Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Health Sciences profile

Professor Richard Cannon

PositionProfessor and Director SJWRI
DepartmentDepartment of Oral Sciences
QualificationsBA PhD(Cantab)
Research summaryOral microbiology and antifungal drug resistance

Research

Professor Cannon is a molecular microbiologist interested in how microorganisms cause oral diseases and in how treatments for patients with these diseases can be improved. His research has a number of themes, one being oral adhesion. He is interested in how oral microbes, particularly yeast, adhere and colonize surfaces in the oral cavity.

He has found that saliva increases the adhesion of the yeast Candida albicans to several oral surfaces, including denture acrylics and voice prosthesis silicone. Interestingly, saliva reduced the adhesion of Staphylococcus epidermidis to the same surfaces. C. albicans is a diploid yeast that was, until recently, thought to be asexual. The yeast can, however, undergo sexual recombination in vitro, and Professor Cannon is currently investigating whether C. albicans strains can mate in the oral cavity and if so, whether the offspring can out-compete their parents.

C. albicans is a polymorphic fungus that grows mainly as yeast or mycelia. Professor Cannon is using metabolomics to investigate the changes in metabolism that are associated with the change from yeast to hyphal growth. A major focus of his research is the drug resistance of human fungal pathogens. He has found that clinically significant fungal drug resistance is due to energy-dependent drug efflux from the cell. His research group has developed a unique system for expressing and studying these efflux pumps in baker's yeast Saccharomyces cerevisiae.

They are currently using S. cerevisiae strains expressing fungal efflux pumps to study pump function and to search for pump inhibitors. Professor Cannon is also using the S. cerevisiae expression system to investigate the resistance of sheep intestinal nematodes to antihelmintics.

Publications

Cannon, R. D., Lyons, K. M., Chong, K., Newsham-West, K., Niimi, K., & Holmes, A. R. (2017). Adhesion of yeast and bacteria to oral surfaces. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 165-190). New York, NY: Springer. doi: 10.1007/978-1-4939-6685-1_10

Lamping, E., Zhu, J.-y., Niimi, M., & Cannon, R. D. (2017). Role of ectopic gene conversion in the evolution of a Candida krusei pleiotropic drug resistance transporter family. Genetics, 205(4), 1619-1639. doi: 10.1534/genetics.116.194811

Weerasekera, M. M., Sissons, C. H., Wong, L., Anderson, S. A., & Cannon, R. D. (2017). Denaturant gradient gel electrophoresis profiles of bacteria from the saliva of twenty four different individuals form clusters that showed no relationship to the yeasts present. Archives of Oral Biology, 82, 6-10. doi: 10.1016/j.archoralbio.2017.05.014

Meredith, L., Farella, M., Lowrey, S., Cannon, R. D., & Mei, L. (2017). Atomic force microscopy analysis of enamel nanotopography after interproximal reduction. American Journal of Orthodontics & Dentofacial Orthopedics, 151(4), 750-757. doi: 10.1016/j.ajodo.2016.09.021

Schmid, J., Magee, P. T., Holland, B. R., Zhang, N., Cannon, R. D., & Magee, B. B. (2016). Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans. Current Genetics, 62(1), 81-85. doi: 10.1007/s00294-015-0516-8

Chapter in Book - Research

Cannon, R. D., Lyons, K. M., Chong, K., Newsham-West, K., Niimi, K., & Holmes, A. R. (2017). Adhesion of yeast and bacteria to oral surfaces. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 165-190). New York, NY: Springer. doi: 10.1007/978-1-4939-6685-1_10

Monk, B. C., Niimi, K., Holmes, A. R., Strouse, J. J., Sklar, L. A., & Cannon, R. D. (2012). Fungal efflux-mediated resistance: From targets to inhibitors. In G. Tegos & E. Mylonakis (Eds.), Antimicrobial drug discovery: Emerging strategies. (pp. 77-88). Oxford, UK: CABI.

