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Health Sciences profile

Dr David Chyou

PositionResearch Assistant
QualificationsBAppSc PhD(Otago)
Research summaryPharmacoepidemiological study using population-level data

Research

My research looks at drug usage, de-prescription and prevalence of polypharmacy in older people with limited life expectancy. In New Zealand, the population is aging. By 2061, people aged 65 years and older will comprise 22–30% of the total population. While older people are more susceptible to adverse drug reactions than young adults, as the population ages, controlling for drug prescription and polypharmacy in older people becomes increasingly important. Research was conducted by statistical analyses based on real-world prescription data from NZ's healthcare databases. With a PhD degree in mathematics, my research also looks at statistical methods and mathematical algorithms that aid to healthcare data analysis.

Publications

Nishtala, P. S., & Chyou, T.-y. (2017). Exploring New Zealand prescription data using sequence symmetry analyses for predicting adverse drug reactions. Journal of Clinical Pharmacy & Therapeutics, 42(2), 189-194. doi: 10.1111/jcpt.12491

Nishtala, P. S., & Chyou, T.-y. (2017). Zopiclone use and risk of fractures in older people: Population-based study. Journal of the American Medical Directors Association. Advance online publication. doi: 10.1016/j.jamda.2016.12.085

Nishtala, P. S., & Chyou, T.-y. (2017). Real-world risk of diabetes with antipsychotic use in older New Zealanders: A case-crossover study. European Journal of Clinical Pharmacology, 73(2), 233-239. doi: 10.1007/s00228-016-2158-2

Nishtala, P. S., Ndukwe, H. C., Chyou, T.-y., Salahudeen, M. S., & Narayan, S. W. (2017). An overview of pharmacoepidemiology in New Zealand: Medical databases, registries and research achievements. New Zealand Medical Journal, 130(1449), 52-61. Retrieved from https://www.nzma.org.nz/journal

Nishtala, P. S., Gnjidic, D., Chyou, T., & Hilmer, S. N. (2016). Discontinuation of statins in a population of older New Zealanders with limited life expectancy. Internal Medicine Journal, 46(4), 493-496. doi: 10.1111/imj.13024

Journal - Research Article

Nishtala, P. S., & Chyou, T.-y. (2017). Exploring New Zealand prescription data using sequence symmetry analyses for predicting adverse drug reactions. Journal of Clinical Pharmacy & Therapeutics, 42(2), 189-194. doi: 10.1111/jcpt.12491

Nishtala, P. S., & Chyou, T.-y. (2017). Real-world risk of diabetes with antipsychotic use in older New Zealanders: A case-crossover study. European Journal of Clinical Pharmacology, 73(2), 233-239. doi: 10.1007/s00228-016-2158-2

Nishtala, P. S., & Chyou, T.-y. (2017). Zopiclone use and risk of fractures in older people: Population-based study. Journal of the American Medical Directors Association. Advance online publication. doi: 10.1016/j.jamda.2016.12.085

Nishtala, P. S., Gnjidic, D., Chyou, T., & Hilmer, S. N. (2016). Discontinuation of statins in a population of older New Zealanders with limited life expectancy. Internal Medicine Journal, 46(4), 493-496. doi: 10.1111/imj.13024

Salahudeen, M. S., Chyou, T.-y., & Nishtala, P. S. (2016). Serum anticholinergic activity and cognitive and functional adverse outcomes in older people: A systematic review and meta-analysis of the literature. PLoS ONE, 11(3), e0151084. doi: 10.1371/journal.pone.0151084

Chyou, T., Liddell, G. F., & Paulin, M. G. (2011). An upper-body can improve the stability and efficiency of passive dynamic walking. Journal of Theoretical Biology, 285(1), 126-135. doi: 10.1016/j.jtbi.2011.06.032

Chyou, D. T., Rawle, V. L., & Trotman, C. N. A. (2007). Quaternary structure of Artemia haemoglobin II: Analysis of T and C polymer alignment and interpolymer interface. BMC Structural Biology, 7, 26. doi: 10.1186/1472-6807-7-26

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Journal - Research Other

Nishtala, P. S., Ndukwe, H. C., Chyou, T.-y., Salahudeen, M. S., & Narayan, S. W. (2017). An overview of pharmacoepidemiology in New Zealand: Medical databases, registries and research achievements. New Zealand Medical Journal, 130(1449), 52-61. Retrieved from https://www.nzma.org.nz/journal

More publications...