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Health Sciences profile

Dr Mihnea Bostina

PositionSenior Lecturer Department of Microbiology and Immunology
DepartmentDepartment of Microbiology and Immunology
QualificationsMSc PhD
Research summaryStructural biology, viral pathogenesis and molecular virology

Research

Our research interests are in understanding molecular architectures and relating those structures to their functional mechanisms. To do this, we are employing cryo-electron microscopy and electron tomography combined with image analysis techniques.

Publications

Abedi, S., Karimi, B., Kazemi, F., Bostina, M., & Vali, H. (2013). Amorphous TiO2 coated into periodic mesoporous organosilicate channels as a new binary photocatalyst for regeneration of carbonyl compounds from oximes under sunlight irradiation. Organic & Biomolecular Chemistry, 11(3), 416-419. doi: 10.1039/c2ob26907d

Schotte, L., Strauss, M., Thys, B., Halewyck, H., Filman, D. J., Bostina, M., … Rombaut, B. (2014). Mechanism of action and capsid-stabilizing properties of VHHs with an in vitro antipolioviral activity. Journal of Virology, 88(8), 4403-4413. doi: 10.1128/JVI.03402-13

Grishin, A. M., Ajamian, E., Tao, L., Bostina, M., Zhang, L., Trempe, J.-F., … Cygler, M. (2013). Family of phenylacetyl-CoA monooxygenases differs in subunit organization from other monooxygenases. Journal of Structural Biology, 184(2), 147-154. doi: 10.1016/j.jsb.2013.09.012

Strauss, M., Levy, H. C., Bostina, M., Filman, D. J., & Hogle, J. M. (2013). RNA transfer from poliovirus 135S particles across membranes is mediated by long umbilical connectors. Journal of Virology, 87(7), 3903-3914. doi: 10.1128/jvi.03209-12

Karimi, B., Behzadnia, H., Bostina, M., & Vali, H. (2012). A nano-fibrillated mesoporous carbon as an effective support for palladium nanoparticles in the aerobic oxidation of alcohols "on pure water". Chemistry: A European Journal, 18(28), 8634-8640. doi: 10.1002/chem.201200373

Chapter in Book - Research

Levy, H., Bostina, M., Filman, D. J., & Hogle, J. M. (2010). Cell entry: A biochemical and structural perspective. In E. Ehrenfeld, E. Domingo & R. P. Roos (Eds.), The Picornaviruses. (pp. 87-104). Washington, DC: ASM Press.

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Journal - Research Article

Kalynych, S., Cherney, M., Bostina, M., Rouiller, I., & Cygler, M. (2015). Quaternary structure of WzzB and WzzE polysaccharide co-polymerases. Protein Science, 24(1), 58-69. doi: 10.1002/pro.2586

Schoderboeck, L., Riad, S., Bokor, A. M., Wicky, H. E., Strauss, M., Bostina, M., Oswald, M. J., Empson, R. M., & Hughes, S. M. (2015). Chimeric rabies SADB19-VSVg-pseudotyped lentiviral vectors mediate long-range retrograde transduction from the mouse spinal cord. Gene Therapy, 22, 357-364. doi: 10.1038/gt.2015.3

Schotte, L., Strauss, M., Thys, B., Halewyck, H., Filman, D. J., Bostina, M., … Rombaut, B. (2014). Mechanism of action and capsid-stabilizing properties of VHHs with an in vitro antipolioviral activity. Journal of Virology, 88(8), 4403-4413. doi: 10.1128/JVI.03402-13

Abedi, S., Karimi, B., Kazemi, F., Bostina, M., & Vali, H. (2013). Amorphous TiO2 coated into periodic mesoporous organosilicate channels as a new binary photocatalyst for regeneration of carbonyl compounds from oximes under sunlight irradiation. Organic & Biomolecular Chemistry, 11(3), 416-419. doi: 10.1039/c2ob26907d

Grishin, A. M., Ajamian, E., Tao, L., Bostina, M., Zhang, L., Trempe, J.-F., … Cygler, M. (2013). Family of phenylacetyl-CoA monooxygenases differs in subunit organization from other monooxygenases. Journal of Structural Biology, 184(2), 147-154. doi: 10.1016/j.jsb.2013.09.012

Strauss, M., Levy, H. C., Bostina, M., Filman, D. J., & Hogle, J. M. (2013). RNA transfer from poliovirus 135S particles across membranes is mediated by long umbilical connectors. Journal of Virology, 87(7), 3903-3914. doi: 10.1128/jvi.03209-12