Lamping, E., & Cannon, R. D. (2010). Use of a yeast-based membrane protein expression technology to overexpress drug resistance efflux pumps. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology. (pp. 219-250). New York: Springer. doi: 10.1007/978-1-60761-820-1_15

Cannon, R. D., Lyons, K. M., Chong, K., & Holmes, A. R. (2010). Adhesion of yeast and bacteria to oral surfaces. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology. (pp. 103-124). New York: Springer. doi: 10.1007/978-1-60761-820-1_8

Niimi, M., Cannon, R. D., & Monk, B. C. (2001). Candida albicans pathology: A proteomic perspective. In M. J. Dunn (Ed.), Proteomics Reviews 2001. (pp. 28-37). Weinheim, Germany: Wiley-VCH.

Cannon, R. D., Albertson, G. D., Niimi, M., & Jenkinson, H. F. A. (1996). Fluconazole uptake and resistance in Candida. In K. Tanaka, H. Yamaguchi & P. T. Magee (Eds.), Genes and Genomes in Medically Important Fungi. (pp. 157-165). Foundation for Advancement of International Scienc.

^ Top of page

Chapter in Book - Other

Cannon, R. D., & Firth, N. A. (2013). Fungi and fungal infections of the oral cavity. In R. J. Lamont, G. N. Hajishengallis & H. F. Jenkinson (Eds.), Oral microbiology and immunology. (2nd ed.) (pp. 343-360). Washington, DC: ASM Press. doi: 10.1128/9781555818906.ch17

Cannon, R. D., & Firth, N. A. (2006). Fungi and fungal infections of the oral cavity. In R. J. Lamont, R. A. Burne, M. S. Lantz & D. J. LeBlanc (Eds.), Oral microbiology and immunology. (pp. 333-348). Washington, DC: American Society for Microbiology.

^ Top of page

Journal - Research Article

Lamping, E., Zhu, J.-y., Niimi, M., & Cannon, R. D. (2017). Role of ectopic gene conversion in the evolution of a Candida krusei pleiotropic drug resistance transporter family. Genetics, 205(4), 1619-1639. doi: 10.1534/genetics.116.194811

Meredith, L., Farella, M., Lowrey, S., Cannon, R. D., & Mei, L. (2017). Atomic force microscopy analysis of enamel nanotopography after interproximal reduction. American Journal of Orthodontics & Dentofacial Orthopedics, 151(4), 750-757. doi: 10.1016/j.ajodo.2016.09.021

Weerasekera, M. M., Sissons, C. H., Wong, L., Anderson, S. A., & Cannon, R. D. (2017). Denaturant gradient gel electrophoresis profiles of bacteria from the saliva of twenty four different individuals form clusters that showed no relationship to the yeasts present. Archives of Oral Biology, 82, 6-10. doi: 10.1016/j.archoralbio.2017.05.014

Schmid, J., Magee, P. T., Holland, B. R., Zhang, N., Cannon, R. D., & Magee, B. B. (2016). Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans. Current Genetics, 62(1), 81-85. doi: 10.1007/s00294-015-0516-8

Panapruksachat, S., Iwatani, S., Oura, T., Vanittanakom, N., Chindamporn, A., Niimi, K., Niimi, M., Lamping, E., Cannon, R. D., & Kajiwara, S. (2016). Identification and functional characterization of Penicillium marneffei pleiotropic drug resistance transporters ABC1 and ABC2. Medical Mycology, 54, 478-491. doi: 10.1093/mmy/myv117

Farella, M., Loke, C., Sander, S., Songini, A., Allen, M., Mei, L., & Cannon, R. D. (2016). Simultaneous wireless assessment of intra-oral pH and temperature. Journal of Dentistry, 51, 49-55. doi: 10.1016/j.jdent.2016.05.012

Rawal, M. K., Banerjee, A., Shah, A. H., Khan, M. F., Sen, S., Saxena, A. K., Monk, B. C., Cannon, R. D., … Prasad, R. (2016). Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric. Scientific Reports, 6, 27132. doi: 10.1038/srep27132

