Noda, T., Hidaka, I., Inagaki, M., Katare, R. G., Ando, M., … Sugimachi, M. (2015). Acetylcholine suppresses ventricular arrhythmias and improves conduction and connexin-43 properties during myocardial ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 26, 678-685. doi: 10.1111/jce.12663

Ascione, R., Rowlinson, J., Avolio, E., Katare, R., Meloni, M., Spencer, H. L., … Madeddu, P. (2015). Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction. Stem Cell Research & Therapy, 6, 53. doi: 10.1186/s13287-015-0028-y

Purvis, N., Bahn, A., & Katare, R. (2015). The role of microRNAs in cardiac stem cells. Stem Cells International, 2015(2015), 194894. doi: 10.1155/2015/194894

Dixit, P., & Katare, R. (2015). Challenges in identifying the best source of stem cells for cardiac regeneration therapy. Stem Cell Research & Therapy, 6, 26. doi: 10.1186/s13287-015-0010-8

Caporali, A., Meloni, M., Nailor, A., Mitić, T., Shantikumar, S., Riu, F., … Katare, R., … Emanueli, C. (2015). p75NTR-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia. Nature Communications, 6(8024). doi: 10.1038/ncomms9024

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R., … Katare, R. (2015). Data supporting the activation of autophagy genes in the diabetic heart. Data in Brief, 5, 269-275. doi: 10.1016/j.dib.2015.09.003

Avolio, E., Meloni, M., Spencer, H. L., Riu, F., Katare, R., Mangialardi, G., … Madeddu, P. (2015). Combined intramyocardial delivery of human pericytes and cardiac stem cells additively improves the healing of mouse infarcted hearts through stimulation of vascular and muscular repair. Circulation Research, 116, e81-e94. doi: 10.1161/circresaha.115.306146

Rawal, S., Manning, P., & Katare, R. (2014). Cardiovascular microRNAs: As modulators and diagnostic biomarkers of diabetic heart disease. Cardiovascular Diabetology, 13(1), 44. doi: 10.1186/1475-2840-13-44

Moore, A., Shindikar, A., Fomison-Nurse, I., Riu, F., Munasinghe, P., Parshu Ram, T., Saxena, P., Coffey, S., Bunton, R. W., Galvin, I. F., Williams, M. J. A., … Katare, R. (2014). Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1. Cardiovascular Diabetology, 13, 68. doi: 10.1186/1475-2840-13-68

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13(1), 72. doi: 10.1186/1475-2840-13-72

Avolio, E., Gianfranceschi, G., Cesselli, D., Caragnano, A., Athanasakis, E., Katare, R., … Beltrami, A. P. (2014). Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction. Stem Cells, 32(9), 2373-2385. doi: 10.1002/stem.1728

Katare, R., Stroemer, P., Hicks, C., Stevanato, L., Patel, S., Corteling, R., … Madeddu, P. (2014). Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. Arteriosclerosis, Thrombosis, & Vascular Biology, 34, 408-418. doi: 10.1161/ATVBAHA.113.302592

Mangialardi, G., Katare, R., Oikawa, A., Meloni, M., Reni, C., Emanueli, C., & Madeddu, P. (2013). Diabetes causes bone marrow endothelial barrier dysfunction by activation of the RhoA-Rho-associated kinase signaling pathway. Arteriosclerosis, Thrombosis, & Vascular Biology, 33, 555-564. doi: 10.1161/ATVBAHA.112.300424

Katare, R., Oikawa, A., Cesselli, D., Beltrami, A. P., Avolio, E., Muthukrishnan, D., Munasinghe, P. E., … Madeddu, P. (2013). Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes. Cardiovascular Research, 97(1), 55-65. doi: 10.1093/cvr/cvs291

Aditi, Mahajan, N., Rawal, S., & Katare, R. (2013). An insight in to the pathogenesis of diabetic vascular diseases: Role of oxidative stress and antioxidants. Pharmaceutica Analytica Acta, 4(10), 273. doi: 10.4172/2153-2435.1000273

Katare, R. G., & Madeddu, P. (2013). Pericytes from human veins for treatment of myocardial ischemia. Trends in Cardiovascular Medicine, 23, 66-70. doi: 10.1016/j.tcm.2012.09.002

Katare, R., Riu, F., Rowlinson, J., Lewis, A., Holden, R., Meloni, M., … Madeddu, P. (2013). Perivascular delivery of encapsulated mesenchymal stem cells improves postischemic angiogenesis via paracrine activation of VEGF-A. Arteriosclerosis, Thrombosis, & Vascular Biology, 33, 1872-1880. doi: 10.1161/atvbaha.113.301217

Amadesi, S., Reni, C., Katare, R., Meloni, M., Oikawa, A., Beltrami, A. P., … Madeddu, P. (2012). Role for substance P-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in nice and in human subject. Circulation, 125, 1774-1786. doi: 10.1161/CIRCULATIONAHA.111.089763