Kulczyk, A. W., Akabayov, B., Lee, S.-J., Bostina, M., Berkowitz, S. A., & Richardson, C. C. (2012). An interaction between DNA polymerase and helicase is essential for the high processivity of the bacteriophage T7 replisome. Journal of Biological Chemistry, 287(46), 39050-39060. doi: 10.1074/jbc.M112.410647

Karimi, B., Behzadnia, H., Bostina, M., & Vali, H. (2012). A nano-fibrillated mesoporous carbon as an effective support for palladium nanoparticles in the aerobic oxidation of alcohols "on pure water". Chemistry: A European Journal, 18(28), 8634-8640. doi: 10.1002/chem.201200373

Grishin, A. M., Ajamian, E., Zhang, L., Rouiller, I., Bostina, M., & Cygler, M. (2012). Protein-protein interactions in the β-oxidation part of the phenylacetate utilization pathway: Crystal structure of the PaaF-PaaG hydratase-isomerase complex. Journal of Biological Chemistry, 287(45), 37986-37996. doi: 10.1074/jbc.M112.388231

Bostina, M., Levy, H., Filman, D. J., & Hogle, J. M. (2011). Poliovirus RNA is released from the capsid near a twofold symmetry axis. Journal of Virology, 85(2), 776-783. doi: 10.1128/jvi.00531-10

Gopalakrishnan, G., Yam, P. T., Madwar, C., Bostina, M., Rouiller, I., Colman, D. R., & Lennox, R. B. (2011). Label-free visualization of ultrastructural features of artificial synapses via cryo-EM. ACS Chemical Neuroscience, 2(12), 700-704. doi: 10.1021/cn200094j

Levy, H. C., Bostina, M., Filman, D. J., & Hogle, J. M. (2010). Catching a virus in the act of RNA release: A novel poliovirus uncoating intermediate characterized by cryo-electron microscopy. Journal of Virology, 84(9), 4426-4441. doi: 10.1128/jvi.02393-09

Burga, L. N., Tung, N. M., Troyan, S. L., Bostina, M., Konstantinopoulos, P. A., Fountzilas, H., … Wulf, G. M. (2009). Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers. Cancer Research, 69(4), 1273-1278. doi: 10.1158/0008-5472.can-08-2954

Bostina, M., Bubeck, D., Schwartz, C., Nicastro, D., Filman, D. J., & Hogle, J. M. (2007). Single particle cryoelectron tomography characterization of the structure and structural variability of poliovirus-receptor-membrane complex at 30 Å resolution. Journal of Structural Biology, 160(2), 200-210. doi: 10.1016/j.jsb.2007.08.009

Peng, G., Bostina, M., Radermacher, M., Rais, I., Karas, M., & Michel, H. (2006). Biochemical and electron microscopic characterization of the F1F0 ATP synthase from the hyperthermophilic eubacterium Aquifex aeolicus. FEBS Letters, 580(25), 5934-5940. doi: 10.1016/j.febslet.2006.09.062

Raunser, S., Hasse, W., Bostina, M., Parcej, D. N., & Kühlbrandt, W. (2005). High-yield expression, reconstitution and structure of the recombinant, fully functional glutamate transporter GLT-1 from Rattus norvegicus. Journal of Molecular Biology, 351(3), 598-613. doi: 10.1016/j.jmb.2005.06.036

Bostina, M., Mohsin, B., Kühlbrandt, W., & Collinson, I. (2005). Atomic model of the E. coli membrane-bound protein translocation complex SecYEG. Journal of Molecular Biology, 352(5), 1035-1043. doi: 10.1016/j.jmb.2005.08.005

Abdrakhmanova, A., Zickermann, V., Bostina, M., Radermacher, M., Schägger, H., Kerscher, S., & Brandt, U. (2004). Subunit composition of mitochondrial complex I from the yeast Yarrowia lipolytica. Biochimica et Biophysica Acta: Bioenergetics, 1658(1-2), 148-156. doi: 10.1016/j.bbabio.2004.04.019

Zickermann, V., Bostina, M., Hunte, C., Ruiz, T., Radermacher, M., & Brandt, U. (2003). Functional implications from an unexpected position of the 49-kDa subunit of NADH:Ubiquinone oxidoreductase. Journal of Biological Chemistry, 278(31), 29072-29078. doi: 10.1074/jbc.M302713200

Peng, G., Fritzsch, G., Zickermann, V., Schägger, H., Mentele, R., Lottspeich, F., Bostina, M., … Michel, H. (2003). Isolation, characterization and electron microscopic single particle analysis of the NADH:Ubiquinone oxidoreductase (complex I) from the hyperthermophilic eubacterium Aquifex aeolicus. Biochemistry, 42(10), 3032-3039. doi: 10.1021/bi026876v

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