Tong, Y., Liu, M., Zhang, Y., Liu, X., Huang, R., Song, F., … Cannon, R. D., … Zhang, L. (2016). Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. Synthetic and Systems Biotechnology, 1(3), 158-168. doi: 10.1016/j.synbio.2016.10.001

van der Wielen, P. A., Holmes, A. R., & Cannon, R. D. (2016). Secretory component mediates Candida albicans binding to epithelial cells. Oral Diseases, 22(1), 69-74. doi: 10.1111/odi.12397

Holmes, A. R., Cardno, T. S., Strouse, J. J., Ivnitski-Steele, I., Keniya, M. V., Lackovic, K., Monk, B. C., … Cannon, R. D. (2016). Targeting efflux pumps to overcome antifungal drug resistance. Future Medicinal Chemistry, 8(12), 1485-1501. doi: 10.4155/fmc-2016-0050

Choo, K. H., Lee, H. J., Knight, N. J., Holmes, A. R., & Cannon, R. D. (2016). Multilocus sequence typing (MLST) analysis of Candida albicans isolates colonizing acrylic dentures before and after denture replacement. Medical Mycology. Advance online publication. doi: 10.1093/mmy/myw128

Watanasrisin, W., Iwatani, S., Oura, T., Tomita, Y., Ikushima, S., Chindamporn, A., Niimi, M., Niimi, K., Lamping, E., Cannon, R. D., & Kajiwara, S. (2016). Identification and characterization of Candida utilis multidrug efflux transporter CuCdr1p. FEMS Yeast Research, 16, fow042. doi: 10.1093/femsyr/fow042

Bennani, V., Hwang, L., Tawse-Smith, A., Dias, G. J., & Cannon, R. D. (2015). Effect of air-polishing on titanium surfaces, biofilm removal, and biocompatibility: A pilot study. BioMed Research International, 2015, 491047. doi: 10.1155/2015/491047

Bakri, M. M., Rich, A. M., Cannon, R. D., & Holmes, A. R. (2015). In vitro expression of Candida albicans alcohol dehydrogenase genes involved in acetaldehyde metabolism. Molecular Oral Microbiology, 30(1), 27-38. doi: 10.1111/omi.12064

Zhang, N., Magee, B. B., Magee, P. T., Holland, B. R., Rodrigues, E., Holmes, A. R., Cannon, R. D., & Schmid, J. (2015). Selective advantages of a parasexual cycle for the yeast Candida albicans. Genetics, 200(4), 1117-1132. doi: 10.1534/genetics.115.177170

Keniya, M. V., Fleischer, E., Klinger, A., Cannon, R. D., & Monk, B. C. (2015). Inhibitors of the Candida albicans Major Facilitator Superfamily transporter Mdr1p responsible for fluconazole resistance. PLoS ONE, e0126350. doi: 10.1371/journal.pone.0126350

Cannon, R. D., & Holmes, A. R. (2015). Learning the ABC of oral fungal drug resistance [Invited review]. Molecular Oral Microbiology, 30(6), 425-437. doi: 10.1111/omi.12109

Yuan, H., Li, J., Chen, L., Cheng, L., Cannon, R. D., & Mei, L. (2014). Esthetic comparison of white-spot lesion treatment modalities using spectrometry and fluorescence. Angle Orthodontist, 84(2), 343-349. doi: 10.2319/032113-232.1

Holmes, A. R., Rodrigues, E., van der Wielen, P., Lyons, K. M., Haigh, B. J., Wheeler, T. T., Dawes, P. J. D., & Cannon, R. D. (2014). Adherence of Candida albicans to silicone is promoted by the human salivary protein SPLUNC2/PSP/BPIFA2. Molecular Oral Microbiology, 29(2), 90-98. doi: 10.1111/mom.12048

Monk, B. C., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., O'Connell, III, J. D., Cannon, R. D., … Stroud, R. M. (2014). Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. PNAS, 111(10), 3865-3870. doi: 10.1073/pnas.1324245111