Spinetti, G., Fortunato, O., Cordella, D., Portararo, P., Kränkel, N., Katare, R., … Madeddu, P. (2011). Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells. Circulation Research, 108, 284-293. doi: 10.1161/CIRCRESAHA.110.236786

Katare, R., Riu, F., Mitchell, K., Gubernator, M., Campagnolo, P., Cui, Y., … Madeddu, P. (2011). Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circulation Research, 109, 894-906. doi: 10.1161/CIRCRESAHA.111.251546

Katare, R., Caporali, A., Zentilin, L., Avolio, E., Sala-Newby, G., Oikawa, A., … Madeddu, P. (2011). Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circulation Research, 108, 1238-1251. doi: 10.1161/CIRCRESAHA.110.239111

Katare, R. G., Caporali, A., Oikawa, A., Meloni, M., Emanueli, C., & Maddedu, P. (2010). Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1—mediated survival pathway. Circulation: Heart Failure, 3(2), 294-305. doi: 10.1161/CIRCHEARTFAILURE.109.903450

Siragusa, M., Katare, R., Meloni, M., Damilano, F., Hirsch, E., Emanueli, C., & Madeddu, P. (2010). Involvement of phosphoinositide 3-kinase γ in angiogenesis and healing of experimental myocardial infarction in mice. Circulation Research, 106, 757-768. doi: 10.1161/CIRCRESAHA.109.207449

Oikawa, A., Siragusa, M., Quaini, F., Mangialardi, G., Katare, R. G., Caporali, A., … Madeddu, P. (2010). Diabetes mellitus induces bone marrow microangiopathy. Arteriosclerosis, Thrombosis, & Vascular Biology, 30, 498-508. doi: 10.1161/ATVBAHA.109.200154

Katare, R. G., Ando, M., Kakinuma, Y., Arikawa, M., Yamasaki, F., & Sato, T. (2010). Differential regulation of TNF receptors by vagal nerve stimulation protects heart against acute ischemic injury. Journal of Molecular & Cellular Cardiology, 49(2), 234-244. doi: 10.1016/j.yjmcc.2010.03.007

Katare, R. G., Ando, M., Kakinuma, Y., & Sato, T. (2010). Engineered heart tissue: A novel tool to study the ischemic changes of the heart in vitro. PLoS ONE, 5(2), e9275. doi: 10.1371/journal.pone.0009275

Handa, T., Katare, R. G., Nishimori, H., Wariishi, S., Fukutomi, T., Yamamoto, M., … Sato, T. (2010). New device for intraoperative graft assessment: HyperEye charge-coupled device camera system. General Thoracic & Cardiovascular Surgery, 58, 68-77. doi: 10.1007/s11748-009-0536-8

Kakinuma, Y., Furihata, M., Akiyama, T., Arikawa, M., Handa, T., Katare, R. G., & Sato, T. (2010). Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model. Journal of Molecular & Cellular Cardiology, 48(4), 680-693. doi: 10.1016/j.yjmcc.2009.11.010

Katare, R., Caporali, A., Emanueli, C., & Madeddu, P. (2010). Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response. Journal of Molecular & Cellular Cardiology, 49, 625-638. doi: 10.1016/j.yjmcc.2010.05.014

Meloni, M., Caporali, A., Graiani, G., Lagrasta, C., Katare, R., van Linthout, S., … Emanueli, C. (2010). Nerve growth factor promotes cardiac repair following myocardial infarction. Circulation Research, 106, 1275-1284. doi: 10.1161/CIRCRESAHA.109.210088

Campagnolo, P., Cesselli, D., Al Haj Zen, A., Beltrami, A. P., Kränkel, N., Katare, R., … Madeddu, P. (2010). Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential. Circulation, 121, 1735-1745. doi: 10.1161/CIRCULATIONAHA.109.899252

Stone, O. A., Richer, C., Emanueli, C., van Weel, V., Quax, P. H. A., Katare, R., … Madeddu, P. (2009). Critical role of tissue kallikrein in vessel formation and maturation: Implications for therapeutic revascularization. Arteriosclerosis, Thrombosis, & Vascular Biology, 29, 657-664. doi: 10.1161/ATVBAHA.108.182139

Barcelos, L. S., Duplaa, C., Kränkel, N., Graiani, G., Invernici, G., Katare, R., … Madeddu, P. (2009). Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circulation Research, 104, 1095-1102. doi: 10.1161/CIRCRESAHA.108.192138

Handa, T., Katare, R. G., Kakinuma, Y., Arikawa, M., Ando, M., Sasaguri, S., … Sato, T. (2009). Anti-Alzheimer's drug, Donepezil, markedly improves long-term survival after chronic heart failure in mice. Journal of Cardiac Failure, 15(9), 805-811. doi: 10.1016/j.cardfail.2009.05.008

Handa, T., Katare, R. G., Sasaguri, S., & Sato, T. (2009). Preliminary experience for the evaluation of the intraoperative graft patency with real color charge-coupled device camera system: An advanced device for simultaneous capturing of color and near-infrared images during coronary artery bypass graft. Interactive Cardiovascular & Thoracic Surgery, 9, 150-154. doi: 10.1510/icvts.2008.201418

