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Health Sciences profile

Professor Alison Heather

PositionProfessor
DepartmentDepartment of Physiology
Research summaryAtherosclerosis

Research

My research focuses on how the sex hormones, estrogen and testosterone, affect non-reproductive tissues in the body. My primary research investigates how these sex hormones promote calcification of atherosclerotic plaques. Atherosclerosis is the major cardiovascular disease and calcification of plaques leads to more ruptures causing heart attacks and strokes. The work performed in my laboratory is aimed at improving the understanding and safety of hormone replacement treatment use.

My research team also develops bioassays for the detection of designer androgens and estrogens that are used as doping agents in sports.

Publications

Cawley, A. T., Blakey, K., Waller, C. C., McLeod, M. D., Boyd, S., Heather, A., … Willis, A. C. (2016). Detection and metabolic investigations of a novel designer steroid: 3-chloro-17α-methyl-5α-androstan-17β-ol. Drug Testing & Analysis, 8(7), 621-632. doi: 10.1002/dta.1832

McGrath, K. C., Li, X. H., Whitworth, P. T., Kasz, R., Tan, J. T., McLennan, S. V., … Heather, A. K. (2014). High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation. Journal of Lipid Research, 55(3), 421-430. doi: 10.1194/jlr.M043281

Brown, B. E., Kim, C. H. J., Torpy, F. R., Bursill, C. A., McRobb, L. S., Heather, A. K., … van Reyk, D. M. (2014). Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E-/- mice. Atherosclerosis, 232(2), 403-409. doi: 10.1016/j.atherosclerosis.2013.11.068

Lim, H. Y., Chiam, C. H., Yeo, K. P., Bisoendial, R., Hii, C. S., McGrath, K. C. Y., … Heather, A., … Angeli, V. (2013). Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-Mediated transport of HDL. Cell Metabolism, 17(5), 671-684. doi: 10.1016/j.cmet.2013.04.002

Akram, O. N., Bursill, C., Desai, R., Heather, A. K., Kaslzuskas, R., Handelsman, D. J., & Lambert, G. (2011). Evaluation of androgenic activity of nutraceutical-derived steroids using mammalian and yeast in vitro androgen bioassays. Analytical Chemistry, 83(6), 2065-2074. doi: 10.1021/ac102845y

Journal - Research Article

Cawley, A. T., Blakey, K., Waller, C. C., McLeod, M. D., Boyd, S., Heather, A., … Willis, A. C. (2016). Detection and metabolic investigations of a novel designer steroid: 3-chloro-17α-methyl-5α-androstan-17β-ol. Drug Testing & Analysis, 8(7), 621-632. doi: 10.1002/dta.1832

McGrath, K. C., Li, X. H., Whitworth, P. T., Kasz, R., Tan, J. T., McLennan, S. V., … Heather, A. K. (2014). High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation. Journal of Lipid Research, 55(3), 421-430. doi: 10.1194/jlr.M043281

Brown, B. E., Kim, C. H. J., Torpy, F. R., Bursill, C. A., McRobb, L. S., Heather, A. K., … van Reyk, D. M. (2014). Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E-/- mice. Atherosclerosis, 232(2), 403-409. doi: 10.1016/j.atherosclerosis.2013.11.068

Lim, H. Y., Chiam, C. H., Yeo, K. P., Bisoendial, R., Hii, C. S., McGrath, K. C. Y., … Heather, A., … Angeli, V. (2013). Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-Mediated transport of HDL. Cell Metabolism, 17(5), 671-684. doi: 10.1016/j.cmet.2013.04.002

Akram, O. N., Bursill, C., Desai, R., Heather, A. K., Kaslzuskas, R., Handelsman, D. J., & Lambert, G. (2011). Evaluation of androgenic activity of nutraceutical-derived steroids using mammalian and yeast in vitro androgen bioassays. Analytical Chemistry, 83(6), 2065-2074. doi: 10.1021/ac102845y

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