Bakri, M. M., Cannon, R. D., Holmes, A. R., & Rich, A. M. (2014). Detection of Candida albicans ADH1 and ADH2 mRNAs in human archival oral biopsy samples. Journal of Oral Pathology & Medicine, 43(9), 704-710. doi: 10.1111/jop.12193

Pei, Z., Wang, B., Zhang, F., Niu, Z., Shi, S., Cannon, R. D., & Mei, L. (2014). Response of human periodontal ligament cells to baicalin. Journal of Periodontology, 85(9), 1283-1290. doi: 10.1902/jop.2014.130635

Keniya, M. V., Holmes, A. R., Niimi, M., Lamping, E., Gillet, J.-P., Gottesman, M. M., & Cannon, R. D. (2014). Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. Molecular Pharmaceutics, 11(10), 3452-3462. doi: 10.1021/mp500230b

Inger, M., Bennani, V., Farella, M., Bennani, F., & Cannon, R. D. (2014). Efficacy of air/water syringe tip sterilization. Australian Dental Journal, 59(1), 87-92. doi: 10.1111/adj.12146

Weerasekera, M. M., Sissons, C. H., Wong, L., Anderson, S., Holmes, A. R., & Cannon, R. D. (2013). Use of denaturing gradient gel electrophoresis for the identification of mixed oral yeasts in human saliva. Journal of Medical Microbiology, 62, 319-330. doi: 10.1099/jmm.0.050237-0

Rawal, M. K., Khan, M. F., Kapoor, K., Goyal, N., Sen, S., Saxena, A. K., … Tyndall, J. D. A., Monk, B. C., Cannon, R. D., … Prasad, R. (2013). Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains. Journal of Biological Chemistry, 288(34), 24480-24493. doi: 10.1074/jbc.M113.488353

Lamping, E., Niimi, M., & Cannon, R. D. (2013). Small, synthetic, GC-rich mRNA stem-loop modules 5' proximal to the AUG start-codon predictably tune gene expression in yeast. Microbial Cell Factories, 12, 74. doi: 10.1186/1475-2859-12-74

Keniya, M. V., Cannon, R. D., Nguyễn, Ấ., Tyndall, J. D. A., & Monk, B. C. (2013). Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae. FEMS Yeast Research, 13(3), 302-311. doi: 10.1111/1567-1364.12035

Han, T.-L., Tumanov, S., Cannon, R. D., & Villas-Boas, S. G. (2013). Metabolic response of Candida albicans to phenylethyl alcohol under hyphae-inducing conditions. PLoS ONE, 8(8), e71364. doi: 10.1371/journal.pone.0071364

Niimi, K., Woods, M. A., Maki, K., Nakayama, H., Hatakenaka, K., Chibana, H., … Niimi, M., Cannon, R. D., & Monk, B. C. (2012). Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression. Journal of Antimicrobial Chemotherapy, 67(7), 1666-1676. doi: 10.1093/jac/dks112

Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G. (2012). Metabolome analysis during the morphological transition of Candida albicans. Metabolomics, 8(6), 1204-1217. doi: 10.1007/s11306-012-0416-6

Hayama, K., Ishibashi, H., Ishijima, S. A., Niimi, K., Tansho, S., Ono, Y., Monk, B. C., Holmes, A. R., … Cannon, R. D., & Abe, S. (2012). A D-octapeptide drug efflux pump inhibitor acts synergistically with azoles in a murine oral candidiasis infection model. FEMS Microbiology Letters, 328(2), 130-137. doi: 10.1111/j.1574-6968.2011.02490.x

Niimi, K., Harding, D. R. K., Holmes, A. R., Lamping, E., Niimi, M., Tyndall, J. D. A., Cannon, R. D., & Monk, B. C. (2012). Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor. Molecular Microbiology, 85(4), 747-767. doi: 10.1111/j.1365-2958.2012.08140.x