Katare, R. G., Ando, M., Kakinuma, Y., Arikawa, M., Handa, T., Yamasaki, F., & Sato, T. (2009). Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect. Journal of Thoracic & Cardiovascular Surgery, 137(1), 223-231. doi: 10.1016/j.jtcvs.2008.08.020

Katare, R. G., Kakinuma, Y., Arikawa, M., Yamasaki, F., & Sato, T. (2009). Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway. Journal of Molecular & Cellular Cardiology, 46, 405-412. doi: 10.1016/j.yjmcc.2008.10.027

Kakinuma, Y., Katare, R. G., Arikawa, M., Muramoto, K., Yamasaki, F., & Sato, T. (2008). A HIF-1alpha-related gene involved in cell protection from hypoxia by suppression of mitochondrial function. FEBS Letters, 582, 332-340. doi: 10.1016/j.febslet.2007.12.026

Yamamoto, M., Hironori, M., Hirose, N., Yamamoto, M., Nakagawa, A., Radhakrishnan, G., Katare, R. G., … Sasaguri, S. (2008). Biphasic elevation of bilirubin oxidation during myocardial ischemia reperfusion. Circulation Journal, 72(9), 1520-1527.

Radhakrishnan, G., Suzuki, R., Maeda, H., Yamamoto, M., Hirose, N., Katare, R. G., … Sasaguri, S. (2008). Inhibition of neointimal hyperplasia developement by MCI-186 is correlated with downregulation of nuclear factor-κB pathway. Circulation Journal, 72, 800-806.

Kränkel, N., Katare, R. G., Siragusa, M., Barcelos, L. S., Campagnolo, P., Mangialardi, G., … Madeddu, P. (2008). Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circulation Research, 103, 1335-1343. doi: 10.1161/CIRCRESAHA.108.179952

Katare, R. G., Zhitian, Z., Sodeoka, M., & Sasaguri, S. (2007). Novel bisindolylmaleimide derivative inhibits mitochondrial permeability transition pore and protects the heart from reperfusion injury. Canadian Journal of Physiology & Pharmacology, 85(10), 979-985. doi: 10.1139/Y07-071

Kuwabara, M., Kakinuma, Y., Katare, R. G., Ando, M., Yamasaki, F., Doi, Y., & Sato, T. (2007). Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of β-catenin and cadherin. FEBS Letters, 581, 4821-4830. doi: 10.1016/j.febslet.2007.09.007

Katare, R. G., Zhitian, Z., Sodeoka, M., & Sasaguri, S. (2007). A novel bisindolylmaleimide derivative enhances functional recovery of heart after long-term hypothermic heart preservation. Transplantation, 83(12), 1588-1594. doi: 10.1097/01.tp.0000267019.93796.aa

Yamamoto, M., Maeda, H., Hirose, N., Radhakrishnan, G., Katare, R. G., Hayashi, Y., … Sasaguri, S. (2007). Bilirubin oxidation provoked by nitric oxide radicals predicts the progression of acute cardiac allograft rejection. American Journal of Transplantation, 7, 1897-1906. doi: 10.1111/j.1600-6143.2007.01868.x

Kuwabara, M., Kakinuma, Y., Ando, M., Katare, R. G., Yamasaki, F., Doi, Y., & Sato, T. (2006). Nitric oxide stimulates vascular endothelial growth factor production in cardiomyocytes involved in angiogenesis. Journal of Physiological Sciences, 56(1), 95-101. doi: 10.2170/physiolsci.RP002305

Zhang, Y., Kakinuma, Y., Ando, M., Katare, R. G., Yamasaki, F., Sugiura, T., & Sato, T. (2006). Acetylcholine inhibits the hypoxia-induced reduction of connexin43 protein in rat cardiomyocytes. Journal of Pharmacological Sciences, 101, 214-222. doi: 10.1254/jphs. FP0051023

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Journal - Research Other

Lew, J. K. S., Pearson, J. T., Schwenke, D. O., & Katare, R. (2017). Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways. Cardiovascular Diabetology, 16(1), 10. doi: 10.1186/s12933-016-0484-4

Munasinghe, P. E., & Katare, R. (2017). Reply to the letter to editor "Autophagy may be impelled by collected fatty acids in type 2 diabetic myocardial cells". International Journal of Cardiology, 229, 4. doi: 10.1016/j.ijcard.2016.12.007

Ram, T. P., Fomison-Nurse, I., Gandhi, S., Coffey, S., Saxena, P., Galvin, I., Bunton, R., Williams, M. J. A., Lamberts, R. R., & Katare, R. (2017). The diagnostic sensitivity of circulating cardio-enriched microRNAs is increased after normalization of high-density lipoprotein levels [Short communication]. International Journal of Cardiology, 236, 498-500. doi: 10.1016/j.ijcard.2017.01.119

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