Ishijima, S. A., Hayama, K., Takahashi, M., Holmes, A. R., Cannon, R. D., & Abe, S. (2012). N-acetylglucosamine increases symptoms and fungal burden in a murine model of oral candidiasis. Medical Mycology, 50(3), 252-258. doi: 10.3109/13693786.2011.598194

Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G. (2012). The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions. FEMS Yeast Research, 12(8), 879-889. doi: 10.1111/j.1567-1364.2012.00837.x

Holmes, A. R., Chong, K., Rodrigues, E., Cannon, R. D., Carpenter, E., Ruske, D. R., & Dawes, P. J. D. (2012). Yeast colonization of voice prostheses: Pilot study investigating effect of a bovine milk product containing anti-Candida albicans immunoglobulin A antibodies on yeast colonization and valve leakage. Annals of Otology, Rhinology & Laryngology, 121(1), 61-66.

Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G. (2011). The metabolic basis of Candida albicans morphogenesis and quorum sensing. Fungal Genetics & Biology, 48(8), 747-763. doi: 10.1016/j.fgb.2011.04.002

Tanabe, K., Lamping, E., Nagi, M., Okawada, A., Holmes, A. R., Miyazaki, Y., Cannon, R. D., Monk, B. C., & Niimi, M. (2011). Chimeras of Candida albicans Cdr1p and Cdr2p reveal features of pleiotropic drug resistance transporter structure and function. Molecular Microbiology, 82(2), 416-433. doi: 10.1111/j.1365-2958.2011.07820.x

Holmes, A. R., Keniya, M. V., Ivnitski-Steele, I., Monk, B. C., Lamping, E., Sklar, L. A., & Cannon, R. D. (2011). The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. Antimicrobial Agents & Chemotherapy, 56(3), 1508-1515. doi: 10.1128/aac.05706-11

Niimi, K., Monk, B. C., Hirai, A., Hatakenaka, K., Umeyama, T., Lamping, E., … Cannon, R. D., & Niimi, M. (2010). Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthase catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity. Journal of Antimicrobial Chemotherapy, 65, 842-852. doi: 10.1093/jac/dkq073

Zhang, N., Cannon, R. D., Holland, B. R., Patchett, M. L., & Schmid, J. (2010). Impact of genetic background on allele selection in a highly mutable Candida albicans gene, PNG2. PLoS ONE, 5(3), e9614. doi: 10.1371/journal.pone.0009614

Mohd Bakri, M., Hussaini, H. M., Holmes, A. R., Cannon, R. D., & Rich, A. M. (2010). Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma. Journal of Oral Microbiology, 2, 5780. doi: 10.3402/jom.v2i0.5780

Lamping, E., Baret, P. V., Holmes, A. R., Monk, B. C., Goffeau, A., & Cannon, R. D. (2010). Fungal PDR transporters: Phylogeny, topology, motifs and function. Fungal Genetics & Biology, 47(2), 127-142. doi: 10.1016/j.fgb.2009.10.007

Niimi, M., Firth, N. A., & Cannon, R. D. (2010). Antifungal drug resistance of oral fungi. Odontology, 98(1), 15-25. doi: 10.1007/s10266-009-0118-3

Zhang, N., Upritchard, J. E., Holland, B. R., Fenton, L. E., Ferguson, M. M., Cannon, R. D., & Schmid, J. (2009). Distribution of mutations distinguishing the most prevalent disease-causing Candida albicans genotype from other genotypes. Infection, Genetics & Evolution, 9(4), 493-500. doi: 10.1016/j.meegid.2009.01.007

Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J. D. A., Niimi, K., Holmes, A. R., Niimi, M., & Cannon, R. D. (2009). Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrobial Agents & Chemotherapy, 53(2), 354-369. doi: 10.1128/AAC.01095-08

Ivnitski-Steele, I., Holmes, A. R., Lamping, E., Monk, B. C., Cannon, R. D., & Sklar, L. A. (2009). Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p. Analytical Biochemistry, 394(1), 87-91. doi: 10.1016/j.ab.2009.07.001

Rodrigues, E., Chong, K., Holmes, A. R., Cannon, R. D., Ruske, D. R., & Dawes, P. J. D. (2009). An in-vitro device for the assessment of biofilm mediated voice prosthesis damage: How we do it [Letter to the editor]. Clinical Otolaryngology, 34(5), 481-484. doi: 10.1111/j.1749-4486.2009.01996.x

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., … Niimi, M., … Monk, B. C. (2009). Efflux-mediated antifungal drug resistance. Clinical Microbiology Reviews, 22(2), 291-321. doi: 10.1128/cmr.00051-08

Deng, D., Lauren, D. R., Cooney, J. M., Jensen, D. J., Wurms, K. V., Upritchard, J. E., Cannon, R. D., … Li, M. Z. (2008). Antifungal saponins from Paris polyphylla Smith. Planta Medica, 74(11), 1397-1402. doi: 10.1055/s-2008-1081345

Holmes, A. R., Lin, Y.-H., Niimi, K., Lamping, E., Keniya, M., Niimi, M., … Monk, B. C., & Cannon, R. D. (2008). ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates. Antimicrobial Agents & Chemotherapy, 52(11), 3851-3862. doi: 10.1128/AAC.00463-08

Cannon, R. (2007). The Sir John Walsh Research Institute: A national institute for oral health research in New Zealand. New Zealand Dental Journal, 103(1), 17.

Lamping, E., Monk, B. C., Niimi, K., Holmes, A. R., Tsao, S., Tanabe, K., Niimi, M., … Cannon, R. D. (2007). Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae. Eukaryotic Cell, 6(7), 1150-1165.

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Tanabe, K., & Monk, B. C. (2007). Candida albicans drug resistance: Another way to cope with stress. Microbiology, 153, 3211-3217.

Hodgkinson, A. J., Cannon, R. D., Holmes, A. R., Fischer, F. J., & Willix-Payne, D. J. (2007). Production from dairy cows of semi-industrial quantities of milk-protein concentrate (MPC) containing efficacious anti-Candida albicans IgA antibodies. Journal of Dairy Research, 74, 269-275.

Niimi, K., Maki, K., Ikeda, F., Holmes, A. R., Lamping, E., Niimi, M., Monk, B. C., & Cannon, R. D. (2006). Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility. Antimicrobial Agents & Chemotherapy, 50(4), 1148-1155.

Holmes, A. R., Tsao, S., Ong, S.-W., Lamping, E., Niimi, K., Monk, B. C., Niimi, M., … Cannon, R. D. (2006). Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2. Molecular Microbiology, 62(1), 170-186.

Holmes, A. R., van der Wielen, P., Cannon, R. D., Ruske, D., & Dawes, P. (2006). Candida albicans binds to saliva proteins selectively adsorbed to silicone. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodontology, 102(4), 488-494.

Monk, B. C., Niimi, K., Lin, S., Knight, A., Kardos, T. B., Cannon, R. D., … Harding, D. R. K. (2005). Surface-active fungicidal D-peptide inhibitors of the plasma membrane proton pump that block azole resistance. Antimicrobial Agents & Chemotherapy, 49(1), 57-70. doi: 10.1128/AAC.49.1.57-70.2005

Niimi, M., Wada, S.-I., Tanabe, K., Kaneko, A., Takano, Y., Umeyama, T., … Lamping, E., Niimi, K., Tsao, S., Holmes, A. R., Monk, B. C., & Cannon, R. D. (2005). Functional analysis of fungal drug efflux transporters by heterologous expression in Saccharomyces cerevisiae. Japanese Journal of Infectious Diseases, 58, 1-7.

Wada, S.-I., Tanabe, K., Yamazaki, A., Niimi, M., Uehara, Y., Niimi, K., Lamping, E., Cannon, R. D., & Monk, B. C. (2005). Phosphorylation of Candida glabrata ATP-binding cassette transporter Cdr1p regulates drug efflux activity and ATPase stability. Journal of Biological Chemistry, 280(1), 94-103.

Jeng, H.-W., Holmes, A. R., & Cannon, R. D. (2005). Characterization of two Candida albicans surface mannoprotein adhesins that bind immobilized saliva components. Medical Mycology, 43, 209-217.

Niimi, M., Tanabe, K., Wada, S.-I., Yamazaki, A., Uehara, Y., Niimi, K., Lamping, E., Holmes, A. R., Monk, B. C., & Cannon, R. D. (2005). ABC transporters of pathogenic fungi: Recent advances in functional analyses. Japanese Journal of Medical Mycology / Nippon Ishinkin Gakkai Zasshi, 46(4), 249-260.

Lamping, E., Tanabe, K., Niimi, M., Uehara, Y., Monk, B. C., & Cannon, R. D. (2005). Characterization of the Saccharomyces cerevisiae sec6-41 mutation and tools to create S. cerevisiae strains containing the sec6-4 allele. Gene, 361, 57-66.

Schmid, J., Cannon, R. D., & Holland, B. (2004). A futile act? Thoughts on the reproductive biology of Candida albicans. Mycologist, 18, 158-163.

Niimi, K., Harding, D. R. K., Parshot, R., King, A., Lun, D. J., Decottignies, A., Niimi, M., … Cannon, R. D., … Monk, B. C. (2004). Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative. Antimicrobial Agents & Chemotherapy, 48(4), 1256-1271.

Beggs, K. T., Holmes, A. R., Cannon, R. D., & Rich, A. M. (2004). Detection of Candida albicans mRNA in archival histopathology samples by reverse transcription-PCR. Journal of Clinical Microbiology, 42(5), 2275-2278.

Niimi, M., Niimi, K., Takano, Y., Holmes, A. R., Fischer, F. J., Uehara, Y., & Cannon, R. D. (2004). Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance. Journal of Antimicrobial Chemotherapy, 54(6), 999-1006.

Zhang, N., Harrex, A. L., Holland, B. R., Fenton, L. E., Cannon, R. D., & Schmid, J. (2003). Sixty alleles of the ALS7 open reading frame in Candida albicans: ALS7 Is a hypermutable contingency locus. Genome Research, 13, 2005-2017.

Monk, B. C., & Cannon, R. D. (2002). Genomic pathways to antifungal discovery. Current Drug Targets: Infectious Disorders, 2, 309-329.

Wada, S., Niimi, M., Niimi, K., Holmes, A. R., Monk, B. C., Cannon, R. D., & Uehara, Y. (2002). Candida glabrata ATP-binding cassette transporters Cdr1p and Pdh1p expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping properties. Journal of Biological Chemistry, 277, 46809-46821.

Niimi, M., Nagai, Y., Niimi, K., Wada, S.-I., Cannon, R. D., Uehara, Y., & Monk, B. C. (2002). Identification of two proteins induced by exposure of the pathogenic fungus Candida glabrata to fluconazole. Journal of Chromatography B, 782, 245-252.

Holmes, A. R., Bandara, M. K., & Cannon, R. D. (2002). Saliva promotes Candida albicans adherence to human epithelial cells. Journal of Dental Research, 81, 28-32.

Holmes, A. R., Niimi, M., Girgis, J. M., Boyd, D. H., & Cannon, R. D. (2002). Antifungal drug susceptibilities of commensal Candida isolates. New Zealand Dental Journal, 98, 36-49.

Niimi, K., Shepherd, M. G., & Cannon, R. D. (2001). Distinguishing Candida species by β-N-acetylhexosaminidase activity. Journal of Clinical Microbiology, 39, 2089-2097.

Maebashi, K., Niimi, M., Kudoh, M., Fischer, F. J., Makimura, K., Niimi, K., Piper, R. J., … Cannon, R. D., & Yamaguchi, H. (2001). Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients. Journal of Antimicrobial Chemotherapy, 47, 527-536.

Cannon, R. D., & Chaffin, W. L. (2001). Colonization is a crucial factor in oral candidiasis. Journal of Dental Education, 65, 785-787.

Nakamura, K., Niimi, M., Niimi, K., Holmes, A. R., Yates, J. E., Decottignies, A., Monk, B. C., … Cannon, R. D. (2001). Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters. Antimicrobial Agents & Chemotherapy, 45, 3366-3374.

Niimi, K., Niimi, M., Shepherd, M. G., & Cannon, R. D. (2000). N-Acetylhexosaminidase of the pathogenic yeast Candida albicans. Recent Research Development in Microbiology, 4, 85-100.

O'Sullivan, J. M., Jenkinson, H. F., & Cannon, R. D. (2000). Adhesion of Candida albicans to oral streptococci is promoted by selective adsorbtion of salivary proteins to the streptococcal cell surface. Microbiology, 146, 41-48.

Calderone, R., Suzuki, S., Cannon, R., Cho, T., Boyd, D., Calera, J., … Holmes, A., Jeng, H.-W., … O'Sullivan, J. M., … Tompkins, G. R., & Watanabe, T. (2000). Candida albicans: Adherence, signalling and virulence. Medical Mycology, 38(Suppl. 1), 125-137.

Niimi, M., Niimi, K., & Cannon, R. D. (1999). Drug resistance mechanisms in opportunistic fungal pathogens. Dental Outlook, 93, 1368-1376.

Perepnikhatka, V., Fischer, F. J., Niimi, M., Baker, R. A., Cannon, R. D., Wang, Y.-K., … Rustchenko, E. (1999). Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans. Journal of Bacteriology, 181, 4041-4049.

Niimi, M., Cannon, R. D., & Monk, B. C. (1999). Candida albicans pathogenicity: A proteomic perspective. Electrophoresis, 20, 2299-2308.

Schmid, J., Herd, S., Hunter, P. R., Cannon, R. D., Yasin, M. S. M., Samad, S., … Schousboe, M., … Singh, K. P. (1999). Evidence for a general-purpose genotype in Candida albicans, highly prevalent in multiple geographical regions, patient types and types of infection. Microbiology, 145, 2405-2413.

Cannon, R. D., & Chaffin, W. L. (1999). Oral colonization by Candida albicans. Critical Reviews in Oral Biology & Medicine, (10), 359-383.

Cannon, R. D., Fischer, F. J., Niimi, K., Niimi, M., & Arisawa, M. (1998). Drug pumping mechanisms in Candida albicans. Japanese Journal of Medical Mycology / Nippon Ishinkin Gakkai Zasshi, 39, 73-78.

Niimi, K., Shepherd, M. G., & Cannon, R. D. (1998). Candida albicans HEX1 gene, a reporter of gene expression in Saccharomyces cerevisiae. Archives of Microbiology, 170, 113-119.

Niimi, M., Cannon, R. D., & Arisawa, M. (1997). Multidrug resistance genes in Candida albicans. Japanese Journal of Medical Mycology / Nippon Ishinkin Gakkai Zasshi, 38, 297-302.

O'Sullivan, J. M., Cannon, R. D., Sullivan, P. A., & Jenkinson, H. F. (1997). Identification of salivary basic proline-rich proteins as receptors for Candida albicans adhesion. Microbiology, 143, 341-348.

Mirbod, F., Nakashima, S., Kitajima, Y., Cannon, R. D., & Nozawa, Y. (1997). Molecular cloning of a Rho family, CDC42Ca gene from Candida albicans and its mRNA expression changes during morphogenesis. Journal of Medical & Veterinary Mycology, 35, 173-179.

Niimi, M., Niimi, K., & Cannon, R. D. (1997). Temperature-related expression of the vacuolar aspartic proteinase (APR1) gene and Beta-N-acetylglucosaminidase (HEX1) gene during Candida albicans morphogenesis. FEMS Microbiology Letters, 148, 247-254.

More publications...